STAT1 (signal transducer and activator of transcription 1) - Rat Genome Database

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Gene: STAT1 (signal transducer and activator of transcription 1) Canis lupus familiaris
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Symbol: STAT1
Name: signal transducer and activator of transcription 1
RGD ID: 12329024
Description: ENCODES a protein that exhibits CCR5 chemokine receptor binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); blood circulation (ortholog); cellular response to cytokine stimulus (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH angiomyolipoma (ortholog); Brain Injuries (ortholog); breast cancer (ortholog); FOUND IN axon (ortholog); chromatin (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,513,438 - 1,549,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,507,219 - 1,550,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,461,622 - 2,502,035 (-)NCBI
ROS_Cfam_1.0371,400,933 - 1,441,368 (-)NCBI
UMICH_Zoey_3.1371,410,525 - 1,450,952 (-)NCBI
UNSW_CanFamBas_1.0371,378,532 - 1,418,954 (-)NCBI
UU_Cfam_GSD_1.0371,407,084 - 1,447,502 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
blood circulation  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interferon-beta  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to organic cyclic compound  (ISO)
cytokine-mediated signaling pathway  (ISO)
defense response to virus  (ISO)
endothelial cell migration  (ISO)
interferon-gamma-mediated signaling pathway  (ISO)
interleukin-27-mediated signaling pathway  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
macrophage derived foam cell differentiation  (ISO)
negative regulation by virus of viral protein levels in host cell  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of macrophage fusion  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of defense response to virus by host  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
receptor signaling pathway via JAK-STAT  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
renal tubule development  (ISO)
response to bacterium  (ISO)
response to cAMP  (ISO)
response to cytokine  (ISO)
response to exogenous dsRNA  (ISO)
response to hydrogen peroxide  (ISO)
response to interferon-beta  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to type I interferon  (ISO)
response to xenobiotic stimulus  (ISO)
transcription, DNA-templated  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)
type I interferon signaling pathway  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:16611743   PMID:20861313  


Genomics

Comparative Map Data
STAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,513,438 - 1,549,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,507,219 - 1,550,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,461,622 - 2,502,035 (-)NCBI
ROS_Cfam_1.0371,400,933 - 1,441,368 (-)NCBI
UMICH_Zoey_3.1371,410,525 - 1,450,952 (-)NCBI
UNSW_CanFamBas_1.0371,378,532 - 1,418,954 (-)NCBI
UU_Cfam_GSD_1.0371,407,084 - 1,447,502 (-)NCBI
STAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2190,908,460 - 191,020,960 (-)EnsemblGRCh38hg38GRCh38
GRCh382190,968,989 - 191,014,197 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372191,833,875 - 191,878,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,542,121 - 191,587,181 (-)NCBINCBI36hg18NCBI36
Build 342191,665,769 - 191,704,442NCBI
Celera2185,428,361 - 185,473,577 (-)NCBI
Cytogenetic Map2q32.2NCBI
HuRef2183,693,413 - 183,738,626 (-)NCBIHuRef
CHM1_12191,839,599 - 191,884,801 (-)NCBICHM1_1
Stat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,158,588 - 52,201,024 (+)NCBIGRCm39mm39
GRCm39 Ensembl152,158,599 - 52,201,024 (+)Ensembl
GRCm38152,119,438 - 52,161,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,119,440 - 52,161,865 (+)EnsemblGRCm38mm10GRCm38
MGSCv37152,176,282 - 52,218,707 (+)NCBIGRCm37mm9NCBIm37
MGSCv36152,064,002 - 52,105,508 (+)NCBImm8
Celera152,657,880 - 52,700,334 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.81NCBI
Stat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2949,419,561 - 49,459,969 (-)NCBImRatBN7.2
Rnor_6.0954,287,540 - 54,327,958 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,998,204 - 54,038,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,455,635 - 46,497,560 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1946,458,584 - 46,495,612 (-)NCBI
Celera947,082,882 - 47,123,002 (-)NCBICelera
Cytogenetic Map9q22NCBI
Stat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,156,660 - 8,194,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,156,660 - 8,192,018 (+)NCBIChiLan1.0ChiLan1.0
STAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B196,186,906 - 196,232,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,186,906 - 196,232,280 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B78,270,642 - 78,316,074 (-)NCBIMhudiblu_PPA_v0panPan3
Stat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,602,218 - 149,641,217 (-)NCBI
SpeTri2.0NW_0049365067,196,860 - 7,235,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,593,211 - 95,646,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11595,593,201 - 95,646,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
STAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,492,859 - 76,537,689 (-)NCBI
ChlSab1.1 Ensembl1076,492,533 - 76,533,393 (-)Ensembl
Vero_WHO_p1.0NW_023666040122,939,721 - 122,984,472 (+)NCBI
Stat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248545,067,578 - 5,106,052 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000015583   ⟹   ENSCAFP00000014419
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl371,514,225 - 1,549,819 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000015587   ⟹   ENSCAFP00000014423
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl371,518,839 - 1,550,178 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070990   ⟹   ENSCAFP00000048445
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl371,507,219 - 1,549,819 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000079380   ⟹   ENSCAFP00000057505
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl371,518,541 - 1,549,819 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000087084   ⟹   ENSCAFP00000063877
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl371,537,652 - 1,549,819 (-)Ensembl
RefSeq Acc Id: XM_038447421   ⟹   XP_038303349
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0371,400,933 - 1,441,368 (-)NCBI
RefSeq Acc Id: XM_038463634   ⟹   XP_038319562
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha372,461,622 - 2,502,035 (-)NCBI
RefSeq Acc Id: XM_038521486   ⟹   XP_038377414
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1371,410,525 - 1,450,952 (-)NCBI
RefSeq Acc Id: XM_038585186   ⟹   XP_038441114
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0371,407,084 - 1,447,502 (-)NCBI
RefSeq Acc Id: XM_038649593   ⟹   XP_038505521
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0371,378,532 - 1,418,954 (-)NCBI
RefSeq Acc Id: XM_843260   ⟹   XP_848353
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1371,513,438 - 1,549,837 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_848353   ⟸   XM_843260
- Sequence:
RefSeq Acc Id: ENSCAFP00000014423   ⟸   ENSCAFT00000015587
RefSeq Acc Id: ENSCAFP00000014419   ⟸   ENSCAFT00000015583
RefSeq Acc Id: ENSCAFP00000057505   ⟸   ENSCAFT00000079380
RefSeq Acc Id: ENSCAFP00000048445   ⟸   ENSCAFT00000070990
RefSeq Acc Id: ENSCAFP00000063877   ⟸   ENSCAFT00000087084
RefSeq Acc Id: XP_038377414   ⟸   XM_038521486
RefSeq Acc Id: XP_038505521   ⟸   XM_038649593
RefSeq Acc Id: XP_038303349   ⟸   XM_038447421
RefSeq Acc Id: XP_038319562   ⟸   XM_038463634
RefSeq Acc Id: XP_038441114   ⟸   XM_038585186


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000048528 Ensembl, ENTREZGENE
NCBI Gene STAT1 ENTREZGENE