Gene: Cplx2 (complexin 2) Rattus norvegicus
Analyze
Symbol:
Cplx2
Name:
complexin 2
Description:
Exhibits calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in synaptic vesicle exocytosis. Localizes to several cellular components, including the dendrite; neuronal cell body; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Orthologous to human CPLX2 (complexin 2); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; alachlor.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
complexin II; complexin-2; CPX II; synaphin-1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CPLX2 (complexin 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Cplx2 (complexin 2) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cplx2 (complexin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CPLX2 (complexin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CPLX2 (complexin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cplx2 (complexin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CPLX2 (complexin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
CPLX2 (complexin 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Cplx2 (complexin 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cplx2 (complexin 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
cpx
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, PANTHER, TreeFam)
Caenorhabditis elegans (roundworm):
cpx-1
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 17 10,756,871 - 10,828,811 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 17 10,756,285 - 10,818,835 (-) Ensembl Rnor_5.0 17 12,880,802 - 12,952,180 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 17 16,314,592 - 16,322,938 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 17 16,314,591 - 16,322,938 (-) NCBI Celera 17 10,295,626 - 10,303,931 (-) NCBI Celera Cytogenetic Map 17 p14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
2-butoxyethanol decreases expression ISO RGD:732284 6480464 n-butoxyethanol results in decreased expression of CPLX2 mRNA CTD PMID:19812364 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of CPLX2 mRNA CTD PMID:24780913 acrylamide multiple interactions ISO RGD:732284 6480464 Acrylamide binds to and affects the metabolism of CPLX2 protein CTD PMID:17698512 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of CPLX2 mRNA CTD PMID:28959563 aflatoxin B1 decreases methylation ISO RGD:732283 6480464 Aflatoxin B1 results in decreased methylation of CPLX2 gene CTD PMID:27153756 alachlor increases expression EXP 6480464 alachlor results in increased expression of CPLX2 mRNA CTD PMID:12419858 amiodarone increases expression ISO RGD:732283 6480464 Amiodarone results in increased expression of CPLX2 mRNA CTD PMID:19774075 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CPLX2 mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:732283 6480464 Arsenic affects the methylation of CPLX2 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:732283 6480464 Arsenic affects the methylation of CPLX2 gene CTD PMID:25304211 arsenite(3-) increases methylation ISO RGD:732283 6480464 arsenite results in increased methylation of CPLX2 promoter CTD PMID:23974009 benzo[a]pyrene decreases expression ISO RGD:732284 6480464 Benzo(a)pyrene results in decreased expression of CPLX2 mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:732284 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA CTD PMID:27858113 benzo[b]fluoranthene multiple interactions ISO RGD:732284 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA CTD PMID:27858113 Benzo[ghi]perylene decreases expression ISO RGD:732284 6480464 1, 12-benzoperylene results in decreased expression of CPLX2 mRNA CTD PMID:26377693 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CPLX2 mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:732283 6480464 bisphenol A affects the expression of CPLX2 mRNA CTD PMID:30903817 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of CPLX2 gene CTD PMID:28505145 butanal decreases expression ISO RGD:732283 6480464 butyraldehyde results in decreased expression of CPLX2 mRNA CTD PMID:26079696 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of CPLX2 mRNA CTD PMID:19167457 calcidiol decreases expression EXP 6480464 Calcifediol deficiency results in decreased expression of CPLX2 mRNA CTD PMID:17293106 carbon nanotube decreases expression ISO RGD:732284 6480464 Nanotubes, Carbon analog results in decreased expression of CPLX2 mRNA, Nanotubes, Carbon results in decreased expression of CPLX2 mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:732284 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CPLX2 gene CTD PMID:20938992 chrysene multiple interactions ISO RGD:732284 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA CTD PMID:27858113 clozapine decreases expression ISO RGD:732284 6480464 Clozapine results in decreased expression of CPLX2 mRNA CTD PMID:17266109 copper atom multiple interactions ISO RGD:732284 6480464 Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX2 protein] CTD PMID:25352456 copper(0) multiple interactions ISO RGD:732284 6480464 Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX2 protein] CTD PMID:25352456 copper(II) chloride decreases expression ISO RGD:732284 6480464 cupric chloride results in decreased expression of CPLX2 protein CTD PMID:29617964 diazinon increases methylation ISO RGD:732283 6480464 Diazinon results in increased methylation of CPLX2 gene CTD PMID:22964155 dicrotophos increases expression ISO RGD:732283 6480464 dicrotophos results in increased expression of CPLX2 mRNA CTD PMID:28302478 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of CPLX2 mRNA CTD PMID:29391264 ethanol decreases expression ISO RGD:732283 6480464 Ethanol results in decreased expression of CPLX2 mRNA CTD PMID:28986285 fisetin multiple interactions EXP 6480464 fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of CPLX2 mRNA] CTD PMID:30890323 folic acid multiple interactions ISO RGD:732284 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CPLX2 gene CTD PMID:20938992 gamma-tocopherol increases expression ISO RGD:732284 6480464 Tocopherols results in increased expression of CPLX2 mRNA CTD PMID:17654050 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of CPLX2 mRNA CTD PMID:21396975 L-methionine multiple interactions ISO RGD:732284 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CPLX2 gene CTD PMID:20938992 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of CPLX2 mRNA CTD PMID:28801915 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of CPLX2 protein CTD PMID:19826936 methylazoxymethanol increases expression ISO RGD:732284 6480464 methylazoxymethanol results in increased expression of CPLX2 mRNA CTD PMID:17107856 methylmercury chloride multiple interactions EXP 6480464 fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of CPLX2 mRNA] CTD PMID:30890323 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of CPLX2 mRNA CTD PMID:30890323 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of CPLX2 mRNA CTD PMID:28801915 perfluorooctanoic acid increases expression ISO RGD:732283 6480464 perfluorooctanoic acid results in increased expression of CPLX2 protein CTD PMID:26879310 phencyclidine decreases expression ISO RGD:732284 6480464 Phencyclidine results in decreased expression of CPLX2 mRNA CTD PMID:17266109 propanal decreases expression ISO RGD:732283 6480464 propionaldehyde results in decreased expression of CPLX2 mRNA CTD PMID:26079696 sarin decreases expression EXP 6480464 Sarin results in decreased expression of CPLX2 protein CTD PMID:28973502 silicon dioxide decreases expression ISO RGD:732283 6480464 Silicon Dioxide analog results in decreased expression of CPLX2 mRNA CTD PMID:25895662 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of CPLX2 mRNA CTD PMID:31150632 tetraphene multiple interactions ISO RGD:732284 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA CTD PMID:27858113 tocopherol increases expression ISO RGD:732284 6480464 Tocopherols results in increased