Cacna1a (calcium voltage-gated channel subunit alpha1 A) - Rat Genome Database

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Gene: Cacna1a (calcium voltage-gated channel subunit alpha1 A) Rattus norvegicus
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Symbol: Cacna1a
Name: calcium voltage-gated channel subunit alpha1 A
RGD ID: 2244
Description: Enables calmodulin binding activity and high voltage-gated calcium channel activity. Involved in calcium ion import; chemical synaptic transmission; and regulation of voltage-gated calcium channel activity. Located in perikaryon. Part of voltage-gated calcium channel complex. Is active in calyx of Held and presynaptic active zone membrane. Used to study childhood absence epilepsy. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in brain disease (multiple) and episodic ataxia type 2. Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BccA1; BI; brain calcium channel 1; brain calcium channel I; brain class A; Calcium channel alpha 1A; calcium channel, L type, alpha-1 polypeptide; calcium channel, L type, alpha-1 polypeptide, isoform 4; calcium channel, voltage-dependent, alpha 1A subunit; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; Cav2.1; LOC688360; rbA-1; RBA-I; similar to Voltage-dependent P/Q-type calcium channel alpha-1A subunit (Voltage-gated calcium channel alpha subunit Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI); voltage-dependent P/Q-type calcium channel subunit alpha-1A; voltage-gated calcium channel subunit alpha Cav2.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cacna1agry  
Is Marker For: Strains:   WTC.GRY-Cacna1agry/Kyo   F344-Cacna1agryScn1am1Kyo/Okym  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,425,560 - 40,724,810 (-)NCBIGRCr8
mRatBN7.21923,520,741 - 23,819,971 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,520,741 - 23,823,225 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,343,968 - 30,567,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,998,339 - 31,221,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,221,032 - 33,444,209 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,453,236 - 25,749,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,526,751 - 25,749,550 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,502,533 - 36,727,039 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,188,170 - 25,424,495 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,194,294 - 25,429,321 (-)NCBI
Celera1923,074,249 - 23,295,970 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aicardi-Goutieres Syndrome 4  (ISO)
alpha-mannosidosis  (ISO)
Alternating Hemiplegia of Childhood 1  (ISO)
amyotrophic lateral sclerosis  (ISO)
Ataxia  (ISO)
attention deficit hyperactivity disorder  (ISO)
Auditory Neuropathy  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bone marrow disease  (ISO)
cerebellar ataxia  (ISO,ISS)
cerebral palsy  (ISO)
cerebral venous thrombosis  (ISO)
Charcot-Marie-Tooth disease dominant intermediate B  (ISO)
childhood absence epilepsy  (IAGP,ISO)
childhood electroclinical syndrome  (ISS)
combined immunodeficiency  (ISO)
combined T cell and B cell immunodeficiency  (ISO)
developmental and epileptic encephalopathy 1  (ISO)
developmental and epileptic encephalopathy 2  (ISO)
developmental and epileptic encephalopathy 42  (ISO)
developmental and epileptic encephalopathy 52  (ISO)
Developmental Disabilities  (ISO)
disorder of sexual development  (ISO)
Dysarthria  (ISO)
epilepsy  (ISO)
episodic ataxia  (ISO)
episodic ataxia type 2  (ISO,ISS)
exfoliation syndrome  (ISO)
familial hemiplegic migraine  (ISO,ISS)
familial hemiplegic migraine 1  (ISO)
generalized dystonia  (ISS)
generalized epilepsy  (ISO)
genetic disease  (ISO)
glutaric acidemia I  (ISO)
intellectual disability  (ISO)
Lambert-Eaton myasthenic syndrome  (ISS)
learning disability  (ISO)
Marshall-Smith syndrome  (ISO)
migraine  (ISO)
migraine with aura  (ISO)
Muscle Spasticity  (ISO)
Muscle Weakness  (ISO)
myelitis  (ISO)
myoclonic-atonic epilepsy  (ISO)
Nervous System Malformations  (ISO)
neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures  (ISO)
Neurodevelopmental Disorders  (ISO)
neurogenic bladder  (ISO)
Neurologic Gait Disorders  (ISO)
progressive bulbar palsy  (ISO)
spastic ataxia  (ISO)
Spastic Paraparesis  (ISO)
spinocerebellar ataxia type 6  (ISO,ISS)
Spinocerebellar Ataxias  (ISO)
Sporadic Hemiplegic Migraine  (ISO)
subependymal giant cell astrocytoma  (ISO)
