Stat1 (signal transducer and activator of transcription 1) - Rat Genome Database

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Gene: Stat1 (signal transducer and activator of transcription 1) Rattus norvegicus
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Symbol: Stat1
Name: signal transducer and activator of transcription 1
RGD ID: 3771
Description: Enables CCR5 chemokine receptor binding activity; protein phosphatase 2A binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; positive regulation of nitric oxide biosynthetic process; and positive regulation of smooth muscle cell proliferation. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in axon and dendrite. Used to study pulmonary fibrosis. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1); PARTICIPATES IN Jak-Stat signaling pathway; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH (+)-schisandrin B; 15-deoxy-Delta(12,14)-prostaglandin J2; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DD6G4-4; signal transducer and activator of transcription 1-alpha/beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,911,522 - 56,951,926 (-)NCBIGRCr8
mRatBN7.2949,419,561 - 49,459,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,419,340 - 49,588,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,969,129 - 58,009,299 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,091,965 - 63,132,135 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,387,952 - 61,428,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,287,540 - 54,327,958 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,998,204 - 54,038,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,455,635 - 46,497,560 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,458,584 - 46,495,612 (-)NCBI
Celera947,082,882 - 47,123,002 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
angiomyolipoma  (ISO)
Brain Injuries  (IMP)
breast cancer  (ISO,ISS)
breast carcinoma  (ISO)
bronchiectasis  (ISO)
chronic mucocutaneous candidiasis  (ISO)
Cognitive Dysfunction  (ISO)
colon adenocarcinoma  (ISO)
combined immunodeficiency  (ISO)
combined T cell and B cell immunodeficiency  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
Diarrhea 9  (ISO)
Disease Progression  (ISO)
Dwarfism  (ISO)
Experimental Arthritis  (IDA,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IDA)
Experimental Mammary Neoplasms  (ISO)
Failure to Thrive  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Human Influenza  (ISO)
hypothyroidism  (ISO)
immunodeficiency 31A  (ISO)
immunodeficiency 31B  (ISO)
immunodeficiency 31C  (ISO)
Liver Abscess  (ISO)
liver cirrhosis  (ISO)
lupus nephritis  (ISO)
lymphangioleiomyomatosis  (ISO)
lymphocytic choriomeningitis  (ISO)
Mycobacterium Infections  (ISO)
Myocardial Reperfusion Injury  (IDA)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Nervous System Trauma  (IDA)
Neurodevelopmental Disorders  (ISO)
Nontuberculous Mycobacterium Infections  (ISO)
pancreatic adenocarcinoma  (ISO)
periodontitis  (ISO)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary fibrosis  (IDA)
Reoviridae Infections  (ISO)
Reperfusion Injury  (IDA,IEP)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Sepsis  (IDA)
severe acute respiratory syndrome  (ISS)
T-cell acute lymphoblastic leukemia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-nitrofluorene  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amantadine  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amorolfine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antigen  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
Azoxymethane  (EXP)
baricitinib  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
busulfan  (ISO)
butenafine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
Cannabinol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
cerium  (ISO)
chlorophyllin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
Cirsimarin  (ISO)
cisplatin  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl malate  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP,ISO)
dimemorfan  (EXP)
dimethylarsinous acid  (ISO)
dinitrogen oxide  (ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
fingolimod hydrochloride  (ISO)
flavonoids  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
herbimycin  (EXP)
hesperetin  (ISO)
hexachlorobenzene  (EXP)
hydrazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
ICI D1694  (ISO)
indometacin  (ISO)
Interferon beta-1b  (ISO)
iopamidol  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoprenaline  (EXP)
itraconazole  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
L-arginine  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
Luliconazole  (ISO)
lycorine  (ISO)
Mecamylamine  (ISO)
melatonin  (ISO)
mercury dichloride  (ISO)
metam  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
Methylthiouracil  (ISO)
mevalonic acid  (EXP,ISO)
MitoTEMPO  (ISO)
monocrotaline  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitrofurantoin  (ISO)
