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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | RGD:1320916 | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of HOOK2 mRNA | CTD | PMID:24763279 | 1,2-dichloroethane | decreases expression | ISO | RGD:1557904 | 6480464 | ethylene dichloride results in decreased expression of HOOK2 mRNA | CTD | PMID:28189721, PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:1557904 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of HOOK2 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:1557904 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HOOK2 mRNA | CTD | PMID:22206623 | 2,2',5,5'-tetrachlorobiphenyl | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:23829299 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1557904 | 6480464 | Tetrachlorodibenzodioxin affects the expression of HOOK2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HOOK2 mRNA | CTD | PMID:33387578 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:1320916 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HOOK2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOOK2 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | RGD:1320916 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HOOK2 mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:1557904 | 6480464 | Fenretinide results in increased expression of HOOK2 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of HOOK2 mRNA | CTD | PMID:24780913 | aflatoxin B1 | increases methylation | ISO | RGD:1320916 | 6480464 | Aflatoxin B1 results in increased methylation of HOOK2 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | RGD:1320916 | 6480464 | aflatoxin B2 results in increased methylation of HOOK2 intron | CTD | PMID:30157460 | aristolochic acid A | increases expression | ISO | RGD:1320916 | 6480464 | aristolochic acid I results in increased expression of HOOK2 mRNA | CTD | PMID:33212167 | arsenous acid | decreases expression | ISO | RGD:1557904 | 6480464 | Arsenic Trioxide results in decreased expression of HOOK2 mRNA | CTD | PMID:29095437 | arsenous acid | multiple interactions | ISO | RGD:1557904 | 6480464 | Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HOOK2 mRNA] | CTD | PMID:29095437 | benzo[a]pyrene | affects methylation | ISO | RGD:1320916 | 6480464 | Benzo(a)pyrene affects the methylation of HOOK2 intron | CTD | PMID:30157460 | benzo[e]pyrene | increases methylation | ISO | RGD:1320916 | 6480464 | benzo(e)pyrene results in increased methylation of HOOK2 intron | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:1557904 | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HOOK2 mRNA] | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | increases expression | ISO | RGD:1557904 | 6480464 | Diethylhexyl Phthalate results in increased expression of HOOK2 mRNA | CTD | PMID:19850644 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HOOK2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | ISO | RGD:1320916 | 6480464 | bisphenol A results in decreased methylation of HOOK2 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | RGD:1557904 | 6480464 | bisphenol A results in decreased expression of HOOK2 mRNA | CTD | PMID:35598803 | bisphenol F | multiple interactions | ISO | RGD:1320916 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOOK2 mRNA | CTD | PMID:28628672 | captan | increases expression | ISO | RGD:1557904 | 6480464 | Captan results in increased expression of HOOK2 mRNA | CTD | PMID:31558096 | carbon nanotube | decreases expression | ISO | RGD:1557904 | 6480464 | Nanotubes, Carbon results in decreased expression of HOOK2 mRNA | CTD | PMID:25620056 | CGP 52608 | multiple interactions | ISO | RGD:1320916 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to HOOK2 gene] | CTD | PMID:28238834 | clofibrate | affects expression | ISO | RGD:1557904 | 6480464 | Clofibrate affects the expression of HOOK2 mRNA | CTD | PMID:23811191 | copper(II) sulfate | decreases expression | ISO | RGD:1320916 | 6480464 | Copper Sulfate results in decreased expression of HOOK2 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1320916 | 6480464 | Cyclosporine results in decreased expression of HOOK2 mRNA | CTD | PMID:25562108, PMID:27989131 | dexamethasone | multiple interactions | ISO | RGD:1320916 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HOOK2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOOK2 mRNA | CTD | PMID:28628672 | dextran sulfate | increases expression | ISO | RGD:1557904 | 6480464 | Dextran Sulfate results in increased expression of HOOK2 mRNA | CTD | PMID:35093514 | diarsenic