sudden infant death syndrome  (ISO)
temporal lobe epilepsy  (IEP)
Tremor  (ISO)
vascular dementia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
barium(0)  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Butylparaben  (EXP)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cypermethrin  (ISO)
DDE  (EXP)
DDT  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
gabapentin  (EXP,ISO)
gamma-aminobutyric acid  (EXP)
glyphosate  (EXP)
haloperidol  (EXP,ISO)
L-methionine  (ISO)
linuron  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-D-aspartic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nitric oxide  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chloride  (EXP,ISO)
prochloraz  (EXP)
procymidone  (EXP)
rotenone  (ISO)
sarin  (EXP)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
behavioral response to pain  (ISO)
calcium ion import  (IDA,IMP)
calcium ion import across plasma membrane  (IBA)
calcium ion transmembrane transport  (IEA,ISO)
calcium ion transport  (IDA,IEA,IMP,ISO)
calcium ion-regulated exocytosis of neurotransmitter  (ISO)
calcium-ion regulated exocytosis  (ISO)
cellular response to amyloid-beta  (IEA,ISO)
central nervous system neuron differentiation  (ISO)
cerebellar molecular layer development  (ISO)
cerebellar Purkinje cell differentiation  (ISO)
cerebellar Purkinje cell layer development  (ISO)
cerebellum maturation  (ISO)
chemical synaptic transmission  (IMP,ISO)
cholecystokinin signaling pathway  (ISO)
dendrite morphogenesis  (ISO)
establishment of localization in cell  (ISO)
G protein-coupled opioid receptor signaling pathway  (ISO)
gamma-aminobutyric acid secretion  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
glucose homeostasis  (ISO)
hormone biosynthetic process  (ISO)
intracellular chloride ion homeostasis  (ISO)
membrane depolarization  (ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
musculoskeletal movement, spinal reflex action  (ISO)
negative regulation of hormone biosynthetic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
nervous system process  (ISO)
neuromuscular process  (ISO)
neuromuscular process controlling balance  (ISO)
neuromuscular synaptic transmission  (ISO)
neuron apoptotic process  (ISO)
neuron cellular homeostasis  (ISO)
neuron-neuron synaptic transmission  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO,ISS)
receptor clustering  (ISO)
regulation of acetylcholine secretion, neurotransmission  (ISO)
regulation of axonogenesis  (ISO)
regulation of calcium ion-dependent exocytosis  (ISO)
regulation of hormone levels  (ISO)
regulation of membrane potential  (ISO)
regulation of presynaptic cytosolic calcium ion concentration  (IEA)
regulation of sulfur amino acid metabolic process  (ISO)
regulation of voltage-gated calcium channel activity  (IMP)
response to amyloid-beta  (IEA,ISO)
response to pain  (ISO)
rhythmic synaptic transmission  (ISO)
somatostatin signaling pathway  (ISO)
spinal cord motor neuron differentiation  (ISO)
synapse assembly  (ISO)
synaptic transmission, GABAergic  (ISO)
synaptic transmission, glutamatergic  (ISO)
transmembrane transport  (IEA)
transmission of nerve impulse  (ISO)
vestibular nucleus development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway  (IEA,ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
gliclazide pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
glyburide pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway   (ISO)
insulin secretion pathway  (TAS)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term depression  (IEA)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway   (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway   (ISO)
potassium channel inhibitors pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway   (ISO)
type 2 diabetes mellitus pathway  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Berkefeld H, etal., Science. 2006 Oct 27;314(5799):615-20.
2. Genetic heterogeneity in Italian families with familial hemiplegic migraine. Carrera P, etal., Neurology. 1999 Jul 13;53(1):26-33.
3. Voltage-gated calcium channels. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
4. Two sets of amino acids of the domain I of Cav2.3 Ca(2+) channels contribute to their high sensitivity to extracellular protons. Cens T, etal., Pflugers Arch. 2011 Aug;462(2):303-14. doi: 10.1007/s00424-011-0974-x. Epub 2011 May 25.
5. Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel. Charvin N, etal., EMBO J. 1997 Aug 1;16(15):4591-6.