NORCANTHARIDIN  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oridonin  (ISO)
oroxylin A  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
PF-956980  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phosphatidic acid  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resiniferatoxin  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
Ro 41-5253  (ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
stattic  (ISO)
sulfates  (ISO)
T-2 toxin  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurocholic acid  (EXP)
temozolomide  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
Trachelogenin  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
ursodeoxycholic acid  (ISO)
valsartan  (ISO)
vancomycin  (ISO)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vinyl carbamate  (ISO)
vitamin E  (ISO)
withaferin A  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood circulation  (IMP)
cell population proliferation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (IBA,IMP,ISO,TAS)
cell surface receptor signaling pathway via STAT  (ISO)
cellular response to cytokine stimulus  (IDA)
cellular response to insulin stimulus  (IDA)
cellular response to interferon-beta  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to type II interferon  (ISO)
cytokine-mediated signaling pathway  (ISO)
defense response  (IBA)
defense response to virus  (ISO)
DNA-templated transcription  (ISO)
endothelial cell migration  (ISO)
interleukin-27-mediated signaling pathway  (ISO)
interleukin-7-mediated signaling pathway  (ISO)
interleukin-9-mediated signaling pathway  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
negative regulation by virus of viral protein levels in host cell  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of macrophage fusion  (ISO)
obsolete cellular response to organic cyclic compound  (IDA)
positive regulation of apoptotic process  (ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of defense response to virus by host  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (IBA)
regulation of transcription by RNA polymerase II  (IBA,ISO)
renal tubule development  (ISO)
response to bacterium  (ISO)
response to cAMP  (IDA)
response to cytokine  (IDA)
response to exogenous dsRNA  (ISO)
response to hydrogen peroxide  (IEP)
response to interferon-beta  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (IDA)
response to nutrient  (IDA)
response to peptide hormone  (IBA,IDA)
response to type I interferon  (ISO)
response to type II interferon  (ISO)
response to xenobiotic stimulus  (IDA)
tumor necrosis factor-mediated signaling pathway  (ISO)
type I interferon-mediated signaling pathway  (IBA,ISO)
type II interferon-mediated signaling pathway  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Specific transcription factors prognostic for prostate cancer progression. Aoyagi K, etal., Clin Cancer Res. 1998 Sep;4(9):2153-60.
2. Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli. Banes AK, etal., Am J Physiol Renal Physiol. 2004 Apr;286(4):F653-9. Epub 2003 Dec 16.
3. Upregulation of Penile Brain-Derived Neurotrophic Factor (BDNF) and Activation of the JAK/STAT Signalling Pathway in the Major Pelvic Ganglion of the Rat After Cavernous Nerve Transection. Bella AJ, etal., Eur Urol. 2006 Oct 30;.
4. Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). Bhanoori M, etal., Oncogene 2003 Jan 9;22(1):117-30.
5. Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer. Buess M, etal., Genome Biol. 2007;8(9):R191.
6. Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. Chen G, etal., J Biol Chem 2001 Jan 5;276(1):766-72.
7. Differentiation decreased telomerase activity in rat glioblastoma C6 cells and increased sensitivity to IFN-gamma and taxol for apoptosis. Das A, etal., Neurochem Res. 2007 Dec;32(12):2167-83. Epub 2007 Aug 13.
8. Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Dupuis S, etal., Science. 2001 Jul 13;293(5528):300-3.
9. Interferon-gamma-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a potential therapeutic target. El-Hashemite N and Kwiatkowski DJ, Am J Respir Cell Mol Biol. 2005 Sep;33(3):227-30. Epub 2005 Jun 30.
10. [STAT1 antisense oligonucleotides inhibit secretion of TNF-alpha, IL-8 and NO in alveolar macrophages of rats suffering from interstitial pulmonary fibrosis] Fan XM, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006 Jul;22(4):487-9, 492.
11. Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins. Fujitani Y, etal., Biochem Biophys Res Commun. 1994 Jul 29;202(2):1181-7.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Specific localization of signal transducer and activator of transcription 1 immunoreactivity in oxytocin neurons of the rat hypothalamus. Gautron L, etal., Brain Res. 2003 Dec 24;994(2):260-4.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. JAK-STAT signaling pathways are activated in the brain following reovirus infection. Goody RJ, etal., J Neurovirol. 2007 Aug;13(4):373-83.
16. Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490. Gorina R, etal., Glia. 2007 Oct;55(13):1313-24.
