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Strain Registration

Strain: PCK-P2rx7em8Mcwi

Symbol: PCK-P2rx7em8Mcwi
Strain: PCK-P2rx7em8
Substrain: Mcwi
RGD ID: 12790679
Citation ID: RRID:RGD_12790679
Ontology ID: RS:0004349
Alleles: P2rx7em8Mcwi;   Pkhd1pck
Also Known As: PCK-P2rx7em8Mcwi; PCK-P2rx7^[em8Mcwi]
Type: mutant
Available Source: Contact MCW rat distribution at mcwcustomrats@mcw.edu
Origination: MCW Gene Editing Rat Resource Center
Description: CRISPR/Cas9 system was used to introduce a mutation in the P2rx7 gene of PCK/CrljCrl-Pkhd1pck/Crl rat embryos. The resulting mutation is a 1-bp insertion in Exon 2 of the P2rx7 gene.
Last Known Status: Cryopreserved Sperm (as of 2021-11-03)
Genotyping Protocol Download Genotyping Protocol
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,917,661 - 33,917,662RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0926,164,969 - 26,736,704RGD_MAPPER_PIPELINERnor6.0
Rnor_6.01239,353,613 - 39,396,042RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01241,242,368 - 41,808,755RGD_MAPPER_PIPELINERnor5.0
Rnor_5.0925,025,958 - 25,593,163RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41235,074,025 - 35,117,152RGD_MAPPER_PIPELINERGSC3.4
RGSC_v3.4918,833,903 - 19,338,716RGD_MAPPER_PIPELINERGSC3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Knockout of P2rx7 purinergic receptor attenuates cyst growth in a rat model of ARPKD. Arkhipov SN, etal., Am J Physiol Renal Physiol. 2019 Oct 21. doi: 10.1152/ajprenal.00395.2019.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
P2rx7em8Mcwi-var1 chr12 33917661 33917662 - A insertion mRatBN7.2

Additional Information