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Gene: Pkhd1 (PKHD1 ciliary IPT domain containing fibrocystin/polyductin) Rattus norvegicus

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Symbol:

Pkhd1

Name:

PKHD1 ciliary IPT domain containing fibrocystin/polyductin

RGD ID:

1308476

Description:

Predicted to be involved in several processes, including establishment of centrosome localization; regulation of epithelial cell proliferation; and regulation of intracellular signal transduction. Predicted to act upstream of with a positive effect on branching morphogenesis of an epithelial tube and cell-cell junction organization. Predicted to act upstream of or within cilium assembly and kidney development. Predicted to be located in several cellular components, including apical plasma membrane; extracellular exosome; and microtubule cytoskeleton. Used to study autosomal recessive polycystic kidney disease. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease and polycystic kidney disease 4. Orthologous to human PKHD1 (PKHD1 ciliary IPT domain containing fibrocystin/polyductin); INTERACTS WITH bisphenol A; cefaloridine; rotenone.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

AABR07067023.1; fibrocystin; LOC301287; PKHD1, fibrocystin/polyductin; polycystic kidney and hepatic disease 1; polycystic kidney and hepatic disease 1 (autosomal recessive); polycystic kidney and hepatic disease 1 homolog; polycystic kidney and hepatic disease 1 homolog (human)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Pkhd1^pck

Genetic Models:

PCK-P2rx7^em8Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	30,040,466 - 30,533,834 (-)	NCBI		GRCr8
mRatBN7.2	9	22,547,396 - 23,037,443 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	22,549,513 - 23,037,381 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	9	26,164,969 - 26,736,704 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	26,636,334 - 26,707,571 (-)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	25,025,958 - 25,065,045 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	9	25,159,062 - 25,593,163 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	18,833,903 - 19,338,716 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	18,831,224 - 19,254,940 (-)	NCBI
Celera	9	20,127,204 - 20,618,569 (-)	NCBI		Celera
Cytogenetic Map	9	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant polycystic kidney disease (ISO)

autosomal recessive polycystic kidney disease (IAGP,IEP,ISO,ISS)

Caroli disease (ISO)

Caroli syndrome (ISS)

cholangitis (ISO)

choledochal cyst (ISO)

colon cancer (ISO)

Congenital Hepatic Fibrosis (ISO)

cystic kidney disease (ISO)

familial Mediterranean fever (ISO)

genetic disease (ISO)

Habitual Abortions (ISO)

homocystinuria (ISO)

Isolated Caroli Disease (ISO)

liver cirrhosis (ISO)

Medullary Sponge Kidney (ISO)

oligohydramnios (ISO)

Pancreatic Cyst (ISO)

polycystic kidney disease (ISO)

polycystic kidney disease 3 (ISO)

polycystic kidney disease 4 (ISO,ISS)

polycystic liver disease (ISO)

polycystic liver disease 1 (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

choline (ISO)

cyclosporin A (ISO)

folic acid (ISO)

fulvestrant (ISO)

hydroquinone O-beta-D-glucopyranoside (ISO)

L-methionine (ISO)

methotrexate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

ozone (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

rotenone (EXP)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

theophylline (ISO)

triptonide (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

branching morphogenesis of an epithelial tube (ISO)

cell-cell junction organization (ISO)

cilium assembly (ISO)

epithelial cell morphogenesis (ISO)

establishment of centrosome localization (ISO)

establishment of mitotic spindle orientation (ISO)

intracellular calcium ion homeostasis (ISO)

kidney development (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of epithelial cell apoptotic process (ISO)

negative regulation of NF-kappaB transcription factor activity (ISO)

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of epithelial cell proliferation (ISO)

regulation of cell adhesion (ISO)

regulation of cell-cell adhesion (ISO)

regulation of cell-matrix adhesion (ISO)

regulation of centrosome duplication (ISO)

regulation of cholangiocyte proliferation (ISO)

regulation of ERK1 and ERK2 cascade (ISO)

regulation of establishment of planar polarity (ISO)

regulation of TOR signaling (ISO)

Cellular Component

9+0 non-motile cilium (ISO)

apical plasma membrane (ISO)

centrosome (ISO)

ciliary basal body (ISO)

cilium (ISO)

cytoplasm (ISO)

cytosol (IEA,ISO)

endoplasmic reticulum (ISO)

extracellular exosome (ISO)

Golgi apparatus (ISO)

mitotic spindle (ISO)

perinuclear region of cytoplasm (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Milder presentation of recessive polycystic kidney disease requires presence of amino acid substitution mutations.	Furu L, etal., J Am Soc Nephrol. 2003 Aug;14(8):2004-14.
2.	Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1.	Gallagher AR, etal., Am J Pathol. 2008 Feb;172(2):417-29. doi: 10.2353/ajpath.2008.070381. Epub 2008 Jan 17.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Predominant extrahepatic biliary disease in autosomal recessive polycystic kidney disease: a new association.	Goilav B, etal., Pediatr Transplant. 2006 May;10(3):294-8.
5.	Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice.	Hiesberger T, etal., J Clin Invest. 2004 Mar;113(6):814-25.
6.	A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis.	Huang W, etal., J Immunol. 2018 Jan 1;200(1):147-162. doi: 10.4049/jimmunol.1701087. Epub 2017 Nov 20.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD).	Moser M, etal., Hepatology. 2005 May;41(5):1113-21. doi: 10.1002/hep.20655.
9.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	Heterozygous Pkhd1C642* mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidney.	Shan D, etal., Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F463-F472. doi: 10.1152/ajprenal.00181.2018. Epub 2019 Jan 2.
15.	Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.	Ward CJ, etal., Hum Mol Genet. 2003 Oct 15;12(20):2703-10. Epub 2003 Aug 12.
16.	The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein.	Ward CJ, etal., Nat Genet 2002 Mar;30(3):259-69.
17.	A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation.	Woollard JR, etal., Kidney Int. 2007 Aug;72(3):328-36. doi: 10.1038/sj.ki.5002294. Epub 2007 May 23.
18.	Short article: Sequence variations of PKHD1 underlie congenital hepatic fibrosis in a Chinese family.	Yang N, etal., Eur J Gastroenterol Hepatol. 2019 Mar;31(3):363-367. doi: 10.1097/MEG.0000000000001295.
19.	PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells.	Zhang MZ, etal., Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2311-6.

Additional References at PubMed

PMID:14978161	PMID:15458427	PMID:15509540	PMID:16243292	PMID:16783394	PMID:17669261	PMID:18235088	PMID:19056867	PMID:19158352	PMID:19524688	PMID:19943112	PMID:20554582
PMID:20709014	PMID:21300060	PMID:25367197	PMID:26136112	PMID:28154160

Genomics

Comparative Map Data

Pkhd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	30,040,466 - 30,533,834 (-)	NCBI		GRCr8
mRatBN7.2	9	22,547,396 - 23,037,443 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	22,549,513 - 23,037,381 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	9	26,164,969 - 26,736,704 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	26,636,334 - 26,707,571 (-)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	25,025,958 - 25,065,045 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	9	25,159,062 - 25,593,163 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	18,833,903 - 19,338,716 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	18,831,224 - 19,254,940 (-)	NCBI
Celera	9	20,127,204 - 20,618,569 (-)	NCBI		Celera
Cytogenetic Map	9	q13	NCBI

PKHD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	51,615,299 - 52,087,615 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	51,615,299 - 52,087,613 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	51,480,097 - 51,952,411 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	51,588,104 - 52,060,382 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	53,139,903 - 53,613,559 (-)	NCBI		Celera
Cytogenetic Map	6	p12.3-p12.2	NCBI
HuRef	6	51,314,936 - 51,783,413 (-)	NCBI		HuRef
CHM1_1	6	51,482,653 - 51,954,627 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	51,458,672 - 51,926,294 (-)	NCBI		T2T-CHM13v2.0

Pkhd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	20,128,003 - 20,688,306 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	20,128,003 - 20,688,288 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	20,057,779 - 20,618,082 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	20,057,779 - 20,618,064 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	20,047,860 - 20,608,138 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	20,042,930 - 20,603,208 (-)	NCBI		MGSCv36	mm8
Celera	1	19,948,411 - 20,498,116 (-)	NCBI		Celera
Cytogenetic Map	1	A4	NCBI
cM Map	1	6.27	NCBI

Pkhd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	5,990,316 - 6,432,301 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	5,988,100 - 6,434,369 (+)	NCBI	ChiLan1.0	ChiLan1.0

PKHD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	66,083,287 - 66,550,385 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	61,960,485 - 62,427,247 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	51,166,516 - 51,635,057 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	52,435,455 - 52,903,309 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	52,435,462 - 52,903,309 (-)	Ensembl	panpan1.1		panPan2

PKHD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	19,280,866 - 19,744,669 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	19,286,822 - 19,744,141 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	19,173,042 - 19,651,204 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	19,781,225 - 20,253,821 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	19,783,877 - 20,243,554 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	19,289,289 - 19,759,402 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	19,392,649 - 19,862,367 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	19,530,405 - 20,000,289 (-)	NCBI		UU_Cfam_GSD_1.0

Pkhd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	54,799,690 - 55,229,420 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	8,730,842 - 9,159,863 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	8,730,766 - 9,160,102 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PKHD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	45,450,950 - 45,925,149 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	45,447,354 - 45,925,141 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	52,029,750 - 52,373,563 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PKHD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	20,411,746 - 20,873,601 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666044	51,528,670 - 51,991,959 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pkhd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624855	4,019,056 - 4,536,324 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624855	4,019,088 - 4,539,289 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pkhd1
3655 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	12
Count of miRNA genes:	10
Interacting mature miRNAs:	11
Transcripts:	ENSRNOT00000060760
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5109826	50109826	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	1254084	46254084	Rat
7411609	Foco16	Food consumption QTL 16	25.6	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	8952560	53952560	Rat
631680	Cm11	Cardiac mass QTL 11	3.1	0.00089	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	9	20430519	65430519	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	1254084	46254084	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5109826	42921101	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
724543	Cm20	Cardiac mass QTL 20	3.9		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	16961398	40594091	Rat
1600365	Mcs20	Mammary carcinoma susceptibility QTL 20	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	9	13533770	42791750	Rat
11353947	Bp392	Blood pressure QTL 392			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	7283252	52283252	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
9589133	Insul26	Insulin level QTL 26	17.96	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	9	8952560	53952560	Rat
1598823	Memor16	Memory QTL 16	1.9		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	22133322	49968732	Rat

Markers in Region

D9Got30

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	22,911,264 - 22,911,504 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	26,612,243 - 26,612,482	NCBI	Rnor6.0
Rnor_5.0	9	25,469,745 - 25,469,984	UniSTS	Rnor5.0
RGSC_v3.4	9	19,203,614 - 19,203,854	RGD	RGSC3.4
RGSC_v3.4	9	19,203,615 - 19,203,854	UniSTS	RGSC3.4
RGSC_v3.1	9	19,200,937 - 19,201,176	RGD
Celera	9	20,492,634 - 20,492,873	UniSTS
RH 3.4 Map	9	212.1	UniSTS
RH 3.4 Map	9	212.1	RGD
RH 2.0 Map	9	174.6	RGD
Cytogenetic Map	9	q13	UniSTS

AU028005

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	22,862,453 - 22,862,619 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	26,563,227 - 26,563,392	NCBI	Rnor6.0
Rnor_5.0	9	25,421,225 - 25,421,390	UniSTS	Rnor5.0
RGSC_v3.4	9	19,154,986 - 19,155,151	UniSTS	RGSC3.4
Celera	9	20,444,082 - 20,444,247	UniSTS
Cytogenetic Map	9	q13	UniSTS

AU049041

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	22,626,409 - 22,626,629 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	26,326,879 - 26,327,096	NCBI	Rnor6.0
Rnor_5.0	9	25,182,167 - 25,182,384	UniSTS	Rnor5.0
RGSC_v3.4	9	18,913,421 - 18,913,638	UniSTS	RGSC3.4
Celera	9	20,208,062 - 20,208,263	UniSTS
Cytogenetic Map	9	q13	UniSTS

Genetic Models

This gene Pkhd1 is modified in the following models/strains:

PCK-P2rx7^em8Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_001070557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008757980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008757981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008757985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008766937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000080948 ⟹ ENSRNOP00000072399

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	22,549,513 - 23,037,381 (-)	Ensembl

RefSeq Acc Id:

XM_008766937 ⟹ XP_008765159

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	30,040,466 - 30,533,834 (-)	NCBI
mRatBN7.2	9	22,547,396 - 23,037,443 (-)	NCBI
Rnor_6.0	9	26,164,969 - 26,736,704 (-)	NCBI

Sequence:

show sequence

TAAACTTGCCCTGTGGTCATTTTTGAACTTTTACTCTGGTGCACGTTTGGCCAGGCCAGAAACG
AGTTAGGTGAGTTACACTCCAATATGAAGCGAGCTACCTGCATGGTAGCTAGCTAGCTGCAGGC
TGGCCCATCACCAGATAACGCGGCGTCATTTTGAAGGGACCGGTTTCTCTCATTTGAAGCACAA
AGCGGACACAGCATCAGGCACAAAAGCTACATCATGCCAGTCGACCCTAAAAATGTGCTTCTAA
CATATGAGAGGTCTCAAGAGAGCTGAGCTACCCTGATGTGATGCCTGCCTGGCGGATCTCTCTG
TTGAGTGTGGAACTACTACTTTTAGCAAATGCTTACTCAAGTTTCCGGATTGAACCGACAGAAG
GTAGCCTTGCAGGGGGAACATGGATCACACTTGTTTTTGACGGTTTGGAAACAAGTATTCTTTA
CCCCAACAATGGCTCTCAGCTGGCGATAGACCTGGTGAATGTGGCAACACCCGCCTTGAAGATC
CCTTGTGACATCTCTCCCCTCTTCGTGGATTTGCCCGTGGTGACGTGCCAGACGAGGTCTCTTC
CATCAGAAGCACCTGAAGGTCTTTATTCTCTGGAGATACGCTCTGGGGATCAACTGCTAGGCAG
CCCGTGTGCCAGATTACTGGACAACTGTACTTTCAAGTTTTCCAAGGAGCAGACACCTGTTTTA
TATCAAGTTAACCCATCAAGTGGAGTTCCAGGAGAAGTAGTGCATGTGTATGGCTGGGTCATTA
CTGATCGGATGGAAATTTTTGATCCTGATGTGGACTACATGGAGAGCCCATTAATCCTGGAAGC
TGGAGGAGACAAATGGCTTACTCCTTGTTCTCTTATAAACAGGAAGACAGGAATCTGTTTTCCC
ATCCAGGAGGAACATGGCCTTGGGACTGTGCAGTGTCGCGTGGAAGGCAGTTATATTGGTTCCC
AGAATGTTAGTTTCTCAGTATTTAACAAAGGAAGGTCGATGGTGCATAAGGAAGCCTGGCTGAT
CAGTGCTAAACAGGAACTGTTCCTGTACCAGACATACCCAGAAATCCACTCTGTGTTTCCAAAA
GTTGGGAGCCTTGGGGGAAGAACAGACATCACTATTACTGGAGATTTCTTTGACCCTTCTGCCC
GGGTTACCATTGCAGGCATTCCATGTGATATTAGACATGTGTCTCCCAGGAAGATTGAGTGCAC
CACCAGGGCTCCAGGAAATGGAGCAAGGCTCACTGCTCCCCAGGCAGGTAATCGAGGACTCCTT
TTTGAAGTTGGAAATGCTGTTAAGGATGAGGAGCTGACTGAAGCCACCCCAGGGTACAGGTGGC
AGATAGTTCCTAATGCTAGTTCTCCATCTGGCTTTTGGTCCAAGGAAGGGAGACCTTTCAGAGC
ACGGCTCAGCGGGTTCTTCGTGGCTCCAGAGACCAACAATTACACATTCTGGATCCAGGCAGAC
AGCCAAGCTTTCTTGCGTTTCAGTTCTTCAGAGGAGCCAAGGATGAAGGTAGAAGTGGCTTCCA
TTGCAGTTGGCACTGCTGACTGGTTTGACTCTTGGGAGCAGAACGGGAATGAAGGGAGCTGGCA
ACAGAAGACAAATAAGCTAGAACTGCAGGGCGGAGCCAAGTACTACTTGGAAGCAGAGCAGCAT
GGGATAGCTCCCAGCAGGGGGATGAGAATTGCTGTCCAGATCCACAACACCTGGCTGAATCCAG
ATGTGGTCAACACTTACCTTCTGGAGAAACACCAGATCCGAGCCCAAGCCCAGAGACTTCCAGA
AATACAGGTGTTGAACATGTCAGGTAAAGGAAACTTTTTCCTTACTTGGGGCAATGTCTCCAGC
CAACCAGTTCCTGCAAATGCCACAGCCCAACAGATCCAAACCATCATCGAGGAGTTGCTGGTGG
TGAAATGCAATCTGGTACCCCTTTCAGCTCGTGTTCTCCTCTGGCTTGGATTTGAGCAAGGCTT
AGATGGCTCCAGGTCTGATGGGGTCCTCACCAGTTCAACCGAACCATTCTGTGGCAGATTCAGC
CTTGGTCAACTTCGACATCTTATCCTAAGCCCTGGGGCTGTCAGTAAGGGCTATCAGCTGGATC
GATACCCATATTTGTGCTTTGCATACAGAGGTCATATGAACAGGACCCTGGACATGACTGTTTC
TTTCCTATTTGGCTTCCAAAATGTCATGAAGAATATCACCTGTGACTGGAGTCTGATGGAACCC
CACCCTGAGAGCTGGCACTTTACTTGCAATAACCTCTGGGACACATGTGTACGCCATTCTGAGG
AGCTCCAGTCTTCTCTGGCAAACACCCCATTGCTGGTTCATCGGATCGACATCTTCCCTGTGGT
TCCAGAGGCAGACTTGCTCTATGTGGATGAAATTATTCTTGCAGATACCAACGTAACAGTTTCT
CAAGCCGATTCTGGAGTAGCCCGCCCAGGTGGGAATGTGGTGGAGTCAGTGTCTGTGGTGGGAG
TCCCTCCAGTCTACAGCATAGCCTCTTGGATGGCAGGATGTGGCTCAGAACTTCCTCTCATCAC
TGCATGCTATGTGCCCACCCAGGGGACAGGCGAAGGATCAGAACTGATTGAGGTGACAGCGAAA
AGACTCCAGAGGACAAGCCCACCTTTGGGAGGACACTTCTCCCTCCACCTCTCTGATACAGTGA
TACCTGATGTTCCAGTGCATGTGTCTGCCAGACAGCTTCATAAGCTACTGCAGGACAATGCTGA
TGAGTCCACATCTGGATATCTCAATGCCGATGACTTCATTGTGACAAAGGATCAAAATTCCTGC
TATGAACATGTGTGGACTCTTTCCTGGACCACTCAGATTGGGGATTTGCCCAATTTCATCAGGG
TCTCCGATCAAAATCTTACGGGGTTGAATCCCACCATAACTGCTCGTGTAGTATACGATGGCGG
AGTTTTCCTTGGGCCCATTCTTGGAGACACACTGGCTACTGCCAACCAGCAGACTCAGGTGACT
GTACAAGTGAATGACATACCAGCCCATTGTTCAGGCTCCTGCTCCTTCCAATACCAGCGAGCGT
CAACTCCCAGCGTGGACTGTGTGTGGTATTCCCTTGGTAGTGATGTCAACCTGCTGGTTCATTT
TACTGGAAATGGTTTCCCTAGAGATGCCCAGTTCTTACAGGTCACGGTGATCAACACGAGTTGT
GAAGTTATTTTCTCAAATGAAACCAACGTTGCCTGTGAGCTTGCCCTACTACCAGTTGGAGTGC
ACCGGGTTTTTATGCTGGTGAGACCTTCTGGCCTTGCTCTTAATGCCAGTGGAGAAGGCCTCTT
