Gene: Brd7 (bromodomain containing 7) Rattus norvegicus
Analyze
Symbol:
Brd7
Name:
bromodomain containing 7
Description:
Predicted to have several functions, including lysine-acetylated histone binding activity; p53 binding activity; and transcription coregulator activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of histone acetylation; and regulation of transcription, DNA-templated. Predicted to localize to cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7); PARTICIPATES IN histone modification pathway; SWI/SNF family mediated chromatin remodeling pathway; INTERACTS WITH 17alpha-ethynylestradiol; bisphenol A; cobalt dichloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
bromodomain-containing protein 7; LOC361374
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
BRD7 (bromodomain containing 7) HGNC
Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):
Brd7 (bromodomain containing 7) HGNC
NCBI, OMA, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Brd7 (bromodomain containing 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
BRD7 (bromodomain containing 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
BRD7 (bromodomain containing 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Brd7 (bromodomain containing 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
BRD7 (bromodomain containing 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
BRD7 (bromodomain containing 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Brd7 (bromodomain containing 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
BRD7 (bromodomain containing 7)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Mus musculus (house mouse):
Brd7 (bromodomain containing 7)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Danio rerio (zebrafish):
brd7 (bromodomain containing 7)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
CG7154
Alliance
DIOPT (PANTHER|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
swsn-9
Alliance
DIOPT (PANTHER|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 19 19,672,780 - 19,701,484 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 19,672,856 - 19,701,484 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 19 30,698,139 - 30,726,814 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 20,019,637 - 20,048,264 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 19 20,021,019 - 20,053,087 (+) NCBI Celera 19 18,594,033 - 18,622,660 (+) NCBI Celera Cytogenetic Map 19 p11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Malignant Granular Cell Tumor ISO RGD:1320478 8554872 ClinVar Annotator: match by term: malignant granular cell tumor ClinVar
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol multiple interactions ISO RGD:1320479 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRD7 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of BRD7 mRNA CTD PMID:29097150 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:1320478 6480464 2 more ... CTD PMID:19095052 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1320479 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRD7 mRNA CTD PMID:17942748 2-methylcholine affects expression ISO RGD:1320478 6480464 beta-methylcholine affects the expression of BRD7 mRNA CTD PMID:21179406 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1320478 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BRD7 mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1320479 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of BRD7 mRNA CTD PMID:18648102 antirheumatic drug increases expression ISO RGD:1320478 6480464 Antirheumatic Agents results in increased expression of BRD7 mRNA CTD PMID:24449571 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of BRD7 mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO RGD:1320478 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BRD7 mRNA CTD PMID:28628672 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of BRD7 gene CTD PMID:28505145 choline multiple interactions ISO RGD:1320479 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BRD7 gene CTD PMID:20938992 chrysene increases expression ISO RGD:1320479 6480464 chrysene results in increased expression of BRD7 mRNA CTD PMID:26377693 clobetasol decreases expression ISO RGD:1320479 6480464 Clobetasol results in decreased expression of BRD7 mRNA CTD PMID:27462272 cobalt dichloride increases expression ISO RGD:1320479 6480464 cobaltous chloride results in increased expression of BRD7 mRNA