Gadd45gip1 (growth arrest and DNA-damage-inducible, gamma interacting protein 1) - Rat Genome Database
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Gene: Gadd45gip1 (growth arrest and DNA-damage-inducible, gamma interacting protein 1) Mus musculus
Analyze
Symbol: Gadd45gip1
Name: growth arrest and DNA-damage-inducible, gamma interacting protein 1
RGD ID: 1319488
MGI Page MGI
Description: Exhibits mitochondrial ribosome binding activity. Involved in positive regulation of cell population proliferation and positive regulation of oxidative phosphorylation. Localizes to mitochondrion. Is expressed in several structures, including brain; early conceptus; intestine epithelium; and secondary oocyte. Used to study type 2 diabetes mellitus. Orthologous to human GADD45GIP1 (GADD45G interacting protein 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310040G17Rik; 39S ribosomal protein L59, mitochondrial; AI425883; Cri; Crif1; growth arrest and DNA damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible proteins-interacting protein 1; MRP-L59; papillomavirus L2 interacting nuclear protein 1; Plinp1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,558,911 - 85,562,111 (+)NCBIGRCm39mm39
GRCm38884,832,282 - 84,835,482 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,831,522 - 84,835,482 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,356,181 - 87,359,381 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,722,387 - 87,725,587 (+)NCBImm8
Celera889,131,201 - 89,134,616 (+)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (HDA,IDA,ISO)
nucleoplasm  (ISO)
nucleus  (IEA)
ribosome  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:7671812   PMID:7704013   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12904583   PMID:14610273  
PMID:15459248   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18200042   PMID:18614015   PMID:18799693   PMID:19801644   PMID:21873635   PMID:22819524   PMID:23308255   PMID:23456335  
PMID:23516375   PMID:24906005   PMID:25361083   PMID:25660120   PMID:27480124   PMID:27986797   PMID:29474366   PMID:29674655   PMID:30585643   PMID:31925461   PMID:32325033   PMID:32330194  
PMID:32691494  


Genomics

Comparative Map Data
Gadd45gip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,558,911 - 85,562,111 (+)NCBIGRCm39mm39
GRCm38884,832,282 - 84,835,482 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,831,522 - 84,835,482 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,356,181 - 87,359,381 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,722,387 - 87,725,587 (+)NCBImm8
Celera889,131,201 - 89,134,616 (+)NCBICelera
Cytogenetic Map8C3NCBI
GADD45GIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,953,119 - 12,957,223 (-)EnsemblGRCh38hg38GRCh38
GRCh381912,953,119 - 12,957,223 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,064,970 - 13,068,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,925,972 - 12,929,050 (-)NCBINCBI36hg18NCBI36
Build 341912,925,971 - 12,929,050NCBI
Celera1912,954,701 - 12,957,779 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,636,867 - 12,639,965 (-)NCBIHuRef
CHM1_11913,065,490 - 13,068,588 (-)NCBICHM1_1
Gadd45gip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,946,979 - 25,949,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,946,979 - 25,949,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,922,602 - 36,925,151 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,976,861 - 24,979,410 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11924,982,098 - 24,984,236 (-)NCBI
Celera1922,877,527 - 22,880,076 (-)NCBICelera
Cytogenetic Map19q11NCBI
Gadd45gip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,994,319 - 32,000,250 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,997,679 - 32,000,009 (-)NCBIChiLan1.0ChiLan1.0
GADD45GIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,258,995 - 13,262,059 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,259,047 - 13,262,044 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,516,581 - 12,519,673 (-)NCBIMhudiblu_PPA_v0panPan3
GADD45GIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2049,241,962 - 49,243,837 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12049,241,956 - 49,243,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gadd45gip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,008,025 - 2,010,052 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GADD45GIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,087,448 - 66,090,707 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,087,421 - 66,089,578 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,296,296 - 66,298,525 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GADD45GIP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,634,435 - 11,637,462 (-)NCBI
ChlSab1.1 Ensembl611,632,641 - 11,637,419 (-)Ensembl
Gadd45gip1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901523,744 - 526,240 (-)NCBI

Position Markers
AI425883  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,834,149 - 84,834,314UniSTSGRCm38
MGSCv37887,358,048 - 87,358,213UniSTSGRCm37
Celera889,133,282 - 89,133,447UniSTS
Cytogenetic Map8C3UniSTS
Whitehead/MRC_RH81006.82UniSTS
RH125456  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,834,692 - 84,834,829UniSTSGRCm38
MGSCv37887,358,591 - 87,358,728UniSTSGRCm37
Celera889,133,825 - 89,133,960UniSTS
Cytogenetic Map8C3UniSTS
Gadd45gip1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS
Gadd45gip1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS
cM Map841.19UniSTS
Rad23a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,835,155 - 84,835,591UniSTSGRCm38
MGSCv37887,359,054 - 87,359,490UniSTSGRCm37
Celera889,134,287 - 89,134,744UniSTS
Cytogenetic Map8C3UniSTS
cM Map8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:341
Count of miRNA genes:268
Interacting mature miRNAs:282
Transcripts:ENSMUST00000036734
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000036734   ⟹   ENSMUSP00000037783
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,831,522 - 84,835,482 (+)Ensembl
RefSeq Acc Id: NM_183358   ⟹   NP_899202
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,558,911 - 85,562,111 (+)NCBI
GRCm38884,832,282 - 84,835,482 (+)ENTREZGENE
MGSCv37887,356,181 - 87,359,381 (+)RGD
Celera889,131,201 - 89,134,616 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_899202   ⟸   NM_183358
- UniProtKB: Q9CR59 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000037783   ⟸   ENSMUST00000036734

Promoters
RGD ID:8667691
Promoter ID:EPDNEW_M11877
Type:multiple initiation site
Name:Gadd45gip1_1
Description:Mus musculus growth arrest and DNA-damage-inducible, gamma interactingprotein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,832,282 - 84,832,342EPDNEW
RGD ID:6843175
Promoter ID:MM_KWN:55095
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6,   Spleen
Transcripts:OTTMUST00000074396
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36887,355,914 - 87,356,414 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914947 AgrOrtholog
Ensembl Genes ENSMUSG00000033751 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000037783 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000036734 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.1430 UniProtKB/Swiss-Prot
InterPro Damage-induce-interact_sf UniProtKB/Swiss-Prot
  Damage-induce-interacting_prot UniProtKB/Swiss-Prot
KEGG Report mmu:102060 UniProtKB/Swiss-Prot
MGD MGI:1914947 ENTREZGENE
NCBI Gene 102060 ENTREZGENE
PANTHER PTHR31761 UniProtKB/Swiss-Prot
Pfam CR6_interact UniProtKB/Swiss-Prot
PhenoGen Gadd45gip1 PhenoGen
UniGene Mm.489649 ENTREZGENE
UniProt G45IP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8BT05 UniProtKB/Swiss-Prot