Slc6a3 (solute carrier family 6 member 3) - Rat Genome Database

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Gene: Slc6a3 (solute carrier family 6 member 3) Rattus norvegicus
Analyze
Symbol: Slc6a3
Name: solute carrier family 6 member 3
RGD ID: 3715
Description: Enables several functions, including amine binding activity; enzyme binding activity; and sodium:chloride symporter activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (S)-amphetamine; (S)-nicotine; 1-(2-(diphenylmethoxy)ethyl)-4-(2-(4-azido-3-iodophenyl)ethyl)piperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DA transporter; DAT; Dat1; sodium-dependent dopamine transporter; Solute carrier family 6 (neurotransmitter transporter dopamine) member 3; solute carrier family 6 (neurotransmitter transporter), member 3; Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; solute carrier family 6, member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Slc6a3m1Span  
Genetic Models: F344-Slc6a3m1Span
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2129,709,443 - 29,750,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,709,443 - 29,750,413 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,510,573 - 29,551,545 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0135,510,418 - 35,551,390 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0129,711,198 - 29,752,170 (-)NCBIRnor_WKY
Rnor_6.0132,323,011 - 32,363,983 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,321,580 - 32,363,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,745,060 - 33,788,878 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,516,568 - 30,557,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1130,518,078 - 30,558,861 (-)NCBI
Celera128,357,426 - 28,397,883 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (ISO)
(R)-noradrenaline  (ISO)
(R)-octopamine  (ISO)
(S)-amphetamine  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-(2-(diphenylmethoxy)ethyl)-4-(2-(4-azido-3-iodophenyl)ethyl)piperazine  (EXP)
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,5-dimethoxy-4-bromophenethylamine  (ISO)
2-aminopropiophenone  (ISO)
2-phenylethylamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[2-(diphenylmethoxy)ethyl]-1-[(4-azidophenyl)-methyl]-piperidine  (EXP)
4-nitrotoluene  (EXP)
7-NITROINDAZOLE  (ISO)
acrylamide  (EXP)
albiflorin  (EXP)
alcohol  (ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
AM-251  (EXP)
aminorex  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
atrazine  (EXP)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bupropion  (ISO)
butyric acid  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
citalopram  (ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyhalothrin  (EXP)
DDD  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dieldrin  (EXP,ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (EXP)
dihydro-beta-erythroidine  (EXP)
dithionite(2-)  (ISO)
dopamine  (EXP,ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
estrone  (ISO)
ethanol  (ISO)
fluoxetine  (EXP,ISO)
fulvestrant  (ISO)
ganglioside GM1  (EXP)
geraniol  (ISO)
glyburide  (ISO)
haloperidol  (EXP,ISO)
heptachlor  (EXP,ISO)
herbicide  (EXP)
ibogaine  (ISO)
ibuprofen  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoliquiritigenin  (ISO)
ketamine  (ISO)
linalool  (EXP)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
Mazindol  (EXP,ISO)
Mecamylamine  (EXP)
melatonin  (EXP,ISO)
melittin  (ISO)
mephedrone  (EXP,ISO)
mepyramine  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methcathinone  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
minocycline  (ISO)
modafinil  (EXP,ISO)
monensin A  (ISO)
n-[4-(3-iodo-4-azidophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naltrexone  (ISO)
nicotine  (EXP,ISO)
nomifensine  (EXP,ISO)
Nonylphenol  (EXP)
octopamine  (ISO)
oleic acid  (ISO)
oxidopamine  (EXP,ISO)
paraquat  (EXP,ISO)
permethrin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
piperazines  (ISO)
piperidines  (ISO)
pirinixic acid  (EXP,ISO)
probenecid  (ISO)
propofol  (ISO)
quinolinic acid  (EXP)
quinpirole  (EXP,ISO)
raloxifene  (EXP)
reboxetine  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
SCH 23390  (ISO)
selenium atom  (EXP)
serotonin  (ISO)
simazine  (EXP,ISO)
staurosporine  (ISO)
sulpiride  (ISO)
tamoxifen  (EXP)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thifluzamide  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (EXP)
triphenyl phosphate  (EXP)
tryptamine  (ISO)
tyramine  (ISO)
valproic acid  (EXP,ISO)
vanoxerine dihydrochloride  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
WIN 55212-2  (EXP)
wortmannin  (ISO)
zinc atom  (ISO)
zinc sulfate  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
Parkinson's disease pathway  (IEA)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism. Baucum AJ 2nd, etal., J Neurosci. 2004 Mar 31;24(13):3436-43.
