BRD7 (bromodomain containing 7) - Rat Genome Database

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Gene: BRD7 (bromodomain containing 7) Homo sapiens
Analyze
Symbol: BRD7
Name: bromodomain containing 7
RGD ID: 1320478
HGNC Page HGNC
Description: Enables several functions, including lysine-acetylated histone binding activity; p53 binding activity; and transcription coactivator activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of histone acetylation; and regulation of transcription, DNA-templated. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Implicated in acute myeloid leukemia. Biomarker of acute myeloid leukemia; carcinoma (multiple); and high grade glioma (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 75 kDa bromodomain protein; BP75; bromodomain protein; bromodomain-containing 7; bromodomain-containing protein 7; CELTIX1; NAG4; protein CELTIX-1; SMARCI1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AC063923.1   BRD7P1   BRD7P2   BRD7P3   BRD7P4   BRD7P5   BRD7P6  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1650,313,487 - 50,368,988 (-)EnsemblGRCh38hg38GRCh38
GRCh381650,315,957 - 50,368,988 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371650,349,868 - 50,402,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361648,910,442 - 48,960,330 (-)NCBINCBI36hg18NCBI36
Build 341648,910,441 - 48,960,330NCBI
Celera1634,867,347 - 34,917,271 (-)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1636,240,844 - 36,290,809 (-)NCBIHuRef
CHM1_11651,760,032 - 51,809,939 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (TAS)
cytosol  (IDA)
nucleoplasm  (IDA,TAS)
nucleus  (HDA,IBA,IDA,IEA,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10526152   PMID:11025449   PMID:12477932   PMID:12489984   PMID:12600283   PMID:12766061   PMID:12918109   PMID:12941796   PMID:14702039   PMID:15137061   PMID:15383276   PMID:15489334  
PMID:16169070   PMID:16265664   PMID:16344560   PMID:16475162   PMID:16786191   PMID:16792505   PMID:17081983   PMID:18329849   PMID:18778484   PMID:18809673   PMID:19111069   PMID:19505873  
PMID:19909775   PMID:20130577   PMID:20211142   PMID:20215511   PMID:20228809   PMID:20305087   PMID:20360068   PMID:20467437   PMID:20561408   PMID:20660729   PMID:21630459   PMID:21873635  
PMID:21873788   PMID:22015043   PMID:22864638   PMID:23110154   PMID:24124411   PMID:24657164   PMID:24840027   PMID:24981860   PMID:25447205   PMID:25743841   PMID:26010572   PMID:26149213  
PMID:26186194   PMID:26344197   PMID:26407966   PMID:26496610   PMID:26527279   PMID:26620707   PMID:26919247   PMID:26949251   PMID:27010857   PMID:27248496   PMID:27270427   PMID:27580131  
PMID:27609421   PMID:27626385   PMID:27634302   PMID:28481362   PMID:28514442   PMID:28951988   PMID:29128334   PMID:29509190   PMID:29559001   PMID:29568061   PMID:30355451   PMID:30419336  
PMID:30592293   PMID:30862715   PMID:30940648   PMID:31043422   PMID:31527615   PMID:31753913   PMID:31929348   PMID:32296183   PMID:32694731   PMID:32877691   PMID:33257797   PMID:33961781  
PMID:34038745   PMID:34079125  


Genomics

Comparative Map Data
BRD7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1650,313,487 - 50,368,988 (-)EnsemblGRCh38hg38GRCh38
GRCh381650,315,957 - 50,368,988 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371650,349,868 - 50,402,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361648,910,442 - 48,960,330 (-)NCBINCBI36hg18NCBI36
Build 341648,910,441 - 48,960,330NCBI
Celera1634,867,347 - 34,917,271 (-)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1636,240,844 - 36,290,809 (-)NCBIHuRef
CHM1_11651,760,032 - 51,809,939 (-)NCBICHM1_1
Brd7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,056,522 - 89,089,249 (-)NCBIGRCm39mm39
GRCm39 Ensembl889,057,667 - 89,088,822 (-)Ensembl
GRCm38888,329,894 - 88,362,252 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,331,039 - 88,362,194 (-)EnsemblGRCm38mm10GRCm38
MGSCv37890,856,210 - 90,886,090 (-)NCBIGRCm37mm9NCBIm37
MGSCv36891,222,416 - 91,252,261 (-)NCBImm8
MGSCv36888,068,281 - 88,097,933 (-)NCBImm8
Celera892,606,276 - 92,636,084 (-)NCBICelera
Cytogenetic Map8C3NCBI
