CACNA1A (calcium voltage-gated channel subunit alpha1 A) - Rat Genome Database
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Gene: CACNA1A (calcium voltage-gated channel subunit alpha1 A) Sus scrofa
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Symbol: CACNA1A
Name: calcium voltage-gated channel subunit alpha1 A
RGD ID: 14040283
Description: ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); syntaxin binding (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); autistic disorder (ortholog); FOUND IN cell projection (ortholog); cytoplasm (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A; SCA6; spinocerebellar ataxia type 6
Orthologs:
Homo sapiens (human) : CACNA1A (calcium voltage-gated channel subunit alpha1 A)  HGNC  Alliance
Mus musculus (house mouse) : Cacna1a (calcium channel, voltage-dependent, P/Q type, alpha 1A subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cacna1a (calcium voltage-gated channel subunit alpha1 A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cacna1a (calcium voltage-gated channel subunit alpha1 A)
Pan paniscus (bonobo/pygmy chimpanzee) : CACNA1A (calcium voltage-gated channel subunit alpha1 A)
Canis lupus familiaris (dog) : CACNA1A (calcium voltage-gated channel subunit alpha1 A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cacna1a (calcium voltage-gated channel subunit alpha1 A)
Chlorocebus sabaeus (African green monkey) : CACNA1A (calcium voltage-gated channel subunit alpha1 A)
Heterocephalus glaber (naked mole-rat) : Cacna1a (calcium voltage-gated channel subunit alpha1 A)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1265,491,784 - 65,871,068 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,921,411 - 66,176,189 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
behavioral response to pain  (ISO)
calcium ion import  (ISO)
calcium ion transmembrane transport  (IEA)
calcium ion transport  (ISO)
calcium ion-regulated exocytosis of neurotransmitter  (ISO)
calcium-ion regulated exocytosis  (ISO)
cell death  (ISO)
cellular chloride ion homeostasis  (ISO)
cellular response to amyloid-beta  (ISO)
central nervous system neuron differentiation  (ISO)
cerebellar molecular layer development  (ISO)
cerebellar Purkinje cell differentiation  (ISO)
cerebellar Purkinje cell layer development  (ISO)
cerebellum maturation  (ISO)
chemical synaptic transmission  (ISO)
dendrite morphogenesis  (ISO)
gamma-aminobutyric acid secretion  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
glucose homeostasis  (ISO)
membrane depolarization  (ISO)
modulation of chemical synaptic transmission  (ISO)
musculoskeletal movement, spinal reflex action  (ISO)
negative regulation of hormone biosynthetic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
nervous system process  (ISO)
neuromuscular process  (ISO)
neuromuscular process controlling balance  (ISO)
neuromuscular synaptic transmission  (ISO)
neuron-neuron synaptic transmission  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
receptor clustering  (ISO)
regulation of acetylcholine secretion, neurotransmission  (ISO)
regulation of axonogenesis  (ISO)
regulation of calcium ion-dependent exocytosis  (ISO)
regulation of hormone levels  (ISO)
regulation of membrane potential  (ISO)
regulation of neurotransmitter levels  (ISO)
regulation of sulfur amino acid metabolic process  (ISO)
regulation of voltage-gated calcium channel activity  (ISO)
response to amyloid-beta  (ISO)
response to pain  (ISO)
rhythmic synaptic transmission  (ISO)
sensory perception of pain  (ISO)
spinal cord motor neuron differentiation  (ISO)
synapse assembly  (ISO)
synaptic transmission, GABAergic  (ISO)
synaptic transmission, glutamatergic  (ISO)
transmission of nerve impulse  (ISO)
vestibular nucleus development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
calcium transport pathway  (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
gliclazide pharmacodynamics pathway  (ISO)
glyburide pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
insulin secretion pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
potassium channel inhibitors pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

Genomics

Comparative Map Data
CACNA1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1265,491,784 - 65,871,068 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,921,411 - 66,176,189 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,206,442 - 13,633,025 (-)EnsemblGRCh38hg38GRCh38
GRCh381913,206,442 - 13,506,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,317,256 - 13,617,274 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,178,256 - 13,478,274 (-)NCBINCBI36hg18NCBI36
Build 341913,179,114 - 13,478,317NCBI
Celera1913,207,639 - 13,507,772 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,889,634 - 13,189,171 (-)NCBIHuRef
CHM1_11913,318,256 - 13,618,198 (-)NCBICHM1_1
Cacna1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,065,257 - 85,366,880 (+)NCBI
GRCm38884,338,631 - 84,640,251 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,338,639 - 84,640,246 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,939,263 - 87,164,148 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,305,469 - 87,530,351 (+)NCBImm8
Celera888,715,985 - 88,942,662 (+)NCBICelera
Cytogenetic Map8C2- C3NCBI
cM Map840.95NCBI
Cacna1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,453,236 - 25,749,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,526,751 - 25,749,550 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,502,533 - 36,727,039 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,188,170 - 25,424,495 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,194,294 - 25,429,321 (-)NCBI
Celera1923,074,249 - 23,295,970 (-)NCBICelera
Cytogenetic Map19q11NCBI
Cacna1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,183,442 - 32,400,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,182,536 - 32,457,511 (-)NCBIChiLan1.0ChiLan1.0
CACNA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,506,232 - 13,804,815 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,507,102 - 13,804,729 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,769,586 - 13,189,022 (-)NCBIMhudiblu_PPA_v0panPan3
CACNA1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2048,821,025 - 49,036,032 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12048,747,087 - 49,036,627 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cacna1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,201,606 - 2,269,625 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,883,353 - 12,307,023 (-)NCBI
Cacna1a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901707,322 - 932,658 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021083710   ⟹   XP_020939369
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1265,491,784 - 65,871,068 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020939369 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABK76247 (Get FASTA)   NCBI Sequence Viewer  
  ABK76248 (Get FASTA)   NCBI Sequence Viewer  
  ABK76249 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020939369   ⟸   XM_021083710
- Sequence:
Protein Domains
Ion_trans


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013754 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000038048 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000042437 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.350 UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  VDCC_N_a1su UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene CACNA1A ENTREZGENE
PANTHER PTHR45628:SF6 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
UniProt A0A287A2T8_PIG UniProtKB/TrEMBL
VGNC ID VGNC:99705 ENTREZGENE