Gipc1 (GIPC PDZ domain containing family, member 1) - Rat Genome Database

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Gene: Gipc1 (GIPC PDZ domain containing family, member 1) Rattus norvegicus
Analyze
Symbol: Gipc1
Name: GIPC PDZ domain containing family, member 1
RGD ID: 68338
Description: Enables PDZ domain binding activity. Predicted to be involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of melanin biosynthetic process; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including cellular response to interleukin-7; endothelial cell migration; and glutamate secretion. Located in brush border and endocytic vesicle. Is active in Schaffer collateral - CA1 synapse; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 2. Orthologous to human GIPC1 (GIPC PDZ domain containing family member 1); PARTICIPATES IN syndecan signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GAIP C-terminus-interacting protein; Gipc; GLUT1 C-terminal-binding protein; GLUT1CBP; PDZ domain-containing protein GIPC1; regulator of G-protein signaling 19; regulator of G-protein signaling 19 interacting protein 1; RGS-GAIP interacting protein C-terminus; RGS-GAIP interacting protein, C-terminus; RGS-GAIP-interacting protein; Rgs19; RGS19-interacting protein 1; Rgs19ip1; synectin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21924,474,291 - 24,487,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,453,123 - 24,486,997 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1931,296,524 - 31,300,339 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,950,945 - 31,954,760 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,173,772 - 34,177,589 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,786,604 - 24,798,231 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,786,628 - 24,798,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01935,765,772 - 35,778,495 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41926,165,658 - 26,177,206 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11926,170,483 - 26,174,300 (-)NCBI
Celera1924,018,366 - 24,029,872 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Bunn RC, etal., Mol Biol Cell 1999 Apr;10(4):819-32.
2. Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. Cai H and Reed RR, J Neurosci. 1999 Aug 1;19(15):6519-27.
3. GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. De Vries L, etal., Proc Natl Acad Sci U S A 1998 Oct 13;95(21):12340-5.
4. Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP. Fischer T, etal., Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8270-5. Epub 2003 Jun 25.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors. Jeanneteau F, etal., Mol Biol Cell. 2004 Feb;15(2):696-705. Epub 2003 Nov 14.
7. Synectin in the nervous system: expression pattern and potential as a binding partner of neurotrophin receptors. Kato H, etal., FEBS Lett. 2004 Aug 13;572(1-3):123-8.
8. A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Liu M and Horowitz A, Mol Biol Cell. 2006 Apr;17(4):1880-7. Epub 2006 Feb 8.
9. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. Lou X, etal., J Am Soc Nephrol. 2002 Apr;13(4):918-27.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Yano H, etal., Nat Neurosci. 2006 Aug;9(8):1009-18. doi: 10.1038/nn1730. Epub 2006 Jul 2.
Additional References at PubMed
PMID:11251075   PMID:11546783   PMID:12857860   PMID:14499480   PMID:15458844   PMID:15459234   PMID:15975910   PMID:16316992   PMID:16908842   PMID:17959809   PMID:19056867   PMID:19581409  
PMID:19946888   PMID:21291857   PMID:22888021   PMID:23376485   PMID:25468996   PMID:29581031  


Genomics

Comparative Map Data
Gipc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21924,474,291 - 24,487,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,453,123 - 24,486,997 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1931,296,524 - 31,300,339 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,950,945 - 31,954,760 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,173,772 - 34,177,589 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,786,604 - 24,798,231 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,786,628 - 24,798,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01935,765,772 - 35,778,495 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41926,165,658 - 26,177,206 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11926,170,483 - 26,174,300 (-)NCBI
Celera1924,018,366 - 24,029,872 (-)NCBICelera
Cytogenetic Map19q11NCBI
GIPC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,477,762 - 14,496,127 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,477,760 - 14,496,149 (-)EnsemblGRCh38hg38GRCh38
GRCh371914,588,574 - 14,606,939 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,449,571 - 14,467,944 (-)NCBINCBI36Build 36hg18NCBI36
Build 341914,449,571 - 14,467,944NCBI
Celera1914,482,692 - 14,501,043 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,158,686 - 14,177,001 (-)NCBIHuRef
CHM1_11914,588,560 - 14,606,924 (-)NCBICHM1_1
T2T-CHM13v2.01914,604,395 - 14,622,744 (-)NCBIT2T-CHM13v2.0
Gipc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,376,037 - 84,391,418 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,379,306 - 84,391,323 (+)EnsemblGRCm39 Ensembl
GRCm38883,649,408 - 83,664,789 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,652,677 - 83,664,694 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,176,577 - 86,188,688 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36886,542,783 - 86,554,894 (+)NCBIMGSCv36mm8
Celera887,943,499 - 87,955,588 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
Gipc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541533,067,689 - 33,074,730 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541533,067,689 - 33,077,749 (-)NCBIChiLan1.0ChiLan1.0
GIPC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11918,409,821 - 18,428,123 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,041,192 - 14,059,402 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,884,529 - 14,897,247 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,885,185 - 14,889,701 (-)Ensemblpanpan1.1panPan2
GIPC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,144,076 - 48,155,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,150,498 - 48,157,191 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,020,555 - 48,030,681 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02048,660,996 - 48,673,506 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,661,602 - 48,678,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12047,874,912 - 47,885,049 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,301,291 - 48,311,404 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,544,132 - 48,554,244 (+)NCBIUU_Cfam_GSD_1.0
Gipc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,324,418 - 207,334,872 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366593,012,012 - 3,026,883 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366593,019,829 - 3,030,280 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GIPC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl264,780,442 - 64,794,919 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1264,780,447 - 64,794,922 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,158,635 - 65,174,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GIPC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,136,647 - 13,155,259 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,136,624 - 13,142,002 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660746,500,986 - 6,519,302 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gipc1
77 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:60
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000005374
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat

