Junb (JunB proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Junb (JunB proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
Analyze
Symbol: Junb
Name: JunB proto-oncogene, AP-1 transcription factor subunit
RGD ID: 2944
Description: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including response to 4-nitroquinoline N-oxide; response to cAMP; and response to steroid hormone. Located in nucleus. Biomarker of renal carcinoma. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and melanoma. Orthologous to human JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); PARTICIPATES IN interleukin-6 signaling pathway; INTERACTS WITH (+)-pilocarpine; (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one; (R)-noradrenaline.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: PROVISIONAL
Previously known as: jun B proto-oncogene; Jun-B oncogene; transcription factor AP-1 subunit JunB; transcription factor jun-B; transcription factor JunB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Tcas5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,176,265 - 23,178,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,176,294 - 23,178,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1929,999,230 - 30,001,014 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01930,653,592 - 30,655,376 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01932,876,269 - 32,878,053 (+)NCBIRnor_WKY
Rnor_6.01926,092,972 - 26,094,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,092,974 - 26,094,756 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,068,595 - 37,070,379 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,831,536 - 24,833,320 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,836,361 - 24,838,144 (+)NCBI
Celera1922,733,824 - 22,735,608 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-citrinin  (ISO)
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (EXP)
(E)-thiamethoxam  (ISO)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (EXP,ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitrotoluene  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-OH-DPAT  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atropine  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzoyl peroxide  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butyric acid  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
camostat  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
DDT  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazepam  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dichromium trioxide  (ISO)
dieldrin  (EXP,ISO)
dioxygen  (EXP,ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
eticlopride(1+)  (EXP)
fenthion  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-linolenic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glafenine  (EXP)
gliotoxin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
glyphosate  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP,ISO)
kainic acid  (EXP,ISO)
kenpaullone  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
luteolin  (ISO)
mechlorethamine  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
Mezerein  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
morphine  (ISO)
Muraglitazar  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosomorpholine  (EXP)
naphthalenes  (EXP)
neurotensin  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nilotinib  (ISO)
nitric oxide  (EXP)
nitroprusside  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxazepam  (ISO)
oxidopamine  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirenzepine  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinomethionate  (ISO)
quinpirole  (EXP)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
reserpine  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saccharin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sulfadimethoxine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thiamethoxam  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zebularine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Bergman MR, etal., Biochem J 2003 Feb 1;369(Pt 3):485-96.
2. Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment. Bisler S, etal., J Chem Neuroanat 2002 Mar;23(3):187-98.
3. Is light-regulated AP-1 binding in the rat suprachiasmatic nucleus gated by the circadian clock? Francois-Bellan AM, etal., Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):161-70.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
7. Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge. Hansson AC and Fuxe K, Brain Res. 2008 Jun 18;1215:1-10. Epub 2008 Apr 10.
8. Transcription factor AP-1 in esophageal squamous cell carcinoma: alterations in activity and expression during human Papillomavirus infection. Hussain S, etal., BMC Cancer. 2009 Sep 16;9:329. doi: 10.1186/1471-2407-9-329.
9. JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma. Hyakusoku H, etal., J Exp Clin Cancer Res. 2016 Jan 12;35:6. doi: 10.1186/s13046-016-0284-4.
10. Conserved structural motifs among mammalian junB genes. Kawakami Z, etal., Nucleic Acids Res 1992 Feb 25;20(4):914.
11. Two cis-regulatory elements that mediate different signaling pathways for serum-dependent activation of the junB gene. Kitabayashi I, etal., J Biol Chem 1993 Jul 5;268(19):14482-9.
12. Cancer drug addiction is relayed by an ERK2-dependent phenotype switch. Kong X, etal., Nature. 2017 Oct 12;550(7675):270-274. doi: 10.1038/nature24037. Epub 2017 Oct 4.
13. Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex. Kontkanen O, etal., Neuropsychopharmacology. 2002 Aug;27(2):152-62.
14. PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer. Lian S, etal., Oncotarget. 2015 Oct 6;6(30):29076-86. doi: 10.18632/oncotarget.4931.
15. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. Mathas S, etal., EMBO J 2002 Aug 1;21(15):4104-13.
16. Rapid effects of triiodothyronine on immediate-early gene expression in Schwann cells. Mercier G, etal., Glia. 2001 Aug;35(2):81-9.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Differential expression of activator protein-1 transcription factors in pregnant rat myometrium. Mitchell JA and Lye SJ, Biol Reprod. 2002 Jul;67(1):240-6.
19. Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells. Mitchell JA, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E439-45. Epub 2004 May 4.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers. Ohyama M, etal., Pathol Int. 2004 Jan;54(1):35-40.
22. Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes. Papachristou D, etal., Eur J Orthod. 2006 Feb;28(1):20-6. Epub 2005 Dec 22.
23. RAC2 promotes abnormal proliferation of quiescent cells by enhanced JUNB expression via the MAL-SRF pathway. Pei H, etal., Cell Cycle. 2018;17(9):1115-1123. doi: 10.1080/15384101.2018.1480217. Epub 2018 Jul 9.
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. Cell selective induction and transcriptional activation of immediate early genes by hypoxia. Prabhakar NR, etal., Brain Res. 1995 Oct 30;697(1-2):266-70. doi: 10.1016/0006-8993(95)00994-2.
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. Sharma SC and Richards JS, J Biol Chem. 2000 Oct 27;275(43):33718-28.
29. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
30. LINC00657 played oncogenic roles in esophageal squamous cell carcinoma by targeting miR-615-3p and JunB. Sun Y, etal., Biomed Pharmacother. 2018 Dec;108:316-324. doi: 10.1016/j.biopha.2018.09.003. Epub 2018 Sep 15.
31. Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors. Szabo-Fresnais N, etal., Mol Cell Endocrinol. 2008 Mar 12;284(1-2):28-37. Epub 2008 Jan 8.
32. Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes. Tice DA, etal., J Biol Chem. 2002 Feb 22;277(8):6118-23. doi: 10.1074/jbc.M111255200. Epub 2001 Dec 18.
33. Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model. Urakami S, etal., Biochem Biophys Res Commun. 1997 Dec 8;241(1):24-30.
34. Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Varghese S, etal., Endocrinology. 2000 Jun;141(6):2185-91.
35. Characterization of key transcription factors as molecular signatures of HPV-positive and HPV-negative oral cancers. Verma G, etal., Cancer Med. 2017 Mar;6(3):591-604. doi: 10.1002/cam4.983. Epub 2017 Feb 3.
36. Expression of Jun family members in human colorectal adenocarcinoma. Wang H, etal., Carcinogenesis. 2000 Jul;21(7):1313-7.
37. Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation. Williams JM, etal., Brain Res Mol Brain Res. 2000 May 5;77(2):258-66.
38. The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes. Won JS and Suh HW, Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):41-51.
Additional References at PubMed
PMID:10022836   PMID:10508860   PMID:11456449   PMID:11818961   PMID:12220541   PMID:14769860   PMID:15189336   PMID:15489334   PMID:17681951   PMID:18976709   PMID:19289495   PMID:19303854  
PMID:29703907  


Genomics

Comparative Map Data
Junb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,176,265 - 23,178,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,176,294 - 23,178,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1929,999,230 - 30,001,014 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01930,653,592 - 30,655,376 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01932,876,269 - 32,878,053 (+)NCBIRnor_WKY
Rnor_6.01926,092,972 - 26,094,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,092,974 - 26,094,756 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,068,595 - 37,070,379 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,831,536 - 24,833,320 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,836,361 - 24,838,144 (+)NCBI
Celera1922,733,824 - 22,735,608 (+)NCBICelera
Cytogenetic Map19q11NCBI
JUNB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,791,486 - 12,793,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1912,791,486 - 12,793,315 (+)EnsemblGRCh38hg38GRCh38
GRCh371912,902,300 - 12,904,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,763,310 - 12,765,125 (+)NCBINCBI36Build 36hg18NCBI36
Build 341912,763,309 - 12,765,124NCBI
Celera1912,792,018 - 12,793,833 (+)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,474,046 - 12,475,861 (+)NCBIHuRef
CHM1_11912,902,786 - 12,904,601 (+)NCBICHM1_1
T2T-CHM13v2.01912,915,978 - 12,917,807 (+)NCBIT2T-CHM13v2.0
Junb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,703,538 - 85,705,377 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,701,113 - 85,705,347 (-)EnsemblGRCm39 Ensembl
GRCm38884,976,909 - 84,978,748 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,976,910 - 84,978,718 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl884,974,484 - 84,978,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,500,811 - 87,502,617 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,867,037 - 87,868,853 (-)NCBIMGSCv36mm8
Celera889,271,597 - 89,273,403 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.41NCBI
Junb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,876,793 - 31,877,836 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,876,508 - 31,878,289 (+)NCBIChiLan1.0ChiLan1.0
