Nol3 (nucleolar protein 3) - Rat Genome Database

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Gene: Nol3 (nucleolar protein 3) Rattus norvegicus
Analyze
Symbol: Nol3
Name: nucleolar protein 3
RGD ID: 708558
Description: Enables death effector domain binding activity and enzyme binding activity. Involved in several processes, including inhibition of cysteine-type endopeptidase activity; negative regulation of cell death; and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrion and sarcoplasmic reticulum. Orthologous to human NOL3 (nucleolar protein 3); INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apoptosis repressor with CARD; Arc; nucleolar protein 3 (apoptosis repressor with CARD domain); unknown Glu-Pro dipeptide repeat protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,154,061 - 33,158,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,154,062 - 33,158,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1939,972,172 - 39,973,839 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01940,625,491 - 40,627,158 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01942,914,430 - 42,916,067 (+)NCBIRnor_WKY
Rnor_6.01937,232,567 - 37,236,668 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,235,001 - 37,236,649 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,098,203 - 48,102,390 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,094,345 - 35,096,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,099,225 - 35,100,893 (+)NCBI
Celera1932,585,344 - 32,587,011 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
Brevetoxin B  (ISO)
butanal  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
furosemide  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lactacystin  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
Mitotane  (EXP)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
razoxane  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (IEA,ISO)
cardiac muscle cell apoptotic process  (IEA,ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IDA)
inhibition of cysteine-type endopeptidase activity  (IDA,IMP)
inhibition of cysteine-type endopeptidase activity involved in apoptotic process  (IBA,ISO)
intrinsic apoptotic signaling pathway  (IEA,ISO)
mRNA splice site selection  (ISO,ISS)
myoblast differentiation  (IDA)
negative regulation of apoptotic process  (IDA,IMP,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
negative regulation of cytosolic calcium ion concentration  (IMP)
negative regulation of death-inducing signaling complex assembly  (IDA)
negative regulation of extrinsic apoptotic signaling pathway  (IBA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IMP)
negative regulation of hydrogen peroxide-induced cell death  (IDA,IMP)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  (IDA)
negative regulation of intrinsic apoptotic signaling pathway  (IBA,IMP)
negative regulation of mitochondrial calcium ion concentration  (IDA)
negative regulation of mitochondrial membrane permeability involved in apoptotic process  (IEA,ISO)
negative regulation of muscle atrophy  (IEA,ISO)
negative regulation of necrotic cell death  (IEA,ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of protein targeting to mitochondrion  (IDA)
negative regulation of release of cytochrome c from mitochondria  (IBA,IDA,ISO)
negative regulation of striated muscle cell apoptotic process  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
protein complex oligomerization  (ISO,ISS)
regulation of apoptotic process  (IEA,TAS)
regulation of gene expression  (IEA,ISO)
regulation of NIK/NF-kappaB signaling  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IMP)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
response to hypoxia  (IEA,IEP,ISO)
response to injury involved in regulation of muscle adaptation  (IEA,ISO)
response to ischemia  (IEA,ISO)
smooth muscle cell proliferation  (IMP)

Cellular Component
cytoplasm  (IDA,ISO)
membrane  (IEA)
mitochondrion  (IBA,IDA,IEA,ISO)
nucleolus  (ISO,ISS)
sarcoplasm  (IEA,ISO)
sarcoplasmic reticulum  (IDA)

