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Gene: Cflar (CASP8 and FADD-like apoptosis regulator) Mus musculus
Symbol: Cflar
Name: CASP8 and FADD-like apoptosis regulator
Description: Exhibits peptidase activator activity. Involved in several processes, including negative regulation of myoblast fusion; negative regulation of programmed cell death; and positive regulation of NF-kappaB transcription factor activity. Localizes to cytoplasm. Is expressed in several structures, including central nervous system; gut; heart; peripheral nervous system ganglion; and retina. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator); PARTICIPATES IN FasL mediated signaling pathway; Trail mediated signaling pathway; apoptotic cell death pathway; INTERACTS WITH 1,1-dichloroethene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310024N18Rik; A430105C05Rik; AI646576; AU021929; c-Flip; Cash; caspase homolog; caspase-eight-related protein; caspase-like apoptosis regulatory protein; Casper; cellular FLICE-like inhibitory protein; CLARP; ENSMUSG00000050533; ENSMUSG00000072980; expressed sequence AU021929; FADD-like antiapoptotic molecule 1; FLAME; FLAME-1; Flip; Gm9845; I-FLICE; inhibitor of FLICE; MACH-related inducer of toxicity; MGC103395; MRIT; usurpin
Homo sapiens (human) : CFLAR (CASP8 and FADD like apoptosis regulator)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cflar (CASP8 and FADD-like apoptosis regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cflar (CASP8 and FADD like apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CFLAR (CASP8 and FADD like apoptosis regulator)
Canis lupus familiaris (dog) : CFLAR (CASP8 and FADD like apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cflar (CASP8 and FADD like apoptosis regulator)
Sus scrofa (pig) : CFLAR (CASP8 and FADD like apoptosis regulator)
Chlorocebus sabaeus (African green monkey) : CFLAR (CASP8 and FADD like apoptosis regulator)
Heterocephalus glaber (naked mole-rat) : Cflar (CASP8 and FADD like apoptosis regulator)
more info ...
Related Pseudogenes: Gm9845  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl158,711,508 - 58,758,884 (+)EnsemblGRCm38mm10GRCm38
GRCm38158,711,311 - 58,758,884 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37158,770,130 - 58,815,728 (+)NCBIGRCm37mm9NCBIm37
MGSCv36158,657,840 - 58,699,711 (+)NCBImm8
Celera159,232,248 - 59,277,933 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Cflar
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731977
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.