Gadd45gip1 (GADD45G interacting protein 1) - Rat Genome Database

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Gene: Gadd45gip1 (GADD45G interacting protein 1) Rattus norvegicus
Analyze
Symbol: Gadd45gip1
Name: GADD45G interacting protein 1
RGD ID: 1309249
Description: Predicted to enable mitochondrial ribosome binding activity. Predicted to act upstream of or within positive regulation of cell population proliferation and positive regulation of oxidative phosphorylation. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrion. Orthologous to human GADD45GIP1 (GADD45G interacting protein 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 39S ribosomal protein L59, mitochondrial; growth arrest and DNA damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible, gamma interacting protein 1; large ribosomal subunit protein mL64; LOC288916; MRP-L59
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,225,503 - 40,228,052 (-)NCBIGRCr8
mRatBN7.21923,320,662 - 23,323,211 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,320,159 - 23,323,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,143,511 - 30,146,059 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,797,871 - 30,800,419 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,020,556 - 33,023,104 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,946,979 - 25,949,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,946,979 - 25,949,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,922,602 - 36,925,151 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,976,861 - 24,979,410 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,982,098 - 24,984,236 (-)NCBI
Celera1922,877,527 - 22,880,076 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7704013   PMID:12477932   PMID:15489334   PMID:18614015   PMID:24520316  


Genomics

Comparative Map Data
Gadd45gip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,225,503 - 40,228,052 (-)NCBIGRCr8
mRatBN7.21923,320,662 - 23,323,211 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,320,159 - 23,323,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,143,511 - 30,146,059 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,797,871 - 30,800,419 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,020,556 - 33,023,104 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,946,979 - 25,949,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,946,979 - 25,949,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,922,602 - 36,925,151 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,976,861 - 24,979,410 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,982,098 - 24,984,236 (-)NCBI
Celera1922,877,527 - 22,880,076 (-)NCBICelera
Cytogenetic Map19q11NCBI
GADD45GIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,953,119 - 12,957,223 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,953,119 - 12,957,223 (-)EnsemblGRCh38hg38GRCh38
GRCh371913,063,933 - 13,068,037 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,925,972 - 12,929,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 341912,925,971 - 12,929,050NCBI
Celera1912,954,701 - 12,957,779 (-)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,636,867 - 12,639,965 (-)NCBIHuRef
CHM1_11913,065,490 - 13,068,588 (-)NCBICHM1_1
T2T-CHM13v2.01913,077,602 - 13,081,710 (-)NCBIT2T-CHM13v2.0
Gadd45gip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,558,911 - 85,562,111 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,558,151 - 85,562,111 (+)EnsemblGRCm39 Ensembl
GRCm38884,832,282 - 84,835,482 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,831,522 - 84,835,482 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,356,181 - 87,359,381 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,722,387 - 87,725,587 (+)NCBIMGSCv36mm8
Celera889,131,201 - 89,134,616 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.19NCBI
Gadd45gip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,994,319 - 32,000,250 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,997,679 - 32,000,009 (-)NCBIChiLan1.0ChiLan1.0
GADD45GIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,883,610 - 17,886,731 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,884,251 - 16,887,345 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,516,581 - 12,519,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,258,995 - 13,262,059 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,259,047 - 13,262,044 (-)Ensemblpanpan1.1panPan2
GADD45GIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,241,956 - 49,243,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,241,962 - 49,243,837 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,114,216 - 49,116,085 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,758,834 - 49,760,703 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,758,827 - 49,760,702 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,970,030 - 48,971,899 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,396,516 - 49,398,385 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,639,056 - 49,640,925 (+)NCBIUU_Cfam_GSD_1.0
Gadd45gip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,344,647 - 208,346,689 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,007,452 - 2,010,215 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366592,008,025 - 2,010,052 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GADD45GIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,087,453 - 66,090,710 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,087,421 - 66,089,578 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,296,296 - 66,298,525 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GADD45GIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,634,435 - 11,637,462 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,632,641 - 11,637,419 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,149,859 - 8,152,877 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gadd45gip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901523,771 - 526,448 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901523,744 - 526,240 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gadd45gip1
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:46
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000004027
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat

Markers in Region
RH134416  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,320,451 - 23,320,658 (-)MAPPERmRatBN7.2
Rnor_6.01925,949,532 - 25,949,738NCBIRnor6.0
Rnor_5.01936,925,155 - 36,925,361UniSTSRnor5.0
RGSC_v3.41924,976,651 - 24,976,857UniSTSRGSC3.4
Celera1922,877,317 - 22,877,523UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004027   ⟹   ENSRNOP00000004027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,320,159 - 23,323,236 (-)Ensembl
Rnor_6.0 Ensembl1925,946,979 - 25,949,528 (+)Ensembl
RefSeq Acc Id: NM_001100504   ⟹   NP_001093974
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,225,503 - 40,228,052 (-)NCBI
mRatBN7.21923,320,662 - 23,323,211 (-)NCBI
Rnor_6.01925,946,979 - 25,949,528 (+)NCBI
Rnor_5.01936,922,602 - 36,925,151 (+)NCBI
RGSC_v3.41924,976,861 - 24,979,410 (-)RGD
Celera1922,877,527 - 22,880,076 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001093974 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83178 (Get FASTA)   NCBI Sequence Viewer  
  EDL92200 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004027.4
  ENSRNOP00055010356
  ENSRNOP00060016990
  ENSRNOP00065012824
GenBank Protein Q5XJW2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001093974   ⟸   NM_001100504
- UniProtKB: Q5XJW2 (UniProtKB/Swiss-Prot),   A6IY72 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004027   ⟸   ENSRNOT00000004027

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XJW2-F1-model_v2 AlphaFold Q5XJW2 1-228 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701023
Promoter ID:EPDNEW_R11547
Type:multiple initiation site
Name:Gadd45gip1_1
Description:GADD45G interacting protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01925,946,970 - 25,947,030EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309249 AgrOrtholog
BioCyc Gene G2FUF-6121 BioCyc
Ensembl Genes ENSRNOG00000003011 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055007751 UniProtKB/Swiss-Prot
  ENSRNOG00060012653 UniProtKB/Swiss-Prot
  ENSRNOG00065010378 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004027.8 UniProtKB/Swiss-Prot
  ENSRNOT00055012972 UniProtKB/Swiss-Prot
  ENSRNOT00060021493 UniProtKB/Swiss-Prot
  ENSRNOT00065016782 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.280.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7300805 IMAGE-MGC_LOAD
InterPro Damage-induce-interact_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Damage-induce-interacting_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:288916 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105646 IMAGE-MGC_LOAD
NCBI Gene 288916 ENTREZGENE
PANTHER GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam CR6_interact UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gadd45gip1 PhenoGen
RatGTEx ENSRNOG00000003011 RatGTEx
  ENSRNOG00055007751 RatGTEx
  ENSRNOG00060012653 RatGTEx
  ENSRNOG00065010378 RatGTEx
UniProt A6IY72 ENTREZGENE, UniProtKB/TrEMBL
  G45IP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Gadd45gip1  GADD45G interacting protein 1  Gadd45gip1  growth arrest and DNA-damage-inducible, gamma interacting protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Gadd45gip1  growth arrest and DNA-damage-inducible, gamma interacting protein 1  Gadd45gip1_predicted  growth arrest and DNA-damage-inducible, gamma interacting protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gadd45gip1_predicted  growth arrest and DNA-damage-inducible, gamma interacting protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED