Cabp1 (calcium binding protein 1) - Rat Genome Database

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Gene: Cabp1 (calcium binding protein 1) Rattus norvegicus
Analyze
Symbol: Cabp1
Name: calcium binding protein 1
RGD ID: 620385
Description: Enables several functions, including nuclear localization sequence binding activity; transmembrane transporter binding activity; and type 3 metabotropic glutamate receptor binding activity. Involved in several processes, including negative regulation of transport; postsynapse to nucleus signaling pathway; and regulation of postsynapse to nucleus signaling pathway. Located in several cellular components, including neuronal cell body; postsynaptic density; and subplasmalemmal coating. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of temporal lobe epilepsy. Orthologous to human CABP1 (calcium binding protein 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium-binding protein 1; caldendrin; LOC108353433; uncharacterized LOC108353433
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21241,385,234 - 41,448,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,378,897 - 41,448,927 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,591,942 - 42,616,455 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01243,205,596 - 43,230,109 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01242,266,164 - 42,290,676 (+)NCBIRnor_WKY
Rnor_6.01247,185,449 - 47,209,785 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,179,664 - 47,209,784 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,980,523 - 49,004,882 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,696,383 - 42,720,566 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,568,234 - 42,583,529 (+)NCBI
Celera1243,043,462 - 43,067,622 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia. Bernstein HG, etal., Schizophr Res. 2007 Nov;96(1-3):246-56. doi: 10.1016/j.schres.2007.05.038. Epub 2007 Aug 23.
2. Ca2+ binding protein-1 inhibits Ca2+ currents and exocytosis in bovine chromaffin cells. Chen ML, etal., J Biomed Sci. 2008 Mar;15(2):169-81. Epub 2007 Oct 25.
3. Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. Dieterich DC, etal., PLoS Biol. 2008 Feb;6(2):e34. doi: 10.1371/journal.pbio.0060034.
4. Dynamic cellular translocation of caldendrin is facilitated by the Ca2+-myristoyl switch of recoverin. Fries R, etal., J Neurochem. 2010 Jun;113(5):1150-62. doi: 10.1111/j.1471-4159.2010.06676.x. Epub 2010 Mar 17.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Association of Caldendrin splice isoforms with secretory vesicles in neurohypophyseal axons and the pituitary. Landwehr M, etal., FEBS Lett. 2003 Jul 17;547(1-3):189-92.
8. The neuron-specific Ca2+-binding protein caldendrin: gene structure, splice isoforms, and expression in the rat central nervous system. Laube G, etal., Mol Cell Neurosci. 2002 Mar;19(3):459-75. doi: 10.1006/mcne.2001.1078.
9. Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Lee A, etal., Nat Neurosci 2002 Mar;5(3):210-7.
10. The diversity of calcium sensor proteins in the regulation of neuronal function. McCue HV, etal., Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a004085. doi: 10.1101/cshperspect.a004085. Epub 2010 Jul 28.
11. Ca2+-dependent binding of calcium-binding protein 1 to presynaptic group III metabotropic glutamate receptors and blockage by phosphorylation of the receptors. Nakajima Y Biochem Biophys Res Commun. 2011 Sep 9;412(4):602-5. doi: 10.1016/j.bbrc.2011.08.006. Epub 2011 Aug 10.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment. Seidenbecher CI, etal., J Biol Chem 1998 Aug 14;273(33):21324-31.
16. Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain. Smalla KH, etal., Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):159-62.
17. Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis. Smalla KH, etal., Neurochem Res. 2009 Aug;34(8):1405-9. doi: 10.1007/s11064-009-9925-8. Epub 2009 Feb 18.
18. Caldendrin, a neuron-specific modulator of Cav/1.2 (L-type) Ca2+ channels. Tippens AL and Lee A, J Biol Chem. 2007 Mar 16;282(11):8464-73. Epub 2007 Jan 15.
19. Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. Wong LL, etal., Hum Exp Toxicol. 2011 Sep;30(9):1369-81. doi: 10.1177/0960327110391388. Epub 2010 Dec 7.
20. Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels. Zhou H, etal., J Neurosci. 2004 May 12;24(19):4698-708.