2. Neonatal iron deficiency results in irreversible changes in dopamine function in rats. Beard J, etal., J Nutr. 2003 Apr;133(4):1174-9.
3. Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Cremona ML, etal., Nat Neurosci. 2011 Apr;14(4):469-77. doi: 10.1038/nn.2781. Epub 2011 Mar 13.
4. Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. du Bois TM, etal., Neurochem Res. 2008 Jul;33(7):1224-31. Epub 2008 Feb 8.
5. Dopamine transporter genotype as a risk factor for obesity in African-American smokers. Epstein LH, etal., Obes Res. 2002 Dec;10(12):1232-40.
6. Dopamine transporters are dephosphorylated in striatal homogenates and in vitro by protein phosphatase 1. Foster JD, etal., Brain Res Mol Brain Res 2003 Jan 31;110(1):100-8.
7. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Gainetdinov RR, etal., Science 1999 Jan 15;283(5400):397-401.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Cloning and functional characterization of a cocaine-sensitive dopamine transporter. Giros B, etal., FEBS Lett 1991 Dec 16;295(1-3):149-54.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. Gu H, etal., J Biol Chem. 1994 Mar 11;269(10):7124-30.
12. Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. Kahn RS, etal., J Pediatr 2003 Jul;143(1):104-10.
13. Cloning and expression of a cocaine-sensitive rat dopamine transporter. Kilty JE, etal., Science 1991 Oct 25;254(5031):578-9.
14. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Kitayama S, etal., Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7782-5. doi: 10.1073/pnas.89.16.7782.
15. PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids. Kuge H, etal., J Lipid Res. 2020 Dec;61(12):1747-1763. doi: 10.1194/jlr.RA120001087. Epub 2020 Sep 22.
16. Chronic nicotine and smoking treatment increases dopamine transporter mRNA expression in the rat midbrain. Li S, etal., Neurosci Lett. 2004 Jun 3;363(1):29-32.
17. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Li Y, etal., Med Sci Monit. 2017 Jun 9;23:2805-2815.
18. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. Loder MK and Melikian HE, J Biol Chem 2003 Jun 13;278(24):22168-74. Epub 2003 Apr 7.
19. Alteration of striatal dopaminergic function induced by glioma development: a microdialysis and immunohistological study in the rat striatum. Lonjon M, etal., Neurosci Lett. 2004 Jan 9;354(2):131-4.
20. Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. Mengual E and Pickel VM, J Comp Neurol. 2004 Jan 12;468(3):395-409.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Obesity is associated with genetic variants that alter dopamine availability. Need AC, etal., Ann Hum Genet. 2006 May;70(Pt 3):293-303.
24. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. Nirenberg MJ, etal., J Neurosci. 1996 Jan 15;16(2):436-47.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine. Owens WA, etal., J Neurochem. 2005 Sep;94(5):1402-10. Epub 2005 Jun 30.
27. The up-regulation of the striatal dopamine transporter's activity by cAMP is PKA-, CaMK II- and phosphatase-dependent. Page G, etal., Neurochem Int. 2004 Oct;45(5):627-32.
28. Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats. Perry ML, etal., J Neurochem. 2010 Aug;114(3):666-74. Epub 2010 Apr 20.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats. Ramamoorthy S, etal., Biochem Biophys Res Commun. 2010 Jan 15;391(3):1517-21. doi: 10.1016/j.bbrc.2009.12.110. Epub 2009 Dec 24.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline. Richardson RM, etal., Brain Res. 2005 Jan 25;1032(1-2):11-22.
36. Acute ethanol decreases dopamine transporter velocity in rat striatum: in vivo and in vitro electrochemical measurements. Robinson DL, etal., Alcohol Clin Exp Res. 2005 May;29(5):746-55.
37. Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes. Salkovic-Petrisic M and Lackovic Z, J Neural Transm. 2003 Jan;110(1):15-29.
38. Decreased plasma membrane expression of striatal dopamine transporter in aging. Salvatore MF, etal., Neurobiol Aging. 2003 Dec;24(8):1147-54.
39. Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Shimada S, etal., Science 1991 Oct 25;254(5031):576-8.
40. Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter. Simoni D, etal., J Med Chem. 2005 May 5;48(9):3337-43.
41. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
42. Affinity labeling the dopamine transporter ligand binding site. Vaughan RA, etal., J Neurosci Methods. 2005 Apr 15;143(1):33-40. Epub 2004 Dec 2.
43. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Wang D, etal., Neurosci Lett. 2015 Oct 8;606:60-5. doi: 10.1016/j.neulet.2015.08.024. Epub 2015 Aug 18.
44. Brain dopamine transporter in spontaneously hypertensive rats. Watanabe Y, etal., J Nucl Med. 1997 Mar;38(3):470-4.
45. Regulation of dopamine transporter activity by carboxypeptidase E. Zhang H, etal., Mol Brain. 2009 May 6;2:10.
Additional References at PubMed
PMID:8628395   PMID:9247269   PMID:9520487   PMID:11150348   PMID:11343649   PMID:12480180   PMID:12521926   PMID:12958153   PMID:14499307   PMID:15128747   PMID:15505207   PMID:15935059  
PMID:16024787   PMID:16708013   PMID:16765459   PMID:16885233   PMID:17255098   PMID:17363452   PMID:17439486   PMID:17561841   PMID:17651428   PMID:17761882   PMID:17873367   PMID:17978168  
PMID:18198344   PMID:18216182   PMID:18588534   PMID:18671743   PMID:18845198   PMID:19046383   PMID:19135135   PMID:19357284   PMID:19766189   PMID:20170186   PMID:20688912   PMID:20816972  
PMID:21118819   PMID:21396352   PMID:21698001   PMID:21957239   PMID:22133315   PMID:22570010   PMID:22722938   PMID:22778840   PMID:23161550   PMID:23300642   PMID:23567316   PMID:23612789  
PMID:25179220   PMID:25943760   PMID:26048990   PMID:26056032   PMID:26658810   PMID:26707058   PMID:26911894   PMID:27789384   PMID:28116523   PMID:28167616   PMID:28495886   PMID:28894302  
PMID:30472113   PMID:30745563   PMID:31599465   PMID:31728018   PMID:33211914   PMID:34329711   PMID:35772468  


Genomics

Comparative Map Data
Slc6a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2129,709,443 - 29,750,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,709,443 - 29,750,413 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,510,573 - 29,551,545 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0135,510,418 - 35,551,390 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0129,711,198 - 29,752,170 (-)NCBIRnor_WKY
Rnor_6.0132,323,011 - 32,363,983 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,321,580 - 32,363,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,745,060 - 33,788,878 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,516,568 - 30,557,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1130,518,078 - 30,558,861 (-)NCBI
Celera128,357,426 - 28,397,883 (-)NCBICelera
Cytogenetic Map1p11NCBI
SLC6A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3851,392,794 - 1,445,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl51,392,794 - 1,445,440 (-)EnsemblGRCh38hg38GRCh38
GRCh3751,392,909 - 1,445,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,445,909 - 1,498,538 (-)NCBINCBI36Build 36hg18NCBI36
Build 3451,445,908 - 1,498,543NCBI