6. Association between the alpha(1a) calcium channel gene CACNA1A and idiopathic generalized epilepsy. Chioza B, etal., Neurology 2001 May 8;56(9):1245-6.
7. The E1015K variant in the synprint region of the CaV2.1 channel alters channel function and is associated with different migraine phenotypes. Condliffe SB, etal., J Biol Chem. 2013 Nov 22;288(47):33873-83. doi: 10.1074/jbc.M113.497701. Epub 2013 Oct 9.
8. Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice. Doyle J, etal., Mamm Genome. 1997 Feb;8(2):113-20.
9. Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density. Ferron L, etal., Nat Commun. 2014 Apr 7;5:3628. doi: 10.1038/ncomms4628.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Release probability of hippocampal glutamatergic terminals scales with the size of the active zone. Holderith N, etal., Nat Neurosci. 2012 Jun 10;15(7):988-97. doi: 10.1038/nn.3137.
12. Abundant expression and cytoplasmic aggregations of 1A voltage-dependent calcium channel protein associated with neurodegeneration in spinocerebellar ataxia type 6. Ishikawa K, etal., Hum Mol Genet. 1999 Jul;8(7):1185-93.
13. Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain. Jiang X, etal., Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):341-6. Epub 2007 Dec 27.
14. RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Kaeser PS, etal., Cell. 2011 Jan 21;144(2):282-95. doi: 10.1016/j.cell.2010.12.029.
15. Sisters homozygous for the spinocerebellar ataxia type 6 (SCA6)/CACNA1A gene associated with different clinical phenotypes. Kato T, etal., Clin Genet 2000 Jul;58(1):69-73.
16. Novel splice site CACNA1A mutation causing episodic ataxia type 2. Kaunisto MA, etal., Neurogenetics 2004 Feb;5(1):69-73. Epub 2003 Oct 7.
17. Modulation of CaV2.1 channels by the neuronal calcium-binding protein visinin-like protein-2. Lautermilch NJ, etal., J Neurosci. 2005 Jul 27;25(30):7062-70.
18. Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Lee A, etal., Nat Neurosci 2002 Mar;5(3):210-7.
19. Molecular determinants of Ca(2+)/calmodulin-dependent regulation of Ca(v)2.1 channels. Lee A, etal., Proc Natl Acad Sci U S A 2003 Dec 23;100(26):16059-64. Epub 2003 Dec 12.
20. Class A calcium channel variants in pancreatic islets and their role in insulin secretion. Ligon B, etal., J Biol Chem 1998 May 29;273(22):13905-11.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Voltage-gated calcium channels in adult rat inferior colliculus neurons. N'Gouemo P and Morad M, Neuroscience 2003;120(3):815-26.
23. Nanoscale distribution of presynaptic Ca(2+) channels and its impact on vesicular release during development. Nakamura Y, etal., Neuron. 2015 Jan 7;85(1):145-158. doi: 10.1016/j.neuron.2014.11.019. Epub 2014 Dec 18.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. The polyglutamine expansion in spinocerebellar ataxia type 6 causes a beta subunit-specific enhanced activation of P/Q-type calcium channels in Xenopus oocytes. Restituito S, etal., J Neurosci. 2000 Sep 1;20(17):6394-403.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses. Scheuber A, etal., J Neurosci. 2004 Nov 17;24(46):10402-9.
33. Primary structure of a calcium channel that is highly expressed in the rat cerebellum. Starr TV, etal., Proc Natl Acad Sci U S A 1991 Jul 1;88(13):5621-5.
34. Role of spinal Cav2.2 and Cav2.1 ion channels in bladder nociception. Su X, etal., J Urol. 2008 Jun;179(6):2464-9. doi: 10.1016/j.juro.2008.01.088. Epub 2008 Apr 23.
35. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
36. The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca(2+) channel alpha(1A) subunit gene and exhibits absence seizures. Tokuda S, etal., Brain Res. 2006 Dec 28;.
37. Regulation of calcium channel alpha(1A) subunit splice variant mRNAs in kainate-induced temporal lobe epilepsy. Vigues S, etal., Neurobiol Dis. 1999 Aug;6(4):288-301.
38. Differential distribution of voltage-gated calcium channels in dopaminergic neurons of the rat retina. Witkovsky P, etal., J Comp Neurol. 2006 Jul 20;497(3):384-96.