17. Vitamin C inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts. Guaiquil VH, etal., Free Radic Biol Med. 2004 Nov 1;37(9):1419-29.
18. Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. Guo L, etal., Am J Transl Res. 2020 Sep 15;12(9):4977-4997. eCollection 2020.
19. Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. Hofer MJ, etal., J Virol. 2012 Jun;86(12):6932-46. doi: 10.1128/JVI.07147-11. Epub 2012 Apr 11.
20. Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-kappaB signaling pathways. Jia Y, etal., PLoS One. 2011;6(10):e27006. Epub 2011 Oct 31.
21. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
22. Regulation by cAMP of STAT1 activation in hepatic stellate cells. Kawada N, etal., Biochem Biophys Res Commun. 1997 Apr 17;233(2):464-9.
23. JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. Kim OS, etal., J Biol Chem 2002 Oct 25;277(43):40594-601. Epub 2002 Aug 20.
24. Mangiferin ameliorates Porphyromonas gingivalis-induced experimental periodontitis by inhibiting phosphorylation of nuclear factor-κB and Janus kinase 1-signal transducer and activator of transcription signaling pathways. Li H, etal., J Periodontal Res. 2017 Feb;52(1):1-7. doi: 10.1111/jre.12360. Epub 2016 Jan 30.
25. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Lv N, etal., Exp Cell Res. 2009 Jul 15;315(12):2064-71. doi: 10.1016/j.yexcr.2009.04.021. Epub 2009 May 3.
26. Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells. Masamune A, etal., World J Gastroenterol. 2005 Jun 14;11(22):3385-91.
27. Janus kinase-2 signaling mediates apoptosis in rat cardiomyocytes. Mascareno E, etal., Vascul Pharmacol. 2005 Nov;43(5):327-35. Epub 2005 Nov 2.
28. Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury. McCormick J, etal., FASEB J. 2006 Oct;20(12):2115-7. Epub 2006 Aug 25.
29. A proteomic investigation of drug-induced steatosis in rat liver. Meneses-Lorente G, etal., Chem Res Toxicol. 2004 May;17(5):605-12.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
32. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
33. JAK-STAT signaling pathway mediates astrogliosis in brains of scrapie-infected mice. Na YJ, etal., J Neurochem. 2007 Oct;103(2):637-49.
34. Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: differential role of FGFR3 in skeletal development and fracture repair. Nakajima A, etal., Endocrinology 2003 Oct;144(10):4659-68. Epub 2003 Jul 3.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Overexpression of the mTOR alpha4 phosphoprotein activates protein phosphatase 2A and increases Stat1alpha binding to PIAS1. Nien WL, etal., Mol Cell Endocrinol. 2007 Jan 15;263(1-2):10-7. Epub 2006 Nov 2.
37. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
38. 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. Park EJ, etal., J Biol Chem 2003 Apr 25;278(17):14747-52. Epub 2003 Feb 12.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
41. [Transcription factors STAT1 and STAT3 are localized in different compartments of rat embryo fibroblasts transformed by E1A and Ha-Ras oncogenes] Poselova TV, etal., Tsitologiia. 1998;40(12):1074-9.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J. Robinson K, etal., J Am Coll Surg. 2006 May;202(5):788-96.
46. Biology of interleukin-10. Sabat R, etal., Cytokine Growth Factor Rev. 2010 Oct;21(5):331-44. doi: 10.1016/j.cytogfr.2010.09.002. Epub 2010 Nov 5.
47. Dysregulation of mammary Stats 1,3 and 5 and PRL receptors by overexpression of TGFalpha. Schroeder MD, etal., Mol Cell Endocrinol. 2001 Apr 25;175(1-2):173-83.
48. Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis. Shahrara S, etal., Arthritis Rheum. 2003 Dec;48(12):3568-83.
49. Fluvastatin inhibits activation of JAK and STAT proteins in diabetic rat glomeruli and mesangial cells under high glucose conditions. Shi YH, etal., Acta Pharmacol Sin. 2007 Dec;28(12):1938-46.
50. JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. Slattery ML, etal., Mol Carcinog. 2013 Feb;52(2):155-66. doi: 10.1002/mc.21841. Epub 2011 Nov 28.