expression of CPLX2 mRNA CTD PMID:17654050 trimellitic anhydride decreases expression ISO RGD:732284 6480464 trimellitic anhydride results in decreased expression of CPLX2 mRNA CTD PMID:19042947 tungsten decreases expression ISO RGD:732284 6480464 Tungsten results in decreased expression of CPLX2 mRNA CTD PMID:30912803 urethane decreases expression ISO RGD:732283 6480464 Urethane results in decreased expression of CPLX2 mRNA CTD PMID:28818685 valproic acid decreases methylation ISO RGD:732283 6480464 Valproic Acid results in decreased methylation of CPLX2 gene CTD PMID:29154799 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of CPLX2 mRNA CTD PMID:29427782 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of CPLX2 mRNA CTD PMID:19015723
Gene Ontology Annotations
Biological Process mast cell degranulation IEA UniProtKB-KW:KW-0467 1600115 GO_REF:0000037 UniProt GO_REF:0000037 positive regulation of synaptic plasticity ISO RGD:732284 1624291 (MGI:MGI:5009363, PMID:19900895) RGD MGI:MGI:5009363 , PMID:19900895 positive regulation of synaptic plasticity ISS UniProtKB:P84086 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of neurotransmitter secretion IBA FB:FBgn0041605 more ... 13792537 PMID:21873635 GO_Central regulation of synaptic vesicle fusion to presynaptic active zone membrane IEA UniProtKB:P84086 , ensembl:ENSMUSP000000269851600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of synaptic vesicle fusion to presynaptic active zone membrane ISO RGD:732284 1624291 (MGI:MGI:2679622, PMID:11163241) RGD MGI:MGI:2679622 , PMID:11163241 synaptic vesicle exocytosis IDA 727333 RGD synaptic vesicle exocytosis IBA FB:FBgn0041605 more ... 13792537 PMID:21873635 GO_Central vesicle docking involved in exocytosis TAS 70701 PMID:7553862 PINC Cellular Component calyx of Held IEA UniProtKB:P84086 , ensembl:ENSMUSP000000269851600115 GO_REF:0000107 Ensembl GO_REF:0000107 calyx of Held ISO RGD:732284 1624291 (MGI:MGI:5644180, PMID:26019341) RGD MGI:MGI:5644180 , PMID:26019341 cell junction IEA UniProtKB-KW:KW-0965 1600115 GO_REF:0000037 UniProt GO_REF:0000037 cytosol IEA UniProtKB-SubCell:SL-0091 1600115 GO_REF:0000039 UniProt GO_REF:0000039 dendrite IDA 70701 PMID:7553862 MGI glutamatergic synapse IEA UniProtKB:P84086 , ensembl:ENSMUSP000000269851600115 GO_REF:0000107 Ensembl GO_REF:0000107 glutamatergic synapse ISO RGD:732284 1624291 (MGI:MGI:2679622, PMID:11163241) RGD MGI:MGI:2679622 , PMID:11163241 mast cell granule IEA GO:0043303 1600115 GO_REF:0000108 GOC GO_REF:0000108 neuronal cell body IDA 70701 PMID:7553862 MGI nucleus IEA UniProtKB-SubCell:SL-0191 1600115 GO_REF:0000039 UniProt GO_REF:0000039 perikaryon IEA UniProtKB-SubCell:SL-0197 1600115 GO_REF:0000039 UniProt GO_REF:0000039 postsynapse IDA 13702170 PMID:10430466 SynGO presynapse IDA 13702170 PMID:10430466 SynGO presynapse ISO RGD:732284 1624291 (MGI:MGI:5644180, PMID:26019341) RGD MGI:MGI:5644180 , PMID:26019341 SNARE complex IDA 727333 RGD SNARE complex IBA MGI:MGI:104727 more ... 13792537 PMID:21873635 GO_Central SNARE complex IBA MGI:MGI:104727 more ... 13792537 PMID:21873635 GO_Central synapse IDA 70701 PMID:7553862 MGI synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IDA 7205655 RGD terminal bouton HDA 10047219 PMID:24876496 ParkinsonsUK-UCL terminal bouton IBA FB:FBgn0041605 more ... 13792537 PMID:21873635 GO_Central Molecular Function calcium-dependent protein binding IPI RGD:3803 7205655 RGD SNARE binding IDA 727333 ; 7205655 RGD SNARE binding IBA MGI:MGI:2384571 more ... 13792537 PMID:21873635 GO_Central syntaxin-1 binding IDA 70701 PMID:7553862 MGI syntaxin-1 binding IBA PANTHER:PTN000422956 , RGD:70945 13792537 PMID:21873635 GO_Central
