Syt1 (synaptotagmin 1) - Rat Genome Database

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Gene: Syt1 (synaptotagmin 1) Rattus norvegicus
Symbol: Syt1
Name: synaptotagmin 1
RGD ID: 3803
Description: Enables several functions, including calmodulin binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in several processes, including positive regulation of dopamine secretion; regulation of vesicle-mediated transport; and response to calcium ion. Located in several cellular components, including excitatory synapse; neuron projection terminus; and secretory vesicle. Is active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SYT1 (synaptotagmin 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: P65; synaptotagmin I; synaptotagmin-1; sytI
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2743,813,204 - 44,358,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl743,815,785 - 44,357,803 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx745,726,193 - 46,271,079 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0747,929,286 - 48,474,187 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0747,707,065 - 48,251,959 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0750,084,063 - 50,638,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl750,084,060 - 50,638,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0750,097,034 - 50,289,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4747,243,375 - 47,795,496 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1747,261,066 - 47,815,950 (-)NCBI
Celera740,680,324 - 41,216,966 (-)NCBICelera
RH 3.4 Map7348.01RGD
Cytogenetic Map7q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
calcidiol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
diallyl disulfide  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
heroin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
inulin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
Ptaquiloside  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. Bacaj T, etal., PLoS Biol. 2015 Oct 5;13(10):e1002267. doi: 10.1371/journal.pbio.1002267. eCollection 2015 Oct.
2. Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Bakkaloglu B, etal., Am J Hum Genet. 2008 Jan;82(1):165-73. doi: 10.1016/j.ajhg.2007.09.017.
3. Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms. Bhalla A, etal., J Biol Chem. 2008 Aug 1;283(31):21799-807. doi: 10.1074/jbc.M709628200. Epub 2008 May 28.
4. A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerization. Chapman ER, etal., J Biol Chem. 1996 Mar 8;271(10):5844-9. doi: 10.1074/jbc.271.10.5844.
5. Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin. Chapman ER, etal., J Biol Chem. 1998 Dec 4;273(49):32966-72.
6. Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel. Charvin N, etal., EMBO J. 1997 Aug 1;16(15):4591-6.
7. Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain. Cheng Y, etal., Protein Sci. 2004 Oct;13(10):2665-72. Epub 2004 Aug 31.
8. Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex. Choi UB, etal., Nat Struct Mol Biol. 2010 Mar;17(3):318-24. doi: 10.1038/nsmb.1763. Epub 2010 Feb 21.
9. Direct interaction of the rab3 effector rim with ca2+ channels, snap-25, and synaptotagmin. Coppola T, etal., J Biol Chem 2001 Aug 31;276(35):32756-62.
10. Rab3A Inhibition of Ca2+ -Dependent Dopamine Release From PC12 Cells Involves Interaction With Synaptotagmin I. Dai Z, etal., J Cell Biochem. 2017 Nov;118(11):3696-3705. doi: 10.1002/jcb.26016. Epub 2017 May 16.
11. A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. Davletov BA and Sudhof TC, J Biol Chem. 1993 Dec 15;268(35):26386-90.
12. Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I. Evans GJ and Morgan A, Biochem J 2002 Jun 1;364(Pt 2):343-7.
13. RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells. Fukuda M Biochem J. 2004 Jun 15;380(Pt 3):875-9.
14. Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. Fukuda M, etal., J Biol Chem. 2002 Feb 15;277(7):4601-4. Epub 2001 Dec 21.
15. The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex. Galli T, etal., J Biol Chem. 1996 Jan 26;271(4):2193-8.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. Harada A, etal., J Biol Chem 2000 Nov 24;275(47):36885-91.
19. Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells. Hayashi T, etal., Biochem Biophys Res Commun. 2012 Mar 16;419(3):511-6. doi: 10.1016/j.bbrc.2012.02.047. Epub 2012 Feb 15.
20. The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis. Jarousse N and Kelly RB, J Cell Biol. 2001 Aug 20;154(4):857-66. Epub 2001 Aug 13.
21. Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2. Jung N, etal., J Cell Biol. 2007 Dec 31;179(7):1497-510. doi: 10.1083/jcb.200708107.
22. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. Ko J, etal., EMBO J. 2009 Oct 21;28(20):3244-55. doi: 10.1038/emboj.2009.249. Epub 2009 Sep 3.
23. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Krapivinsky G, etal., Neuron. 2006 Nov 9;52(3):485-96.
24. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
25. The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor. Lai Y and Shin YK, Biochem J. 2012 Apr 1;443(1):223-9. doi: 10.1042/BJ20112044.
26. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Li C, etal., Nature 1995 Jun 15;375(6532):594-9.
27. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Li H, etal., Nat Cell Biol. 2013 Jul;15(7):773-85. doi: 10.1038/ncb2791. Epub 2013 Jun 23.
28. A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes. Maienschein V, etal., Glia. 1999 May;26(3):233-44.
29. Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. Matthew WD, etal., J Cell Biol. 1981 Oct;91(1):257-69.
30. Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. Maximov A, etal., J Cell Biol. 2007 Jan 1;176(1):113-24. Epub 2006 Dec 26.
31. The juxtamembrane region of synaptotagmin 1 interacts with dynamin 1 and regulates vesicle fission during compensatory endocytosis in endocrine cells. McAdam RL, etal., J Cell Sci. 2015 Jun 15;128(12):2229-35. doi: 10.1242/jcs.161505. Epub 2015 May 11.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release. Mori Y, etal., EMBO J. 2008 Jan 9;27(1):76-87. Epub 2007 Nov 29.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Perin MS, etal., Nature 1990 May 17;345(6272):260-3.
36. GOA pipeline RGD automated data pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels. Sampo B, etal., Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3666-71.
40. Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin. Schivell AE, etal., J Biol Chem. 1996 Nov 1;271(44):27770-5.
41. Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. Shin OH, etal., Neuron. 2003 Jan 9;37(1):99-108.
42. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
43. Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism. Tang X, etal., Int J Biol Macromol. 2017 Mar;96:736-742. doi: 10.1016/j.ijbiomac.2016.12.074. Epub 2017 Jan 3.
44. Functional and biochemical analysis of the C2 domains of synaptotagmin IV. Thomas DM, etal., Mol Biol Cell. 1999 Jul;10(7):2285-95.
45. Two synaptotagmin genes, Syt1 and Syt4, are differentially regulated in adult brain and during postnatal development following kainic acid-induced seizures. Tocco G, etal., Brain Res Mol Brain Res 1996 Sep 1;40(2):229-39.
46. Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. Tokumaru H, etal., Brain Cell Biol. 2008 Dec;36(5-6):173-89. doi: 10.1007/s11068-008-9032-9. Epub 2009 Jan 9.
47. Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. Tucker WC, etal., J Cell Biol. 2003 Jul 21;162(2):199-209. Epub 2003 Jul 14.
48. Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold. van den Bogaart G, etal., J Biol Chem. 2012 May 11;287(20):16447-53. doi: 10.1074/jbc.M112.343418. Epub 2012 Mar 23.
49. Cis- and trans-membrane interactions of synaptotagmin-1. Vennekate W, etal., Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):11037-42. doi: 10.1073/pnas.1116326109. Epub 2012 Jun 18.
50. Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating. Walther K, etal., EMBO Rep. 2001 Jul;2(7):634-40. Epub 2001 Jul 3.
51. Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. Wang Z and Chapman ER, J Biol Chem. 2010 Oct 1;285(40):30759-66. doi: 10.1074/jbc.M110.137745. Epub 2010 Aug 5.
52. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
53. Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin. Willshaw A, etal., FEBS Lett. 2004 Feb 13;559(1-3):13-21.
54. The synaptotagmins: calcium sensors for vesicular trafficking. Yoshihara M and Montana ES, Neuroscientist. 2004 Dec;10(6):566-74.
55. LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Yun HJ, etal., Exp Mol Med. 2013 Aug 16;45:e36. doi: 10.1038/emm.2013.68.
56. Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells. Zhang Z, etal., Mol Biol Cell. 2011 Jul 1;22(13):2324-36. doi: 10.1091/mbc.E11-02-0159. Epub 2011 May 5.
57. Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Zhou Q, etal., Nature. 2015 Sep 3;525(7567):62-7. doi: 10.1038/nature14975. Epub 2015 Aug 17.
58. Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles. Zhu D, etal., Biochem Biophys Res Commun. 2007 Oct 5;361(4):922-7. Epub 2007 Jul 25.
Additional References at PubMed
PMID:7553862   PMID:7697723   PMID:7954835   PMID:7993622   PMID:8132583   PMID:8626542   PMID:8889548   PMID:9194562   PMID:9819203   PMID:10715114   PMID:11242035   PMID:11562488  
PMID:11754837   PMID:12145198   PMID:12220627   PMID:12496247   PMID:12645522   PMID:12782290   PMID:12873386   PMID:12963743   PMID:14504267   PMID:14622145   PMID:14709554   PMID:14718921  
PMID:14983047   PMID:15016962   PMID:15044754   PMID:15046725   PMID:15071120   PMID:15082773   PMID:15197251   PMID:15238157   PMID:15350218   PMID:15561725   PMID:15628842   PMID:15774481  
PMID:15866046   PMID:16262243   PMID:16293646   PMID:16407767   PMID:16477143   PMID:16491093   PMID:16612384   PMID:16808897   PMID:16893168   PMID:17183698   PMID:17264148   PMID:17360631  
PMID:17478680   PMID:17913838   PMID:18058942   PMID:18410172   PMID:18468511   PMID:18585366   PMID:18622390   PMID:18703708   PMID:18799625   PMID:18956883   PMID:19302798   PMID:19501597  
PMID:19608642   PMID:19632983   PMID:19723500   PMID:20448186   PMID:20573977   PMID:20735850   PMID:20824061   PMID:20978127   PMID:21040848   PMID:21087613   PMID:21287204   PMID:21307259  
PMID:21320440   PMID:21322640   PMID:21344950   PMID:21456023   PMID:21521611   PMID:21576241   PMID:21610074   PMID:21646859   PMID:21928778   PMID:22008253   PMID:22398727   PMID:22609930  
PMID:22810233   PMID:22871113   PMID:22960622   PMID:23091625   PMID:23300284   PMID:23321072   PMID:23617808   PMID:23665582   PMID:23884218   PMID:23954480   PMID:23999003   PMID:24001110  
PMID:24327345   PMID:24423395   PMID:24472545   PMID:24973220   PMID:25716318   PMID:25716321   PMID:26030874   PMID:26202512   PMID:26389740   PMID:26400647   PMID:26667128   PMID:26792839  
PMID:27001899   PMID:27083046   PMID:27791979   PMID:28111077   PMID:28515322   PMID:28686803   PMID:29115943   PMID:29476059   PMID:30964765   PMID:31160571   PMID:31301806   PMID:31431523  
PMID:31932584   PMID:32024024   PMID:32401194   PMID:32808925   PMID:33160605   PMID:33468652   PMID:33536412   PMID:35537054  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2743,813,204 - 44,358,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl743,815,785 - 44,357,803 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx745,726,193 - 46,271,079 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0747,929,286 - 48,474,187 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0747,707,065 - 48,251,959 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0750,084,063 - 50,638,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl750,084,060 - 50,638,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0750,097,034 - 50,289,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4747,243,375 - 47,795,496 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1747,261,066 - 47,815,950 (-)NCBI
Celera740,680,324 - 41,216,966 (-)NCBICelera
RH 3.4 Map7348.01RGD
Cytogenetic Map7q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381278,863,982 - 79,452,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1278,863,993 - 79,452,008 (+)EnsemblGRCh38hg38GRCh38
