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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2244
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna1a
Name: calcium voltage-gated channel subunit alpha1 A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna1aaffects methylationISOCACNA1A (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CACNA1A intronPMID:30157460
Cacna1adecreases expressionISOCacna1a (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CACNA1A mRNAPMID:22228805
Cacna1adecreases methylationISOCACNA1A (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of CACNA1A exonPMID:27901495
Cacna1aincreases methylationISOCACNA1A (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CACNA1A promoterPMID:27901495
Cacna1aincreases mutagenesisISOCACNA1A (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of CACNA1A genePMID:25435355
Cacna1amultiple interactionsISOCacna1a (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CACNA1A mRNA]PMID:22228805
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