Ppp2ca (protein phosphatase 2 catalytic subunit alpha) - Rat Genome Database

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Gene: Ppp2ca (protein phosphatase 2 catalytic subunit alpha) Rattus norvegicus
Analyze
Symbol: Ppp2ca
Name: protein phosphatase 2 catalytic subunit alpha
RGD ID: 3380
Description: Enables several functions, including beta-2 adrenergic receptor binding activity; enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of transport; and regulation of cellular protein metabolic process. Acts upstream of or within regulation of protein autophosphorylation; regulation of protein catabolic process; and regulation of signaling receptor activity. Located in cytosol; postsynaptic density; and terminal bouton. Part of protein phosphatase type 2A complex. Biomarker of type 2 diabetes mellitus. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; dopamine signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103694903; PP2A-alpha; Pp2a1; Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase-2A-alpha; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21036,358,110 - 36,377,864 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1036,358,101 - 36,377,862 (+)Ensembl
Rnor_6.01037,534,449 - 37,554,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,535,871 - 37,554,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,324,233 - 37,343,985 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,621,256 - 37,641,008 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11037,627,685 - 37,647,436 (+)NCBI
Celera1035,713,154 - 35,732,937 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
5-azacytidine  (ISO)
5-methoxypsoralen  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
choline  (ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
daunorubicin  (ISO)
dehydroepiandrosterone  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
Estragole  (EXP)
ethanol  (EXP,ISO)
fenthion  (ISO)
fingolimod hydrochloride  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (EXP)
gentamycin  (EXP)
glycine betaine  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
imipramine  (EXP)
ionomycin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
lipopolysaccharide  (ISO)
Maduramicin  (EXP)
memantine  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
okadaic acid  (EXP,ISO)
ozone  (EXP)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
razoxane  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tadalafil  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
trichloroethene  (ISO)
uranium atom  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac ventricle development  (IEP)
cellular response to calcium ion  (IEP)
cellular response to cytokine stimulus  (IEP)
cellular response to ethanol  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucose stimulus  (IEP,IMP)
cellular response to insulin stimulus  (IEP)
cellular response to steroid hormone stimulus  (IEP)
heart development  (IEP)
meiotic cell cycle  (IEA)
mesoderm development  (ISO)
mitotic cell cycle  (IBA)
negative regulation of calcium ion transmembrane transporter activity  (IMP)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of protein import into nucleus  (IMP)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein phosphorylation  (IMP)
negative regulation of transcription by RNA polymerase II  (IMP)
peptidyl-threonine dephosphorylation  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of microtubule binding  (IMP)
positive regulation of phosphoprotein phosphatase activity  (IMP)
positive regulation of protein dephosphorylation  (IDA,IMP)
positive regulation of protein serine/threonine kinase activity  (ISO)
protein dephosphorylation  (IDA,ISO)
regulation of G1/S transition of mitotic cell cycle  (ISO)
regulation of protein autophosphorylation  (IMP)
regulation of protein catabolic process  (IMP)
regulation of protein phosphorylation  (IMP)
regulation of signaling receptor activity  (IMP)
response to lead ion  (IDA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam. Arif M, etal., Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1144-9. doi: 10.1073/pnas.1322614111. Epub 2014 Jan 6.
2. Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET. Arnaud L, etal., FEBS Lett. 2011 Sep 2;585(17):2653-9. doi: 10.1016/j.febslet.2011.07.020. Epub 2011 Jul 28.
3. High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 beta-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit. Arora DK, etal., Endocrinology. 2014 Feb;155(2):380-91. doi: 10.1210/en.2013-1773. Epub 2013 Nov 21.
4. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
5. Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells. Bishop JD, etal., J Endocrinol. 2006 Aug;190(2):307-12.
6. PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway. Chan PM, etal., J Biol Chem. 2008 Sep 5;283(36):24949-61. doi: 10.1074/jbc.M801728200. Epub 2008 Jun 27.
7. An NMDA receptor signaling complex with protein phosphatase 2A. Chan SF and Sucher NJ, J Neurosci. 2001 Oct 15;21(20):7985-92.
8. I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. Chen S, etal., J Biol Chem. 2008 Apr 18;283(16):10513-21. doi: 10.1074/jbc.M709852200. Epub 2008 Feb 1.