39. The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology. Yang SN and Berggren PO, Endocr Rev. 2006 Oct;27(6):621-76. Epub 2006 Jul 25.
40. Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney. Yu AS, etal., Proc Natl Acad Sci U S A 1992 Nov 1;89(21):10494-8.
41. Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1. Zhou H, etal., J Biol Chem. 2005 Aug 19;280(33):29612-9. Epub 2005 Jun 26.
42. Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel. Zhuchenko O, etal., Nat Genet. 1997 Jan;15(1):62-9.
Additional References at PubMed
PMID:572084   PMID:1306163   PMID:1355109   PMID:1469420   PMID:1485534   PMID:1486501   PMID:1572065   PMID:1686215   PMID:1692134   PMID:4799944   PMID:4941467   PMID:6167317  
PMID:6462226   PMID:6945603   PMID:7697385   PMID:7834360   PMID:8100981   PMID:8158221   PMID:8229069   PMID:8565963   PMID:8632762   PMID:8692999   PMID:8719615   PMID:8719807  
PMID:8929530   PMID:8957685   PMID:9614225   PMID:9742139   PMID:9857013   PMID:9882694   PMID:10322048   PMID:10328888   PMID:10336181   PMID:10611370   PMID:10630211   PMID:10670432  
PMID:10686170   PMID:10753886   PMID:10899223   PMID:10908603   PMID:11160387   PMID:11182254   PMID:11344116   PMID:11718712   PMID:11756409   PMID:12040045   PMID:12065603   PMID:12151514  
PMID:12401561   PMID:12451115   PMID:12624181   PMID:12827191   PMID:13950100   PMID:14973254   PMID:15090043   PMID:15451373   PMID:15548652   PMID:15577901   PMID:15728831   PMID:15750602  
PMID:15768038   PMID:15953418   PMID:16049184   PMID:16278278   PMID:16373336   PMID:16474392   PMID:16540584   PMID:16595610   PMID:16820014   PMID:16890369   PMID:17156092   PMID:17893194  
PMID:18216187   PMID:18390553   PMID:18536931   PMID:19883739   PMID:20511524   PMID:21389298   PMID:21883149   PMID:22504905   PMID:22589533   PMID:22869375   PMID:23376566   PMID:24205277  
PMID:24344901   PMID:24453334   PMID:24836863   PMID:25483588   PMID:25741235   PMID:26283199   PMID:26507659   PMID:26716990   PMID:27260834   PMID:28167673   PMID:29277284   PMID:30756238  
PMID:30922876   PMID:31104951   PMID:32318899   PMID:32630015   PMID:32803504   PMID:33045260   PMID:35729466  


Genomics

Comparative Map Data
Cacna1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,425,560 - 40,724,810 (-)NCBIGRCr8
mRatBN7.21923,520,741 - 23,819,971 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,520,741 - 23,823,225 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,343,968 - 30,567,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,998,339 - 31,221,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,221,032 - 33,444,209 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,453,236 - 25,749,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,526,751 - 25,749,550 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,502,533 - 36,727,039 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,188,170 - 25,424,495 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,194,294 - 25,429,321 (-)NCBI
Celera1923,074,249 - 23,295,970 (-)NCBICelera
Cytogenetic Map19q11NCBI
CACNA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381913,206,442 - 13,506,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1913,206,442 - 13,624,489 (-)EnsemblGRCh38hg38GRCh38
GRCh371913,317,256 - 13,617,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,178,256 - 13,478,274 (-)NCBINCBI36Build 36hg18NCBI36
Build 341913,179,114 - 13,478,317NCBI
Celera1913,207,639 - 13,507,772 (-)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,889,634 - 13,189,171 (-)NCBIHuRef
CHM1_11913,318,256 - 13,618,198 (-)NCBICHM1_1
T2T-CHM13v2.01913,331,719 - 13,631,840 (-)NCBIT2T-CHM13v2.0
Cacna1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,065,257 - 85,366,880 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,065,268 - 85,366,875 (+)EnsemblGRCm39 Ensembl
GRCm38884,338,631 - 84,640,251 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,338,639 - 84,640,246 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,939,263 - 87,164,148 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,305,469 - 87,530,351 (+)NCBIMGSCv36mm8
Celera888,715,985 - 88,942,662 (+)NCBICelera
Cytogenetic Map8C2- C3NCBI
cM Map840.95NCBI
Cacna1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,183,442 - 32,400,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,182,536 - 32,457,511 (-)NCBIChiLan1.0ChiLan1.0
CACNA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22018,136,613 - 18,555,581 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11917,137,272 - 17,556,602 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,769,586 - 13,189,022 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,506,232 - 13,804,815 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,507,102 - 13,804,729 (-)Ensemblpanpan1.1panPan2