CCTACGTGTGGAACCCAGGCTGGATGCTGTGGAGCCTTCTACAGGCGCAGAGATTGGAGGATGG
TGGGTTACACTCCGAGGCTCTAGTCTAGAAGGCGTTAGCCTGGTGTTATTTGGAACTCGGTCGT
GTGTCATTGATGTCATTAGAAGCAATTCGCAACAGATTCAATGCAAAGTCCCACCTAGGGGGAA
AGATGGATACACTGTGAATGTGACTGTGATCAATGGGGACCACTCCACAGTTCTTGCCAGAGCA
TTTACTTATGTCTCCTCTTTAAATCCAGTGATTGTGTCTTTGAGCAGAAATAGAAGCAACATAG
CAGGAGGTGAGATTCTGTTCCTTGGGATGACACTGATGGTGAACTATACAGATCTGAATGTGCA
AATCTACATTCAGAACACTTCTGCTCAGGTCCTTGCAAAGACGGCATGGGGACTGGAGGTGCTG
TTGCCTCCGTTGCTGCCTGGCATCTATGTGATTTCAGCATTCATCAATGGAATCAGCATTCGTT
CACAAGGGGTTGATCTCCACATCCAGTACCTCACTGAAGTTTTCAGCATGGAACCTTGCTCCGG
GTCTCTCTTGGGTGGAACTATCCTCCAGACTCTCAGGAGCAGGACTGGCAGAGACCCAGCTCTG
ATTCGGGTGCTTGTGGACAACCGTCTTGCTTGTGATACTGTGAAGTTAACAGAAGTGAACATTG
GTGTGAGACTCCCGAGTCTACTACCACCCAGAGCAGATGTTCTCACTGTCCCAGCATCTGTGGA
GATCTGGGCTGGCAACACTTCCTTCGTGGGGAAGGCCTTCCATCTTCACATATGAAGCTGCAGC
CAACTCCCAGTGGTCACTGCCTATGGGGGGGTGAACTCCATTGAACAACAGTGTTAAGGTTTAT
GTGGAAGAAATAACCTCTCCGACTCAGTCATTCTTTTGGGATCCCTTGAAATGGACCTTCAAGT
GCAATTGTTTGGGATAACATGAACCTGTCTGGGCTCCCTTCTTCTCCACAGTTTGGAAGCTGGG
NTCTATGCTCTCCAAGTTCGTCACNAGAGAGGATGGTTTGCCAATATGTCTGCGGTGCTCAGAA
GTTTGAGGCTGTCACCGCAGATTATCGACATCTTCCCANCACATGGTTCATAATATGGTGGGAC
AGTGCTTACTGTGAAGGGCACGGCTTTCAGGTCCAGAAGGAGGGTCTGTTCATGTGACCTTTCA
GGTCCTTTTACTTGCGGGATTTTGAGTTTGGGAGACCACAACAGTCCTAGCCAGACCAAGTTTG
TGGGTGATCAGTTTTCTGAAACATCANCTGCTCTAAACATCACAGTTCATGGCAATGGGCTGAC
CAGCAAGTGTGAGGGGAACTGTACTCTCTTCCTGGAGGAAGCAGCAACTCCTATTGTGGATGCT
TTGACTATAAGTATCAGTGGCTCTCTAACCACAGTGCTGATGAGAGGACAGAGGTTAGGCTCTG
CTGGTGAGCCAACAGCCTTTGTGGATGGTCAACTTCTTTGCCATACAACTTTCTTTAATACCAG
CTATGTGGCATGCCAGATGAGAGATTTGGCCCCGGGGTTCCACTATCTGTCAGCTGTTCGTACA
AGTGCTGGATATGCTTGCCTCAATAGTGTTTCTAGAAACTTCTTCGTTGTGCCTCAGGTGTTCG
ATTATTTTCCTAAGGATTTTAGCATCCATGGTGGAAGTCTCTTGACTATAAAAGGCACAACCCT
TCGAGGATGGAAAACTACATTTGTCTATGTTGGCCAGCAGGCTTGTCTAACAGTGAACATCAGT
TCTGAGTTCATCCAGTGCATTGTTCCCGCAGGAAATGGCTCTGCTGCTCTGGAAATAGATGTAG
ATGGAGTTTTATACCACATGGGATTTGTTGACTACAGCAGCATCTTTACCCCAGAATTGCTTTC
TGTTTCACGGAGTCATGACATCTTGACCTTTACAGTGGCCCGGATCTCAGGGGCTGCAAATGTT
GACATTCTTATTGGGACGTCACCGTGTCTAGATGTTGCTGGTAACCGTACGATTCTCCGGTGCA
TGGTCCCTCTGCTTCCTGCTGGGGAGTATGCTGTCACAGGTTATGACCACAGCAGAGGATGGGT
CTCATCCACTCTCATTCTCGTGCTGAGAGCCACTGTGACCTCAGTGACTGAGAACTATGGCTGC
CTGGGTGGAAGGCTTTTGCATGTGCTCGGAGCAGGATTTTCTCCAGGGAACATCTCAGCTGCTG
TATGTGGTGCTCCGTGCCAAGTCTTGGCTAATGCGACAGTGTCTGCCTTCAGCTGCTTGGTTCT
GCCCCTGGATGCGTCCTTGGCTTTCCTCTGTAACCTGAGGCATGCAGAAGACAGCTGTGGAGTT
AGCAGGCCCACCTACTTGCAATGTGACTTGACTGTCTCCGTGGGGATGGAGAGACTGCCTGGAT
CCTGGCCTTACGTCTACCTTTGTGAAGAGAGTTCCCAGGGCCTCTTCGTACCAGATCACCAGAT
CTTCCTTTCCTTCTCAGGCCTCTTCCTCAGCCCTAAAGTGGAAAGAGATGAAGTTCTCATCTAT
AATAGCTCCTGTAACATTACCATGGAAACTGAGGCAGAGATGGAGTGCGGGACACCTAATCAGC
CAATTACCGCCAAGATTACTGAAATACAGAAAAGCCGGGGCCAGAACACTCAGGGCAACTTTTC
CTTCCAATTCTGCCGAAGGTGGTCCAGGCCTCACAGTTGGTTTCCTCACAGAGTGCCACAAGAT
GGCGACAATGTCACAGTGGAGACCAGTCACCTGCTACTGCTAGATGCGAATACAAGTCTCCTGA
ACTCCCTGCACATTAAAGGTGGCAAGCTGATTTTCATGGAGCCCGGACCCATTGATCTCAGAGC
CCATTCTATCCTAATTACAGACGGTGGAGAGCTCCATATTGGATCTGAGGACAAGCCTTTCCAA
GGCAAAGCTCGGATCAAACTCTATGGAAGTGTCCACTCCACTTCCTTCTTTCCCTATGGAGTCA
AGTTCCTGGCTGTGAGGAATGGAACTCTTTCTCTGCATGGTTCTGTTCCAGAAGTTACTTTTAC
CTATCTTCGAGCAGCTGCATGTGCAGGAGACACCGTGTTGGCTCTGGAAGAGGCCGTGGCTTGG
CACCCTGGGGATGAGGCTGTCATTAGCAGTGGAGCGACTGTAGAAGGTGCTGAAGCAACAGAAG
AGGTGGTTGTTGTAGAAACTGTCCACGATGCGGACCTCCATCTCAGGAACCCCCTGAGATACTC
CTACAACTTCACAGAAAACTGGGTAACTGGAGTGAATCATATTTTGAAGGCTACAGTGGCTCTT
CTCAGCAGGAACATTATTGTCCAAGGAAATCTCACTCTCGAGAGGGTAAAGCTTCTTGATTCAT