51. STAT-1 decoy oligonucleotide improves microcirculation and reduces acute rejection in allogeneic rat small bowel transplants. Stojanovic T, etal., Gene Ther. 2007 Jun;14(11):883-90. Epub 2007 Mar 15.
52. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
53. Differential expression of STAT1 and p21 proteins predicts pancreatic cancer progression and prognosis. Sun Y, etal., Pancreas. 2014 May;43(4):619-23. doi: 10.1097/MPA.0000000000000074.
54. Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness. Sung PS, etal., Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10443-8. doi: 10.1073/pnas.1513341112. Epub 2015 Jul 27.
55. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
56. Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis. Timofeeva OA, etal., Oncogene. 2006 Dec 7;25(58):7555-64. Epub 2006 Jun 26.
57. Fludarabine Prevents Smooth Muscle Proliferation In Vitro and Neointimal Hyperplasia In Vivo Through Specific Inhibition of Stat-1 Activation. Torella D, etal., Am J Physiol Heart Circ Physiol. 2007 Feb 9;.
58. Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Torella D, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2935-43. Epub 2007 Feb 9.
59. Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A(2)-IIA in microvascular endothelial cells of the injured brain. Wang G, etal., J Neuroinflammation. 2012 Jul 12;9:170. doi: 10.1186/1742-2094-9-170.
60. Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway. Wang TL, etal., J Mol Cell Cardiol. 2004 Sep;37(3):785-94.
61. MR image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischemia. West DA, etal., Neuroscience. 2004;127(2):333-9.
62. Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer. Widschwendter A, etal., Clin Cancer Res. 2002 Oct;8(10):3065-74.
63. Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1. Xu J, etal., J Endocrinol. 2005 Mar;184(3):481-92.
64. Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat. Yang N, etal., Nephrol Dial Transplant. 2008 Jan;23(1):91-100. Epub 2007 Jul 31.
65. [The potential mechanism on signal transduction pathway in regulation of mRNA expression of high mobility group box-1 protein in septic rats] Yao YM, etal., Zhonghua Wai Ke Za Zhi. 2006 Jul 1;44(13):916-20.
66. Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats. Zhao JB, etal., Neurosci Lett. 2011 Jul 8;498(2):147-52. Epub 2011 May 10.
Additional References at PubMed
PMID:1299057   PMID:8605877   PMID:8657134   PMID:8889548   PMID:9630226   PMID:10692450   PMID:10820245   PMID:10848577   PMID:10973496   PMID:12138178   PMID:12538627   PMID:12634107  
PMID:12872135   PMID:12947022   PMID:12957148   PMID:14522949   PMID:14984365   PMID:15485925   PMID:15590660   PMID:15630703   PMID:15659221   PMID:15661922   PMID:15825084   PMID:15956343  
PMID:16027122   PMID:16212889   PMID:16255958   PMID:16306601   PMID:16555329   PMID:16585190   PMID:16616937   PMID:17116388   PMID:17251186   PMID:17275127   PMID:17505916   PMID:17982005  
PMID:18035482   PMID:18348986   PMID:18499741   PMID:18511434   PMID:18514629   PMID:18582404   PMID:18591661   PMID:18721488   PMID:19176616   PMID:19182904   PMID:19426591   PMID:19563079  
PMID:19606498   PMID:19609277   PMID:19615126   PMID:19781632   PMID:19782030   PMID:20117981   PMID:20307504   PMID:20861313   PMID:20980260   PMID:21069420   PMID:21102409   PMID:21268089  
PMID:21396905   PMID:21419645   PMID:21545521   PMID:21606371   PMID:21929289   PMID:22002246   PMID:22302831   PMID:22865856   PMID:23386060   PMID:23451164   PMID:24097101   PMID:24280128  
PMID:24598055   PMID:24882218   PMID:25129435   PMID:25468996   PMID:25986861   PMID:26479788   PMID:26617765   PMID:27742579   PMID:27796300   PMID:27940139   PMID:27994058   PMID:28086195  
PMID:28129651   PMID:28283061   PMID:28601953   PMID:28753426   PMID:28782829   PMID:31982878   PMID:32503893   PMID:32741247   PMID:35124149   PMID:37199563   PMID:37365519   PMID:37479855  
PMID:37920469  


Genomics

Comparative Map Data
Stat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,911,522 - 56,951,926 (-)NCBIGRCr8
mRatBN7.2949,419,561 - 49,459,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,419,340 - 49,588,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,969,129 - 58,009,299 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,091,965 - 63,132,135 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,387,952 - 61,428,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,287,540 - 54,327,958 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,998,204 - 54,038,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,455,635 - 46,497,560 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,458,584 - 46,495,612 (-)NCBI