Brd7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21918,708,792 - 18,737,500 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1918,709,022 - 18,737,494 (+)Ensembl
Rnor_6.01919,672,780 - 19,701,484 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,672,856 - 19,701,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,698,139 - 30,726,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41920,019,637 - 20,048,264 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11920,021,019 - 20,053,087 (+)NCBI
Celera1918,594,033 - 18,622,660 (+)NCBICelera
Cytogenetic Map19p11NCBI
Brd7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,424,949 - 8,461,802 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,425,976 - 8,462,431 (-)NCBIChiLan1.0ChiLan1.0
BRD7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11649,462,040 - 49,510,825 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,463,048 - 49,514,386 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01630,576,449 - 30,630,409 (-)NCBIMhudiblu_PPA_v0panPan3
BRD7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,966,636 - 65,002,800 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,966,392 - 65,002,799 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,538,574 - 61,580,817 (+)NCBI
ROS_Cfam_1.0265,511,076 - 65,553,367 (+)NCBI
ROS_Cfam_1.0 Ensembl265,511,161 - 65,551,740 (+)Ensembl
UMICH_Zoey_3.1262,334,601 - 62,376,839 (+)NCBI
UNSW_CanFamBas_1.0263,354,209 - 63,396,511 (+)NCBI
UU_Cfam_GSD_1.0264,242,470 - 64,284,777 (+)NCBI
Brd7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934956,156,077 - 56,194,652 (+)NCBI
SpeTri2.0NW_0049364753,394,423 - 3,432,998 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRD7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,478,012 - 34,519,664 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,478,008 - 34,519,622 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BRD7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,114,951 - 36,168,786 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl536,112,289 - 36,168,728 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604740,334,506 - 40,388,517 (+)NCBIVero_WHO_p1.0
Brd7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247576,294,559 - 6,335,401 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH12903  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373159,820,443 - 159,820,577UniSTSGRCh37
GRCh371650,353,123 - 50,353,877UniSTSGRCh37
Build 363161,303,137 - 161,303,271RGDNCBI36
Celera1634,867,541 - 34,868,295UniSTS
Celera3158,242,050 - 158,242,184RGD
Cytogenetic Map16q12UniSTS
Cytogenetic Map3q25.33UniSTS
HuRef1636,241,038 - 36,241,792UniSTS
HuRef3157,219,182 - 157,219,316UniSTS
RH18317  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373159,819,636 - 159,819,826UniSTSGRCh37
Build 363161,302,330 - 161,302,520RGDNCBI36
Celera3158,241,243 - 158,241,433RGD
Cytogenetic Map16q12UniSTS
Cytogenetic Map3q25.33UniSTS
HuRef3157,218,375 - 157,218,565UniSTS
D3S2934E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373159,819,625 - 159,819,798UniSTSGRCh37
GRCh376118,823,164 - 118,823,337UniSTSGRCh37
Build 363161,302,319 - 161,302,492RGDNCBI36
Celera3158,241,232 - 158,241,405RGD
Celera6119,566,489 - 119,566,662UniSTS
Cytogenetic Map6q22.31UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map6q22UniSTS
Cytogenetic Map16q12UniSTS
HuRef3157,218,364 - 157,218,537UniSTS
HuRef6116,404,930 - 116,405,103UniSTS
SHGC-64341  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376111,752,894 - 111,752,986UniSTSGRCh37
GRCh373159,820,485 - 159,820,577UniSTSGRCh37
Build 363161,303,179 - 161,303,271RGDNCBI36
Celera6112,499,455 - 112,499,547UniSTS
Celera3158,242,092 - 158,242,184RGD
Cytogenetic Map6q21UniSTS
Cytogenetic Map16q12UniSTS
Cytogenetic Map3q25.33UniSTS
HuRef6109,324,107 - 109,324,199UniSTS
HuRef3157,219,224 - 157,219,316UniSTS
SHGC-2534  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373159,820,389 - 159,820,559UniSTSGRCh37
GRCh371650,353,141 - 50,353,931UniSTSGRCh37
Build 363161,303,083 - 161,303,253RGDNCBI36
Celera1634,867,559 - 34,868,349UniSTS
Celera3158,241,996 - 158,242,166RGD
Cytogenetic Map16q12UniSTS
