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Gene: Cacna1a (calcium channel, voltage-dependent, P/Q type, alpha 1A subunit) Mus musculus
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Symbol: Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
RGD ID: 10265
Description: Exhibits high voltage-gated calcium channel activity and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including cellular ion homeostasis; chemical synaptic transmission; and nervous system development. Localizes to several cellular components, including glutamatergic synapse; neuronal cell body; and voltage-gated calcium channel complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; and trigeminal nerve. Used to study Lambert-Eaton myasthenic syndrome; brain disease (multiple); and episodic ataxia type 2. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: al; alpha1A; APCA; BI; brain calcium channel I; Caca1a; Cacn; Cacnl1a4; calcium channel, L type, alpha-1 polypeptide; calcium channel, P/Q type, alpha 1A; Cav2.1; Ccha; Ccha1a; EA2; FHM; HPCA; la; leaner; MHP; MHP1; nmf35; nmf352; P/Q-type calcium channel alpha1A subunit; rkr; rocker; s; SC; SCA6; smrl; tg; tottering; voltage-dependent P/Q-type calcium channel subunit alpha-1A; voltage-gated calcium channel subunit alpha Cav2.1
Orthologs:
Homo sapiens (human) : CACNA1A (calcium voltage-gated channel subunit alpha1 A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cacna1a (calcium voltage-gated channel subunit alpha1 A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cacna1a (calcium voltage-gated channel subunit alpha1 A)
Pan paniscus (bonobo/pygmy chimpanzee) : CACNA1A (calcium voltage-gated channel subunit alpha1 A)
Canis lupus familiaris (dog) : CACNA1A (calcium voltage-gated channel subunit alpha1 A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cacna1a (calcium voltage-gated channel subunit alpha1 A)
Sus scrofa (pig) : CACNA1A (calcium voltage-gated channel subunit alpha1 A)
Chlorocebus sabaeus (African green monkey) : CACNA1A (calcium voltage-gated channel subunit alpha1 A)
Heterocephalus glaber (naked mole-rat) : Cacna1a (calcium voltage-gated channel subunit alpha1 A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,065,257 - 85,366,880 (+)NCBI
GRCm38884,338,631 - 84,640,251 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,338,639 - 84,640,246 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,939,263 - 87,164,148 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,305,469 - 87,530,351 (+)NCBImm8
Celera888,715,985 - 88,942,662 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated

Genomics

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QTLs in Region (GRCm38)
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Expression


Sequence

Nucleotide Sequences
Protein Sequences