RGD Reference Report - The synaptotagmins: calcium sensors for vesicular trafficking. - Rat Genome Database

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The synaptotagmins: calcium sensors for vesicular trafficking.

Authors: Yoshihara, M  Montana, ES 
Citation: Yoshihara M and Montana ES, Neuroscientist. 2004 Dec;10(6):566-74.
RGD ID: 7204679
Pubmed: PMID:15534041   (View Abstract at PubMed)
DOI: DOI:10.1177/1073858404268770   (Journal Full-text)

The synaptotagmin family of vesicle proteins is believed to mediate calcium-dependent regulation of membrane trafficking. Detailed biochemical and in vivo studies of the most characterized isoform, synaptotagmin 1 (syt 1), have provided compelling evidence that it functions as a calcium sensor for fast neurotransmitter release at synapses. However, the function of the remaining isoforms is unclear, and multiple roles have been hypothesized for several of these. Recent evidence in Drosophila has given insight into the function of some of the remaining synaptotagmin family members. Of the five evolutionarily conserved isoforms in Drosophila, only two, syt 1 and syt 4, localize to most, if not all, synapses. The former is localized to presynaptic terminals, whereas the latter is predominantly postsynaptic. This suggests an intriguing possibility that syt 4 may mediate a postsynaptic vesicle trafficking pathway, providing a molecular basis for an evolutionarily conserved bidirectional vesicular trafficking communication system at synapses.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Objects Annotated

Genes (Rattus norvegicus)
Syt1  (synaptotagmin 1)
Syt7  (synaptotagmin 7)

Genes (Mus musculus)
Syt1  (synaptotagmin I)
Syt7  (synaptotagmin VII)

Genes (Homo sapiens)
SYT1  (synaptotagmin 1)
SYT7  (synaptotagmin 7)

Objects referenced in this article
Gene SYT4 synaptotagmin 4 Homo sapiens
Gene Syt4 synaptotagmin IV Mus musculus
Gene Syt4 synaptotagmin 4 Rattus norvegicus

Additional Information