GRCh371279,257,762 - 79,845,788 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361278,135,414 - 78,368,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 341278,113,750 - 78,347,311NCBI
Celera1278,924,230 - 79,512,467 (+)NCBICelera
Cytogenetic Map12q21.2NCBI
HuRef1276,312,006 - 76,901,927 (+)NCBIHuRef
CHM1_11279,224,059 - 79,812,179 (+)NCBICHM1_1
T2T-CHM13v2.01278,842,458 - 79,430,647 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910108,333,511 - 108,846,852 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10108,333,511 - 108,846,843 (-)EnsemblGRCm39 Ensembl
GRCm3810108,497,650 - 109,010,980 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10108,497,650 - 109,010,982 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710107,935,305 - 108,447,675 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610107,902,359 - 108,414,729 (-)NCBIMGSCv36mm8
Celera10110,439,113 - 110,956,164 (-)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1056.52NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540517,839,884 - 18,372,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540517,840,012 - 18,372,156 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11286,909,416 - 87,498,045 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01276,392,955 - 76,981,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11279,240,646 - 79,829,923 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1279,595,704 - 79,829,923 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11521,629,061 - 22,042,734 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1521,834,763 - 22,042,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1521,934,859 - 22,469,519 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01521,856,608 - 22,392,551 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1521,856,444 - 22,390,979 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11521,446,653 - 21,981,053 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01521,507,116 - 22,042,283 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01521,747,161 - 22,282,182 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494538,336,962 - 38,847,320 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936698377,179 - 575,802 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493669865,210 - 575,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl5101,871,314 - 102,215,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15101,871,313 - 102,394,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25106,815,507 - 107,335,980 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11174,442,890 - 75,032,756 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1174,795,207 - 75,032,915 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037170,421,409 - 171,012,159 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475018,774,570 - 18,989,659 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475018,774,670 - 19,313,932 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Syt1
3067 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:134
Interacting mature miRNAs:147
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,910,536 - 43,910,683 (+)MAPPERmRatBN7.2
Rnor_6.0750,181,371 - 50,181,517NCBIRnor6.0
Rnor_5.0750,191,794 - 50,191,940UniSTSRnor5.0
RGSC_v3.4747,338,134 - 47,338,281RGDRGSC3.4
RGSC_v3.4747,338,135 - 47,338,281UniSTSRGSC3.4
RGSC_v3.1747,358,406 - 47,358,552RGD
Celera740,774,551 - 40,774,698UniSTS
RH 3.4 Map7349.8RGD
RH 3.4 Map7349.8UniSTS
RH 2.0 Map7332.8RGD
SHRSP x BN Map727.21RGD
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2744,108,104 - 44,108,355 (+)MAPPERmRatBN7.2
Rnor_6.0750,382,631 - 50,382,881NCBIRnor6.0
Rnor_5.0750,393,982 - 50,394,232UniSTSRnor5.0
