Prcs1 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Prcs1 (Prostate cancer susceptibility QTL 1) Rattus norvegicus

Symbol: Prcs1
Name: Prostate cancer susceptibility QTL 1
RGD ID: 1558656
Previously known as: Pcs1
Trait: prostate integrity trait   (VT:0010571)    
Measurement Type: percentage of study population developing ventral prostate tumorous lesions during a period of time   (CMO:0000943)    
LOD Score: 5.0
P Value: Not Available
Variance: 17.6
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81931,287,532 - 51,431,640RGD_MAPPER_PIPELINE
mRatBN7.21915,114,598 - 34,521,833RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01915,939,528 - 38,798,459RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01927,017,884 - 49,665,957RGDRnor5.0
RGSC_v3.41916,245,310 - 36,472,155RGDRGSC3.4
RGSC_v3.11916,250,136 - 36,477,036RGD
Cross Type: Not Available
Strains Crossed: ACI/SegHsd F344/Jcl 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prcs1RatProstatic Neoplasms  IAGP 1358944 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prcs1Ratabnormal prostate gland morphology  IAGP 1358944 RGD 
Prcs1Ratabnormal prostate gland physiology  IAGP 1358944 RGD 
Prcs1Ratincreased prostate gland tumor incidence  IDA 1358944 RGD 
Prcs1Ratprostate gland hyperplasia  IAGP 1358944 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prcs1Ratpercentage of study population developing ventral prostate tumorous lesions during a period of time  IDA 1358944 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prcs1Ratcontrol condition  IDA 1358944 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prcs1Ratex vivo light microscopy  IDA 1358944 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prcs1RatACI/SegHsd  IEA 1358944 RGD 
Prcs1RatF344/Jcl  IEA 1358944 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prcs1Ratprostate integrity trait  IDA 1358944 RGD 


#
Reference Title
Reference Citation
1. Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged. Yamashita S, etal., Cancer Res 2005 Apr 1;65(7):2610-6.


1 to 20 of 363 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1307424Irx3iroquois homeobox 3191521188215215317Rat
1305121FtoFTO, alpha-ketoglutarate dependent dioxygenase191528489815692142Rat
7661148LOC102556484uncharacterized LOC102556484191530716315311101Rat
1311099Rpgrip1lRpgrip1-like191569218915785083Rat
1311170AktipAKT interacting protein191586681115877123Rat
3541Rbl2RB transcriptional corepressor like 2191587685215923632Rat
41323723LOC120098695small nucleolar RNA SNORA17191593431215934444Rat
1306795Chd9chromodomain helicase DNA binding protein 9191594153516146220Rat
11448883LOC108348876U1 small nuclear ribonucleoprotein C pseudogene191595711915960185Rat
1593026Mif-ps3macrophage migration inhibitory factor, pseudogene 3191626166116263204Rat
11478525LOC108348902uncharacterized LOC108348902191649266416500151Rat
11362355LOC108348901uncharacterized LOC108348901191650019716516868Rat
1591794Ldha-ps22lactate dehydrogenase A, pseudogene 22191653834216539830Rat
41023938LOC120098523uncharacterized LOC120098523191659814016642551Rat
1311529Tox3TOX high mobility group box family member 3191664833816757151Rat
7542010LOC102549475uncharacterized LOC102549475191700136617025361Rat
7532016LOC102549581uncharacterized LOC102549581191722091617225036Rat
40937786LOC120098536uncharacterized LOC120098536191722538217232395Rat
41254820LOC120098502uncharacterized LOC120098502191729079017291512Rat
41366286LOC120098701small nucleolar RNA SNORA17191735007517350206Rat

1 to 20 of 363 rows
1 to 20 of 387 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
33917D19Mit4242191560502315605265Ratregion
34033D19Mit5111193306179233061905Ratregion
11471D19Mit9161192481604124816202Ratregion
11472D19Wox8125192481797824818103Ratregion
33597D19Mit13197192468134024681546Ratregion
33602D19Mit10183193108194131082124Ratregion
33698D19Mit12132191896158218961714Ratregion
33741D15Mit4201192605267726052794Ratregion
36165D19Rat13227192306926523069484Ratregion
35376D19Rat12211192570467125704884Ratregion
37668D19Rat42236192069611320696349Ratregion
34904D19Rat23172193445536834455540Ratregion
35747D19Rat26170191970939619709566Ratregion
35775D19Rat27130191857978518579915Ratregion
35881D19Rat11120192968965629689776Ratregion
39760D19Rat93239191954154819541787Ratregion
38008D19Rat39249191935220919352458Ratregion
38032D19Rat101191191511459815114789Ratregion
38242D19Rat41151192629651126296662Ratregion
38298D19Rat48179192702113127021310Ratregion
1 to 20 of 387 rows

Flank 1: (D19Rat101)
Rat AssemblyChrPosition (strand)Source
GRCr81931,287,532 - 31,287,723 (+)Marker Load Pipeline
mRatBN7.21915,114,598 - 15,114,789 (-)MAPPER
Rnor_6.01915,939,528 - 15,939,718NCBI
Rnor_5.01927,017,884 - 27,018,074UniSTS
RGSC_v3.41916,245,310 - 16,245,501RGD
RGSC_v3.41916,245,311 - 16,245,501UniSTS
RGSC_v3.11916,250,136 - 16,250,327RGD
FHH x ACI Map1918.9799RGD
FHH x ACI Map1918.9799UniSTS
Peak: (D19Rat75)
Rat AssemblyChrPosition (strand)Source
GRCr81940,860,996 - 40,861,200 (+)Marker Load Pipeline
mRatBN7.21923,956,224 - 23,956,428 (-)MAPPER
Rnor_6.01925,317,225 - 25,317,428NCBI
Rnor_5.01936,293,413 - 36,293,616UniSTS
RGSC_v3.41925,639,971 - 25,640,175RGD
RGSC_v3.41925,639,972 - 25,640,175UniSTS
RGSC_v3.11925,644,797 - 25,645,001RGD
Celera1923,505,073 - 23,505,276UniSTS
SHRSP x BN Map1916.8698RGD
SHRSP x BN Map1916.8698UniSTS
Flank 2: (D19Rat46)
Rat AssemblyChrPosition (strand)Source
GRCr81951,431,501 - 51,431,640 (+)Marker Load Pipeline
mRatBN7.21934,521,694 - 34,521,833 (+)MAPPER
Rnor_6.01938,798,321 - 38,798,459NCBI
Rnor_5.01949,665,819 - 49,665,957UniSTS
RGSC_v3.41936,472,016 - 36,472,155RGD
RGSC_v3.41936,472,017 - 36,472,155UniSTS
RGSC_v3.11936,476,898 - 36,477,036RGD
Celera1933,948,364 - 33,948,502UniSTS
RH 3.4 Map19293.3RGD
RH 3.4 Map19293.3UniSTS
RH 2.0 Map19421.3RGD
SHRSP x BN Map1923.6499RGD
FHH x ACI Map1929.06RGD
Cytogenetic Map19q12UniSTS


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat

1 to 10 of 34 rows


Note Type Note Reference
qtl_statistics_details significant linkage also to number of lesions in prostate (LOD = 3.2) and lesions with a solid structure (LOD = 3.0) 1358944
qtl_statistics_details MAPMAKER/EXP(version 3.0b) and MAPMAKER/QTL (version 1.1b) were used for linkage analysis and maps 1358944