References

References - curated
# Reference Title Reference Citation
1. ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Ekhterae D, etal., Circ Res. 1999 Dec 9;85(12):e70-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Cloning and characterization of cDNAs for novel proteins with glutamic acid-proline dipeptide tandem repeats. Geertman R, etal., Biochim Biophys Acta 1996 May 2;1306(2-3):147-52.
4. Down-regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia/hypoxia. Hong YM, etal., FEBS Lett 2003 May 22;543(1-3):170-3.
5. Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation. Hunter AL, etal., FEBS Lett. 2007 Mar 6;581(5):879-84. Epub 2007 Feb 2.
6. Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells. Irie Y, etal., J Biol Chem 2000 Jan 28;275(4):2647-53.
7. Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC. Li PF, etal., Mol Cell 2002 Aug;10(2):247-58.
8. p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Li YZ, etal., Mol Cell Biol. 2008 Jan;28(2):564-74. Epub 2007 Nov 12.
9. Transcription factor Foxo3a prevents apoptosis by regulating calcium through the apoptosis repressor with caspase recruitment domain. Lu D, etal., J Biol Chem. 2013 Mar 22;288(12):8491-504. doi: 10.1074/jbc.M112.442061. Epub 2013 Feb 4.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Nam YJ, etal., Mol Cell. 2004 Sep 24;15(6):901-12.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Novel cardiac apoptotic pathway: the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin. Tan WQ, etal., Circulation. 2008 Nov 25;118(22):2268-76. doi: 10.1161/CIRCULATIONAHA.107.750869. Epub 2008 Nov 10.
17. Hydrogen peroxide predisposes neonatal rat ventricular myocytes to Fas-mediated apoptosis. Yaniv G, etal., Biochem Biophys Res Commun. 2005 Oct 28;336(3):740-6. doi: 10.1016/j.bbrc.2005.08.167.
18. A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Zaiman AL, etal., Circulation. 2011 Dec 6;124(23):2533-42. doi: 10.1161/CIRCULATIONAHA.111.034512. Epub 2011 Nov 14.
19. ARC protects rat cardiomyocytes against oxidative stress through inhibition of caspase-2 mediated mitochondrial pathway. Zhang YQ and Herman B, J Cell Biochem. 2006 Oct 1;99(2):575-88.
Additional References at PubMed
PMID:9560245   PMID:10196175   PMID:14645204   PMID:14732288   PMID:15004034   PMID:15509781   PMID:15774698   PMID:15848180   PMID:16189514   PMID:16505176   PMID:17594520   PMID:18171680  
PMID:18782777   PMID:19130235   PMID:19139834   PMID:20026055   PMID:21233493   PMID:22508833   PMID:24312627   PMID:24440909   PMID:28731195   PMID:31257698   PMID:31505169   PMID:31587299  


Genomics

Comparative Map Data
Nol3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,154,061 - 33,158,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,154,062 - 33,158,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1939,972,172 - 39,973,839 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01940,625,491 - 40,627,158 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01942,914,430 - 42,916,067 (+)NCBIRnor_WKY
Rnor_6.01937,232,567 - 37,236,668 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,235,001 - 37,236,649 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,098,203 - 48,102,390 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,094,345 - 35,096,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,099,225 - 35,100,893 (+)NCBI
Celera1932,585,344 - 32,587,011 (+)NCBICelera
Cytogenetic Map19q11NCBI
NOL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,170,538 - 67,175,737 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1667,170,154 - 67,175,735 (+)EnsemblGRCh38hg38GRCh38
GRCh371667,204,441 - 67,209,640 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,765,371 - 65,767,127 (+)NCBINCBI36Build 36hg18NCBI36
Build 341665,765,370 - 65,767,125NCBI
Celera1651,712,649 - 51,717,887 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,077,589 - 53,082,828 (+)NCBIHuRef
CHM1_11668,611,732 - 68,616,967 (+)NCBICHM1_1
T2T-CHM13v2.01672,964,831 - 72,970,031 (+)NCBIT2T-CHM13v2.0
Nol3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,002,777 - 106,008,571 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,002,772 - 106,008,571 (+)EnsemblGRCm39 Ensembl
GRCm388105,276,145 - 105,281,939 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,276,140 - 105,281,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,800,347 - 107,805,839 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,165,576 - 108,171,068 (+)NCBIMGSCv36mm8
Celera8109,499,596 - 109,505,088 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Nol3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,443,090 - 9,447,095 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554849,443,090 - 9,447,142 (-)NCBIChiLan1.0ChiLan1.0
NOL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11666,904,738 - 66,909,956 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01647,516,156 - 47,521,441 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Nol3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,940,899 - 41,944,816 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,644,653 - 17,648,211 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647517,644,299 - 17,648,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,281,492 - 60,286,865 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604723,033,169 - 23,039,019 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Nol3
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:78
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000020908
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat

Markers in Region
RH127522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,157,893 - 33,158,093 (+)MAPPERmRatBN7.2
Rnor_6.01937,236,327 - 37,236,526NCBIRnor6.0
Rnor_5.01948,102,049 - 48,102,248UniSTSRnor5.0
RGSC_v3.41935,095,671 - 35,095,870UniSTSRGSC3.4
Celera1932,586,670 - 32,586,869UniSTS
RH 3.4 Map19359.82UniSTS
Cytogenetic Map19q11UniSTS
RH143966  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,158,071 - 33,158,215 (+)MAPPERmRatBN7.2
Rnor_6.01937,236,505 - 37,236,648NCBIRnor6.0
Rnor_5.01948,102,227 - 48,102,370UniSTSRnor5.0
RGSC_v3.41935,095,849 - 35,095,992UniSTSRGSC3.4
Celera1932,586,848 - 32,586,991UniSTS
Cytogenetic Map19q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 1 8 11 58 16 11 8
Low 3 20 37 22 19 22 16 35 25
Below cutoff 19 19 19

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020908   ⟹   ENSRNOP00000020908
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,154,062 - 33,158,191 (+)Ensembl
Rnor_6.0 Ensembl1937,235,001 - 37,236,649 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115672   ⟹   ENSRNOP00000097088
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,154,105 - 33,158,250 (+)Ensembl
RefSeq Acc Id: NM_053516   ⟹   NP_445968
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,156,568 - 33,158,235 (+)NCBI
Rnor_6.01937,235,001 - 37,236,668 (+)NCBI
Rnor_5.01948,098,203 - 48,102,390 (+)NCBI
RGSC_v3.41935,094,345 - 35,096,012 (+)RGD
Celera1932,585,344 - 32,587,011 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255539   ⟹   XP_006255601
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,154,061 - 33,158,250 (+)NCBI
Rnor_6.01937,232,567 - 37,236,642 (+)NCBI
Rnor_5.01948,098,203 - 48,102,390 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255542   ⟹   XP_006255604
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,154,095 - 33,158,250 (+)NCBI
Rnor_6.01937,232,567 - 37,236,627 (+)NCBI
Rnor_5.01948,098,203 - 48,102,390 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601394   ⟹   XP_017456883
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,154,100 - 33,158,250 (+)NCBI
Rnor_6.01937,232,610 - 37,236,642 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098044   ⟹   XP_038953972
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,154,122 - 33,158,250 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_445968   ⟸   NM_053516
- UniProtKB: G3V7Z3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255601   ⟸   XM_006255539
- Peptide Label: isoform X1
- UniProtKB: G3V7Z3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255604   ⟸   XM_006255542
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017456883   ⟸   XM_017601394
- Peptide Label: isoform X1
- UniProtKB: G3V7Z3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020908   ⟸   ENSRNOT00000020908
RefSeq Acc Id: XP_038953972   ⟸   XM_039098044
- Peptide Label: isoform X1
- UniProtKB: G3V7Z3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000097088   ⟸   ENSRNOT00000115672
Protein Domains
CARD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62881-F1-model_v2 AlphaFold Q62881 1-221 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708558 AgrOrtholog
BioCyc Gene G2FUF-5847 BioCyc
Ensembl Genes ENSRNOG00000015588 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020908 ENTREZGENE
  ENSRNOP00000020908.2 UniProtKB/TrEMBL
  ENSRNOP00000097088 ENTREZGENE
  ENSRNOP00000097088.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020908 ENTREZGENE
  ENSRNOT00000020908.6 UniProtKB/TrEMBL
  ENSRNOT00000115672 ENTREZGENE
  ENSRNOT00000115672.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85383 UniProtKB/Swiss-Prot
NCBI Gene 85383 ENTREZGENE
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nol3 PhenoGen
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AN50_RAT UniProtKB/TrEMBL
  G3V7Z3 ENTREZGENE, UniProtKB/TrEMBL
  NOL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Nol3  nucleolar protein 3  Nol3  nucleolar protein 3 (apoptosis repressor with CARD domain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Nol3  nucleolar protein 3 (apoptosis repressor with CARD domain)      Symbol and Name status set to approved 1299863 APPROVED