JUNB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,097,640 - 13,099,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,097,931 - 13,098,974 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,353,760 - 12,355,598 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JUNB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,358,904 - 49,360,746 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,359,399 - 49,360,442 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,232,549 - 49,234,383 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,877,333 - 49,879,167 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,877,347 - 49,879,306 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,088,428 - 49,090,262 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,514,724 - 49,516,558 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,757,409 - 49,759,245 (-)NCBIUU_Cfam_GSD_1.0
Junb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,462,083 - 208,463,925 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,891,080 - 1,892,123 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366591,890,786 - 1,892,619 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUNB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,214,138 - 66,217,002 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,214,086 - 66,219,435 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,505,351 - 66,507,024 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JUNB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,479,108 - 11,480,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,479,407 - 11,480,450 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,315,355 - 8,317,197 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Junb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901403,235 - 404,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901402,969 - 404,741 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Junb
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:80
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000067780
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat

Markers in Region
PMC152658P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,176,752 - 23,177,250 (-)MAPPERmRatBN7.2
Rnor_6.01926,093,771 - 26,094,268NCBIRnor6.0
Rnor_5.01937,069,394 - 37,069,891UniSTSRnor5.0
RGSC_v3.41924,832,024 - 24,832,521UniSTSRGSC3.4
Celera1922,734,312 - 22,734,809UniSTS
Cytogenetic Map19q11UniSTS
PMC302098P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,176,550 - 23,176,970 (-)MAPPERmRatBN7.2
Rnor_6.01926,094,051 - 26,094,470NCBIRnor6.0
Rnor_5.01937,069,674 - 37,070,093UniSTSRnor5.0
RGSC_v3.41924,831,822 - 24,832,241UniSTSRGSC3.4
Celera1922,734,110 - 22,734,529UniSTS
Cytogenetic Map19q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 11 30 14 19 14 21 21 12 11
Low 32 27 27 27 8 11 53 14 29 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067780   ⟹   ENSRNOP00000061729
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1926,092,974 - 26,094,756 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108644
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,176,294 - 23,178,035 (+)Ensembl
RefSeq Acc Id: NM_021836   ⟹   NP_068608
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21923,176,265 - 23,178,049 (+)NCBI
Rnor_6.01926,092,972 - 26,094,756 (-)NCBI
Rnor_5.01937,068,595 - 37,070,379 (-)NCBI
RGSC_v3.41924,831,536 - 24,833,320 (+)RGD
Celera1922,733,824 - 22,735,608 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_068608 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61862 (Get FASTA)   NCBI Sequence Viewer  
  CAA38500 (Get FASTA)   NCBI Sequence Viewer  
  EDL92170 (Get FASTA)   NCBI Sequence Viewer  
  P24898 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_068608   ⟸   NM_021836
- UniProtKB: P24898 (UniProtKB/Swiss-Prot),   A0A0G2JSY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061729   ⟸   ENSRNOT00000067780
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24898-F1-model_v2 AlphaFold P24898 1-344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701035
Promoter ID:EPDNEW_R11557
Type:single initiation site
Name:Junb_1
Description:JunB proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01926,094,775 - 26,094,835EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2944 AgrOrtholog
BioCyc Gene G2FUF-6136 BioCyc
Ensembl Genes ENSRNOG00000042838 Ensembl
  ENSRNOG00000067725 Ensembl
IMAGE_CLONE IMAGE:5597977 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
  JNK UniProtKB/Swiss-Prot
  JunB UniProtKB/Swiss-Prot
  Leuzip_Jun UniProtKB/Swiss-Prot
  TF_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:24517 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72460 IMAGE-MGC_LOAD
NCBI Gene 24517 ENTREZGENE
PANTHER PTHR11462:SF37 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
  Jun UniProtKB/Swiss-Prot
PhenoGen Junb PhenoGen
PRINTS LEUZIPPRJUN UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot
  SSF57959 UniProtKB/Swiss-Prot
UniProt A0A0G2JSY8 ENTREZGENE
  JUNB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6P733 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Junb  JunB proto-oncogene, AP-1 transcription factor subunit  Junb  jun B proto-oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Junb  jun B proto-oncogene  Junb  Jun-B oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Junb  jun B proto-oncogene      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor 729189