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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | RGD:732284 | 6480464 | ethylene dichloride results in decreased expression of CPLX2 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:732284 | 6480464 | Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in decreased expression of CPLX2 mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:732284 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of CPLX2 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CPLX2 mRNA | CTD | PMID:33387578 | 2-butoxyethanol | decreases expression | ISO | RGD:732284 | 6480464 | n-butoxyethanol results in decreased expression of CPLX2 mRNA | CTD | PMID:19812364 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of CPLX2 mRNA | CTD | PMID:24780913 | acrylamide | multiple interactions | ISO | RGD:732284 | 6480464 | Acrylamide binds to and affects the metabolism of CPLX2 protein | CTD | PMID:17698512 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of CPLX2 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | ISO | RGD:732283 | 6480464 | Aflatoxin B1 results in decreased methylation of CPLX2 gene | CTD | PMID:27153756 | alachlor | increases expression | EXP | | 6480464 | alachlor results in increased expression of CPLX2 mRNA | CTD | PMID:12419858 | amiodarone | increases expression | ISO | RGD:732283 | 6480464 | Amiodarone results in increased expression of CPLX2 mRNA | CTD | PMID:19774075 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CPLX2 mRNA | CTD | PMID:16483693 | arsane | affects methylation | ISO | RGD:732283 | 6480464 | Arsenic affects the methylation of CPLX2 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RGD:732283 | 6480464 | Arsenic affects the methylation of CPLX2 gene | CTD | PMID:25304211 | arsenite(3-) | increases methylation | ISO | RGD:732283 | 6480464 | arsenite results in increased methylation of CPLX2 promoter | CTD | PMID:23974009 | benzo[a]pyrene | decreases expression | ISO | RGD:732284 | 6480464 | Benzo(a)pyrene results in decreased expression of CPLX2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | RGD:732283 | 6480464 | Benzo(a)pyrene results in increased methylation of CPLX2 exon | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | RGD:732283 | 6480464 | Benzo(a)pyrene affects the methylation of CPLX2 5' UTR, Benzo(a)pyrene affects the methylation of CPLX2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | RGD:732284 | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA | CTD | PMID:27858113 | benzo[b]fluoranthene | multiple interactions | ISO | RGD:732284 | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA | CTD | PMID:27858113 | Benzo[ghi]perylene | decreases expression | ISO | RGD:732284 | 6480464 | 1, 12-benzoperylene results in decreased expression of CPLX2 mRNA | CTD | PMID:26377693 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CPLX2 mRNA | CTD | PMID:25181051 | bisphenol A | affects expression | ISO | RGD:732283 | 6480464 | bisphenol A affects the expression of CPLX2 mRNA | CTD | PMID:30903817 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of CPLX2 gene | CTD | PMID:28505145 | butanal | decreases expression | ISO | RGD:732283 | 6480464 | butyraldehyde results in decreased expression of CPLX2 mRNA | CTD | PMID:26079696 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of CPLX2 mRNA | CTD | PMID:19167457 | cadmium atom | multiple interactions | ISO | RGD:732283 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CPLX2 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | RGD:732283 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CPLX2 mRNA | CTD | PMID:35301059 | calcidiol | decreases expression | EXP | | 6480464 | Calcifediol deficiency results in decreased expression of CPLX2 mRNA | CTD | PMID:17293106 | carbon nanotube | decreases expression | ISO | RGD:732284 | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | RGD:732283 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CPLX2 gene] | CTD | PMID:28238834 | choline | multiple interactions | ISO | RGD:732284 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CPLX2 gene | CTD | PMID:20938992 | chrysene | multiple interactions | ISO | RGD:732284 | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA | CTD | PMID:27858113 | clozapine | decreases expression | ISO | RGD:732284 | 6480464 | Clozapine results in decreased expression of CPLX2 mRNA | CTD | PMID:17266109 | copper atom | multiple interactions | ISO | RGD:732284 | 6480464 | Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX2 protein] | CTD | PMID:25352456 | copper(0) | multiple interactions | ISO | RGD:732284 | 6480464 | Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX2 protein] | CTD | PMID:25352456 | copper(II) chloride | decreases expression | ISO | RGD:732284 | 6480464 | cupric chloride results in decreased expression of CPLX2 protein | CTD | PMID:29617964 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of