RGSC_v3.4747,540,916 - 47,541,167RGDRGSC3.4
RGSC_v3.4747,540,917 - 47,541,167UniSTSRGSC3.4
RGSC_v3.1747,561,188 - 47,561,438RGD
Celera740,971,474 - 40,971,722UniSTS
RH 3.4 Map7347.9UniSTS
RH 3.4 Map7347.9RGD
RH 2.0 Map7341.3RGD
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,815,731 - 43,815,891 (+)MAPPERmRatBN7.2
Rnor_6.0750,086,591 - 50,086,750NCBIRnor6.0
Rnor_5.0750,096,981 - 50,097,140UniSTSRnor5.0
RGSC_v3.4747,243,322 - 47,243,481UniSTSRGSC3.4
Celera740,680,271 - 40,680,430UniSTS
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2744,089,767 - 44,089,943 (+)MAPPERmRatBN7.2
Rnor_6.0750,364,292 - 50,364,467NCBIRnor6.0
Rnor_5.0750,375,643 - 50,375,818UniSTSRnor5.0
RGSC_v3.4747,522,578 - 47,522,753UniSTSRGSC3.4
Celera740,953,342 - 40,953,517UniSTS
RH 3.4 Map7350.6UniSTS
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,813,382 - 43,813,545 (+)MAPPERmRatBN7.2
Rnor_6.0750,084,242 - 50,084,404NCBIRnor6.0
Rnor_5.0750,094,632 - 50,094,794UniSTSRnor5.0
RGSC_v3.4747,240,973 - 47,241,135UniSTSRGSC3.4
Celera740,677,923 - 40,678,085UniSTS
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,813,276 - 43,813,458 (+)MAPPERmRatBN7.2
Rnor_6.0750,084,136 - 50,084,317NCBIRnor6.0
Rnor_5.0750,094,526 - 50,094,707UniSTSRnor5.0
RGSC_v3.4747,240,867 - 47,241,048UniSTSRGSC3.4
Celera740,677,817 - 40,677,998UniSTS
RH 3.4 Map7348.01UniSTS
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,947,624 - 43,947,774 (+)MAPPERmRatBN7.2
Rnor_6.0750,218,457 - 50,218,606NCBIRnor6.0
Rnor_5.0750,229,566 - 50,229,715UniSTSRnor5.0
RGSC_v3.4747,375,907 - 47,376,056UniSTSRGSC3.4
Celera740,811,608 - 40,811,757UniSTS
RH 3.4 Map7351.92UniSTS
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2744,206,754 - 44,206,956 (+)MAPPERmRatBN7.2
Rnor_6.0750,485,630 - 50,485,831NCBIRnor6.0
Rnor_5.0750,496,981 - 50,497,182UniSTSRnor5.0
RGSC_v3.4747,642,642 - 47,642,843UniSTSRGSC3.4
Celera741,066,296 - 41,066,497UniSTS
RH 3.4 Map7348.0UniSTS
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2744,323,779 - 44,323,950 (+)MAPPERmRatBN7.2
Rnor_6.0750,603,557 - 50,603,727NCBIRnor6.0
Rnor_5.0750,616,068 - 50,616,238UniSTSRnor5.0
RGSC_v3.4747,762,240 - 47,762,410UniSTSRGSC3.4
Celera741,182,950 - 41,183,120UniSTS
RH 3.4 Map7379.1UniSTS
Cytogenetic Map7q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,815,871 - 43,816,058 (+)MAPPERmRatBN7.2
Rnor_6.0750,086,731 - 50,086,917NCBIRnor6.0
Rnor_5.0750,097,121 - 50,097,307UniSTSRnor5.0
RGSC_v3.4747,243,462 - 47,243,648UniSTSRGSC3.4
Celera740,680,411 - 40,680,597UniSTS
RH 3.4 Map7350.91UniSTS
Cytogenetic Map7q21UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 68 1
Low 3 8 23 9 6 9 2 2 6 25 40 11 2
Below cutoff 35 29 27 13 27 6 7 10 6


Nucleotide Sequences
RefSeq Transcripts NM_001033680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA924659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB615786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB731032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO398869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ181550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000048880   ⟹   ENSRNOP00000049624
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl743,815,785 - 44,357,803 (-)Ensembl
Rnor_6.0 Ensembl750,086,644 - 50,638,798 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088950   ⟹   ENSRNOP00000069194
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl743,815,785 - 44,357,803 (-)Ensembl
Rnor_6.0 Ensembl750,084,060 - 50,278,842 (-)Ensembl
RefSeq Acc Id: NM_001033680   ⟹   NP_001028852
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2743,815,785 - 44,357,803 (-)NCBI
Rnor_6.0750,086,644 - 50,638,798 (-)NCBI
Rnor_5.0750,097,034 - 50,289,950 (-)NCBI
