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Gene: Ppp2ca (protein phosphatase 2 catalytic subunit alpha) Rattus norvegicus
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Symbol: Ppp2ca
Name: protein phosphatase 2 catalytic subunit alpha
Description: Exhibits several functions, including beta-2 adrenergic receptor binding activity; enzyme binding activity; and ion channel binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of transport; and regulation of protein metabolic process. Localizes to the cytosol; postsynaptic density; and terminal bouton. Biomarker of type 2 diabetes mellitus. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; dopamine signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: PP2A-alpha; Pp2a1; Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase-2A-alpha; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01037,534,449 - 37,554,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01037,324,233 - 37,343,985 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,621,256 - 37,641,008 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11037,627,685 - 37,647,436 (+)NCBI
Celera1035,713,154 - 35,732,937 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Ppp2ca
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3380
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-06-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.