CPLX2 mRNA | CTD | PMID:26577399 | diazinon | increases methylation | ISO | RGD:732283 | 6480464 | Diazinon results in increased methylation of CPLX2 gene | CTD | PMID:22964155 | dicrotophos | increases expression | ISO | RGD:732283 | 6480464 | dicrotophos results in increased expression of CPLX2 mRNA | CTD | PMID:28302478 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of CPLX2 mRNA | CTD | PMID:29391264 | ethanol | decreases expression | ISO | RGD:732283 | 6480464 | Ethanol results in decreased expression of CPLX2 mRNA | CTD | PMID:28986285 | fisetin | multiple interactions | EXP | | 6480464 | fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of CPLX2 mRNA] | CTD | PMID:30890323 | folic acid | multiple interactions | ISO | RGD:732284 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CPLX2 gene more ... | CTD | PMID:20938992, PMID:22206623 | gamma-tocopherol | increases expression | ISO | RGD:732284 | 6480464 | Tocopherols results in increased expression of CPLX2 mRNA | CTD | PMID:17654050 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of CPLX2 mRNA | CTD | PMID:33387578 | graphene oxide | decreases expression | ISO | RGD:732284 | 6480464 | graphene oxide analog results in decreased expression of CPLX2 mRNA, graphene oxide results in decreased expression of CPLX2 mRNA | CTD | PMID:33227293 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of CPLX2 mRNA | CTD | PMID:21396975 | ivermectin | decreases expression | ISO | RGD:732283 | 6480464 | Ivermectin results in decreased expression of CPLX2 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | RGD:732284 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CPLX2 gene | CTD | PMID:20938992 | Licochalcone B | increases expression | ISO | RGD:732283 | 6480464 | licochalcone B results in increased expression of CPLX2 mRNA | CTD | PMID:33647349 | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of CPLX2 mRNA | CTD | PMID:28801915 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of CPLX2 protein | CTD | PMID:19826936 | methylazoxymethanol | increases expression | ISO | RGD:732284 | 6480464 | methylazoxymethanol results in increased expression of CPLX2 mRNA | CTD | PMID:17107856 | methylmercury chloride | multiple interactions | EXP | | 6480464 | fisetin inhibits the reaction [methylmercuric chloride results in decreased expression of CPLX2 mRNA] | CTD | PMID:30890323 | methylmercury chloride | decreases expression | EXP | | 6480464 | methylmercuric chloride results in decreased expression of CPLX2 mRNA | CTD | PMID:30890323 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of CPLX2 mRNA | CTD | PMID:28801915 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CPLX2 mRNA | CTD | PMID:33387578 | perfluorooctanoic acid | increases expression | ISO | RGD:732283 | 6480464 | perfluorooctanoic acid results in increased expression of CPLX2 protein | CTD | PMID:26879310 | phencyclidine | decreases expression | ISO | RGD:732284 | 6480464 | Phencyclidine results in decreased expression of CPLX2 mRNA | CTD | PMID:17266109 | propanal | decreases expression | ISO | RGD:732283 | 6480464 | propionaldehyde results in decreased expression of CPLX2 mRNA | CTD | PMID:26079696 | resveratrol | multiple interactions | ISO | RGD:732283 | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of CPLX2 mRNA | CTD | PMID:23557933 | sarin | decreases expression | EXP | | 6480464 | Sarin results in decreased expression of CPLX2 protein | CTD | PMID:28973502 | silicon dioxide | decreases expression | ISO | RGD:732283 | 6480464 | Silicon Dioxide analog results in decreased expression of CPLX2 mRNA | CTD | PMID:25895662 | testosterone | decreases expression | ISO | RGD:732283 | 6480464 | Testosterone results in decreased expression of CPLX2 mRNA | CTD | PMID:33359661 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CPLX2 mRNA | CTD | PMID:31150632 | tetraphene | multiple interactions | ISO | RGD:732284 | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA | CTD | PMID:27858113 | tocopherol | increases expression | ISO | RGD:732284 | 6480464 | Tocopherols results in increased expression of CPLX2 mRNA | CTD | PMID:17654050 | trimellitic anhydride | decreases expression | ISO | RGD:732284 | 6480464 | trimellitic anhydride results in decreased expression of CPLX2 mRNA | CTD | PMID:19042947 | tungsten | decreases expression | ISO | RGD:732284 | 6480464 | Tungsten results in decreased expression of CPLX2 mRNA | CTD | PMID:30912803 | urethane | decreases expression | ISO | RGD:732283 | 6480464 | Urethane results in decreased expression of CPLX2 mRNA | CTD | PMID:28818685 | valproic acid | decreases methylation | ISO | RGD:732283 | 6480464 | Valproic Acid results in decreased methylation of CPLX2 gene | CTD | PMID:29154799 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of CPLX2 mRNA | CTD | PMID:29427782 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of CPLX2 mRNA | CTD | PMID:19015723 | |