Pou4f2 (POU class 4 homeobox 2) - Rat Genome Database

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Pathways
Gene: Pou4f2 (POU class 4 homeobox 2) Rattus norvegicus
Analyze
Symbol: Pou4f2
Name: POU class 4 homeobox 2
RGD ID: 620075
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; p53 binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to oxygen levels; positive regulation of cardiac muscle cell apoptotic process; and spermatogenesis. Predicted to be located in cytoplasm; euchromatin; and nuclear speck. Predicted to be part of transcription regulator complex. Orthologous to human POU4F2 (POU class 4 homeobox 2); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: brain-3B; brain-specific homeobox/POU domain protein 3B; Brn-3.2; Brn-3B; Brn3b; POU domain, class 4, transcription factor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81946,390,958 - 46,394,599 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1946,390,958 - 46,394,599 (+)EnsemblGRCr8
mRatBN7.21929,486,686 - 29,490,327 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1929,486,686 - 29,490,327 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1936,334,714 - 36,338,345 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01936,988,601 - 36,992,232 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01939,237,705 - 39,241,336 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01933,160,180 - 33,163,821 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,160,180 - 33,163,821 (+)Ensemblrn6Rnor6.0
Rnor_5.01944,051,763 - 44,055,404 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41931,388,907 - 31,392,548 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1928,985,198 - 28,988,839 (+)NCBICelera
RGSC_v3.11931,395,364 - 31,395,583 (+)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
axon extension  (IEA,ISO)
axon guidance  (IEA,ISO)
axonogenesis  (IEA,ISO)
cell differentiation  (IEA)
cellular response to cytokine stimulus  (IEA,ISO,ISS)
cellular response to estradiol stimulus  (ISO,ISS)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to oxygen levels  (IMP)
dorsal root ganglion development  (IEA,ISO,ISS)
estrogen receptor signaling pathway  (ISO)
heart development  (IEA,ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO,ISS)
MAPK cascade  (ISO)
negative regulation of adipose tissue development  (IEA,ISO)
negative regulation of amacrine cell differentiation  (IEA,ISO,ISS)
negative regulation of cell differentiation  (IEA,ISO,ISS)
negative regulation of DNA-binding transcription factor activity  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuromuscular process controlling balance  (IEA,ISO)
neuron differentiation  (IEA,ISO)
positive regulation of axon extension  (IEA,ISO,ISS)
positive regulation of cardiac muscle cell apoptotic process  (IMP)
positive regulation of cell differentiation  (IEA,ISO,ISS)
positive regulation of D-glucose import  (IEA,ISO)
positive regulation of osteoclast differentiation  (IEA,ISO,ISS)
positive regulation of programmed cell death  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
regulation of DNA-binding transcription factor activity  (ISO,ISS)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IMP)
regulation of retinal ganglion cell axon guidance  (IEA,ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA)
retina development in camera-type eye  (IEA,ISO)
retinal ganglion cell axon guidance  (IEA,ISO)
sensory perception of sound  (IEA,ISO)
spermatogenesis  (IEA,IEP)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
euchromatin  (IEA,ISO)
nuclear speck  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
transcription regulator complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
2. Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults. Budhram-Mahadeo V, etal., Cell Death Dis. 2014 Oct 30;5:e1503. doi: 10.1038/cddis.2014.452.
3. The closely related POU family transcription factors Brn-3a and Brn-3b are expressed in distinct cell types in the testis. Budhram-Mahadeo V, etal., Int J Biochem Cell Biol. 2001 Oct;33(10):1027-39.
4. The BRN-3A transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosis. Ensor E, etal., J Biol Chem 2001 Feb 16;276(7):5204-12.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:7623109   PMID:7691107   PMID:7904822   PMID:7935408   PMID:8290353   PMID:8537352   PMID:8637595   PMID:8670054   PMID:9448000   PMID:9630743   PMID:9735355   PMID:10357904  
PMID:11163266   PMID:11807038   PMID:12609742   PMID:17145718   PMID:17637757   PMID:17668438   PMID:17855369   PMID:18367606   PMID:18368538   PMID:18434421   PMID:19266028   PMID:19389377  
PMID:20609388   PMID:20826655   PMID:21241485   PMID:21875655   PMID:23805044   PMID:24643061   PMID:25587060   PMID:25775587   PMID:25786379   PMID:26670484   PMID:28594399   PMID:31413277  