Markers in Region
RH134027  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,475,484 - 24,475,676 (-)MAPPERmRatBN7.2
Rnor_6.01924,797,955 - 24,798,146NCBIRnor6.0
Rnor_5.01935,777,110 - 35,777,301UniSTSRnor5.0
RGSC_v3.41926,165,743 - 26,165,934UniSTSRGSC3.4
Celera1924,018,451 - 24,018,642UniSTS
Cytogenetic Map19q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 57 41 19 41 4 7 74 35 40 11 4
Low 7 4 4 1 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005374   ⟹   ENSRNOP00000005374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,475,409 - 24,486,997 (-)Ensembl
Rnor_6.0 Ensembl1924,786,628 - 24,798,233 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105318   ⟹   ENSRNOP00000089319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,476,081 - 24,480,327 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112591   ⟹   ENSRNOP00000082767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,453,123 - 24,481,454 (-)Ensembl
RefSeq Acc Id: NM_053341   ⟹   NP_445793
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,475,400 - 24,479,214 (-)NCBI
Rnor_6.01924,786,683 - 24,798,231 (+)NCBI
Rnor_5.01935,765,772 - 35,778,495 (+)NCBI
RGSC_v3.41926,165,658 - 26,177,206 (-)RGD
Celera1924,018,366 - 24,029,872 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601372   ⟹   XP_017456861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,475,405 - 24,486,988 (-)NCBI
Rnor_6.01924,786,604 - 24,798,226 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098035   ⟹   XP_038953963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,474,291 - 24,487,082 (-)NCBI
RefSeq Acc Id: XM_039098036   ⟹   XP_038953964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,474,291 - 24,487,083 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_445793   ⟸   NM_053341
- UniProtKB: Q6GR70 (UniProtKB/Swiss-Prot),   Q9QUQ4 (UniProtKB/Swiss-Prot),   Q9Z254 (UniProtKB/Swiss-Prot),   A6IYD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456861   ⟸   XM_017601372
- Peptide Label: isoform X1
- UniProtKB: Q6GR70 (UniProtKB/Swiss-Prot),   Q9QUQ4 (UniProtKB/Swiss-Prot),   Q9Z254 (UniProtKB/Swiss-Prot),   A6IYD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005374   ⟸   ENSRNOT00000005374
RefSeq Acc Id: XP_038953964   ⟸   XM_039098036
- Peptide Label: isoform X2
- UniProtKB: A6IYD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953963   ⟸   XM_039098035
- Peptide Label: isoform X1
- UniProtKB: Q9Z254 (UniProtKB/Swiss-Prot),   Q6GR70 (UniProtKB/Swiss-Prot),   Q9QUQ4 (UniProtKB/Swiss-Prot),   A6IYD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082767   ⟸   ENSRNOT00000112591
RefSeq Acc Id: ENSRNOP00000089319   ⟸   ENSRNOT00000105318
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z254-F1-model_v2 AlphaFold Q9Z254 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701002
Promoter ID:EPDNEW_R11526
Type:initiation region
Name:Gipc1_1
Description:GIPC PDZ domain containing family, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01924,786,659 - 24,786,719EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68338 AgrOrtholog
BioCyc Gene G2FUF-6020 BioCyc
Ensembl Genes ENSRNOG00000003864 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005374 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000105318.1 UniProtKB/TrEMBL
  ENSRNOT00000112591 ENTREZGENE
  ENSRNOT00000112591.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5620910 IMAGE-MGC_LOAD
  IMAGE:7097697 IMAGE-MGC_LOAD
InterPro GIPC1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83823 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72367 IMAGE-MGC_LOAD
  MGC:91590 IMAGE-MGC_LOAD
NCBI Gene 83823 ENTREZGENE
PANTHER PDZ DOMAIN-CONTAINING PROTEIN GIPC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12259 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gipc1 PhenoGen
PIRSF UCP038083_GIPC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003864 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230181
UniProt A0A8I6ABP2_RAT UniProtKB/TrEMBL
  A0A8I6G7U9_RAT UniProtKB/TrEMBL
  A6IYD6 ENTREZGENE, UniProtKB/TrEMBL
  A6IYD7_RAT UniProtKB/TrEMBL
  GIPC1_RAT UniProtKB/Swiss-Prot
  Q6GR70 ENTREZGENE
  Q9QUQ4 ENTREZGENE
  Q9Z254 ENTREZGENE
UniProt Secondary Q6GR70 UniProtKB/Swiss-Prot
  Q9QUQ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Gipc1  GIPC PDZ domain containing family, member 1  Rgs19ip1  regulator of G-protein signaling 19 interacting protein 1  Symbol and Name updated 1299863 APPROVED
2002-06-10 Rgs19ip1  regulator of G-protein signaling 19 interacting protein 1       Name updated 70584 APPROVED
2002-02-27 Rgs19ip1  regulator of G-protein signaling 19 interacting protein 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the plasma membrane of transfected HEK293 cells 1299148
gene_domains contains a central PDZ domain and a C-terminal acyl carrier protein (ACP) domain 68252
gene_function exclusively binds RGS-GAIP, RGSZ1, and RGSZ2 1299148