CACNA1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,747,087 - 49,036,627 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,821,025 - 49,036,032 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,694,916 - 48,910,172 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,339,396 - 49,554,755 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,280,733 - 49,553,801 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,549,923 - 48,765,101 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,976,279 - 49,191,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,219,720 - 49,435,029 (+)NCBIUU_Cfam_GSD_1.0
LOC101960999
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,078,478 - 208,143,320 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,192,610 - 2,392,638 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366592,201,606 - 2,269,625 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,514,509 - 65,871,182 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,491,784 - 65,871,068 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,921,411 - 66,176,189 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNA1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,883,353 - 12,307,023 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660747,403,914 - 7,900,327 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901708,234 - 932,643 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901707,322 - 932,658 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cacna1a
1775 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:93
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000067921, ENSRNOT00000068563
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat

Markers in Region
Cacna1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,528,755 - 23,529,138 (-)MAPPERmRatBN7.2
Rnor_6.01925,741,154 - 25,741,536NCBIRnor6.0
Rnor_5.01936,718,569 - 36,718,951UniSTSRnor5.0
RGSC_v3.41925,194,835 - 25,195,218UniSTSRGSC3.4
Celera1923,082,377 - 23,082,759UniSTS
Cytogenetic Map19q11UniSTS
RH143033  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,746,224 - 23,746,369 (-)MAPPERmRatBN7.2
mRatBN7.21923,745,974 - 23,746,369 (-)MAPPERmRatBN7.2
Rnor_6.01925,525,749 - 25,525,893NCBIRnor6.0
Rnor_6.01925,525,749 - 25,526,172NCBIRnor6.0
Rnor_5.01936,501,531 - 36,501,954UniSTSRnor5.0
Rnor_5.01936,501,531 - 36,501,675UniSTSRnor5.0
RGSC_v3.41925,425,115 - 25,425,259UniSTSRGSC3.4
Celera1923,296,539 - 23,296,683UniSTS
Cytogenetic Map19q11UniSTS
RH137733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,642,907 - 23,643,067 (-)MAPPERmRatBN7.2
Rnor_6.01925,629,237 - 25,629,396NCBIRnor6.0
Rnor_5.01936,604,642 - 36,604,801UniSTSRnor5.0
RGSC_v3.41925,318,888 - 25,319,047UniSTSRGSC3.4
Celera1923,193,847 - 23,194,006UniSTS
Cytogenetic Map19q11UniSTS
RH140588  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,557,895 - 23,558,114 (-)MAPPERmRatBN7.2
Rnor_6.01925,712,179 - 25,712,397NCBIRnor6.0
Rnor_5.01936,689,645 - 36,689,863UniSTSRnor5.0
RGSC_v3.41925,225,045 - 25,225,263UniSTSRGSC3.4
Celera1923,112,051 - 23,112,269UniSTS
Cytogenetic Map19q11UniSTS


Related Rat Strains
The following Strains have been annotated to Cacna1a
F344-Cacna1agryScn1am1Kyo/Okym     WTC.GRY-Cacna1agry/Kyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 87 86 55 25 55 6 214 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF051526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF051527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM040228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM040229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM040230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM040231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM040232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM040233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM040234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB582288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M99222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000083448   ⟹   ENSRNOP00000070304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,520,741 - 23,745,646 (-)Ensembl
Rnor_6.0 Ensembl1925,526,751 - 25,749,550 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102295   ⟹   ENSRNOP00000080121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,520,741 - 23,823,225 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106526   ⟹   ENSRNOP00000096924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,520,741 - 23,823,225 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114797   ⟹   ENSRNOP00000078109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,520,741 - 23,565,281 (-)Ensembl