GCCAGGAGGCCGGTGCTGCTGAAGGAAACCTGAAGCATTGTTTATATTCTAAGAGTGAGAAGAT
GCTGGGAGCCAGGAATCTGGGGGCCAGAGTTATCATTCAGTCCTTCCCAGAGGAACCCAGCTTG
GTCAAGCTGAAGGGAGTGCAGTTCCGAGACCTGGGACAAGCCTTCCATAAGCATCTAAGCTCAC
TCACCCTGGTGGGAGCTATGAGAGGTTCTTATCTCCACAGCTGTTCAATGTGGGGCTCCTTCAG
CAGAGGCCTCAGCATACACAGGACCTGGGGTCTGAAGGTGGAAAATAATATATTCTATAAGATT
GTAGGTCATGCCCTACTGGTGGGGTCCTACATGGACAGAAGTTTTAGCACTAGTGAGGCTGTTA
TTGGAAGAAAAAATGGTTGGTGGGAAGAGGGAAGTATGATAAGAAACAATGTGATCATCAATGT
TTCTGGGGCTGAGGGACTGTCCAGTTCTGAAATGTTGGCACCAGCAGGCATCTACACTTTCAGT
CCCACCAGTGCGATTGAGGGCAACAGAGTGTGTGCAGCTGGTTATGGCTATGTTCTCCACCTTG
TGACCAGCCAAACAGTGCAAGCTCCACTACTCTCATTCAACTGGAATACTGCACATTCTTGTAC
AAGATATGGTCTCCTTGTATATCCTGAATTTCAACCGCCTTGGAATAATGACACTGGCTTCACT
CTGTTTCAAAACTTCATGGTTTGGGGAAGTGCTGGTGGTGCCCAGATTTTTAGAAGTAACAATC
TGCACCTGAGAAACTTCCAAGTTTATGCATGCAGAGACTTTGGGATTGACATTTTGGAAAGTGA
CACGAACACTTTGGTTACTGACAGCTTCTTACTAGGTCACTTCACCCACGAGGGAAGTCTATGT
ATGTCAGTTGGCATCAAAACTCCCAAAAGATGGGGACTGACGATTTCTAACACAACTTTCGTTA
ATTTTGATCTCAACTGTGTGGCCATCAGAACCTGTTCTGGCTGTTCCCAAGGACAGGGTGGATT
TCCTGTCAAGACCAGGCAATTGAAGTTTGTCAACTCTTCAAATTTAGTAGCATTTCCTTTTCCT
CATGCAGCAGTTTTGCAAGACTTAGATGGGTCCCTGTCTGGGAAAAATGGATCTCATGTTCTTG
CTTCTATGGAAACCCTCTCAGACACATGTTTGACCAATGCAAGCTTCAGCCAGATTGTCTCTGG
CAGCGTCTGTGGGGAAGCTGTTCTCTTCCATCGTATGTCTATTGGTTTAGCTAAGAGCCTCGAC
GTTCCTAAGAATTTAACCATGACTGACATCAGAAATAGGACAATCACTATCAATTATGTGGATG
ACACGTTGTCTAACTCTTATGGCTGGATGGCTCTACTCTTGGACCAAGAGACCTACTTGCTGCA
GTTTGAGGGTCCTTGGACGGACGGATCTTTGCAGTACTCAGCAACCTTTGACAACTTTGCCCCT
GGAAATTACCTCCTGCTAATGCACAGGGACCTACTACCTTATCCCGACATTCTCCTCAGATGTG
GGAGTCGGGTGGGCCAGTCACTTCCCTCTCATCCTTTGCCGAGTCGAGACGGAGCCTGTGATTG
GTTCTTCCACAGGCAGTTAAGGCAGCTCACCTACCTGGTTTCAGGGGAAGGTCAAGTTCACGTA
TTCCTCCAGGTGAAGCATGGTGCACCTCCAACTGTTTCAGCTTCTACATCTGTATCTGAATCAG
CTTTAAAATGGTCCCTTCCTGAAACATGGCAAGATGTTGAAAAAGGCTGGGGAGGATACAACCA
CACCATCCCAGGACCCGGTGATGACGTCTTGATTTTACCCAACAAGACGGTTCTTGTGGATACT
GATCTCCCCGTGCTTAGATGCCTCTATGTGATGGGTACCTTAGAATTCCCTGTGGACAGAAGCA
ACGTTCTGAGTGTGGCGTGCTTACTCATTGCAGGAGGGGAGCTGAAAGTAGGTACTTTGGAAAA
CCCCTTAGGAAAAGACCAAAGACTTCTGATACTCCTCAGAGCCTCAGAAGAAATCTTCTGTGAC
CGTTTTGACGGAATACGTGTTGACCCTGGAACAATTGGAGTTTATGGGAAACTTCGCCTTCACA
GCGCATATCCTAAGAAATCCTGGGTACACCTTGGAGCTGACATTGCCCCGGGAAATGAGAGGAT
TATAGTACATAATGCAGTGGATTGGCAGCCCCATGACAAAATCGTCCTCAGCTCTTCTTCTTAT
GAGCCTCATGAGGCAGAGGTCNCCACTGTGAAGGAAGTCAAGGACCATCACATCAGGATCTATG
AACGTNCTAAACACAGGCACATTGGAAGTGCCCACACCCTGGAGGATAGTCGACAGATTTGTTT
GGCTGCTGAGGTTGGATTGTTGACCAGAAACATTAGAATTCAGTCTGACTCATCCTGTAGAGGG
AGACTCCTTGTGGGGTCCTTCAGGAAATCTAGCGGAGAAGAGTTTTCTGGCATTCTTCAACTTC
TAAATGTAGAAATTCAAAACATGGGGTCACCACTGTATGCATCTATTGAATTCACCGGTGTGTC
AGCTGGATCCTGGGTTATATCTTCTACTGTACATCAAAGCTGCACTGTGGGCATCCATGCATCT
TCTAGTCGTGGGATGGTCTTAAATGACAACATAGTGTTTGGCACAAAAGGCCATGGAATCGATG
TGGAGGGTCAGAACTATTCTCTCACCAATAACCTTGTCATTCTGTCAATGCAGTCAGCAAACTC
CCTTCCTTGGGTGGCAGGAATCAAAGTGAACTATGCCGAAGATATCATTCTCCACGGCAATGTG
GTGGCAGGATCTGAGAGACTTGGCTTTCATGTCCGTGGCCATGGGTGCTCCTCTGAAGTGCTTT
GGTCTGACAATGTGGTCCACTCAAGCCTCCATGGCATTCACCTCTACAAGAAACGTGAACCTAA
TAACTGTACTGGTGTCTCTGGATTTCTGGCTTTTAAGAACTTTGACTATGGTGCCATGGTTCAG
ACAGAGAATAGTGTGGACATACAGAATATCACTCTGGTGGATAATACTGTTGGTCTTTTGGCCA
TCTCGTATGTATCTTCGGCTCCACTGAGATCTGGCAGCACTCTACAGATTACTCTTAGGAATTC
AGTCATCGTAGCCACTAGCTCCTCTTTTGACTGCATCCAAGACAGAAAGGCTCCTCAGTCGGCC
AACTGGACCTCCACAGATAGAGCGCCTTCCAATCCCAGAGGAGGCCGGATCGGTATTCTGTGGC
CTGTATCTGCCTCAGAACCAAATGGATGGCCCCAGGAGCCATGGCACAAAGTAAGGGGCGGTCA