9. Expression of replication factor C 40-kDa subunit is down-regulated during neonatal development in rat ventricular myocardium. Chim SS, etal., J Cell Biochem 2000 Jun 12;78(4):533-40.
10. Deregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcription. Cho IS, etal., PLoS One. 2012;7(4):e34860. doi: 10.1371/journal.pone.0034860. Epub 2012 Apr 3.
11. Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase. Davare MA, etal., J Biol Chem. 2000 Dec 15;275(50):39710-7.
12. Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism. Galbo T, etal., PLoS One. 2011;6(11):e27424. doi: 10.1371/journal.pone.0027424. Epub 2011 Nov 7.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations. Goedert M, etal., J Neurochem. 2000 Nov;75(5):2155-62.
15. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Gong CX, etal., Brain Res. 2000 Jan 24;853(2):299-309.
16. Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation. Hall DD, etal., Biochemistry. 2006 Mar 14;45(10):3448-59.
17. AMP-activated protein kinase: also regulated by ADP? Hardie DG, etal., Trends Biochem Sci. 2011 Sep;36(9):470-7. doi: 10.1016/j.tibs.2011.06.004. Epub 2011 Jul 23.
18. Expression and mapping of protein phosphatase 2A alpha in the developing rat heart. Heller FA, etal., Pediatr Res. 1998 Jan;43(1):68-76.
19. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
20. Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases. Ishida A, etal., Br J Pharmacol. 2008 Jun;154(4):729-40. doi: 10.1038/bjp.2008.127. Epub 2008 May 5.
21. siRNA-mediated depletion of endogenous protein phosphatase 2Acalpha markedly attenuates ceramide-activated protein phosphatase activity in insulin-secreting INS-832/13 cells. Jangati GR, etal., Biochem Biophys Res Commun. 2006 Sep 22;348(2):649-52. doi: 10.1016/j.bbrc.2006.07.100. Epub 2006 Jul 28.
22. Molecular cloning of cDNA for the catalytic subunit of rat liver type 2A protein phosphatase, and detection of high levels of expression of the gene in normal and cancer cells. Kitagawa Y, etal., Biochim Biophys Acta 1988 Nov 10;951(1):123-9.
23. Carboxymethylation of nuclear protein serine/threonine phosphatase X. Kloeker S, etal., Biochem J. 1997 Oct 15;327 ( Pt 2):481-6.
24. PP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGF. Kolupaeva V, etal., PLoS One. 2008;3(10):e3447. doi: 10.1371/journal.pone.0003447. Epub 2008 Oct 17.
25. Differential gene expression in skeletal muscle after induction of heart failure: impact of cytokines on protein phosphatase 2A expression. Krankel N, etal., Mol Genet Metab. 2003 Sep-Oct;80(1-2):262-71.
26. FSH-induced phosphoprotein phosphatase 2A-mediated deactivation of particulate phosphodiesterase-4 activities is abolished after alteration in proteoglycan synthesis in immature rat Sertoli cells. Levallet G, etal., J Endocrinol. 2008 Apr;197(1):45-54. doi: 10.1677/JOE-07-0497.
27. A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C. Li D, etal., J Neurosci. 2005 Feb 23;25(8):1914-23.
28. Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation. Liangpunsakul S, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1173-81. doi: 10.1152/ajpgi.90349.2008. Epub 2008 Oct 2.
29. Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels. Liangpunsakul S, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G1004-12. doi: 10.1152/ajpgi.00482.2009. Epub 2010 Mar 11.
30. Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription. Lin TB, etal., J Pineal Res. 2016 Apr;60(3):263-76. doi: 10.1111/jpi.12307. Epub 2016 Jan 29.
31. Induced TRPC1 expression increases protein phosphatase 2A sensitizing intestinal epithelial cells to apoptosis through inhibition of NF-kappaB activation. Marasa BS, etal., Am J Physiol Cell Physiol. 2008 May;294(5):C1277-87. doi: 10.1152/ajpcell.90635.2007. Epub 2008 Mar 5.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Role of protein phosphatases in malignant transformation. Nagao M, etal., Princess Takamatsu Symp. 1989;20:177-84.