Genomics

Comparative Map Data
Pou4f2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81946,390,958 - 46,394,599 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1946,390,958 - 46,394,599 (+)EnsemblGRCr8
mRatBN7.21929,486,686 - 29,490,327 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1929,486,686 - 29,490,327 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1936,334,714 - 36,338,345 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01936,988,601 - 36,992,232 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01939,237,705 - 39,241,336 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01933,160,180 - 33,163,821 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,160,180 - 33,163,821 (+)Ensemblrn6Rnor6.0
Rnor_5.01944,051,763 - 44,055,404 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41931,388,907 - 31,392,548 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1928,985,198 - 28,988,839 (+)NCBICelera
RGSC_v3.11931,395,364 - 31,395,583 (+)NCBI
Cytogenetic Map19q11NCBI
POU4F2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384146,638,893 - 146,642,474 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4146,638,893 - 146,642,474 (+)Ensemblhg38GRCh38
GRCh374147,560,045 - 147,563,626 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364147,779,495 - 147,783,073 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344147,917,692 - 147,921,228NCBI
Celera4144,880,585 - 144,884,163 (+)NCBICelera
Cytogenetic Map4q31.22NCBI
HuRef4143,287,267 - 143,290,856 (+)NCBIHuRef
CHM1_14147,537,342 - 147,540,923 (+)NCBICHM1_1
T2T-CHM13v2.04149,962,609 - 149,966,195 (+)NCBIT2T-CHM13v2.0
Pou4f2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39879,159,638 - 79,163,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl879,159,639 - 79,163,274 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38878,433,009 - 78,436,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl878,433,010 - 78,436,645 (-)Ensemblmm10GRCm38
MGSCv37880,956,908 - 80,960,551 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36881,329,081 - 81,332,724 (-)NCBIMGSCv36mm8
Celera882,709,269 - 82,712,912 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.99NCBI
Pou4f2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554282,324,834 - 2,329,205 (+)Ensembl
ChiLan1.0NW_0049554282,325,775 - 2,329,122 (+)NCBIChiLan1.0ChiLan1.0
POU4F2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23144,502,661 - 144,505,603 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14144,868,893 - 144,871,835 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04138,969,157 - 138,972,730 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14150,626,392 - 150,629,961 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4150,626,392 - 150,629,961 (+)EnsemblpanPan2panpan1.1
POU4F2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,030,818 - 45,034,446 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,031,094 - 45,032,784 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1545,426,310 - 45,427,991 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01545,704,140 - 45,705,824 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1545,704,140 - 45,705,824 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11544,976,012 - 44,977,696 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01545,068,621 - 45,070,311 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01545,333,613 - 45,335,300 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pou4f2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530145,265,697 - 45,274,468 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365352,705,162 - 2,711,813 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365352,705,184 - 2,711,785 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POU4F2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl882,043,643 - 82,047,675 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1882,044,443 - 82,046,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2887,200,440 - 87,201,609 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POU4F2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1793,150,105 - 93,160,977 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl793,150,186 - 93,151,857 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603772,832,429 - 72,836,291 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pou4f2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248535,446,694 - 5,448,637 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248535,446,575 - 5,448,704 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Pou4f2
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:141
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000016422
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)194172060949971820Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat

Markers in Region
Pou4f2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21929,487,715 - 29,487,806 (+)MAPPERmRatBN7.2
Rnor_6.01933,161,210 - 33,161,300NCBIRnor6.0
Rnor_5.01944,052,793 - 44,052,883UniSTSRnor5.0
Celera1928,986,228 - 28,986,318UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 1 7 81 16 16 8 5 8 5 34 16 75 5 19 8 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000016422   ⟹   ENSRNOP00000016422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1946,390,958 - 46,394,599 (+)Ensembl
mRatBN7.2 Ensembl1929,486,686 - 29,490,327 (+)Ensembl
Rnor_6.0 Ensembl1933,160,180 - 33,163,821 (+)Ensembl
RefSeq Acc Id: NM_134355   ⟹   NP_599182
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81946,390,958 - 46,394,599 (+)NCBI
mRatBN7.21929,486,686 - 29,490,327 (+)NCBI
Rnor_6.01933,160,180 - 33,163,821 (+)NCBI
Rnor_5.01944,051,763 - 44,055,404 (+)NCBI
RGSC_v3.41931,388,907 - 31,392,548 (+)RGD
Celera1928,985,198 - 28,988,839 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_599182 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK70503 (Get FASTA)   NCBI Sequence Viewer  
  EDL92324 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016422
  ENSRNOP00000016422.3
GenBank Protein G3V7L5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_599182   ⟸   NM_134355
- UniProtKB: G3V7L5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016422   ⟸   ENSRNOT00000016422
Protein Domains
POU-specific

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7L5-F1-model_v2 AlphaFold G3V7L5 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620075 AgrOrtholog
BioCyc Gene G2FUF-5927 BioCyc
Ensembl Genes ENSRNOG00000012167 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016422 ENTREZGENE
  ENSRNOT00000016422.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.260.40 UniProtKB/Swiss-Prot
  Homeodomain-like UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Lambda_DNA-bd_dom_sf UniProtKB/Swiss-Prot
  POU UniProtKB/Swiss-Prot
  POU_dom UniProtKB/Swiss-Prot
  POU_domain_TF UniProtKB/Swiss-Prot
KEGG Report rno:171355 UniProtKB/Swiss-Prot
NCBI Gene 171355 ENTREZGENE
PANTHER POU DOMAIN UniProtKB/Swiss-Prot
  POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 2 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
  Pou UniProtKB/Swiss-Prot
PhenoGen Pou4f2 PhenoGen
PRINTS POUDOMAIN UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
  POU_1 UniProtKB/Swiss-Prot
  POU_2 UniProtKB/Swiss-Prot
  POU_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012167 RatGTEx
SMART HOX UniProtKB/Swiss-Prot
  POU UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
  SSF47413 UniProtKB/Swiss-Prot
UniProt G3V7L5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pou4f2  POU domain, class 4, transcription factor 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pou4f2  POU domain, class 4, transcription factor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process enhances the survival of nerve growth factor-dependent sensory but not sympathetic neurons 724643