TTCAGTTCCAGGAATTATGAAGCTTCAAGATGTCACCTTTTCTAGTTTCGTGAAGAGTTGCTAT
AGCGACGATCTGGATGTCTGCATCCTGACTAATGAGCACAGCACTGGAATCATGTACCCAATAA
CAGCAGAGAGGACCAGAATGCTGAAGATAAAGGACAAAAACAAGTTCTACTTTCTTCCATTACA
GTCTGGGAAAGACTTAGTGGGAACCATCTGCCCTGCATCATCGGACTGTGAAATTCCAAGAAAA
TACCTCTTCACAGATCTGGATGGGAGAACCCTGGGTCTGTCCCCACCAGTTTCTGTGTTTCCAA
GGATAGAGGAAGGATGGACTGGATCCTTCTTCAACACAGGTATATTCAGAGAAGAACAGAAATG
CACATTTCGAGCCATGATCCAGGGCTTCTTCTGTAAGCAGACTGAGCATGCAGTCCTAATTCTT
GATAATGTTGATGTAACTTGGACAATCCCCAAATTCTACCCACTTGTATCCATTACTAATGGTT
TTGTGGACACGTTCAGTATTGTGAAGGACAGTGGTCTATGCTTTCCCACAAGCTCCCCGTCTAC
TTTTTATTCCATTTTACCAACCAGACAAATGACCAAAGTATGCTTTCCAGAGCGAACTCCCCCA
TTCCTGCACTTTTTTCTACTGGCAAACAGAAGAGCGTCCAAGCTCATCTTGGCTGTGTTCTACA
ATGAGATTCAGAGCCCCTACGTTTTCTTAGACAAGAGCTTTATTCCACCTACACCAGTAGAGTC
AGCATTTTCACTGTTGGATGAGCCTGTTGGTGCCAACTATTTCGACATCATGAATAACCTCTTG
TATGTTGTCCTGCAAGGAGAGGAGGCTGTTGAAATACGTTCAAGTGTTTCCATTCATTTGGCTT
TGACAGTGACATTTTCAGTCCTAGAAAAGGGCTGGGAGAAAGCAGTGCTTGAAAGTCTAAGAGG
CTTCTTCCAGATTGACCAAAACCAAATCAGACTCACTCTTGAGATGCCTGGCAACAAAGAGACC
TTAAAGGCCATTGCAAACAGTGAAGGAAAACGAAAGCGCAGTTGCCCAACTGTGACTTGTGCTG
TCCCTTCTAGCAGATATGTTCAACGCAGACCTCTCATGGCAGAAATGGCATCATTTACAATCAC
ACCAGCAACCACTCTGGAAACTTTCTCAAAGGTGATTGTCTTTGAAATCGGTGATCTGCCAAAT
GCAAGGGACAGTGAATTCATTCAGTCCTTACCAAGTAACAGATTACAGAAATTGGCTCACCAGG
TTATCACTGCTCAACAGACTGGAGTTCTGGAAAATGTCCTTGGTATGACTGTTGGGGCCCTACT
AGTGGCTCAGTCAGAGGGAGTCACAGGATATAGAAATGCAAGTAGTTTAATAACTGGAAACCAG
ATATATACCCGGCCCTCTGTGGTTTCCATCCTGGTGCAGCCTTCAGATGGGGAAGTGGGAATAG
AATTACCGATTCAGCCACGGCTCATCTTCCTGGATGAGAAGAATGAGAGAGTGGAAGCTTTGGG
TCTCCCCTCAGAACCTTGGATTATTTCAGTTTCCCTGGAAGGGACATCTGAATCAATGCTAAAA
GGGTGTACCCAGGCAGAAACACAGGATGGCTATGTGACCTTCTCCAGATTGGCTGTCTTGACCT
CTGGGTCAAACTGGCACTTAGTTTTTACTGTCACTTTCCCTCCAGGTACTAATTTAACAGCTCG
ATCCAAGACCTTTGCTGTCCTGCCTGTGGCCGGCAAGGAGAGGTCAACTATCATCCTGGCCTTG
TCCCTGTGCTCAGTGGCGTCTTGGGTGGCTCTAAGTTGTCTCATTTGCTGCTGGTTTAAGAAAA
GCAAAACCAGAAAAATAAAACCAGAAGACATATCTGAATCCCAGGCTAAGGAACAAAAGAAGAA
TACCCATATCTCTTCCAAACCCAGAGAACTACAAGTAAAGACCGCAAAAGAAGACGCTATGATG
GGAGAAGACATGAGAATGAAGGTCATGGAGGGAAGGCAGAACCAGTTTTCCCAACACTCAATGG
ATGGAGTGTCCAAAAGAAAAGTTAGCCGCCGTGCTGTCCCAGAGGAAAGAACAGCTACACCTGC
CCTGAAGATTCCCAGAACCACCTGTGTCCCAGGAGCTCTTCCTCAGCAGTTGACTCTGCCGGAG
CCTGGGAACTGGCAGGAGGCCCAACAGCAGCTGCTTAGATACCAGCTGGCAGGCCGCGATCAGC
TGCTTCTGTTATGCCCAGACCTCAGGCAAGAGAGGCAGCAGGGTCAGGAGCCTAGCCAGCTGAA
CAAAGGGAGTGGCCGCTGCATGGGGCTGTCTCAAGAGAAGGCCACTTGCGTTCCCACTGAGACC
TTCTGCCTTCACACAGCTCCACCAGAAACTATCCAGTAACAGCTGTGGGCGCGGAGCACTGTGG
GCGTTTGTATGAAAAGGAGAAACTGTTCAAAATTATTTCTACATGGTGAACGGGGGAGGAGAGG
TCTGATCTGTTTGGACAACTAAGGGAGAATGGGGACGACTGTAATTAAGCTTCTCTTAGAGCCA
ACACTCAGGATGCTTCAGGCTTGTCTTATGGAAGACCTGTGATAGATTTAGTTAGCTGATGTTG
TATCTGCAGGACTACAGAAATACTCAGGAGATATCTTACACCAAAGCTTATCCCCCAAACAGAG
GTAACGTAATAAGAGTTACTTGTAGATTTTATTTCGTGGTTTAAATTTAGTAATTATTGGGAGC
TTTCTGCATTGCAAGCATTATTATTTGCACCTCATGAGTATTTGTACATGAAAGATGATGGTCA
CATAGGCTTTGTTGGGATTTCAGTTAAGAAAAAGATATGAAAACACTAAATTTAGGCAATTTTT
ATGTACTATAGGTACATTTCACACCAGGTATTTATATGAAAAGGGGAAATATTCAAAGCTACTT
CTCTGTGGTAAGTGGGAAAAGAGAGGTCTGATCTGTTTGGACAACTAAGGGAAAAATGTGGACT
CTCAATATTTTGACTTAATAGTTCTAATAATTTCTTCTAGTTGGGTAAAATTTACAACTACCAG
GGAATTTTTCTAGAAGACTAAACATAATCTAATGGTAAAGTGGACTAATGGCTCTCTTATTTAT
CAGAGAACTGATTTTTGTTTCCCACAAAAAGCAAGTATAAGGAGTGCCCAAGAGACTAGAAAAG
AAATCTTAGGTATGGTCTTTTGAAGCTGTGTTTAGGGAGATGAAGCAAAGAGGTAGCTGATGCT
TTAAGAAAGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008765159	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072399.2

