Syt7 (synaptotagmin 7) - Rat Genome Database

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Gene: Syt7 (synaptotagmin 7) Rattus norvegicus
Analyze
Symbol: Syt7
Name: synaptotagmin 7
RGD ID: 62013
Description: Enables several functions, including calcium ion binding activity; calcium-dependent phospholipid binding activity; and syntaxin binding activity. Involved in several processes, including calcium ion regulated lysosome exocytosis; plasma membrane repair; and regulation of vesicle-mediated transport. Located in dense core granule and lysosome. Is active in hippocampal mossy fiber to CA3 synapse and presynaptic membrane. Orthologous to human SYT7 (synaptotagmin 7); PARTICIPATES IN insulin secretion pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: synaptotagmin VII; synaptotagmin-7; SytVII
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Syt7_v1   Syt7_v2   Syt7_v3  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,456,148 - 216,518,718 (+)NCBIGRCr8
mRatBN7.21207,031,359 - 207,093,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,031,592 - 207,089,026 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,409,548 - 215,472,142 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,465,140 - 222,527,610 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,160,142 - 215,222,616 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,435,816 - 226,498,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,435,979 - 226,493,377 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,382,523 - 233,445,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,876,675 - 212,935,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11213,035,183 - 213,093,803NCBI
Celera1204,526,212 - 204,583,576 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
apomorphine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
inulin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
O-methyleugenol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
propanal  (ISO)
Ptaquiloside  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. Bacaj T, etal., PLoS Biol. 2015 Oct 5;13(10):e1002267. doi: 10.1371/journal.pbio.1002267. eCollection 2015 Oct.
2. Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human. Fukuda M, etal., Biochem J 2002 Jul 1;365(Pt 1):173-80.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Synaptotagmins bind calcium to release insulin. Gauthier BR and Wollheim CB, Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1279-86. Epub 2008 Aug 19.
5. Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis. Gauthier BR, etal., FASEB J. 2008 Jan;22(1):194-206. Epub 2007 Aug 20.
6. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Li C, etal., Nature 1995 Jun 15;375(6532):594-9.
7. Silence of Synaptotagmin VII inhibits release of dense core vesicles in PC12 cells. Li J, etal., Sci China C Life Sci. 2009 Dec;52(12):1156-63. doi: 10.1007/s11427-009-0160-y. Epub 2009 Dec 17.
8. Synaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblasts. Martinez I, etal., J Cell Biol. 2000 Mar 20;148(6):1141-49.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Reddy A, etal., Cell. 2001 Jul 27;106(2):157-69.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis. Sugita S, etal., Neuron 2001 May;30(2):459-73.
15. Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling. Virmani T, etal., EMBO J. 2003 Oct 15;22(20):5347-57. doi: 10.1093/emboj/cdg514.
16. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
17. The synaptotagmins: calcium sensors for vesicular trafficking. Yoshihara M and Montana ES, Neuroscientist. 2004 Dec;10(6):566-74.
18. Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells. Zhang Z, etal., Mol Biol Cell. 2011 Jul 1;22(13):2324-36. doi: 10.1091/mbc.E11-02-0159. Epub 2011 May 5.