CTD PMID:21139344 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of BRD7 mRNA CTD PMID:24386269 copper(II) sulfate decreases expression ISO RGD:1320478 6480464 Copper Sulfate results in decreased expression of BRD7 mRNA CTD PMID:19549813 dexamethasone multiple interactions ISO RGD:1320478 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BRD7 mRNA CTD PMID:28628672 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of BRD7 mRNA CTD PMID:21266533 doxorubicin increases expression ISO RGD:1320478 6480464 Doxorubicin results in increased expression of BRD7 mRNA CTD PMID:29803840 flutamide increases expression EXP 6480464 Flutamide results in increased expression of BRD7 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1320479 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BRD7 gene CTD PMID:20938992 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of BRD7 mRNA CTD PMID:22061828 indometacin multiple interactions ISO RGD:1320478 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BRD7 mRNA CTD PMID:28628672 L-methionine multiple interactions ISO RGD:1320479 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BRD7 gene CTD PMID:20938992 lead(0) increases expression ISO RGD:1320478 6480464 Lead results in increased expression of BRD7 mRNA CTD PMID:19921347 lead(2+) increases expression ISO RGD:1320478 6480464 Lead results in increased expression of BRD7 mRNA CTD PMID:19921347 malathion increases expression ISO RGD:1320479 6480464 Malathion results in increased expression of BRD7 mRNA CTD PMID:18214912 methyl methanesulfonate increases expression ISO RGD:1320478 6480464 Methyl Methanesulfonate results in increased expression of BRD7 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:1320478 6480464 methylmercuric chloride results in decreased expression of BRD7 mRNA CTD PMID:28001369 paracetamol increases expression ISO RGD:1320478 6480464 Acetaminophen results in increased expression of BRD7 mRNA CTD PMID:22230336 pirinixic acid multiple interactions ISO RGD:1320478 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BRD7 mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:1320479 6480464 pirinixic acid results in decreased expression of BRD7 mRNA CTD PMID:18445702 progesterone affects expression ISO RGD:1320479 6480464 Progesterone affects the expression of BRD7 mRNA CTD PMID:17251523 quercetin decreases expression ISO RGD:1320478 6480464 Quercetin results in decreased expression of BRD7 mRNA CTD PMID:21632981 tungsten decreases expression ISO RGD:1320479 6480464 Tungsten results in decreased expression of BRD7 mRNA CTD PMID:30912803 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of BRD7 mRNA CTD PMID:23034163
Gene Ontology Annotations
Biological Process biological_process ND 1598407 10/2014: no relevant rat data RGD negative regulation of cell population proliferation ISO RGD:1320478 1624291 (PMID:20228809) RGD PMID:20228809 negative regulation of G1/S transition of mitotic cell cycle ISO RGD:1320478 1624291 (PMID:16265664) RGD PMID:16265664 negative regulation of transcription, DNA-templated ISO RGD:1320478 1624291 (PMID:16265664) RGD PMID:16265664 positive regulation of histone acetylation ISO RGD:1320478 1624291 (PMID:20228809) RGD PMID:20228809 positive regulation of transcription, DNA-templated ISO RGD:1320478 1624291 (PMID:20228809) RGD PMID:20228809 regulation of transcription by RNA polymerase II ISO RGD:1320478 1624291 (PMID:12489984) RGD PMID:12489984 regulation of transcription by RNA polymerase II IBA PANTHER:PTN000525141 , UniProtKB:Q9NPI1 13792537 PMID:21873635 GO_Central Cellular Component cellular_component ND 1598407 10/2014: no relevant rat data RGD cytosol IEA UniProtKB:Q9NPI1 , ensembl:ENSP000003781811600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1320478 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q9NPI1 , ensembl:ENSP000003781811600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:1320478 1624291 RGD GO_REF:0000052 nucleus ISO RGD:1320479 1624291 UniProtKB:Q9NPI1 (MGI:MGI:1349753 , PMID:10526152) RGD MGI:MGI:1349753 , PMID:10526152 nucleus ISO RGD:1320478 1624291 (PMID:11025449), (PMID:12489984), (PMID:16265664), (PMID:20228809) RGD PMID:11025449 more ... nucleus IBA MGI:MGI:1349766 more ... 13792537 PMID:21873635 GO_Central Molecular Function histone binding ISO RGD:1320478 1624291 (PMID:12489984) RGD PMID:12489984 lysine-acetylated histone binding ISO RGD:1320478 1624291 (PMID:16265664) RGD PMID:16265664 lysine-acetylated histone binding IBA PANTHER:PTN000525141 more ... 