34. A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A. Nakashima A, etal., FEBS Lett. 2013 Sep 17;587(18):2924-9. doi: 10.1016/j.febslet.2013.07.027. Epub 2013 Jul 24.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Overexpression of the mTOR alpha4 phosphoprotein activates protein phosphatase 2A and increases Stat1alpha binding to PIAS1. Nien WL, etal., Mol Cell Endocrinol. 2007 Jan 15;263(1-2):10-7. Epub 2006 Nov 2.
37. Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells. O'Malley PG, etal., Biochem J. 2005 Sep 15;390(Pt 3):665-73.
38. Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation. Pallottini V, etal., Mech Ageing Dev. 2007 Nov-Dec;128(11-12):688-95. Epub 2007 Oct 16.
39. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Rahman A, etal., Neurotoxicology. 2012 Jun;33(3):370-83. doi: 10.1016/j.neuro.2012.02.014. Epub 2012 Mar 1.
43. Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats. Ramamoorthy S, etal., Biochem Biophys Res Commun. 2010 Jan 15;391(3):1517-21. doi: 10.1016/j.bbrc.2009.12.110. Epub 2009 Dec 24.
44. GOA pipeline RGD automated data pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Seshacharyulu P, etal., Cancer Lett. 2013 Jul 10;335(1):9-18. doi: 10.1016/j.canlet.2013.02.036. Epub 2013 Feb 20.
48. Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression. Shi K, etal., Biochem Biophys Res Commun. 2007 Nov 23;363(3):626-32. Epub 2007 Sep 17.
49. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
50. Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators. Tamasi V, etal., Mol Pharmacol. 2008 Mar;73(3):968-76. Epub 2007 Dec 13.
51. Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Ugi S, etal., Mol Cell Biol 2002 Apr;22(7):2375-87.
52. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ and Strack S, Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24.
53. Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. Wang D, etal., FASEB J. 2010 Sep;24(9):3511-21. doi: 10.1096/fj.10-156661. Epub 2010 Apr 15.
54. Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Wheat WH, etal., Mol Cell Biol. 1994 Sep;14(9):5881-90.
55. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
56. The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells. Yoo SJ, etal., J Cell Biochem. 2008 Sep 1;105(1):290-300. doi: 10.1002/jcb.21830.
57. Protein phosphatase 2A facilitates axonogenesis by dephosphorylating CRMP2. Zhu LQ, etal., J Neurosci. 2010 Mar 10;30(10):3839-48. doi: 10.1523/JNEUROSCI.5174-09.2010.
Additional References at PubMed
PMID:2174876   PMID:2554255   PMID:2554256   PMID:9770493   PMID:9847399   PMID:9882488   PMID:9920888   PMID:10781942   PMID:11590243   PMID:12606433   PMID:12885400   PMID:15194871  
PMID:15489334   PMID:15661743   PMID:15865439   PMID:16030137   PMID:16123140   PMID:16129692   PMID:16258073   PMID:16420440   PMID:16549018   PMID:16717086   PMID:16754670   PMID:16822951  
PMID:17055435   PMID:17158207   PMID:17174897   PMID:17255109   PMID:17259072   PMID:18084284   PMID:18388891   PMID:18550542   PMID:18835920   PMID:20017541   PMID:20080667   PMID:20106966  
PMID:20458337   PMID:20485545   PMID:20684275   PMID:21080067   PMID:21257729   PMID:22031698   PMID:22082260   PMID:22242112   PMID:22892311   PMID:22892312   PMID:23020770   PMID:23716589  
PMID:23840384   PMID:24475092   PMID:24625528   PMID:25007834   PMID:25038454   PMID:25869568   PMID:26316108   PMID:26378614   PMID:27459928   PMID:27572322   PMID:28442576   PMID:30595372  
PMID:30611118   PMID:31974600   PMID:35043508  


Genomics

Comparative Map Data
Ppp2ca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21036,358,110 - 36,377,864 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1036,358,101 - 36,377,862 (+)Ensembl
Rnor_6.01037,534,449 - 37,554,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,535,871 - 37,554,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,324,233 - 37,343,985 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,621,256 - 37,641,008 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11037,627,685 - 37,647,436 (+)NCBI
Celera1035,713,154 - 35,732,937 (+)NCBICelera
Cytogenetic Map10q22NCBI