9590316 Scort21 Serum corticosterone level QTL 21 4.75 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 17 1 24787908 Rat 10401807 Kidm52 Kidney mass QTL 52 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 17 1 32230361 Rat 70184 BpQTLcluster14 Blood pressure QTL cluster 14 3.38 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 17 1 33303755 Rat 631207 Niddm41 Non-insulin dependent diabetes mellitus QTL 41 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 17 1 38243814 Rat 1354658 Spl8 Serum phospholipid level QTL 8 3.8 blood VLDL phospholipid amount (VT:0010507) blood very low density lipoprotein phospholipid level (CMO:0001571) 17 1 63676140 Rat 1354662 Rf49 Renal function QTL 49 2.9 blood creatinine amount (VT:0005328) plasma creatinine level (CMO:0000537) 17 1 73413148 Rat 1354581 Bp247 Blood pressure QTL 247 4.5 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) 17 1 73413148 Rat 1641902 Colcr7 Colorectal carcinoma resistance QTL 7 3.35 0.0044 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) 17 519770 23422380 Rat 1300123 Bp194 Blood pressure QTL 194 2.82 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 17 519770 36283402 Rat 2324619 Coatc4 Coat color QTL 4 0.001 coat/hair pigmentation trait (VT:0010463) pigmented coat/hair area to total coat/hair area ratio (CMO:0001810) 17 3336972 24030841 Rat 2324619 Coatc4 Coat color QTL 4 0.001 coat/hair pigmentation trait (VT:0010463) pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811) 17 3336972 24030841 Rat 1354613 Kidm14 Kidney mass QTL 14 6.2 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 17 3336972 37790462 Rat 1354596 Bw32 Body weight QTL 32 4.5 body mass (VT:0001259) body weight (CMO:0000012) 17 3336972 63676140 Rat 1354638 Insul1 Insulin level QTL 1 4.8 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 17 3336972 73413148 Rat 1354651 Lmblg2 Limb length QTL 2 6 tibia length (VT:0004357) tibia length (CMO:0000450) 17 3336972 73413148 Rat 1354630 Cm34 Cardiac mass QTL 34 8.7 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) 17 3336972 73413148 Rat 631499 Stl1 Serum triglyceride level QTL 1 3.6 blood triglyceride amount (VT:0002644) blood triglyceride level (CMO:0000118) 17 3414039 28073589 Rat 2293648 Bmd31 Bone mineral density QTL 31 4.5 0.0001 femur size trait (VT:1000369) femoral neck cortical cross-sectional area (CMO:0001702) 17 4716067 27691136 Rat 2293664 Bmd28 Bone mineral density QTL 28 5.1 0.0001 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) 17 4716067 27691136 Rat 2303627 Vencon8 Ventilatory control QTL 8 0.001 respiration trait (VT:0001943) tidal volume (CMO:0000222) 17 5191047 50191047 Rat 10054088 Scort28 Serum corticosterone level QTL 28 2.04 0.0102 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 17 5191047 50191047 Rat 1581553 Pur14 Proteinuria QTL 14 5.3 0.0001 total urine protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 17 8424467 16620067 Rat 1582224 Epfw4 Epididymal fat weight QTL 4 3.5 0.0058 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 17 9730263 21491085 Rat 1582225 Bw67 Body weight QTL 67 6.2 0.0001 body mass (VT:0001259) body weight (CMO:0000012) 17 9730263 21491085 Rat 1582226 Bw64 Body weight QTL 64 4.2 0.0017 body mass (VT:0001259) body weight (CMO:0000012) 17 9730263 21491085 Rat 1582241 Bw70 Body weight QTL 70 4.6 0.0003 body mass (VT:0001259) body weight (CMO:0000012) 17 9730263 21491085 Rat 1582245 Bw73 Body weight QTL 73 4.6 0.0004 body mass (VT:0001259) body weight (CMO:0000012) 17 9730263 21491085 Rat 1582258 Bw76 Body weight QTL 76 4.6 0.0005 body mass (VT:0001259) body weight (CMO:0000012) 17 9730263 21491085 Rat 1582199 Insul5 Insulin level QTL 5 3.4 0.0119 blood insulin amount (VT:0001560) calculated serum insulin level (CMO:0000359) 17 9730263 21491085 Rat 1582208 Kidm32 Kidney mass QTL 32 3.9 0.0018 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 17 9730263 21491085 Rat 2303561 Bw91 Body weight QTL 91 2 body mass (VT:0001259) body weight (CMO:0000012) 17 9827304 54827304 Rat 2300002 Iddm36 Insulin dependent diabetes mellitus QTL 36 1.98 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 17 10529709 42542027 Rat
Predicted Target Of
Count of predictions: 271 Count of miRNA genes: 151 Interacting mature miRNAs: 166 Transcripts: ENSRNOT00000000117 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