trioxide | decreases expression | ISO | RGD:1557904 | 6480464 | Arsenic Trioxide results in decreased expression of HOOK2 mRNA | CTD | PMID:29095437 | diarsenic trioxide | multiple interactions | ISO | RGD:1557904 | 6480464 | Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HOOK2 mRNA] | CTD | PMID:29095437 | dibenz[a,h]anthracene | increases expression | ISO | RGD:1557904 | 6480464 | 1 more ... | CTD | PMID:26377693 | doxorubicin | increases expression | ISO | RGD:1320916 | 6480464 | Doxorubicin results in increased expression of HOOK2 mRNA | CTD | PMID:29803840 | epoxiconazole | decreases expression | ISO | RGD:1557904 | 6480464 | epoxiconazole results in decreased expression of HOOK2 mRNA | CTD | PMID:35436446 | ethyl methanesulfonate | increases expression | ISO | RGD:1320916 | 6480464 | Ethyl Methanesulfonate results in increased expression of HOOK2 mRNA | CTD | PMID:23649840 | folic acid | multiple interactions | ISO | RGD:1557904 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HOOK2 mRNA | CTD | PMID:22206623 | folic acid | increases expression | ISO | RGD:1557904 | 6480464 | Folic Acid results in increased expression of HOOK2 mRNA | CTD | PMID:25629700 | folpet | increases expression | ISO | RGD:1557904 | 6480464 | folpet results in increased expression of HOOK2 mRNA | CTD | PMID:31558096 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of HOOK2 mRNA | CTD | PMID:33387578 | indometacin | multiple interactions | ISO | RGD:1320916 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HOOK2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOOK2 mRNA | CTD | PMID:28628672 | metformin | multiple interactions | ISO | RGD:1557904 | 6480464 | Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HOOK2 mRNA] | CTD | PMID:29095437 | methapyrilene | increases methylation | ISO | RGD:1320916 | 6480464 | Methapyrilene results in increased methylation of HOOK2 intron | CTD | PMID:30157460 | methyl methanesulfonate | increases expression | ISO | RGD:1320916 | 6480464 | Methyl Methanesulfonate results in increased expression of HOOK2 mRNA | CTD | PMID:23649840 | Nivalenol | increases expression | ISO | RGD:1557904 | 6480464 | nivalenol results in increased expression of HOOK2 mRNA | CTD | PMID:35016910 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of HOOK2 mRNA | CTD | PMID:33387578 | parathion | increases expression | ISO | RGD:1557904 | 6480464 | Parathion results in increased expression of HOOK2 mRNA | CTD | PMID:34813904 | phenobarbital | increases expression | ISO | RGD:1557904 | 6480464 | Phenobarbital results in increased expression of HOOK2 mRNA | CTD | PMID:19270015 | quercetin | increases expression | ISO | RGD:1320916 | 6480464 | Quercetin results in increased expression of HOOK2 protein | CTD | PMID:15221776 | sodium arsenite | decreases expression | ISO | RGD:1320916 | 6480464 | sodium arsenite results in decreased expression of HOOK2 protein | CTD | PMID:30528433 | sodium dichromate | increases expression | ISO | RGD:1557904 | 6480464 | sodium bichromate results in increased expression of HOOK2 mRNA | CTD | PMID:31558096 | sunitinib | decreases expression | ISO | RGD:1320916 | 6480464 | Sunitinib results in decreased expression of HOOK2 mRNA | CTD | PMID:31533062 | temozolomide | decreases expression | ISO | RGD:1320916 | 6480464 | Temozolomide results in decreased expression of HOOK2 mRNA | CTD | PMID:31758290 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:1320916 | 6480464 | tert-Butylhydroperoxide results in decreased expression of HOOK2 mRNA | CTD | PMID:15336504 | tetrachloromethane | decreases expression | ISO | RGD:1557904 | 6480464 | Carbon Tetrachloride results in decreased expression of HOOK2 mRNA | CTD | PMID:31919559 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of HOOK2 mRNA | CTD | PMID:23411599 | titanium dioxide | increases expression | ISO | RGD:1557904 | 6480464 | titanium dioxide results in increased expression of HOOK2 mRNA | CTD | PMID:29264374 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of HOOK2 mRNA | CTD | PMID:33387578 | triptonide | decreases expression | ISO | RGD:1557904 | 6480464 | triptonide results in decreased expression of HOOK2 mRNA | CTD | PMID:33045310 | valproic acid | affects expression | ISO | RGD:1320916 | 6480464 | Valproic Acid affects the expression of HOOK2 mRNA | CTD | PMID:25979313 | venlafaxine hydrochloride | increases expression | EXP | | 6480464 | Venlafaxine Hydrochloride results in increased expression of HOOK2 mRNA | CTD | PMID:25423262 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of HOOK2 mRNA | CTD | PMID:23034163 | |