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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cflar
Name: CASP8 and FADD-like apoptosis regulator
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cflaraffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CFLAR mRNAPMID:22298810
Cflarincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CFLAR mRNAPMID:19520675
Cflardecreases expressionISOCFLAR (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CFLAR mRNAPMID:31536130
Cflardecreases expressionISOCflar (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CFLAR mRNA; Tetrachlorodibenzodioxin results in decreased expression of CFLAR proteinPMID:18334599
Cflarincreases expressionISOCflar (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CFLAR mRNAPMID:12167310
Cflarmultiple interactionsISOCflar (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of CFLAR mRNAPMID:25975270
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