Celera947,082,882 - 47,123,002 (-)NCBICelera
Cytogenetic Map9q22NCBI
STAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,969,149 - 191,014,171 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,908,460 - 191,020,960 (-)EnsemblGRCh38hg38GRCh38
GRCh372191,833,875 - 191,878,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,542,121 - 191,587,181 (-)NCBINCBI36Build 36hg18NCBI36
Build 342191,665,769 - 191,704,442NCBI
Celera2185,428,361 - 185,473,577 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2183,693,413 - 183,738,626 (-)NCBIHuRef
CHM1_12191,839,599 - 191,884,801 (-)NCBICHM1_1
T2T-CHM13v2.02191,458,256 - 191,503,284 (-)NCBIT2T-CHM13v2.0
Stat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,158,588 - 52,201,024 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,158,599 - 52,201,024 (+)EnsemblGRCm39 Ensembl
GRCm38152,119,438 - 52,161,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,119,440 - 52,161,865 (+)EnsemblGRCm38mm10GRCm38
MGSCv37152,176,282 - 52,218,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36152,064,002 - 52,105,508 (+)NCBIMGSCv36mm8
Celera152,657,880 - 52,700,334 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.81NCBI
Stat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,156,660 - 8,194,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,156,660 - 8,192,018 (+)NCBIChiLan1.0ChiLan1.0
STAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,651,032 - 93,700,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,666,016 - 93,711,687 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,270,642 - 78,316,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,186,906 - 196,232,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,186,906 - 196,232,280 (-)Ensemblpanpan1.1panPan2
STAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,513,438 - 1,549,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,507,219 - 1,550,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,461,622 - 2,502,035 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,400,933 - 1,441,368 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,395,727 - 1,441,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,410,525 - 1,450,952 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,378,532 - 1,418,954 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,407,084 - 1,447,502 (-)NCBIUU_Cfam_GSD_1.0
Stat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,602,218 - 149,641,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,196,797 - 7,233,756 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,196,860 - 7,235,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,593,211 - 95,646,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11595,593,201 - 95,646,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
STAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,492,859 - 76,537,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,492,533 - 76,533,393 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040122,939,721 - 122,984,472 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,067,535 - 5,102,106 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248545,067,578 - 5,106,052 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:477
Count of miRNA genes:242
Interacting mature miRNAs:295
Transcripts:ENSRNOT00000019465
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH129933  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,420,416 - 49,420,598 (+)MAPPERmRatBN7.2
Rnor_6.0954,288,396 - 54,288,577NCBIRnor6.0
Rnor_5.0953,999,060 - 53,999,241UniSTSRnor5.0
RGSC_v3.4946,456,491 - 46,456,672UniSTSRGSC3.4
Celera947,083,738 - 47,083,919UniSTS
Cytogenetic Map9q31-q32UniSTS
RH141148  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,419,630 - 49,419,817 (+)MAPPERmRatBN7.2
Rnor_6.0954,287,610 - 54,287,796NCBIRnor6.0
Rnor_5.0953,998,274 - 53,998,460UniSTSRnor5.0
RGSC_v3.4946,455,705 - 46,455,891UniSTSRGSC3.4
Celera947,082,952 - 47,083,138UniSTS
Cytogenetic Map9q31-q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001034164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA901120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC094675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF034252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF205604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM386875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF109416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV075250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY564252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019465   ⟹   ENSRNOP00000019465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,419,340 - 49,459,978 (-)Ensembl
