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Strain Registration

Strain: GRY/Idr

Symbol: GRY/Idr
Strain: GRY
Substrain: Idr
Full Name: groggy rat
RGD ID: 1599759
Citation ID: RRID:RGD_1599759
Ontology ID: RS:0001318
Alleles: Cacna1agry
Also Known As: NBRP Rat No: 0368
Type: mutant
Available Source: National BioResource Project for the Rat in Japan, Graduate School of Medicine, Kyoto University Institute of Laboratory Animals, Kyoto Japan
Origination: National BioResource Project for the Rat in Japan, Graduate School of Medicine, Kyoto University Institute of Laboratory Animals, Kyoto Japan
Description: Groggy (gry) mutation was found in wistar rats at the Institute for Developmental Research, Aichi, in 1991. These were moved from the Institute for Developmental Research, Aichi Human Service Center to Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University , Kyoto in September 2003.
Coat Color: Albino
Inbred Generations: F37-40
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2021-02-12)
Research Usage Neurobiology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,644,553 - 23,644,553RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01925,627,751 - 25,627,751RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01936,502,533 - 36,727,039RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41925,188,170 - 25,424,495RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca(2+) channel alpha(1A) subunit gene and exhibits absence seizures. Tokuda S, etal., Brain Res. 2006 Dec 28;.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Cacna1agry-var1 chr19 23644553 23644553 A T point_mutation mRatBN7.2
Cacna1agry-var1 chr19 25627751 25627751 A T point_mutation Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics A nonconserved missense (M251K) mutation was found in the alpha-subunit 1A of the P/Q-type voltage-gated calcium channel within the critical gry-region which was responsible for the absence of epilepsy 1598976
strain_reproduction Good breeding performance 1302502