Additional References at PubMed
PMID:8889548   PMID:15980432   PMID:16049184   PMID:17055077   PMID:17994197   PMID:19338761   PMID:22664934   PMID:23650371   PMID:25058677   PMID:27822497   PMID:28437073   PMID:29478916  


Genomics

Comparative Map Data
Cabp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21241,385,234 - 41,448,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,378,897 - 41,448,927 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,591,942 - 42,616,455 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01243,205,596 - 43,230,109 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01242,266,164 - 42,290,676 (+)NCBIRnor_WKY
Rnor_6.01247,185,449 - 47,209,785 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,179,664 - 47,209,784 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,980,523 - 49,004,882 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,696,383 - 42,720,566 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,568,234 - 42,583,529 (+)NCBI
Celera1243,043,462 - 43,067,622 (+)NCBICelera
Cytogenetic Map12q16NCBI
CABP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812120,640,626 - 120,680,866 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12120,640,626 - 120,667,324 (+)EnsemblGRCh38hg38GRCh38
GRCh3712121,078,429 - 121,105,127 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,562,805 - 119,589,510 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412119,551,090 - 119,567,845NCBI
Celera12120,712,715 - 120,739,394 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12118,087,780 - 118,114,466 (+)NCBIHuRef
CHM1_112121,047,209 - 121,073,905 (+)NCBICHM1_1
T2T-CHM13v2.012120,629,781 - 120,656,452 (+)NCBIT2T-CHM13v2.0
Cabp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,306,750 - 115,332,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,306,748 - 115,332,440 (-)EnsemblGRCm39 Ensembl
GRCm385115,168,691 - 115,194,381 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,168,689 - 115,194,381 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,618,700 - 115,636,130 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365115,429,955 - 115,447,120 (-)NCBIMGSCv36mm8
Celera5112,265,082 - 112,282,516 (-)NCBICelera
Cytogenetic Map5FNCBI
Cabp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545511,000,763 - 11,068,922 (-)NCBIChiLan1.0ChiLan1.0
CABP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112121,605,979 - 121,623,960 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v012118,224,046 - 118,250,696 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CABP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12616,492,484 - 16,523,265 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2616,494,980 - 16,525,873 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02616,758,371 - 16,789,256 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2616,768,053 - 16,789,251 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12616,719,024 - 16,749,945 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,794,703 - 16,825,583 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,836,775 - 16,867,667 (+)NCBIUU_Cfam_GSD_1.0
Cabp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118145,825,410 - 145,847,946 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936668324,299 - 339,334 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CABP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1440,563,159 - 40,587,970 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11440,563,302 - 40,587,975 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,996,071 - 43,055,074 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CABP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,934,747 - 116,021,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037129,075,237 - 129,103,423 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cabp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474713,027,844 - 13,050,165 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474713,027,839 - 13,050,262 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cabp1
457 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:110
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000001551, ENSRNOT00000001552, ENSRNOT00000039281
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
AU048814  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,432,447 - 41,432,668 (+)MAPPERmRatBN7.2
Rnor_6.01247,193,179 - 47,193,399NCBIRnor6.0
Rnor_5.01248,988,404 - 48,988,624UniSTSRnor5.0
RGSC_v3.41242,704,062 - 42,704,282UniSTSRGSC3.4
Celera1243,051,095 - 43,051,315UniSTS
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 1 42 1
Low 3 35 56 40 14 40 4 5 32 35 39 9 4
Below cutoff 8 5 4 6 1 2 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001551   ⟹   ENSRNOP00000001551
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,424,606 - 41,448,927 (+)Ensembl