PPP2CA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,194,332 - 134,226,073 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5134,194,332 - 134,226,073 (-)EnsemblGRCh38hg38GRCh38
GRCh375133,530,023 - 133,561,764 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,560,047 - 133,589,849 (-)NCBINCBI36hg18NCBI36
Build 345133,560,046 - 133,589,849NCBI
Celera5129,655,849 - 129,685,663 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5128,717,117 - 128,746,747 (-)NCBIHuRef
CHM1_15132,964,711 - 132,994,524 (-)NCBICHM1_1
T2T-CHM13v2.05134,717,969 - 134,749,722 (-)NCBI
Ppp2ca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,989,651 - 52,013,576 (+)NCBIGRCm39mm39
GRCm39 Ensembl1151,989,508 - 52,018,605 (+)Ensembl
GRCm381152,098,824 - 52,122,749 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,098,681 - 52,127,778 (+)EnsemblGRCm38mm10GRCm38
MGSCv371151,912,326 - 51,936,251 (+)NCBIGRCm37mm9NCBIm37
MGSCv361151,942,247 - 51,966,172 (+)NCBImm8
Celera1156,667,217 - 56,691,076 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
Ppp2ca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,433,268 - 5,460,361 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554085,435,117 - 5,460,361 (-)NCBIChiLan1.0ChiLan1.0
PPP2CA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15135,751,964 - 135,761,395 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5135,751,958 - 135,765,786 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05129,599,606 - 129,629,312 (-)NCBIMhudiblu_PPA_v0panPan3
PPP2CA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,388,327 - 22,410,052 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,385,257 - 22,410,052 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,134,537 - 21,156,029 (-)NCBI
ROS_Cfam_1.01123,189,481 - 23,211,243 (-)NCBI
ROS_Cfam_1.0 Ensembl1123,188,436 - 23,211,451 (-)Ensembl
UMICH_Zoey_3.11121,889,485 - 21,911,229 (-)NCBI
UNSW_CanFamBas_1.01121,754,643 - 21,776,444 (-)NCBI
UU_Cfam_GSD_1.01122,397,162 - 22,418,841 (-)NCBI
Ppp2ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213114,028,481 - 114,052,523 (+)NCBI
SpeTri2.0NW_0049366471,031,118 - 1,055,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2CA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,494,541 - 136,522,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12136,497,780 - 136,522,630 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22142,095,024 - 142,123,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2CA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12336,999,110 - 37,028,916 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2336,997,078 - 37,029,280 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603440,904,228 - 40,936,193 (+)NCBIVero_WHO_p1.0
Ppp2ca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473338,012,392 - 38,036,914 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473338,012,694 - 38,033,745 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,279,884 - 82,280,069 (+)MAPPERmRatBN7.2
mRatBN7.21036,377,586 - 36,377,771 (+)MAPPERmRatBN7.2
mRatBN7.21036,377,586 - 36,377,771 (-)MAPPERmRatBN7.2
mRatBN7.21182,279,884 - 82,280,069 (-)MAPPERmRatBN7.2
Rnor_6.01186,422,634 - 86,422,818NCBIRnor6.0
Rnor_6.01037,535,201 - 37,535,385NCBIRnor6.0
Rnor_5.01189,523,373 - 89,523,557UniSTSRnor5.0
Rnor_5.01037,343,708 - 37,343,892UniSTSRnor5.0
RGSC_v3.41037,640,731 - 37,640,915UniSTSRGSC3.4
RGSC_v3.41184,271,502 - 84,271,686UniSTSRGSC3.4
Celera1181,056,435 - 81,056,619UniSTS
Celera1035,732,660 - 35,732,844UniSTS
Cytogenetic Map10q22UniSTS
PMC22838P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,278,463 - 82,278,570 (+)MAPPERmRatBN7.2
mRatBN7.21036,358,300 - 36,358,407 (+)MAPPERmRatBN7.2
mRatBN7.21036,358,300 - 36,358,407 (-)MAPPERmRatBN7.2
mRatBN7.21182,278,463 - 82,278,570 (-)MAPPERmRatBN7.2
Rnor_6.01186,421,213 - 86,421,319NCBIRnor6.0
Rnor_6.01037,554,564 - 37,554,670NCBIRnor6.0
Rnor_5.01189,521,952 - 89,522,058UniSTSRnor5.0
Rnor_5.01037,324,424 - 37,324,530UniSTSRnor5.0
RGSC_v3.41037,621,447 - 37,621,553UniSTSRGSC3.4
RGSC_v3.41184,270,081 - 84,270,187UniSTSRGSC3.4
Celera1181,056,065 - 81,056,171UniSTS
Celera1035,713,345 - 35,713,451UniSTS
Cytogenetic Map10q22UniSTS
Ppp2ca  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,278,604 - 82,279,072 (+)MAPPERmRatBN7.2
