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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pou4f2 | Rat | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | decreases expression | ISO | Pou4f2 (Mus musculus) | 6480464 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of POU4F2 mRNA | CTD | PMID:29627306 | Pou4f2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Pou4f2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of POU4F2 mRNA | CTD | PMID:24058054 | Pou4f2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of POU4F2 mRNA | CTD | PMID:32109520 | Pou4f2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pou4f2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of POU4F2 mRNA | CTD | PMID:21570461 | Pou4f2 | Rat | aflatoxin B1 | decreases methylation | ISO | POU4F2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of POU4F2 gene | CTD | PMID:27153756 | Pou4f2 | Rat | all-trans-retinoic acid | decreases expression | ISO | Pou4f2 (Mus musculus) | 6480464 | Tretinoin results in decreased expression of POU4F2 mRNA | CTD | PMID:16604517 | Pou4f2 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of POU4F2 mRNA | CTD | PMID:16483693 | Pou4f2 | Rat | antimycin A | decreases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | Antimycin A results in decreased expression of POU4F2 mRNA | CTD | PMID:33512557 | Pou4f2 | Rat | arsenite(3-) | increases methylation | ISO | POU4F2 (Homo sapiens) | 6480464 | arsenite results in increased methylation of POU4F2 promoter | CTD | PMID:23974009 | Pou4f2 | Rat | benzo[a]pyrene | multiple interactions | ISO | Pou4f2 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to POU4F2 promoter] | CTD | PMID:19654925 | Pou4f2 | Rat | benzo[a]pyrene | increases methylation | ISO | POU4F2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of POU4F2 exon | CTD | PMID:27901495 | Pou4f2 | Rat | benzo[a]pyrene | affects methylation | ISO | POU4F2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of POU4F2 promoter | CTD | PMID:27901495 | Pou4f2 | Rat | benzo[a]pyrene | affects expression | ISO | POU4F2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the expression of POU4F2 mRNA | CTD | PMID:22316170 | Pou4f2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of POU4F2 mRNA | CTD | PMID:25181051 | Pou4f2 | Rat | bisphenol A | affects methylation | ISO | Pou4f2 (Mus musculus) | 6480464 | bisphenol A affects the methylation of POU4F2 promoter | CTD | PMID:27334623 | Pou4f2 | Rat | cadmium dichloride | multiple interactions | EXP | | 6480464 | [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of more ... | CTD | PMID:23680456 | Pou4f2 | Rat | CGP 52608 | multiple interactions | ISO | POU4F2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to POU4F2 gene] | CTD | PMID:28238834 | Pou4f2 | Rat | choline | multiple interactions | ISO | Pou4f2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Pou4f2 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of POU4F2 mRNA | CTD | PMID:26033743 | Pou4f2 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of POU4F2 mRNA | CTD | PMID:26033743 | Pou4f2 | Rat | daidzein | multiple interactions | ISO | POU4F2 (Homo sapiens) | 6480464 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of POU4F2 mRNA | CTD | PMID:16963248 | Pou4f2 | Rat | deguelin | decreases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | deguelin results in decreased expression of POU4F2 mRNA | CTD | PMID:33512557 | Pou4f2 | Rat | diazinon | increases methylation | ISO | POU4F2 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of POU4F2 gene | CTD | PMID:22964155 | Pou4f2 | Rat | entinostat | decreases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | entinostat results in decreased expression of POU4F2 mRNA | CTD | PMID:27188386 | Pou4f2 | Rat | folic acid | multiple interactions | ISO | Pou4f2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Pou4f2 | Rat | fonofos | increases methylation | ISO | POU4F2 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of POU4F2 promoter | CTD | PMID:22847954 | Pou4f2 | Rat | genistein | multiple interactions | ISO | POU4F2 (Homo sapiens) | 6480464 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of POU4F2 mRNA | CTD | PMID:16963248 | Pou4f2 | Rat | glycitein | multiple interactions | ISO | POU4F2 (Homo sapiens) | 6480464 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of POU4F2 mRNA | CTD | PMID:16963248 | Pou4f2 | Rat | L-methionine | multiple interactions | ISO | Pou4f2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Pou4f2 | Rat | lead diacetate | increases expression | ISO | Pou4f2 (Mus musculus) | 6480464 | lead acetate results in increased expression of POU4F2 mRNA | CTD | PMID:20542052 | Pou4f2 | Rat | lead diacetate | multiple interactions | EXP | | 6480464 | [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of more ... | CTD | PMID:23680456 | Pou4f2 | Rat | lead(0) | affects expression | ISO | POU4F2 (Homo sapiens) | 6480464 | Lead affects the expression of POU4F2 mRNA | CTD | PMID:28903495 | Pou4f2 | Rat | lipopolysaccharide | increases expression | ISO | Pou4f2 (Mus musculus) | 6480464 | Lipopolysaccharides results in increased expression of POU4F2 mRNA | CTD | PMID:10975854 | Pou4f2 | Rat | lipopolysaccharide | multiple interactions | ISO | POU4F2 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of POU4F2 mRNA | CTD | PMID:35811015 | Pou4f2 | Rat | methoxychlor | increases methylation | EXP | | 6480464 | Methoxychlor results in increased methylation of POU4F2 gene | CTD | PMID:19589859 | Pou4f2 | Rat | methylmercury chloride | affects expression | ISO | Pou4f2 (Mus musculus) | 6480464 | methylmercuric chloride affects the expression of POU4F2 mRNA | CTD | PMID:21613230 | Pou4f2 | Rat | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | increases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of POU4F2 mRNA | CTD | PMID:12756304 | Pou4f2 | Rat | parathion | increases methylation | ISO | POU4F2 (Homo sapiens) | 6480464 | Parathion results in increased methylation of POU4F2 promoter | CTD | PMID:22847954 | Pou4f2 | Rat | picoxystrobin | decreases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | picoxystrobin results in decreased expression of POU4F2 mRNA | CTD | PMID:33512557 | Pou4f2 | Rat | pirinixic acid | multiple interactions | ISO | Pou4f2 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Pou4f2 | Rat | pyrimidifen | decreases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | pyrimidifen results in decreased expression of POU4F2 mRNA | CTD | PMID:33512557 | Pou4f2 | Rat | rotenone | decreases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of POU4F2 mRNA | CTD | PMID:33512557 | Pou4f2 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | POU4F2 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of POU4F2 mRNA | CTD | PMID:35811015 | Pou4f2 | Rat | sodium arsenite | increases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of POU4F2 mRNA | CTD | PMID:25879800 | Pou4f2 | Rat | sodium arsenite | multiple interactions | EXP | | 6480464 | [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of more ... | CTD | PMID:23680456 | Pou4f2 | Rat | tebufenpyrad | decreases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | 4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of POU4F2 mRNA | CTD | PMID:33512557 | Pou4f2 | Rat | terbufos | increases methylation | ISO | POU4F2 (Homo sapiens) | 6480464 | terbufos results in increased methylation of POU4F2 promoter | CTD | PMID:22847954 | Pou4f2 | Rat | thifluzamide | decreases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | thifluzamide results in decreased expression of POU4F2 mRNA | CTD | PMID:33512557 | Pou4f2 | Rat | titanium dioxide | decreases methylation | ISO | Pou4f2 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of POU4F2 gene | CTD | PMID:35295148 | Pou4f2 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of POU4F2 mRNA | CTD | PMID:33387578 | Pou4f2 | Rat | valproic acid | increases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of POU4F2 mRNA | CTD | PMID:23179753|PMID:24383497 | Pou4f2 | Rat | valproic acid | decreases methylation | ISO | POU4F2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of POU4F2 gene | CTD | PMID:29154799 | Pou4f2 | Rat | valproic acid | affects expression | ISO | POU4F2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of POU4F2 mRNA | CTD | PMID:25979313 | Pou4f2 | Rat | vorinostat | decreases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of POU4F2 mRNA | CTD | PMID:27188386 | Pou4f2 | Rat | zinc sulfate | decreases expression | ISO | POU4F2 (Homo sapiens) | 6480464 | Zinc Sulfate results in decreased expression of POU4F2 mRNA | CTD | PMID:12756304 | |