Additional References at PubMed
PMID:10556508   PMID:12615974   PMID:12860971   PMID:12925704   PMID:14993220   PMID:15456748   PMID:16166648   PMID:16982801   PMID:18308938   PMID:18539119   PMID:19171650   PMID:20573977  
PMID:20824061   PMID:21041449   PMID:21287204   PMID:21576241   PMID:23533145   PMID:24267651   PMID:24569478   PMID:25344253   PMID:25860611   PMID:25931508   PMID:26738595   PMID:27771350  
PMID:28111077   PMID:29476059   PMID:32058590  


Genomics

Comparative Map Data
Syt7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,456,148 - 216,518,718 (+)NCBIGRCr8
mRatBN7.21207,031,359 - 207,093,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,031,592 - 207,089,026 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,409,548 - 215,472,142 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,465,140 - 222,527,610 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,160,142 - 215,222,616 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,435,816 - 226,498,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,435,979 - 226,493,377 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,382,523 - 233,445,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,876,675 - 212,935,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11213,035,183 - 213,093,803NCBI
Celera1204,526,212 - 204,583,576 (+)NCBICelera
Cytogenetic Map1q43NCBI
SYT7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,513,714 - 61,588,387 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,513,714 - 61,581,148 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,281,186 - 61,348,548 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,039,361 - 61,104,874 (-)NCBINCBI36Build 36hg18NCBI36
Build 341161,039,361 - 61,104,874NCBI
Celera1158,618,148 - 58,683,697 (-)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1157,608,716 - 57,651,861 (-)NCBIHuRef
CHM1_11161,164,220 - 61,231,379 (-)NCBICHM1_1
T2T-CHM13v2.01161,502,594 - 61,577,283 (-)NCBIT2T-CHM13v2.0
Syt7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,366,142 - 10,430,545 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,366,454 - 10,430,544 (+)EnsemblGRCm39 Ensembl
GRCm381910,388,802 - 10,453,181 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,389,090 - 10,453,180 (+)EnsemblGRCm38mm10GRCm38
MGSCv371910,463,580 - 10,527,671 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,456,528 - 10,515,489 (+)NCBIMGSCv36mm8
Celera1911,085,012 - 11,149,518 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.58NCBI
Syt7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555116,051,386 - 6,093,651 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555116,051,392 - 6,093,651 (+)NCBIChiLan1.0ChiLan1.0
SYT7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2962,683,382 - 62,749,126 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,727,088 - 63,792,718 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,814,694 - 56,880,439 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11160,175,403 - 60,242,375 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1160,175,403 - 60,242,375 (-)Ensemblpanpan1.1panPan2
SYT7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,863,072 - 54,926,121 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,861,754 - 54,921,367 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1853,437,734 - 53,500,698 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01855,910,339 - 55,973,524 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1855,834,857 - 55,971,881 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,970,585 - 55,033,491 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01854,590,887 - 54,654,036 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01855,472,658 - 55,535,641 (+)NCBIUU_Cfam_GSD_1.0
Syt7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,385,101 - 11,444,169 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365811,512,855 - 1,559,679 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365811,516,199 - 1,557,992 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYT7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl29,947,925 - 10,012,496 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.129,947,962 - 10,012,713 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.229,513,096 - 9,563,737 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SYT7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,267,591 - 12,333,181 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,267,685 - 12,333,185 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038109,644,397 - 109,709,429 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syt7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624926722,224 - 765,033 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624926722,201 - 765,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Syt7
