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Gene: Stat1 (signal transducer and activator of transcription 1) Rattus norvegicus
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Symbol: Stat1
Name: signal transducer and activator of transcription 1
Description: Exhibits CCR5 chemokine receptor binding activity; protein phosphatase 2A binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; and receptor signaling pathway via JAK-STAT. Localizes to the cytoplasm; neuron projection; and nucleus. Used to study pulmonary fibrosis. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; primary immunodeficiency disease; and prostate adenocarcinoma. Orthologous to human STAT1 (signal transducer and activator of transcription 1); PARTICIPATES IN Jak-Stat signaling pathway; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH (R)-mevalonic acid; 15-deoxy-Delta(12,14)-prostaglandin J2; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DD6G4-4; signal transducer and activator of transcription 1-alpha/beta
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0954,287,540 - 54,327,958 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0953,998,204 - 54,038,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,455,635 - 46,497,560 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1946,458,584 - 46,495,612 (-)NCBI
Celera947,082,882 - 47,123,002 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Stat1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3771
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.