Syt6 (synaptotagmin 6) - Rat Genome Database

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Gene: Syt6 (synaptotagmin 6) Rattus norvegicus
Analyze
Symbol: Syt6
Name: synaptotagmin 6
RGD ID: 62012
Description: Enables syntaxin binding activity. Involved in postsynaptic dense core vesicle exocytosis. Is active in glutamatergic synapse and synaptic membrane. Orthologous to human SYT6 (synaptotagmin 6); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC116356; synaptotagmin VI; synaptotagmin-6; sytVI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82193,781,051 - 193,840,741 (+)NCBIGRCr8
mRatBN7.22191,093,009 - 191,152,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2191,093,007 - 191,149,956 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2198,690,257 - 198,749,449 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02196,562,984 - 196,622,178 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02191,379,964 - 191,439,147 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02206,064,181 - 206,119,034 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,064,179 - 206,127,907 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02225,492,367 - 225,547,221 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42198,807,340 - 198,862,227 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12198,770,093 - 198,824,981 (+)NCBI
Celera2183,565,789 - 183,620,107 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The subcellular localizations of atypical synaptotagmins III and VI. Synaptotagmin III is enriched in synapses and synaptic plasma membranes but not in synaptic vesicles. Butz S, etal., J Biol Chem. 1999 Jun 25;274(26):18290-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Li C, etal., Nature 1995 Jun 15;375(6532):594-9.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. Activity-dependent BDNF release via endocytic pathways is regulated by synaptotagmin-6 and complexin. Wong YH, etal., Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4475-84. doi: 10.1073/pnas.1511830112. Epub 2015 Jul 27.
Additional References at PubMed
PMID:8626542   PMID:10531343   PMID:10531344   PMID:10556508   PMID:11437455   PMID:12477932   PMID:12860971   PMID:15774481  


Genomics

Comparative Map Data
Syt6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82193,781,051 - 193,840,741 (+)NCBIGRCr8
mRatBN7.22191,093,009 - 191,152,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2191,093,007 - 191,149,956 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2198,690,257 - 198,749,449 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02196,562,984 - 196,622,178 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02191,379,964 - 191,439,147 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02206,064,181 - 206,119,034 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,064,179 - 206,127,907 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02225,492,367 - 225,547,221 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42198,807,340 - 198,862,227 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12198,770,093 - 198,824,981 (+)NCBI
Celera2183,565,789 - 183,620,107 (+)NCBICelera
Cytogenetic Map2q34NCBI
SYT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,089,292 - 114,153,869 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1114,089,291 - 114,153,880 (-)EnsemblGRCh38hg38GRCh38
GRCh371114,631,914 - 114,696,491 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,433,437 - 114,497,995 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,346,428 - 114,408,514NCBI
Celera1112,861,141 - 112,925,712 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1112,489,973 - 112,554,564 (-)NCBIHuRef
CHM1_11114,746,727 - 114,811,584 (-)NCBICHM1_1
T2T-CHM13v2.01114,100,938 - 114,165,509 (-)NCBIT2T-CHM13v2.0
Syt6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393103,482,561 - 103,552,883 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3103,482,547 - 103,552,885 (+)EnsemblGRCm39 Ensembl
GRCm383103,575,245 - 103,645,567 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,575,231 - 103,645,569 (+)EnsemblGRCm38mm10GRCm38
MGSCv373103,379,204 - 103,439,102 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363103,704,342 - 103,764,239 (+)NCBIMGSCv36mm8
Celera3105,781,488 - 105,842,192 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.45NCBI
Syt6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543517,347,011 - 17,405,526 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543517,349,971 - 17,405,526 (-)NCBIChiLan1.0ChiLan1.0
SYT6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21106,748,881 - 106,818,586 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11106,342,558 - 106,412,360 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0188,397,809 - 88,467,493 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11123,453,698 - 123,514,804 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1123,452,889 - 123,514,795 (+)Ensemblpanpan1.1panPan2
SYT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11751,859,564 - 51,923,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1751,864,774 - 51,924,676 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1751,509,928 - 51,574,570 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01752,737,130 - 52,791,129 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1752,740,102 - 52,799,079 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11751,744,089 - 51,808,674 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01751,815,566 - 51,877,205 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01752,385,301 - 52,449,966 (-)NCBIUU_Cfam_GSD_1.0
Syt6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505814,979,103 - 15,042,151 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366902,435,541 - 2,497,553 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366902,435,573 - 2,497,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4106,425,632 - 106,485,468 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14106,420,614 - 106,485,468 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,560,038 - 116,622,295 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SYT6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12019,497,218 - 19,561,621 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2019,512,540 - 19,563,038 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603822,260,659 - 22,330,080 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syt6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247729,753,416 - 9,810,757 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247729,753,485 - 9,810,815 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Syt6
410 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:93
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000025953
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2190602746192625452Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2190602746192625452Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat

Markers in Region
RH142700  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22191,119,471 - 191,119,643 (+)MAPPERmRatBN7.2
Rnor_6.02206,090,642 - 206,090,813NCBIRnor6.0
Rnor_5.02225,518,828 - 225,518,999UniSTSRnor5.0
RGSC_v3.42198,833,801 - 198,833,972UniSTSRGSC3.4
RH 3.4 Map21324.1UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 8 52 14 4
Low 2 17 1 22 4 24 11
Below cutoff 1 26 21 17 7 17 8 10 16 11 8