Celera51,429,610 - 1,484,220 (-)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef51,373,680 - 1,426,892 (-)NCBIHuRef
CHM1_151,392,820 - 1,445,528 (-)NCBICHM1_1
T2T-CHM13v2.051,303,172 - 1,357,405 (-)NCBIT2T-CHM13v2.0
Slc6a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,684,270 - 73,726,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1373,684,866 - 73,726,791 (+)EnsemblGRCm39 Ensembl
GRCm381373,536,128 - 73,578,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,536,747 - 73,578,672 (+)EnsemblGRCm38mm10GRCm38
MGSCv371373,674,195 - 73,716,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,002,749 - 74,044,674 (+)NCBIMGSCv36mm8
Celera1375,865,546 - 75,907,463 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.1NCBI
Slc6a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504721,429 - 747,630 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955504721,470 - 747,553 (-)NCBIChiLan1.0ChiLan1.0
SLC6A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.151,437,567 - 1,488,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl51,437,567 - 1,488,829 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v051,687,079 - 1,739,729 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC6A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,209,118 - 11,245,456 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,210,939 - 11,246,742 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3415,719,083 - 15,755,282 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,109,747 - 11,147,167 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,109,762 - 11,147,159 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,160,852 - 11,196,981 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,139,913 - 11,176,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,350,821 - 11,387,021 (+)NCBIUU_Cfam_GSD_1.0
Slc6a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,198,128 - 244,239,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815359,775 - 400,690 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936815359,775 - 400,690 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,186,108 - 79,220,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,186,114 - 79,220,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21685,853,611 - 85,887,787 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.141,209,013 - 1,258,797 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl41,209,019 - 1,258,866 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,775,947 - 35,824,591 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc6a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624751694,099 - 719,465 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624751694,165 - 720,287 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc6a3
153 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:59
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000040291
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat

Markers in Region
D1Rat377  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,743,235 - 29,743,400 (+)MAPPERmRatBN7.2
Rnor_6.0132,356,806 - 32,356,970NCBIRnor6.0
Rnor_5.0133,780,289 - 33,780,453UniSTSRnor5.0
RGSC_v3.4130,550,363 - 30,550,527UniSTSRGSC3.4
RGSC_v3.4130,550,362 - 30,550,527RGDRGSC3.4
RGSC_v3.1130,553,307 - 30,553,472RGD
FHH x ACI Map121.7699UniSTS
FHH x ACI Map121.7699RGD
Cytogenetic Map1p11UniSTS
D1Wox51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,708,849 - 29,708,992 (+)MAPPERmRatBN7.2
Rnor_6.0132,322,418 - 32,322,560NCBIRnor6.0
Rnor_5.0133,745,901 - 33,746,043UniSTSRnor5.0
RGSC_v3.4130,515,975 - 30,516,117UniSTSRGSC3.4
Celera128,356,833 - 28,356,975UniSTS
Cytogenetic Map1p11UniSTS
RH94715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,708,645 - 29,708,778 (+)MAPPERmRatBN7.2
Rnor_6.0132,322,214 - 32,322,346NCBIRnor6.0
Rnor_5.0133,745,697 - 33,745,829UniSTSRnor5.0
RGSC_v3.4130,515,771 - 30,515,903UniSTSRGSC3.4
Celera128,356,629 - 28,356,761UniSTS
Cytogenetic Map1p11UniSTS
RH94400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,708,037 - 29,708,210 (+)MAPPERmRatBN7.2
