RGD Reference Report - Complexins: cytosolic proteins that regulate SNAP receptor function. - Rat Genome Database

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Complexins: cytosolic proteins that regulate SNAP receptor function.

Authors: McMahon, HT  Missler, M  Li, C  Sudhof, TC 
Citation: McMahon HT, etal., Cell 1995 Oct 6;83(1):111-9.
RGD ID: 70701
Pubmed: PMID:7553862   (View Abstract at PubMed)

A family of proteins called complexins was discovered that compete with alpha-SNAP, but not synaptotagmin, for SNAP receptor binding. Complexins I and II are highly homologous hydrophilic proteins that are tightly conserved, with 100% identity among mouse, rat, and human complexin II. They are enriched in neurons where they colocalize with syntaxin and SNAP-25; in addition, complexin II is expressed ubiquitously at low levels. Complexins bind weakly to syntaxin alone and not at all to synaptobrevin and SNAP-25, but strongly to the SNAP receptor-core complex composed of these three molecules. They compete with alpha-SNAP for binding to the core complex but not with other interacting molecules, including synaptotagmin I, suggesting that the complexins regulate the sequential interactions of alpha-SNAP and synaptotagmins with the SNAP receptor during exocytosis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cplx2Ratvesicle docking involved in exocytosis involved_inTAS PMID:7553862PINC 

Molecular Function


Objects Annotated

Genes (Rattus norvegicus)
Cplx1  (complexin 1)
Cplx2  (complexin 2)
Napa  (NSF attachment protein alpha)
Snap25  (synaptosome associated protein 25)
Stx1a  (syntaxin 1A)
Stxbp1  (syntaxin binding protein 1)
Syp  (synaptophysin)
Vamp2  (vesicle-associated membrane protein 2)

Objects referenced in this article
Gene CPLX1 complexin 1 Homo sapiens
Gene CPLX2 complexin 2 Homo sapiens
Gene Cplx1 complexin 1 Mus musculus
Gene Cplx2 complexin 2 Mus musculus

Additional Information