305 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:862
Count of miRNA genes:158
Interacting mature miRNAs:185
Transcripts:ENSRNOT00000007429, ENSRNOT00000035576, ENSRNOT00000036168, ENSRNOT00000036180, ENSRNOT00000036232, ENSRNOT00000036283, ENSRNOT00000047964, ENSRNOT00000048704
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1206329708222745518Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat

Markers in Region
D1Rat293  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21207,036,933 - 207,037,121 (+)MAPPERmRatBN7.2
Rnor_6.01226,441,138 - 226,441,325NCBIRnor6.0
Rnor_5.01233,387,844 - 233,388,031UniSTSRnor5.0
RGSC_v3.41212,881,866 - 212,882,054RGDRGSC3.4
RGSC_v3.41212,881,867 - 212,882,054UniSTSRGSC3.4
RGSC_v3.11213,040,296 - 213,040,484RGD
Celera1204,531,587 - 204,531,774UniSTS
SHRSP x BN Map1106.05RGD
SHRSP x BN Map1106.05UniSTS
Cytogenetic Map1q43UniSTS
BE115310  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21207,048,023 - 207,048,191 (+)MAPPERmRatBN7.2
Rnor_6.01226,452,224 - 226,452,391NCBIRnor6.0
Rnor_5.01233,399,232 - 233,399,399UniSTSRnor5.0
RGSC_v3.41212,892,954 - 212,893,121UniSTSRGSC3.4
Celera1204,542,534 - 204,542,701UniSTS
RH 3.4 Map11509.89UniSTS
Cytogenetic Map1q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 8 64 11 7
Low 2 35 18 6 7 6 7 9 10 33 24 4 7
Below cutoff 39 35 12 35 1 2 2 6 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF336852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF336853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF336854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF336855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF336856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF336857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF336858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF336859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF336860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U20106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y19242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000007429   ⟹   ENSRNOP00000007429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,031,592 - 207,088,958 (+)Ensembl
Rnor_6.0 Ensembl1226,436,139 - 226,493,179 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000035576   ⟹   ENSRNOP00000031890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,031,592 - 207,089,026 (+)Ensembl
Rnor_6.0 Ensembl1226,436,139 - 226,493,179 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000036168   ⟹   ENSRNOP00000031944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,031,592 - 207,089,026 (+)Ensembl
Rnor_6.0 Ensembl1226,436,139 - 226,493,179 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000036180   ⟹   ENSRNOP00000032388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,031,592 - 207,089,026 (+)Ensembl
Rnor_6.0 Ensembl1226,436,139 - 226,493,179 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000036232   ⟹   ENSRNOP00000031195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,031,592 - 207,089,026 (+)Ensembl
Rnor_6.0 Ensembl1226,436,090 - 226,493,377 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000036283   ⟹   ENSRNOP00000031816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,031,592 - 207,089,026 (+)Ensembl
Rnor_6.0 Ensembl1226,436,139 - 226,493,179 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000047964   ⟹   ENSRNOP00000049360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,031,592 - 207,089,026 (+)Ensembl
Rnor_6.0 Ensembl1226,436,139 - 226,493,179 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000048704   ⟹   ENSRNOP00000040667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,031,592 - 207,089,026 (+)Ensembl
Rnor_6.0 Ensembl1226,435,979 - 226,493,247 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099457   ⟹   ENSRNOP00000080801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,054,052 - 207,089,026 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099494   ⟹   ENSRNOP00000085392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,031,592 - 207,089,026 (+)Ensembl
RefSeq Acc Id: NM_001398614   ⟹   NP_001385543
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,456,259 - 216,518,718 (+)NCBI
mRatBN7.21207,031,359 - 207,093,787 (+)NCBI
RefSeq Acc Id: NM_001398615   ⟹   NP_001385544
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,456,259 - 216,518,718 (+)NCBI
mRatBN7.21207,031,359 - 207,093,787 (+)NCBI
RefSeq Acc Id: NM_001398616   ⟹   NP_001385545
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,456,259 - 216,518,718 (+)NCBI
mRatBN7.21207,031,359 - 207,093,787 (+)NCBI
RefSeq Acc Id: NM_001398617   ⟹   NP_001385546
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,456,259 - 216,518,718 (+)NCBI
mRatBN7.21207,031,359 - 207,093,787 (+)NCBI
RefSeq Acc Id: NM_001398618   ⟹   NP_001385547
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,456,259 - 216,518,718 (+)NCBI
mRatBN7.21207,031,359 - 207,093,787 (+)NCBI
RefSeq Acc Id: NM_001398620   ⟹   NP_001385549
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,456,259 - 216,518,718 (+)NCBI
mRatBN7.21207,031,359 - 207,093,787 (+)NCBI
RefSeq Acc Id: NM_021659   ⟹   NP_067691
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,456,259 - 216,518,718 (+)NCBI
mRatBN7.21207,031,359 - 207,093,787 (+)NCBI
Rnor_6.01226,435,979 - 226,493,247 (+)NCBI
Rnor_5.01233,382,523 - 233,445,604 (+)NCBI
RGSC_v3.41212,876,675 - 212,935,373 (+)RGD
Celera1204,526,212 - 204,583,576 (+)RGD
Sequence:
RefSeq Acc Id: XM_039088864   ⟹   XP_038944792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,456,151 - 216,517,083 (+)NCBI
mRatBN7.21207,031,371 - 207,093,787 (+)NCBI
RefSeq Acc Id: XM_039088876   ⟹   XP_038944804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,456,156 - 216,517,083 (+)NCBI
mRatBN7.21207,031,374 - 207,093,787 (+)NCBI
RefSeq Acc Id: XM_063272250   ⟹   XP_063128320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,456,148 - 216,517,083 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385543 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385544 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385545 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385546 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385547 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385549 (Get FASTA)   NCBI Sequence Viewer  
  NP_067691 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944792 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944804 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128320 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA87725 (Get FASTA)   NCBI Sequence Viewer  
  AAK01447 (Get FASTA)   NCBI Sequence Viewer  
  AAK01448 (Get FASTA)   NCBI Sequence Viewer  
  AAK01449 (Get FASTA)   NCBI Sequence Viewer  
  AAK01450 (Get FASTA)   NCBI Sequence Viewer  
  AAK01451 (Get FASTA)   NCBI Sequence Viewer  
  AAK01452 (Get FASTA)   NCBI Sequence Viewer  
  AAK01453 (Get FASTA)   NCBI Sequence Viewer  
  AAK01454 (Get FASTA)   NCBI Sequence Viewer  
  AAK01455 (Get FASTA)   NCBI Sequence Viewer  
  EDM12799 (Get FASTA)   NCBI Sequence Viewer  
  EDM12800 (Get FASTA)   NCBI Sequence Viewer  
  EDM12801 (Get FASTA)   NCBI Sequence Viewer  
  EDM12802 (Get FASTA)   NCBI Sequence Viewer  
  EDM12803 (Get FASTA)   NCBI Sequence Viewer  
  EDM12804 (Get FASTA)   NCBI Sequence Viewer  
  EDM12805 (Get FASTA)   NCBI Sequence Viewer  
  EDM12806 (Get FASTA)   NCBI Sequence Viewer  
  EDM12807 (Get FASTA)   NCBI Sequence Viewer  
  EDM12808 (Get FASTA)   NCBI Sequence Viewer  
  EDM12809 (Get FASTA)   NCBI Sequence Viewer  
  EDM12810 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007429.5
  ENSRNOP00000031195
  ENSRNOP00000031195.4
  ENSRNOP00000031816
  ENSRNOP00000031816.4
  ENSRNOP00000031890
  ENSRNOP00000031890.4
  ENSRNOP00000031944
  ENSRNOP00000031944.4
  ENSRNOP00000032388
  ENSRNOP00000032388.5
  ENSRNOP00000040667
  ENSRNOP00000040667.3
  ENSRNOP00000049360
  ENSRNOP00000049360.4
  ENSRNOP00000080801.1
  ENSRNOP00000085392
  ENSRNOP00000085392.1
  ENSRNOP00055024606
  ENSRNOP00060033922
  ENSRNOP00065035358
GenBank Protein Q62747 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067691   ⟸   NM_021659
- Peptide Label: isoform 7
- UniProtKB: Q99P37 (UniProtKB/Swiss-Prot),   Q99P36 (UniProtKB/Swiss-Prot),   Q99P35 (UniProtKB/Swiss-Prot),   Q99P34 (UniProtKB/Swiss-Prot),   Q99P33 (UniProtKB/Swiss-Prot),   Q99J98 (UniProtKB/Swiss-Prot),   F1M262 (UniProtKB/Swiss-Prot),   Q99P38 (UniProtKB/Swiss-Prot),   Q62747 (UniProtKB/TrEMBL),   A6I025 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031890   ⟸   ENSRNOT00000035576
RefSeq Acc Id: ENSRNOP00000049360   ⟸   ENSRNOT00000047964
RefSeq Acc Id: ENSRNOP00000031944   ⟸   ENSRNOT00000036168
RefSeq Acc Id: ENSRNOP00000032388   ⟸   ENSRNOT00000036180
RefSeq Acc Id: ENSRNOP00000031816   ⟸   ENSRNOT00000036283
RefSeq Acc Id: ENSRNOP00000031195   ⟸   ENSRNOT00000036232
RefSeq Acc Id: ENSRNOP00000040667   ⟸   ENSRNOT00000048704