13792537 PMID:21873635 GO_Central molecular_function ND 1598407 10/2014: no relevant rat data RGD p53 binding ISO RGD:1320478 1624291 UniProtKB:P04637 (PMID:20228809) RGD PMID:20228809 protein binding ISO RGD:1320479 1624291 PR:Q64512 more ... RGD MGI:MGI:1349753 more ... protein binding ISO RGD:1320478 1624291 UniProtKB:P04637 more ... RGD PMID:12489984 more ... transcription coactivator activity ISO RGD:1320478 1624291 (PMID:20228809) RGD PMID:20228809 transcription corepressor activity ISO RGD:1320478 1624291 (PMID:16265664) RGD PMID:16265664 transcription corepressor activity ISO RGD:1320479 1624291 (MGI:MGI:4835371, PMID:19909775) RGD MGI:MGI:4835371 , PMID:19909775 transcription factor binding ISO RGD:1320478 1624291 (PMID:11025449) RGD PMID:11025449 transcription regulatory region sequence-specific DNA binding ISO RGD:1320478 1624291 (PMID:20228809) RGD PMID:20228809
Molecular Pathway Annotations
61447 Tcas1 Tongue tumor susceptibility QTL 1 6.08 tongue integrity trait (VT:0010553) squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875) 19 1957707 46957707 Rat 724518 Uae19 Urinary albumin excretion QTL 19 5.5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 19 8072545 47318201 Rat 724565 Tcas5 Tongue tumor susceptibility QTL 5 10.04 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) 19 5007571 43907843 Rat 724566 Uae12 Urinary albumin excretion QTL 12 5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 19 2432963 62275575 Rat 1331737 Uae29 Urinary albumin excretion QTL 29 5.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 19 6506761 60220581 Rat 631678 Cm9 Cardiac mass QTL 9 4.27 0.0001 aorta mass (VT:0002845) aorta weight (CMO:0000076) 19 1 29558305 Rat 631681 Cm12 Cardiac mass QTL 12 3.33 0.00053 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 19 1 29558305 Rat 1331788 Rf45 Renal function QTL 45 2.818 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) 19 17028003 52538299 Rat 631840 Niddm38 Non-insulin dependent diabetes mellitus QTL 38 3.86 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 19 10739929 26201726 Rat 1578764 Stresp19 Stress response QTL 19 3.6 0.001 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) 19 18993982 62275575 Rat 1558656 Prcs1 Prostate cancer susceptibility QTL 1 5 prostate integrity trait (VT:0010571) percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943) 19 15939528 38798459 Rat 1549847 Bss8 Bone structure and strength QTL 8 4 lumbar vertebra strength trait (VT:0010574) vertebra ultimate force (CMO:0001678) 19 1 32379055 Rat 2317848 Alcrsp21 Alcohol response QTL 21 1.899999976158142 0.05 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 19 1044648 46044648 Rat 61407 Scl12 Serum cholesterol level QTL 12 0.001 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) 19 15294524 33991703 Rat 61423 Cia14 Collagen induced arthritis QTL 14 3 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 19 11303927 47879277 Rat 9589102 Slep13 Serum leptin concentration QTL 13 4.63 0.001 blood leptin amount (VT:0005667) plasma leptin level (CMO:0000781) 19 3701835 48701835 Rat 7247442 Uae39 Urinary albumin excretion QTL 39 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 19 2432963 47217667 Rat 9590298 Uminl5 Urine mineral level QTL 5 3.59 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 19 1 38221845 Rat 8694186 Bw152 Body weight QTL 152 3.34 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 19 3701835 48701835 Rat 7411590 Foco7 Food consumption QTL 7 6.8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 19 1 24933090 Rat 8552935 Pigfal10 Plasma insulin-like growth factor 1 level QTL 10 5.7 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 19 1 38221845 Rat 7411549 Bw130 Body weight QTL 130 5 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 19 19177495 62275575 Rat 9590250 Scort11 Serum corticosterone level QTL 11 23.45 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 19 1 38221845 Rat 9590090 Insglur8 Insulin/glucose ratio QTL 8 10.81 0.001 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) 19 1 38221845 Rat 10054132 Srcrt9 Stress Responsive Cort QTL 9 2.87 0.0017 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 19 1 27635288 Rat
Predicted Target Of
Count of predictions: 128 Count of miRNA genes: 104 Interacting mature miRNAs: 112 Transcripts: ENSRNOT00000064275 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