Rnor_6.0 Ensembl954,287,541 - 54,327,958 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000020032   ⟹   ENSRNOP00000020032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,471,395 - 49,588,540 (-)Ensembl
Rnor_6.0 Ensembl954,340,652 - 54,457,753 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080522   ⟹   ENSRNOP00000070183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,424,157 - 49,499,445 (-)Ensembl
Rnor_6.0 Ensembl954,292,312 - 54,351,339 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083514   ⟹   ENSRNOP00000070268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,471,395 - 49,588,540 (-)Ensembl
Rnor_6.0 Ensembl954,340,713 - 54,484,533 (-)Ensembl
RefSeq Acc Id: NM_001034164   ⟹   NP_001029336
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,916,986 - 56,951,926 (-)NCBI
mRatBN7.2949,425,026 - 49,459,969 (-)NCBI
Rnor_6.0954,293,004 - 54,327,958 (-)NCBI
Rnor_5.0953,998,204 - 54,038,463 (-)NCBI
RGSC_v3.4946,455,635 - 46,497,560 (-)RGD
Celera947,088,347 - 47,123,002 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032612   ⟹   NP_116001
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,911,522 - 56,951,926 (-)NCBI
mRatBN7.2949,419,561 - 49,459,969 (-)NCBI
Rnor_6.0954,287,540 - 54,327,958 (-)NCBI
Rnor_5.0953,998,204 - 54,038,463 (-)NCBI
RGSC_v3.4946,455,635 - 46,497,560 (-)RGD
Celera947,082,882 - 47,123,002 (-)RGD
Sequence:
RefSeq Acc Id: NP_116001   ⟸   NM_032612
- Peptide Label: isoform alpha
- UniProtKB: Q9QXK0 (UniProtKB/TrEMBL),   A6INW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029336   ⟸   NM_001034164
- Peptide Label: isoform beta
- UniProtKB: Q6P6Q7 (UniProtKB/TrEMBL),   Q9QXK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070183   ⟸   ENSRNOT00000080522
Ensembl Acc Id: ENSRNOP00000019465   ⟸   ENSRNOT00000019465
Ensembl Acc Id: ENSRNOP00000020032   ⟸   ENSRNOT00000020032
Ensembl Acc Id: ENSRNOP00000070268   ⟸   ENSRNOT00000083514
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX93-F1-model_v2 AlphaFold A0A0G2JX93 1-1083 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696657
Promoter ID:EPDNEW_R7182
Type:initiation region
Name:Stat1_1
Description:signal transducer and activator of transcription 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7183  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0954,327,971 - 54,328,031EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3771 AgrOrtholog
BioCyc Gene G2FUF-27607 BioCyc
Ensembl Genes ENSRNOG00000014079 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019465.8 UniProtKB/TrEMBL
  ENSRNOT00000080522.2 UniProtKB/TrEMBL
  ENSRNOT00000083514.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  6.10.250.3310 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599645 IMAGE-MGC_LOAD
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT1_C_sf UniProtKB/TrEMBL
  STAT1_SH2 UniProtKB/TrEMBL
  STAT1_TAZ2-bd_C UniProtKB/TrEMBL
  STAT4 UniProtKB/TrEMBL
  STAT4_CCD UniProtKB/TrEMBL
  STAT4_SH2 UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_core UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_sub UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
KEGG Report rno:25124 UniProtKB/TrEMBL
MGC_CLONE MGC:72374 IMAGE-MGC_LOAD
NCBI Gene 25124 ENTREZGENE
PANTHER SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA UniProtKB/TrEMBL
  SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4 UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT1_TAZ2bind UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
PharmGKB STAT1 RGD
PhenoGen Stat1 PhenoGen
PROSITE SH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014079 RatGTEx
SMART STAT_int UniProtKB/TrEMBL
Superfamily-SCOP P53_like_DNA_bnd UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
UniProt A0A0G2JX93_RAT UniProtKB/TrEMBL
  A0A0G2JXH1_RAT UniProtKB/TrEMBL
  A6INW8 ENTREZGENE, UniProtKB/TrEMBL
  F1M9D6_RAT UniProtKB/TrEMBL
  Q6P6Q7 ENTREZGENE, UniProtKB/TrEMBL
  Q9QXK0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Stat1  signal transducer and activator of transcription 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function transcription factor that binds to the IFN-stimulated response element (ISRE) and to the GAS element