RGSC_v3.4747,243,375 - 47,795,496 (-)RGD
Celera740,680,324 - 41,216,966 (-)RGD
RefSeq Acc Id: XM_008765353   ⟹   XP_008763575
Rat AssemblyChrPosition (strand)Source
mRatBN7.2743,813,204 - 44,358,020 (-)NCBI
Rnor_6.0750,084,063 - 50,638,996 (-)NCBI
RefSeq Acc Id: XM_017594679   ⟹   XP_017450168
Rat AssemblyChrPosition (strand)Source
mRatBN7.2743,813,204 - 44,358,019 (-)NCBI
Rnor_6.0750,084,063 - 50,638,996 (-)NCBI
RefSeq Acc Id: XM_039078497   ⟹   XP_038934425
Rat AssemblyChrPosition (strand)Source
mRatBN7.2743,813,204 - 44,358,019 (-)NCBI
RefSeq Acc Id: XM_039078499   ⟹   XP_038934427
Rat AssemblyChrPosition (strand)Source
mRatBN7.2743,813,204 - 44,007,996 (-)NCBI
RefSeq Acc Id: NP_001028852   ⟸   NM_001033680
- UniProtKB: Q3S2E6 (UniProtKB/Swiss-Prot),   Q707P5 (UniProtKB/Swiss-Prot),   P21707 (UniProtKB/Swiss-Prot),   A6IGE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763575   ⟸   XM_008765353
- Peptide Label: isoform X2
- UniProtKB: A6IGE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450168   ⟸   XM_017594679
- Peptide Label: isoform X1
- UniProtKB: Q3S2E6 (UniProtKB/Swiss-Prot),   Q707P5 (UniProtKB/Swiss-Prot),   P21707 (UniProtKB/Swiss-Prot),   A6IGE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000049624   ⟸   ENSRNOT00000048880
RefSeq Acc Id: ENSRNOP00000069194   ⟸   ENSRNOT00000088950
RefSeq Acc Id: XP_038934425   ⟸   XM_039078497
- Peptide Label: isoform X1
- UniProtKB: Q3S2E6 (UniProtKB/Swiss-Prot),   P21707 (UniProtKB/Swiss-Prot),   Q707P5 (UniProtKB/Swiss-Prot),   A6IGE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934427   ⟸   XM_039078499
- Peptide Label: isoform X3
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21707-F1-model_v2 AlphaFold P21707 1-421 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3803 AgrOrtholog
BIND 130539
BioCyc Gene G2FUF-34157 BioCyc
Ensembl Genes ENSRNOG00000006426 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055017023 UniProtKB/Swiss-Prot
  ENSRNOG00060003698 UniProtKB/Swiss-Prot
  ENSRNOG00065003237 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048880 ENTREZGENE
  ENSRNOT00000048880.3 UniProtKB/Swiss-Prot
  ENSRNOT00000088950.2 UniProtKB/TrEMBL
  ENSRNOT00055028911 UniProtKB/Swiss-Prot
  ENSRNOT00060006122 UniProtKB/Swiss-Prot
  ENSRNOT00065004587 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptotagmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25716 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10024:SF239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Syt1 PhenoGen
PROSITE PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006426 RatGTEx
  ENSRNOG00055017023 RatGTEx
  ENSRNOG00060003698 RatGTEx
  ENSRNOG00065003237 RatGTEx
SMART SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R1E5_RAT UniProtKB/TrEMBL
  Q707P0_RAT UniProtKB/TrEMBL
  Q707P1_RAT UniProtKB/TrEMBL
  Q707P2_RAT UniProtKB/TrEMBL
  Q707P4_RAT UniProtKB/TrEMBL
  SYT1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q3S2E6 UniProtKB/Swiss-Prot
  Q707P5 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Syt1  synaptotagmin 1  Syt1  synaptotagmin I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Syt1  synaptotagmin I    synaptotagmin 1  Name updated 1299863 APPROVED
2002-06-10 Syt1  synaptotagmin 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression localized on synaptic vesicles 68912
gene_physical_interaction binds to syntaxin-1 68912
gene_physical_interaction binds calmodulin; binds calcium; binds acidic phospholipids with a specificity similar to protein kinase C 729959
gene_process involved in the fast calcium dependent component of neurotransmitter release 68912
gene_regulation binding to syntaxin-1 is stronger in the presence of calcium 68912