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Gene: Cflar (CASP8 and FADD-like apoptosis regulator) Mus musculus
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Symbol: Cflar
Name: CASP8 and FADD-like apoptosis regulator
Description: Exhibits peptidase activator activity. Involved in several processes, including negative regulation of myoblast fusion; negative regulation of programmed cell death; and positive regulation of NF-kappaB transcription factor activity. Localizes to cytoplasm. Is expressed in several structures, including central nervous system; gut; heart; peripheral nervous system ganglion; and retina. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator); PARTICIPATES IN FasL mediated signaling pathway; Trail mediated signaling pathway; apoptotic cell death pathway; INTERACTS WITH 1,1-dichloroethene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310024N18Rik; A430105C05Rik; AI646576; AU021929; c-Flip; Cash; caspase homolog; caspase-eight-related protein; caspase-like apoptosis regulatory protein; Casper; cellular FLICE-like inhibitory protein; CLARP; ENSMUSG00000050533; ENSMUSG00000072980; expressed sequence AU021929; FADD-like antiapoptotic molecule 1; FLAME; FLAME-1; Flip; Gm9845; I-FLICE; inhibitor of FLICE; MACH-related inducer of toxicity; MGC103395; MRIT; usurpin
Orthologs:
Homo sapiens (human) : CFLAR (CASP8 and FADD like apoptosis regulator)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cflar (CASP8 and FADD-like apoptosis regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cflar (CASP8 and FADD like apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CFLAR (CASP8 and FADD like apoptosis regulator)
Canis lupus familiaris (dog) : CFLAR (CASP8 and FADD like apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cflar (CASP8 and FADD like apoptosis regulator)
Sus scrofa (pig) : CFLAR (CASP8 and FADD like apoptosis regulator)
Chlorocebus sabaeus (African green monkey) : CFLAR (CASP8 and FADD like apoptosis regulator)
Heterocephalus glaber (naked mole-rat) : Cflar (CASP8 and FADD like apoptosis regulator)
more info ...
Related Pseudogenes: Gm9845  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl158,711,508 - 58,758,884 (+)EnsemblGRCm38mm10GRCm38
GRCm38158,711,311 - 58,758,884 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37158,770,130 - 58,815,728 (+)NCBIGRCm37mm9NCBIm37
MGSCv36158,657,840 - 58,699,711 (+)NCBImm8
Celera159,232,248 - 59,277,933 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

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Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on Cflar
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731977
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-05-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.