RefSeq Acc Id:

XP_008765159 ⟸ XM_008766937

- UniProtKB:

A0A0G2K2W1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPAWRISLLSVELLLLANAYSSFRIEPTEGSLAGGTWITLVFDGLETSILYPNNGSQLAIDLVN
VATPALKIPCDISPLFVDLPVVTCQTRSLPSEAPEGLYSLEIRSGDQLLGSPCARLLDNCTFKF
SKEQTPVLYQVNPSSGVPGEVVHVYGWVITDRMEIFDPDVDYMESPLILEAGGDKWLTPCSLIN
RKTGICFPIQEEHGLGTVQCRVEGSYIGSQNVSFSVFNKGRSMVHKEAWLISAKQELFLYQTYP
EIHSVFPKVGSLGGRTDITITGDFFDPSARVTIAGIPCDIRHVSPRKIECTTRAPGNGARLTAP
QAGNRGLLFEVGNAVKDEELTEATPGYRWQIVPNASSPSGFWSKEGRPFRARLSGFFVAPETNN
YTFWIQADSQAFLRFSSSEEPRMKVEVASIAVGTADWFDSWEQNGNEGSWQQKTNKLELQGGAK
YYLEAEQHGIAPSRGMRIAVQIHNTWLNPDVVNTYLLEKHQIRAQAQRLPEIQVLNMSGKGNFF
LTWGNVSSQPVPANATAQQIQTIIEELLVVKCNLVPLSARVLLWLGFEQGLDGSRSDGVLTSST
EPFCGRFSLGQLRHLILSPGAVSKGYQLDRYPYLCFAYRGHMNRTLDMTVSFLFGFQNVMKNIT
CDWSLMEPHPESWHFTCNNLWDTCVRHSEELQSSLANTPLLVHRIDIFPVVPEADLLYVDEIIL
ADTNVTVSQADSGVARPGGNVVESVSVVGVPPVYSIASWMAGCGSELPLITACYVPTQGTGEGS
ELIEVTAKRLQRTSPPLGGHFSLHLSDTVIPDVPVHVSARQLHKLLQDNADESTSGYLNADDFI
VTKDQNSCYEHVWTLSWTTQIGDLPNFIRVSDQNLTGLNPTITARVVYDGGVFLGPILGDTLAT
ANQQTQVTVQVNDIPAHCSGSCSFQYQRASTPSVDCVWYSLGSDVNLLVHFTGNGFPRDAQFLQ
VTVINTSCEVIFSNETNVACELALLPVGVHRVFMLVRPSGLALNASGEGLFLRVEPRLDAVEPS
TGAEIGGWWVTLRGSSLEGVSLVLFGTRSCVIDVIRSNSQQIQCKVPPRGKDGYTVNVTVINGD
HSTVLARAFTYVSSLNPVIVSLSRNRSNIAGGEILFLGMTLMVNYTDLNVQIYIQNTSAQVLAK
TAWGLEVLLPPLLPGIYVISAFINGISIRSQGVDLHIQYLTEVFSMEPCSGSLLGGTILQTLRS
RTGRDPALIRVLVDNRLACDTVKLTEVNIGVRLPSLLPPRADVLTVPASVEIWAGNTSFVGKAF
HLHIXSCSQLPVVTAYGGVNSIEQQCXGLCGRNNLSDSVILLGSLEMDLQVQLFGITXTCLGSL
LLHSLEAGXYALQVRHXRGWFANMSAVLRSLRLSPQIIDIFPXHGSXYGGTVLTVKGTAFRSRR
RVCSCDLSGPFTCGILSLGDHNSPSQTKFVGDQFSETSXALNITVHGNGLTSKCEGNCTLFLEE
AATPIVDALTISISGSLTTVLMRGQRLGSAGEPTAFVDGQLLCHTTFFNTSYVACQMRDLAPGF
HYLSAVRTSAGYACLNSVSRNFFVVPQVFDYFPKDFSIHGGSLLTIKGTTLRGWKTTFVYVGQQ
ACLTVNISSEFIQCIVPAGNGSAALEIDVDGVLYHMGFVDYSSIFTPELLSVSRSHDILTFTVA
RISGAANVDILIGTSPCLDVAGNRTILRCMVPLLPAGEYAVTGYDHSRGWVSSTLILVLRATVT
SVTENYGCLGGRLLHVLGAGFSPGNISAAVCGAPCQVLANATVSAFSCLVLPLDASLAFLCNLR
HAEDSCGVSRPTYLQCDLTVSVGMERLPGSWPYVYLCEESSQGLFVPDHQIFLSFSGLFLSPKV
ERDEVLIYNSSCNITMETEAEMECGTPNQPITAKITEIQKSRGQNTQGNFSFQFCRRWSRPHSW
FPHRVPQDGDNVTVETSHLLLLDANTSLLNSLHIKGGKLIFMEPGPIDLRAHSILITDGGELHI
GSEDKPFQGKARIKLYGSVHSTSFFPYGVKFLAVRNGTLSLHGSVPEVTFTYLRAAACAGDTVL
ALEEAVAWHPGDEAVISSGATVEGAEATEEVVVVETVHDADLHLRNPLRYSYNFTENWVTGVNH
ILKATVALLSRNIIVQGNLTLERVKLLDSCQEAGAAEGNLKHCLYSKSEKMLGARNLGARVIIQ
SFPEEPSLVKLKGVQFRDLGQAFHKHLSSLTLVGAMRGSYLHSCSMWGSFSRGLSIHRTWGLKV
ENNIFYKIVGHALLVGSYMDRSFSTSEAVIGRKNGWWEEGSMIRNNVIINVSGAEGLSSSEMLA
PAGIYTFSPTSAIEGNRVCAAGYGYVLHLVTSQTVQAPLLSFNWNTAHSCTRYGLLVYPEFQPP
WNNDTGFTLFQNFMVWGSAGGAQIFRSNNLHLRNFQVYACRDFGIDILESDTNTLVTDSFLLGH
FTHEGSLCMSVGIKTPKRWGLTISNTTFVNFDLNCVAIRTCSGCSQGQGGFPVKTRQLKFVNSS
NLVAFPFPHAAVLQDLDGSLSGKNGSHVLASMETLSDTCLTNASFSQIVSGSVCGEAVLFHRMS
IGLAKSLDVPKNLTMTDIRNRTITINYVDDTLSNSYGWMALLLDQETYLLQFEGPWTDGSLQYS
ATFDNFAPGNYLLLMHRDLLPYPDILLRCGSRVGQSLPSHPLPSRDGACDWFFHRQLRQLTYLV
SGEGQVHVFLQVKHGAPPTVSASTSVSESALKWSLPETWQDVEKGWGGYNHTIPGPGDDVLILP
NKTVLVDTDLPVLRCLYVMGTLEFPVDRSNVLSVACLLIAGGELKVGTLENPLGKDQRLLILLR
ASEEIFCDRFDGIRVDPGTIGVYGKLRLHSAYPKKSWVHLGADIAPGNERIIVHNAVDWQPHDK
IVLSSSSYEPHEAEVXTVKEVKDHHIRIYERXKHRHIGSAHTLEDSRQICLAAEVGLLTRNIRI
QSDSSCRGRLLVGSFRKSSGEEFSGILQLLNVEIQNMGSPLYASIEFTGVSAGSWVISSTVHQS
CTVGIHASSSRGMVLNDNIVFGTKGHGIDVEGQNYSLTNNLVILSMQSANSLPWVAGIKVNYAE
DIILHGNVVAGSERLGFHVRGHGCSSEVLWSDNVVHSSLHGIHLYKKREPNNCTGVSGFLAFKN
FDYGAMVQTENSVDIQNITLVDNTVGLLAISYVSSAPLRSGSTLQITLRNSVIVATSSSFDCIQ
DRKAPQSANWTSTDRAPSNPRGGRIGILWPVSASEPNGWPQEPWHKVRGGHSVPGIMKLQDVTF
SSFVKSCYSDDLDVCILTNEHSTGIMYPITAERTRMLKIKDKNKFYFLPLQSGKDLVGTICPAS
SDCEIPRKYLFTDLDGRTLGLSPPVSVFPRIEEGWTGSFFNTGIFREEQKCTFRAMIQGFFCKQ
TEHAVLILDNVDVTWTIPKFYPLVSITNGFVDTFSIVKDSGLCFPTSSPSTFYSILPTRQMTKV
CFPERTPPFLHFFLLANRRASKLILAVFYNEIQSPYVFLDKSFIPPTPVESAFSLLDEPVGANY
FDIMNNLLYVVLQGEEAVEIRSSVSIHLALTVTFSVLEKGWEKAVLESLRGFFQIDQNQIRLTL
EMPGNKETLKAIANSEGKRKRSCPTVTCAVPSSRYVQRRPLMAEMASFTITPATTLETFSKVIV
FEIGDLPNARDSEFIQSLPSNRLQKLAHQVITAQQTGVLENVLGMTVGALLVAQSEGVTGYRNA
SSLITGNQIYTRPSVVSILVQPSDGEVGIELPIQPRLIFLDEKNERVEALGLPSEPWIISVSLE
GTSESMLKGCTQAETQDGYVTFSRLAVLTSGSNWHLVFTVTFPPGTNLTARSKTFAVLPVAGKE
RSTIILALSLCSVASWVALSCLICCWFKKSKTRKIKPEDISESQAKEQKKNTHISSKPRELQVK
TAKEDAMMGEDMRMKVMEGRQNQFSQHSMDGVSKRKVSRRAVPEERTATPALKIPRTTCVPGAL
PQQLTLPEPGNWQEAQQQLLRYQLAGRDQLLLLCPDLRQERQQGQEPSQLNKGSGRCMGLSQEK
ATCVPTETFCLHTAPPETIQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000072399 ⟸ ENSRNOT00000080948

