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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cflar
Name: CASP8 and FADD-like apoptosis regulator
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cflardecreases expressionISOCFLAR (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of CFLAR mRNA; Arsenic Trioxide results in decreased expression of CFLAR protein; Arsenic Trioxide results in decreased expression of CFLAR protein alternative formPMID:16105982 PMID:16174796 PMID:16434995
Cflardecreases response to substanceISOCFLAR (Homo sapiens)6480464CTDCFLAR protein results in decreased susceptibility to Arsenic TrioxidePMID:16105982
Cflarincreases expressionISOCFLAR (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CFLAR mRNAPMID:22521957
Cflarmultiple interactionsISOCFLAR (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with TNF protein] results in decreased expression of CFLAR protein; Arsenic Trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of CFLAR protein]; BCL2 inhibits the reaction [[Arsenic Trioxide co-treated with TNF protein] results in decreased expression of CFLAR protein]PMID:17673311 PMID:23082001
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