RefSeq Acc Id: NM_012918   ⟹   NP_037050
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,425,560 - 40,650,468 (-)NCBI
mRatBN7.21923,520,741 - 23,745,646 (-)NCBI
Rnor_6.01925,526,751 - 25,749,550 (+)NCBI
Rnor_5.01936,502,533 - 36,727,039 (+)NCBI
RGSC_v3.41925,188,170 - 25,424,495 (-)RGD
Celera1923,074,249 - 23,295,970 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097487   ⟹   XP_038953415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,426,808 - 40,724,802 (-)NCBI
mRatBN7.21923,521,989 - 23,819,963 (-)NCBI
RefSeq Acc Id: XM_063277789   ⟹   XP_063133859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,426,808 - 40,724,802 (-)NCBI
RefSeq Acc Id: XM_063277790   ⟹   XP_063133860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,426,808 - 40,724,803 (-)NCBI
RefSeq Acc Id: XM_063277791   ⟹   XP_063133861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,426,808 - 40,724,802 (-)NCBI
RefSeq Acc Id: XM_063277792   ⟹   XP_063133862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,426,808 - 40,724,802 (-)NCBI
RefSeq Acc Id: XM_063277793   ⟹   XP_063133863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,426,808 - 40,724,803 (-)NCBI
RefSeq Acc Id: XM_063277794   ⟹   XP_063133864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,426,808 - 40,651,714 (-)NCBI
RefSeq Acc Id: XM_063277795   ⟹   XP_063133865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,426,808 - 40,724,801 (-)NCBI
RefSeq Acc Id: XM_063277796   ⟹   XP_063133866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,467,473 - 40,724,810 (-)NCBI
RefSeq Acc Id: XM_063277797   ⟹   XP_063133867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,464,371 - 40,724,810 (-)NCBI
RefSeq Acc Id: XM_063277798   ⟹   XP_063133868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,463,531 - 40,724,809 (-)NCBI
RefSeq Acc Id: XM_063277799   ⟹   XP_063133869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,464,431 - 40,724,809 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037050 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953415 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133859 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133860 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133861 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133862 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133863 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133864 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133865 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133866 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133867 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133868 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133869 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40806 (Get FASTA)   NCBI Sequence Viewer  
  AAA40896 (Get FASTA)   NCBI Sequence Viewer  
  AAC24516 (Get FASTA)   NCBI Sequence Viewer  
  AAC24517 (Get FASTA)   NCBI Sequence Viewer  
  CAJ09863 (Get FASTA)   NCBI Sequence Viewer  
  CAJ09864 (Get FASTA)   NCBI Sequence Viewer  
  CAJ09865 (Get FASTA)   NCBI Sequence Viewer  
  CAJ09866 (Get FASTA)   NCBI Sequence Viewer  
  CAJ09867 (Get FASTA)   NCBI Sequence Viewer  
  CAJ09868 (Get FASTA)   NCBI Sequence Viewer  
  CAJ09869 (Get FASTA)   NCBI Sequence Viewer  
  EDL92217 (Get FASTA)   NCBI Sequence Viewer  
  EDL92218 (Get FASTA)   NCBI Sequence Viewer  
  EDL92219 (Get FASTA)   NCBI Sequence Viewer  
  EDL92220 (Get FASTA)   NCBI Sequence Viewer  
  EDL92221 (Get FASTA)   NCBI Sequence Viewer  
  EDL92222 (Get FASTA)   NCBI Sequence Viewer  
  EDL92223 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070304
  ENSRNOP00000080121
  ENSRNOP00000096924
GenBank Protein P54282 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037050   ⟸   NM_012918
- UniProtKB: A0A0G2JXK1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070304   ⟸   ENSRNOT00000083448
RefSeq Acc Id: XP_038953415   ⟸   XM_039097487
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZPG4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096924   ⟸   ENSRNOT00000106526
Ensembl Acc Id: ENSRNOP00000080121   ⟸   ENSRNOT00000102295
Ensembl Acc Id: ENSRNOP00000078109   ⟸   ENSRNOT00000114797
RefSeq Acc Id: XP_063133860   ⟸   XM_063277790
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZPG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133863   ⟸   XM_063277793