Cytogenetic Map3q25.33UniSTS
HuRef3157,219,128 - 157,219,298UniSTS
HuRef1636,241,056 - 36,241,846UniSTS
GeneMap99-G3 RH Map37635.0UniSTS
RH68546  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371650,352,711 - 50,352,905UniSTSGRCh37
Build 361648,910,212 - 48,910,406RGDNCBI36
Celera1634,867,129 - 34,867,323RGD
Cytogenetic Map16q12UniSTS
HuRef1636,240,626 - 36,240,820UniSTS
GeneMap99-GB4 RH Map16342.97UniSTS
NCBI RH Map16369.2UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR200Chsa-miR-200c-3pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//MFunctional MTI22015043

Predicted Target Of
Summary Value
Count of predictions:3135
Count of miRNA genes:1266
Interacting mature miRNAs:1586
Transcripts:ENST00000394688, ENST00000394689, ENST00000401491, ENST00000475877, ENST00000562383, ENST00000567826, ENST00000569774
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2389 1885 1355 286 1435 127 4285 1776 3431 360 1452 1606 175 1 1200 2722 6 2
Low 50 1106 371 338 516 338 72 421 303 59 8 7 4 66
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_023418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001173984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011523046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011523047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011523048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011523049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011523050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001751896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_933289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_933290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_933291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC023826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF152604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF213969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW615116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD677718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA645362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000394688   ⟹   ENSP00000378180
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1650,315,957 - 50,368,988 (-)Ensembl
RefSeq Acc Id: ENST00000394689   ⟹   ENSP00000378181
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1650,319,030 - 50,368,779 (-)Ensembl
RefSeq Acc Id: ENST00000401491
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1650,349,023 - 50,368,920 (-)Ensembl
RefSeq Acc Id: ENST00000475877
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1650,334,711 - 50,361,833 (-)Ensembl
RefSeq Acc Id: ENST00000562383   ⟹   ENSP00000458430
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1650,313,487 - 50,319,929 (-)Ensembl
RefSeq Acc Id: ENST00000567826
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1650,350,017 - 50,368,920 (-)Ensembl
RefSeq Acc Id: ENST00000569774   ⟹   ENSP00000461556
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1650,315,947 - 50,320,377 (-)Ensembl
RefSeq Acc Id: NM_001173984   ⟹   NP_001167455
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,315,957 - 50,368,988 (-)NCBI
GRCh371650,352,929 - 50,402,845 (-)ENTREZGENE
HuRef1636,240,844 - 36,290,809 (-)ENTREZGENE
CHM1_11651,760,032 - 51,809,939 (-)NCBI
Sequence:
RefSeq Acc Id: NM_013263   ⟹   NP_037395
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,315,957 - 50,368,988 (-)NCBI
GRCh371650,352,929 - 50,402,845 (-)ENTREZGENE
Build 361648,910,442 - 48,960,330 (-)NCBI Archive
HuRef1636,240,844 - 36,290,809 (-)ENTREZGENE
CHM1_11651,760,032 - 51,809,939 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011523046   ⟹   XP_011521348
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,317,563 - 50,368,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011523047   ⟹   XP_011521349
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,317,997 - 50,368,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011523048   ⟹   XP_011521350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,319,022 - 50,368,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011523049   ⟹   XP_011521351