RefSeq Acc Id: ENSRNOP00000007429   ⟸   ENSRNOT00000007429
RefSeq Acc Id: XP_038944792   ⟸   XM_039088864
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944804   ⟸   XM_039088876
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A1J0 (UniProtKB/TrEMBL),   A6I025 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085392   ⟸   ENSRNOT00000099494
RefSeq Acc Id: ENSRNOP00000080801   ⟸   ENSRNOT00000099457
RefSeq Acc Id: NP_001385543   ⟸   NM_001398614
- Peptide Label: isoform 1
- UniProtKB: A0A8L2QJI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385547   ⟸   NM_001398618
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001385545   ⟸   NM_001398616
- Peptide Label: isoform 3
- UniProtKB: A0A8L2QJI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385544   ⟸   NM_001398615
- Peptide Label: isoform 2
- UniProtKB: A0A8L2QJI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385549   ⟸   NM_001398620
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001385546   ⟸   NM_001398617
- Peptide Label: isoform 4
- UniProtKB: A0A8L2QJI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128320   ⟸   XM_063272250
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QJI4 (UniProtKB/TrEMBL)
Protein Domains
C2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62747-F1-model_v2 AlphaFold Q62747 1-403 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62013 AgrOrtholog
BIND 130904
  133976
  133977
  133978
BioCyc Gene G2FUF-56431 BioCyc
Ensembl Genes ENSRNOG00000026432 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055017972 UniProtKB/Swiss-Prot
  ENSRNOG00060023249 UniProtKB/Swiss-Prot
  ENSRNOG00065024873 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007429.9 UniProtKB/Swiss-Prot
  ENSRNOT00000035576 ENTREZGENE
  ENSRNOT00000035576.7 UniProtKB/Swiss-Prot
  ENSRNOT00000036168 ENTREZGENE
  ENSRNOT00000036168.7 UniProtKB/Swiss-Prot
  ENSRNOT00000036180 ENTREZGENE
  ENSRNOT00000036180.7 UniProtKB/TrEMBL
  ENSRNOT00000036232 ENTREZGENE
  ENSRNOT00000036232.7 UniProtKB/Swiss-Prot
  ENSRNOT00000036283 ENTREZGENE
  ENSRNOT00000036283.7 UniProtKB/Swiss-Prot
  ENSRNOT00000047964 ENTREZGENE
  ENSRNOT00000047964.5 UniProtKB/Swiss-Prot
  ENSRNOT00000048704 ENTREZGENE
  ENSRNOT00000048704.6 UniProtKB/Swiss-Prot
  ENSRNOT00000099457.1 UniProtKB/TrEMBL
  ENSRNOT00000099494.1 UniProtKB/TrEMBL
  ENSRNOT00055030561 UniProtKB/Swiss-Prot
  ENSRNOT00060040992 UniProtKB/Swiss-Prot
  ENSRNOT00065043161 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2A_Synaptotagmin-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2B_Synaptotagmin-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptotagmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59267 UniProtKB/Swiss-Prot
NCBI Gene 59267 ENTREZGENE
PANTHER SYNAPTOTAGMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPTOTAGMIN-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Syt7 PhenoGen
PRINTS C2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPTOTAGMN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026432 RatGTEx
  ENSRNOG00055017972 RatGTEx
  ENSRNOG00060023249 RatGTEx
  ENSRNOG00065024873 RatGTEx
SMART SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A1J0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G526_RAT UniProtKB/TrEMBL
  A0A8L2QJI4 ENTREZGENE, UniProtKB/TrEMBL
  A6I025 ENTREZGENE, UniProtKB/TrEMBL
  A6I026_RAT UniProtKB/TrEMBL
  A6I028_RAT UniProtKB/TrEMBL
  A6I029_RAT UniProtKB/TrEMBL
  A6I030_RAT UniProtKB/TrEMBL
  F1M262 ENTREZGENE
  Q62747 ENTREZGENE
  Q99J98 ENTREZGENE
  Q99P33 ENTREZGENE
  Q99P34 ENTREZGENE
  Q99P35 ENTREZGENE
  Q99P36 ENTREZGENE
  Q99P37 ENTREZGENE
  Q99P38 ENTREZGENE
  SYT7_RAT UniProtKB/Swiss-Prot
UniProt Secondary F1M262 UniProtKB/Swiss-Prot
  Q99J98 UniProtKB/Swiss-Prot
  Q99P33 UniProtKB/Swiss-Prot
  Q99P34 UniProtKB/Swiss-Prot
  Q99P35 UniProtKB/Swiss-Prot
  Q99P36 UniProtKB/Swiss-Prot
  Q99P37 UniProtKB/Swiss-Prot
  Q99P38 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-11 Syt7  synaptotagmin 7  Syt7  synaptotagmin VII  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Syt7  synaptotagmin VII    synaptotagmin 7  Name updated 1299863 APPROVED
2002-06-10 Syt7  synaptotagmin 7      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the lysosome of fibroblasts 619692
gene_expression expressed in a regulated pattern in the brain 634203
gene_function responsible for triggering neurotransmitter release by acting as Ca(2+) sensors 634203
gene_process regulates different types of calcium dependent exocytosis 619692
gene_product member of the synaptotagmin family of C-terminal-type tandem C2 proteins 619692