Rnor_6.0 Ensembl1247,179,664 - 47,209,357 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000001552   ⟹   ENSRNOP00000001552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,433,184 - 41,448,927 (+)Ensembl
Rnor_6.0 Ensembl1247,193,964 - 47,209,784 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000039281   ⟹   ENSRNOP00000033685
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,433,233 - 41,448,927 (+)Ensembl
Rnor_6.0 Ensembl1247,193,964 - 47,209,784 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101243   ⟹   ENSRNOP00000078200
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,436,635 - 41,448,927 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114073   ⟹   ENSRNOP00000092742
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,378,897 - 41,448,927 (+)Ensembl
RefSeq Acc Id: NM_001033675   ⟹   NP_001028847
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21241,433,233 - 41,448,930 (+)NCBI
Rnor_6.01247,193,964 - 47,209,785 (+)NCBI
Rnor_5.01248,980,523 - 49,004,882 (+)NCBI
RGSC_v3.41242,696,383 - 42,720,566 (+)RGD
Celera1243,051,880 - 43,067,622 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001033676   ⟹   NP_001028848
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21241,424,606 - 41,448,930 (+)NCBI
Rnor_6.01247,185,449 - 47,209,785 (+)NCBI
Rnor_5.01248,980,523 - 49,004,882 (+)NCBI
RGSC_v3.41242,696,383 - 42,720,566 (+)RGD
Celera1243,043,462 - 43,067,622 (+)RGD
Sequence:
RefSeq Acc Id: NM_133529   ⟹   NP_598213
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21241,433,233 - 41,448,930 (+)NCBI
Rnor_6.01247,193,964 - 47,209,785 (+)NCBI
Rnor_5.01248,980,523 - 49,004,882 (+)NCBI
RGSC_v3.41242,696,383 - 42,720,566 (+)RGD
Celera1243,051,880 - 43,067,622 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089041   ⟹   XP_038944969
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21241,385,234 - 41,448,930 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001028848   ⟸   NM_001033676
- Peptide Label: isoform 3
- UniProtKB: O88751 (UniProtKB/Swiss-Prot),   A0A140TA91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_598213   ⟸   NM_133529
- Peptide Label: isoform 1
- UniProtKB: O88751 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001028847   ⟸   NM_001033675
- Peptide Label: isoform 2
- UniProtKB: O88751 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001552   ⟸   ENSRNOT00000001552
RefSeq Acc Id: ENSRNOP00000001551   ⟸   ENSRNOT00000001551
RefSeq Acc Id: ENSRNOP00000033685   ⟸   ENSRNOT00000039281
RefSeq Acc Id: XP_038944969   ⟸   XM_039089041
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000092742   ⟸   ENSRNOT00000114073
RefSeq Acc Id: ENSRNOP00000078200   ⟸   ENSRNOT00000101243
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88751-F1-model_v2 AlphaFold O88751 1-298 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620385 AgrOrtholog
BioCyc Gene G2FUF-18977 BioCyc
Ensembl Genes ENSRNOG00000001173 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001551 ENTREZGENE
  ENSRNOP00000001551.7 UniProtKB/TrEMBL
  ENSRNOP00000001552 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000033685 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000078200.1 UniProtKB/TrEMBL
  ENSRNOP00000092742.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001551 ENTREZGENE
  ENSRNOT00000001551.8 UniProtKB/TrEMBL
  ENSRNOT00000001552 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000039281 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000101243.1 UniProtKB/TrEMBL
  ENSRNOT00000114073.1 UniProtKB/TrEMBL
InterPro CaBP1/2/4/5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171051 UniProtKB/Swiss-Prot
NCBI Gene 171051 ENTREZGENE
PANTHER PTHR45917 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cabp1 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TA91 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5YC82_RAT UniProtKB/TrEMBL
  A0A8I6AH55_RAT UniProtKB/TrEMBL
  CABP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q711K8 UniProtKB/Swiss-Prot
  Q91WZ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cabp1  calcium binding protein 1  LOC108353433  uncharacterized LOC108353433  Data Merged 737654 PROVISIONAL
2016-08-02 LOC108353433  uncharacterized LOC108353433      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Cabp1  calcium binding protein 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cabp1  calcium binding protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein is localized to cytoskeleton in dendrites and postsynaptic densities 632450
gene_expression mRNA expressed in neurons in cerebral cortex, hippocampus and cerebellum 632450
gene_physical_interaction Cabp1 inhibition of Ca(v)2.1 channels occurs via Capb1 binding to the CaM-binding domain in the Ca(v)2.1 632449
gene_process enhances inactivation of voltage-gated Ca(v)2.1 channels 632449
gene_protein protein masses 36 kDa 632450