Sequence


RefSeq Acc Id: ENSRNOT00000025953   ⟹   ENSRNOP00000025953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2191,093,007 - 191,144,558 (+)Ensembl
Rnor_6.0 Ensembl2206,064,179 - 206,119,034 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077739   ⟹   ENSRNOP00000069764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2191,094,003 - 191,149,953 (+)Ensembl
Rnor_6.0 Ensembl2206,064,394 - 206,127,907 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094540   ⟹   ENSRNOP00000081725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2191,093,007 - 191,149,956 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114478   ⟹   ENSRNOP00000090316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2191,094,130 - 191,149,953 (+)Ensembl
RefSeq Acc Id: NM_022191   ⟹   NP_071527
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82193,781,476 - 193,840,741 (+)NCBI
mRatBN7.22191,093,009 - 191,152,283 (+)NCBI
Rnor_6.02206,064,181 - 206,119,034 (+)NCBI
Rnor_5.02225,492,367 - 225,547,221 (+)NCBI
RGSC_v3.42198,807,340 - 198,862,227 (+)RGD
Celera2183,565,789 - 183,620,107 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103020   ⟹   XP_038958948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82193,781,051 - 193,840,741 (+)NCBI
mRatBN7.22191,093,057 - 191,152,283 (+)NCBI
RefSeq Acc Id: XM_039103021   ⟹   XP_038958949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82193,782,763 - 193,840,741 (+)NCBI
mRatBN7.22191,094,269 - 191,152,283 (+)NCBI
RefSeq Acc Id: XM_039103022   ⟹   XP_038958950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82193,781,652 - 193,840,741 (+)NCBI
mRatBN7.22191,093,114 - 191,152,283 (+)NCBI
RefSeq Acc Id: XM_039103023   ⟹   XP_038958951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82193,782,151 - 193,840,741 (+)NCBI
mRatBN7.22191,093,562 - 191,152,283 (+)NCBI
RefSeq Acc Id: XM_063282441   ⟹   XP_063138511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82193,781,652 - 193,840,741 (+)NCBI
RefSeq Acc Id: XR_005500358
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82193,782,834 - 193,838,141 (+)NCBI
mRatBN7.22191,094,272 - 191,152,283 (+)NCBI
RefSeq Acc Id: XR_005500359
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82193,782,833 - 193,838,141 (+)NCBI
mRatBN7.22191,094,271 - 191,152,283 (+)NCBI
RefSeq Acc Id: NP_071527   ⟸   NM_022191
- UniProtKB: Q4KLI6 (UniProtKB/Swiss-Prot),   Q62746 (UniProtKB/Swiss-Prot),   A6K3L5 (UniProtKB/TrEMBL),   A0A8I6ABK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069764   ⟸   ENSRNOT00000077739
RefSeq Acc Id: ENSRNOP00000025953   ⟸   ENSRNOT00000025953
RefSeq Acc Id: XP_038958948   ⟸   XM_039103020
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QEQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958950   ⟸   XM_039103022
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QEQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958951   ⟸   XM_039103023
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QEQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958949   ⟸   XM_039103021
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ABK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081725   ⟸   ENSRNOT00000094540
RefSeq Acc Id: ENSRNOP00000090316   ⟸   ENSRNOT00000114478
RefSeq Acc Id: XP_063138511   ⟸   XM_063282441
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QEQ5 (UniProtKB/TrEMBL),   A0A0G2JW68 (UniProtKB/TrEMBL)
Protein Domains
C2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62746-F1-model_v2 AlphaFold Q62746 1-511 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62012 AgrOrtholog
BIND 130563
  130911
  130912
  130913
BioCyc Gene G2FUF-51813 BioCyc
Ensembl Genes ENSRNOG00000019163 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018902 UniProtKB/Swiss-Prot
  ENSRNOG00060030707 UniProtKB/Swiss-Prot
  ENSRNOG00065031251 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025953.6 UniProtKB/TrEMBL
  ENSRNOT00000077739 UniProtKB/TrEMBL
  ENSRNOT00000077739.2 UniProtKB/Swiss-Prot
  ENSRNOT00000094540.1 UniProtKB/TrEMBL
  ENSRNOT00000114478.1 UniProtKB/TrEMBL
  ENSRNOT00055032244 UniProtKB/Swiss-Prot
  ENSRNOT00060053428 UniProtKB/Swiss-Prot
  ENSRNOT00065053920 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7383303 IMAGE-MGC_LOAD
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptotagmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60565 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:116356 IMAGE-MGC_LOAD
NCBI Gene 60565 ENTREZGENE
PANTHER PTHR10024:SF45 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPTOTAGMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Syt6 PhenoGen
PRINTS C2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPTOTAGMN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019163 RatGTEx
  ENSRNOG00055018902 RatGTEx
  ENSRNOG00060030707 RatGTEx
  ENSRNOG00065031251 RatGTEx
SMART SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC235357
UniProt A0A0G2JW68 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABK1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QEQ5 ENTREZGENE, UniProtKB/TrEMBL
  A6K3L5 ENTREZGENE, UniProtKB/TrEMBL
  A6K3L6_RAT UniProtKB/TrEMBL
  A6K3L8_RAT UniProtKB/TrEMBL
  Q4KLI6 ENTREZGENE
  Q62746 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q4KLI6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Syt6  synaptotagmin 6  Syt6  synaptotagmin VI  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Syt6  synaptotagmin VI    synaptotagmin 6  Name updated 1299863 APPROVED
2002-06-10 Syt6  synaptotagmin 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression specifically expressed in brain 61762
gene_function bind clathrin-AP2 with high affinity 61762
gene_process play a general role in endocytosis 61762