Rnor_6.01186,421,354 - 86,421,821NCBIRnor6.0
Rnor_5.01189,522,093 - 89,522,560UniSTSRnor5.0
RGSC_v3.41184,270,222 - 84,270,689UniSTSRGSC3.4
Cytogenetic Map10q22UniSTS
Ppp2ca  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,373,858 - 36,373,905 (+)MAPPERmRatBN7.2
mRatBN7.21182,279,039 - 82,279,090 (+)MAPPERmRatBN7.2
Rnor_6.01186,421,789 - 86,421,839NCBIRnor6.0
Rnor_5.01189,522,528 - 89,522,578UniSTSRnor5.0
RGSC_v3.41184,270,657 - 84,270,707UniSTSRGSC3.4
Cytogenetic Map10q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum total immunoglobulin E level (CMO:0001542)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:80
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000007621
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 2 1 1 2 1 2 1 1 2
Below cutoff 3 8 8 6 5 6 3 35 19 17 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007621   ⟹   ENSRNOP00000007621
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,358,110 - 36,377,862 (+)Ensembl
Rnor_6.0 Ensembl1037,535,871 - 37,554,664 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079985   ⟹   ENSRNOP00000071286
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,359,000 - 36,377,862 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101942   ⟹   ENSRNOP00000084457
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,358,101 - 36,376,782 (+)Ensembl
RefSeq Acc Id: NM_017039   ⟹   NP_058735
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21036,358,110 - 36,377,864 (+)NCBI
Rnor_6.01037,535,108 - 37,554,861 (-)NCBI
Rnor_5.01037,324,233 - 37,343,985 (+)NCBI
RGSC_v3.41037,621,256 - 37,641,008 (+)RGD
Celera1035,713,154 - 35,732,937 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058735   ⟸   NM_017039
- UniProtKB: P63331 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007621   ⟸   ENSRNOT00000007621
RefSeq Acc Id: ENSRNOP00000084457   ⟸   ENSRNOT00000101942
RefSeq Acc Id: ENSRNOP00000071286   ⟸   ENSRNOT00000079985

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63331-F1-model_v2 AlphaFold P63331 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3380 AgrOrtholog
BioCyc Gene G2FUF-25177 BioCyc
Ensembl Genes ENSRNOG00000005389 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007621 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000084457.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007621 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000101942.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096821 IMAGE-MGC_LOAD
  IMAGE:7104697 IMAGE-MGC_LOAD
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot
  Metallo-depent_PP-like UniProtKB/Swiss-Prot
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot
KEGG Report rno:24672 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91734 IMAGE-MGC_LOAD
  MGC:91735 IMAGE-MGC_LOAD
NCBI Gene 24672 ENTREZGENE
Pfam Metallophos UniProtKB/Swiss-Prot
PhenoGen Ppp2ca PhenoGen
PRINTS STPHPHTASE UniProtKB/Swiss-Prot
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot
SMART PP2Ac UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot
UniProt A0A8I5ZZ39_RAT UniProtKB/TrEMBL
  P63331 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88591 UniProtKB/Swiss-Prot
  P13353 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-02 Ppp2ca  protein phosphatase 2 catalytic subunit alpha  LOC103694903  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform  Data Merged 737654 PROVISIONAL
2016-02-17 Ppp2ca  protein phosphatase 2 catalytic subunit alpha  Ppp2ca  protein phosphatase 2, catalytic subunit, alpha isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694903  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-06-26 Ppp2ca  protein phosphatase 2, catalytic subunit, alpha isozyme  Ppp2ca  protein phosphatase 2, catalytic subunit, alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Ppp2ca  protein phosphatase 2, catalytic subunit, alpha isoform  Ppp2ca  protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ppp2ca  protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform    protein phosphatase 2a, catalytic subunit, alpha isoform  Name updated 1299863 APPROVED
2002-06-10 Ppp2ca  Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform      Symbol and Name status set to approved 70586 APPROVED