Protein Domains

G8 PA14

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K2W1-F1-model_v2	AlphaFold	A0A0G2K2W1	1-1613	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308476	AgrOrtholog
BioCyc Gene	G2FUF-28044	BioCyc
Ensembl Genes	ENSRNOG00000058742	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000080948.2	UniProtKB/TrEMBL
Gene3D-CATH	2.160.20.10	UniProtKB/TrEMBL
	2.60.40.10	UniProtKB/TrEMBL
InterPro	Beta_helix	UniProtKB/TrEMBL
	Fibrocystin-related	UniProtKB/TrEMBL
	G8_domain	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_E-set	UniProtKB/TrEMBL
	IPT_dom	UniProtKB/TrEMBL
	PA14/GLEYA	UniProtKB/TrEMBL
	PbH1	UniProtKB/TrEMBL
	Pectin_lyas_fold	UniProtKB/TrEMBL
	Pectin_lyase_fold/virulence	UniProtKB/TrEMBL
NCBI Gene	301287	ENTREZGENE
PANTHER	POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1	UniProtKB/TrEMBL
	PTHR46769:SF1	UniProtKB/TrEMBL
Pfam	Beta_helix	UniProtKB/TrEMBL
	PF10162	UniProtKB/TrEMBL
	TIG	UniProtKB/TrEMBL
PhenoGen	Pkhd1	PhenoGen
PROSITE	PA14	UniProtKB/TrEMBL
	PS51484	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000058742	RatGTEx
SMART	IPT	UniProtKB/TrEMBL
	PbH1	UniProtKB/TrEMBL
	SM01225	UniProtKB/TrEMBL
Superfamily-SCOP	Anthrax protective antigen	UniProtKB/TrEMBL
	SSF51126	UniProtKB/TrEMBL
	SSF81296	UniProtKB/TrEMBL
UniProt	A0A0G2K2W1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Pkhd1	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	AABR07067023.1		Data merged from RGD:15012019	737654	PROVISIONAL
2021-09-02	AABR07067023.1		Pkhd1	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Symbol and/or name change	19259462	PROVISIONAL
2021-08-09	Pkhd1	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	AABR07067023.1		Symbol and/or name change	19259462	PROVISIONAL
2019-11-08	AABR07067023.1				Symbol and Name status set to provisional	45752	PROVISIONAL
2012-06-26	Pkhd1	polycystic kidney and hepatic disease 1	Pkhd1	polycystic kidney and hepatic disease 1 homolog (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-04-29	Pkhd1	polycystic kidney and hepatic disease 1 homolog (human)	Pkhd1	polycystic kidney and hepatic disease 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-07	Pkhd1	polycystic kidney and hepatic disease 1	Pkhd1_predicted	polycystic kidney and hepatic disease 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Pkhd1_predicted	polycystic kidney and hepatic disease 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

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