Rnor_6.0132,321,606 - 32,321,778NCBIRnor6.0
Rnor_5.0133,745,089 - 33,745,261UniSTSRnor5.0
RGSC_v3.4130,515,163 - 30,515,335UniSTSRGSC3.4
Celera128,356,021 - 28,356,193UniSTS
Cytogenetic Map1p11UniSTS
PMC304098P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,724,402 - 29,724,503 (+)MAPPERmRatBN7.2
Rnor_6.0132,337,973 - 32,338,073NCBIRnor6.0
Rnor_5.0133,761,456 - 33,761,556UniSTSRnor5.0
RGSC_v3.4130,531,530 - 30,531,630UniSTSRGSC3.4
Celera128,372,004 - 28,372,104UniSTS
Cytogenetic Map1p11UniSTS


Genetic Models
This gene Slc6a3 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4
Low 6 8 32 1 6 1
Below cutoff 3 14 38 28 11 28 6 6 24 26 27 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000040291   ⟹   ENSRNOP00000047272
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,709,443 - 29,750,413 (-)Ensembl
Rnor_6.0 Ensembl132,323,011 - 32,363,983 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079987   ⟹   ENSRNOP00000070728
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl132,321,580 - 32,362,359 (-)Ensembl
RefSeq Acc Id: NM_012694   ⟹   NP_036826
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2129,709,443 - 29,750,413 (-)NCBI
Rnor_6.0132,323,011 - 32,363,983 (-)NCBI
Rnor_5.0133,745,060 - 33,788,878 (-)NCBI
RGSC_v3.4130,516,568 - 30,557,540 (-)RGD
Celera128,357,426 - 28,397,883 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036826 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41100 (Get FASTA)   NCBI Sequence Viewer  
  AAA73143 (Get FASTA)   NCBI Sequence Viewer  
  AAB21099 (Get FASTA)   NCBI Sequence Viewer  
  EDL87653 (Get FASTA)   NCBI Sequence Viewer  
  P23977 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036826   ⟸   NM_012694
- UniProtKB: P23977 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070728   ⟸   ENSRNOT00000079987
RefSeq Acc Id: ENSRNOP00000047272   ⟸   ENSRNOT00000040291

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23977-F1-model_v2 AlphaFold P23977 1-619 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3715 AgrOrtholog
BioCyc Gene G2FUF-61924 BioCyc
Ensembl Genes ENSRNOG00000017302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000047272 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000040291 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Na/ntran_symport UniProtKB/Swiss-Prot
  Na/ntran_symport_dopamine UniProtKB/Swiss-Prot
  SNS_sf UniProtKB/Swiss-Prot
KEGG Report rno:24898 UniProtKB/Swiss-Prot
NCBI Gene 24898 ENTREZGENE
PANTHER PTHR11616 UniProtKB/Swiss-Prot
Pfam SNF UniProtKB/Swiss-Prot
PharmGKB SLC6A3 RGD
PhenoGen Slc6a3 PhenoGen
PRINTS DOPTRANSPORT UniProtKB/Swiss-Prot
  NANEUSMPORT UniProtKB/Swiss-Prot
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/Swiss-Prot
  NA_NEUROTRAN_SYMP_2 UniProtKB/Swiss-Prot
  NA_NEUROTRAN_SYMP_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF161070 UniProtKB/Swiss-Prot
TIGR TC234653
UniProt P23977 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc6a3  solute carrier family 6 member 3  Slc6a3  solute carrier family 6 (neurotransmitter transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc6a3  solute carrier family 6 (neurotransmitter transporter, dopamine), member 3    solute carrier family 6, member 3  Name updated 1299863 APPROVED
2003-04-09 Slc6a3  solute carrier family 6, member 3    Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3  Name updated 629478 APPROVED
2002-06-10 Slc6a3  Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization putative integral plasma membrane protein 730166
gene_expression expressed in substantia nigra and ventral tegmental area 730166
gene_function sodium-dependent dopamine transporter 730166
gene_function sodium-dependent dopamine transporter 730214
gene_function sodium-dependent dopamine transporter 730247
gene_protein 620 amino acid protein 730166
gene_regulation constitutively internalized and recycled to plasma membrane; protein kinase C activation accelerates endocytosis of protein and attenuates recycling to cell surface 1299034