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,319,030 - 50,368,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011523050   ⟹   XP_011521352
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,319,022 - 50,341,183 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017023179   ⟹   XP_016878668
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,319,030 - 50,368,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017023180   ⟹   XP_016878669
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,319,030 - 50,368,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017023181   ⟹   XP_016878670
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,317,997 - 50,341,196 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001751896
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,317,562 - 50,368,834 (-)NCBI
Sequence:
RefSeq Acc Id: XR_933289
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,317,562 - 50,368,969 (-)NCBI
Sequence:
RefSeq Acc Id: XR_933290
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,317,563 - 50,368,969 (-)NCBI
Sequence:
RefSeq Acc Id: XR_933291
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,317,562 - 50,368,969 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037395   ⟸   NM_013263
- Peptide Label: isoform 2
- UniProtKB: Q9NPI1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001167455   ⟸   NM_001173984
- Peptide Label: isoform 1
- UniProtKB: Q9NPI1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011521351   ⟸   XM_011523049
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011521350   ⟸   XM_011523048
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011521348   ⟸   XM_011523046
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011521349   ⟸   XM_011523047
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011521352   ⟸   XM_011523050
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016878670   ⟸   XM_017023181
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016878669   ⟸   XM_017023180
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016878668   ⟸   XM_017023179
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSP00000461556   ⟸   ENST00000569774
RefSeq Acc Id: ENSP00000458430   ⟸   ENST00000562383
RefSeq Acc Id: ENSP00000378180   ⟸   ENST00000394688
RefSeq Acc Id: ENSP00000378181   ⟸   ENST00000394689
Protein Domains
Bromo

Promoters
RGD ID:6792849
Promoter ID:HG_KWN:23771
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000299197,   ENST00000394688,   ENST00000394689,   ENST00000401491,   UC002EGF.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361648,960,179 - 48,960,679 (-)MPROMDB
RGD ID:7232189
Promoter ID:EPDNEW_H21841
Type:initiation region
Name:BRD7_2
Description:bromodomain containing 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21842  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,368,805 - 50,368,865EPDNEW
RGD ID:7232191
Promoter ID:EPDNEW_H21842
Type:initiation region
Name:BRD7_1
Description:bromodomain containing 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21841  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,368,973 - 50,369,033EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q11.2-12.1(chr16:46466829-52314178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052404]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052404]|See cases [RCV000052404] Chr16:46466829..52314178 [GRCh38]
Chr16:46500741..52348090 [GRCh37]
Chr16:45058242..50905591 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-51939304)x1 copy number loss See cases [RCV000053309] Chr16:46466829..51939304 [GRCh38]
Chr16:46500741..51973216 [GRCh37]
Chr16:45058242..50530717 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-51673196)x1 copy number loss See cases [RCV000053310] Chr16:46466829..51673196 [GRCh38]
Chr16:46500741..51707107 [GRCh37]
Chr16:45058242..50264608 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46471520-52405956)x1 copy number loss See cases [RCV000053328] Chr16:46471520..52405956 [GRCh38]
Chr16:46505432..52439868 [GRCh37]
Chr16:45062933..50997369 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q12.1-12.2(chr16:47250644-54121476)x1 copy number loss See cases [RCV000053329] Chr16:47250644..54121476 [GRCh38]