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZPG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133862   ⟸   XM_063277792
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZPG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133861   ⟸   XM_063277791
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZPG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133859   ⟸   XM_063277789
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133865   ⟸   XM_063277795
- Peptide Label: isoform X8
- UniProtKB: Q01541 (UniProtKB/Swiss-Prot),   P54282 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063133864   ⟸   XM_063277794
- Peptide Label: isoform X7
- UniProtKB: A0A0G2JXK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133868   ⟸   XM_063277798
- Peptide Label: isoform X11
- UniProtKB: A6IY89 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133867   ⟸   XM_063277797
- Peptide Label: isoform X10
- UniProtKB: A6IY89 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133869   ⟸   XM_063277799
- Peptide Label: isoform X11
- UniProtKB: A6IY89 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133866   ⟸   XM_063277796
- Peptide Label: isoform X9
- UniProtKB: A6IY89 (UniProtKB/TrEMBL)
Protein Domains
Ion transport   Voltage-dependent calcium channel alpha-1 subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54282-F1-model_v2 AlphaFold P54282 1-2212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2244 AgrOrtholog
BioCyc Gene G2FUF-6106 BioCyc
Ensembl Genes ENSRNOG00000052707 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000083448 ENTREZGENE
  ENSRNOT00000102295 ENTREZGENE
  ENSRNOT00000106526 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
  6.10.250.2180 UniProtKB/Swiss-Prot
  6.10.250.2500 UniProtKB/Swiss-Prot
InterPro CACNA1A UniProtKB/Swiss-Prot
  GPHH_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  VDCC_a1su_IQ UniProtKB/Swiss-Prot
  VDCC_alpha-1_subunit UniProtKB/Swiss-Prot
  VDCCAlpha1 UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25398 UniProtKB/Swiss-Prot
NCBI Gene 25398 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot
  VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A UniProtKB/Swiss-Prot
Pfam Ca_chan_IQ UniProtKB/Swiss-Prot
  GPHH UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
PhenoGen Cacna1a PhenoGen
PRINTS CACHANNEL UniProtKB/Swiss-Prot
  PQVDCCALPHA1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052707 RatGTEx
SMART Ca_chan_IQ UniProtKB/Swiss-Prot
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC228655
UniProt A0A0G2JXK1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y6Y2_RAT UniProtKB/TrEMBL
  A0A8I5ZPG4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B516_RAT UniProtKB/TrEMBL
  A6IY89 ENTREZGENE, UniProtKB/TrEMBL
  A6IY92_RAT UniProtKB/TrEMBL
  A6IY93_RAT UniProtKB/TrEMBL
  A6IY94_RAT UniProtKB/TrEMBL
  A6IY95_RAT UniProtKB/TrEMBL
  CAC1A_RAT UniProtKB/Swiss-Prot
  O70368_RAT UniProtKB/TrEMBL
  P54282 ENTREZGENE
  Q01541 ENTREZGENE
  Q2YS33_RAT UniProtKB/TrEMBL
  Q2YS34_RAT UniProtKB/TrEMBL
  Q2YS35_RAT UniProtKB/TrEMBL
  Q2YS36_RAT UniProtKB/TrEMBL
  Q2YS37_RAT UniProtKB/TrEMBL
  Q2YS38_RAT UniProtKB/TrEMBL
  Q2YS39_RAT UniProtKB/TrEMBL
UniProt Secondary Q01541 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacna1a  calcium voltage-gated channel subunit alpha1 A  Cacna1a  calcium channel, voltage-dependent, P/Q type, alpha 1A subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-29 Cacna1a  calcium channel, voltage-dependent, P/Q type, alpha 1A subunit  LOC688360  similar to Voltage-dependent P/Q-type calcium channel alpha-1A subunit (Voltage-gated calcium channel alpha subunit Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI)  Data merged from RGD:1590014 737654 PROVISIONAL
2006-11-20 LOC688360  similar to Voltage-dependent P/Q-type calcium channel alpha-1A subunit (Voltage-gated calcium channel alpha subunit Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI)      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Cacna1a  calcium channel, voltage-dependent, P/Q type, alpha 1A subunit    calcium channel, voltage-dependent, alpha 1A subunit  Name updated 1299863 APPROVED
2002-11-06 Cacna1a  calcium channel, voltage-dependent, alpha 1A subunit    Calcium channel alpha 1A  Name updated 625702 APPROVED
2002-06-10 Cacna1a  Calcium channel alpha 1A      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in central nervous system, heart and pituitary and not expressed in spleen, kidney or liver 1299846
gene_function a voltage-gated calcium channel 634678
gene_process involved in secretion coupling in beta cells 634678