Chr16:47284555..54155388 [GRCh37]
Chr16:45842056..52712889 [NCBI36]
Chr16:16q12.1-12.2
pathogenic
GRCh38/hg38 16q12.1(chr16:48156593-52220374)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053330]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053330]|See cases [RCV000053330] Chr16:48156593..52220374 [GRCh38]
Chr16:48190504..52254286 [GRCh37]
Chr16:46748005..50811787 [NCBI36]
Chr16:16q12.1
pathogenic
GRCh38/hg38 16q12.1(chr16:49740807-51876620)x1 copy number loss See cases [RCV000053331] Chr16:49740807..51876620 [GRCh38]
Chr16:49774718..51910531 [GRCh37]
Chr16:48332219..50468032 [NCBI36]
Chr16:16q12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-52422170)x1 copy number loss See cases [RCV000137306] Chr16:46466829..52422170 [GRCh38]
Chr16:46500741..52456082 [GRCh37]
Chr16:45058242..51013583 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-52355793)x3 copy number gain See cases [RCV000137170] Chr16:46466829..52355793 [GRCh38]
Chr16:46500741..52389705 [GRCh37]
Chr16:45058242..50947206 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q12.1-12.2(chr16:49570553-53467065)x1 copy number loss See cases [RCV000137722] Chr16:49570553..53467065 [GRCh38]
Chr16:49604464..53500977 [GRCh37]
Chr16:48161965..52058478 [NCBI36]
Chr16:16q12.1-12.2
pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1
pathogenic
NM_013263.5(BRD7):c.1834C>T (p.Arg612Ter) single nucleotide variant Granular cell cancer [RCV000190398] Chr16:50319953 [GRCh38]
Chr16:50353864 [GRCh37]
Chr16:16q12.1
likely pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Ductal breast carcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3
uncertain significance
GRCh38/hg38 16q12.1-12.2(chr16:48543083-53879916)x1 copy number loss Ductal breast carcinoma [RCV000207292] Chr16:48543083..53879916 [GRCh38]
Chr16:48576994..53913828 [GRCh37]
Chr16:16q12.1-12.2
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
GRCh37/hg19 16p11.2-q21(chr16:34197492-64509054)x3 copy number gain See cases [RCV000511791] Chr16:34197492..64509054 [GRCh37]
Chr16:16p11.2-q21
pathogenic
GRCh37/hg19 16q11.2-12.1(chr16:46737110-51838691)x1 copy number loss See cases [RCV000511950] Chr16:46737110..51838691 [GRCh37]
Chr16:16q11.2-12.1
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q12.1(chr16:50263152-50371738)x3 copy number gain not provided [RCV000739154] Chr16:50263152..50371738 [GRCh37]
Chr16:16q12.1
benign
Single allele duplication not provided [RCV001542388] Chr16:46385317..61223349 [GRCh38]
Chr16:16q11.2-21
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14310 AgrOrtholog
COSMIC BRD7 COSMIC
Ensembl Genes ENSG00000166164 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000378180 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000378181 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000458430 UniProtKB/TrEMBL
  ENSP00000461556 UniProtKB/TrEMBL
Ensembl Transcript ENST00000394688 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000394689 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000562383 UniProtKB/TrEMBL
  ENST00000569774 UniProtKB/TrEMBL
Gene3D-CATH 1.20.920.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000166164 GTEx
HGNC ID HGNC:14310 ENTREZGENE
Human Proteome Map BRD7 Human Proteome Map
InterPro Bromodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3512 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:29117 UniProtKB/Swiss-Prot
NCBI Gene 29117 ENTREZGENE
OMIM 618489 OMIM
Pfam Bromodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3512 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25417 PharmGKB
PRINTS BROMODOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BROMODOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BROMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R6Q8_HUMAN UniProtKB/TrEMBL
  BRD7_HUMAN UniProtKB/Swiss-Prot
  I3L0Y7_HUMAN UniProtKB/TrEMBL
  I3L4V5_HUMAN UniProtKB/TrEMBL
  Q9NPI1 ENTREZGENE
UniProt Secondary Q4VC09 UniProtKB/Swiss-Prot
  Q8N2L9 UniProtKB/Swiss-Prot
  Q96KA4 UniProtKB/Swiss-Prot
  Q9BV48 UniProtKB/Swiss-Prot
  Q9UH59 UniProtKB/Swiss-Prot