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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SLC12A4 mRNA] | CTD | PMID:31150632 | 1,1-dichloroethene | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of SLC12A4 mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | decreases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of SLC12A4 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SLC12A4 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SLC12A4 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of SLC12A4 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Estradiol results in increased expression of SLC12A4 mRNA | CTD | PMID:19167446 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:27291303 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SLC12A4 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SLC12A4 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SLC12A4 mRNA | CTD | PMID:33956508 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of SLC12A4 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of SLC12A4 mRNA | CTD | PMID:21346803 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Slc12a4 (Mus musculus) | 6480464 | bis(4-hydroxyphenyl)sulfone affects the methylation of SLC12A4 gene | CTD | PMID:31683443 | 5-aza-2'-deoxycytidine | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Decitabine results in increased expression of SLC12A4 mRNA | CTD | PMID:17908484 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SLC12A4 mRNA | CTD | PMID:25825206 | acrylamide | decreases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of SLC12A4 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of SLC12A4 mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SLC12A4 mRNA | CTD | PMID:23724009 | all-trans-retinoic acid | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of SLC12A4 mRNA | CTD | PMID:30951980 | amiloride | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | Amiloride inhibits the reaction [SLC12A4 protein results in increased transport of Potassium] | CTD | PMID:11703599 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SLC12A4 mRNA | CTD | PMID:16483693 | barium(0) | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | Barium inhibits the reaction [SLC12A4 protein results in increased transport of Potassium] | CTD | PMID:11703599 | benzo[a]pyrene | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SLC12A4 mRNA | CTD | PMID:22610609 | benzo[a]pyrene | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SLC12A4 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | SLC12A4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SLC12A4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | SLC12A4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SLC12A4 exon | CTD | PMID:27901495 | benzo[b]fluoranthene | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of SLC12A4 mRNA | CTD | PMID:26377693 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SLC12A4 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SLC12A4 mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SLC12A4 mRNA | CTD | PMID:30816183 more ... | bisphenol A | decreases methylation | ISO | Slc12a4 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of SLC12A4 promoter | CTD | PMID:27312807 | bisphenol A | decreases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of SLC12A4 mRNA | CTD | PMID:29161229 | Bisphenol B | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of SLC12A4 protein | CTD | PMID:34186270 | bisphenol F | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of SLC12A4 mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of SLC12A4 protein | CTD | PMID:34186270 | caffeine | decreases phosphorylation | ISO | SLC12A4 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of SLC12A4 protein | CTD | PMID:35688186 | chlorpyrifos | multiple interactions | EXP | | 6480464 | FMR1 inhibits the reaction [Chlorpyrifos results in increased expression of SLC12A4 mRNA] | CTD | PMID:35802248 | choline | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC12A4 gene | CTD | PMID:20938992 | clofibrate | decreases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of SLC12A4 mRNA | CTD | PMID:17585979 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of SLC12A4 mRNA | CTD | PMID:30556269 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of SLC12A4 mRNA | CTD | PMID:30556269 | coumestrol | multiple interactions | ISO | SLC12A4 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | coumestrol | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of SLC12A4 mRNA | CTD | PMID:19167446 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of SLC12A4 mRNA | CTD | PMID:26577399 | dextran sulfate | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SLC12A4 mRNA | CTD | PMID:29950665 | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of SLC12A4 mRNA | CTD | PMID:22546817 | dieldrin | affects expression | EXP | | 6480464 | Dieldrin affects the expression of SLC12A4 mRNA | CTD | PMID:22546817 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of SLC12A4 mRNA | CTD | PMID:25152437 | doxorubicin | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of SLC12A4 mRNA | CTD | PMID:29803840 | Enterolactone | multiple interactions | ISO | SLC12A4 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SLC12A4 mRNA | CTD | PMID:19167446 | epoxiconazole | decreases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of SLC12A4 mRNA | CTD | PMID:35436446 | ethanol | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Ethanol results in increased expression of SLC12A4 mRNA | CTD | PMID:30319688 | fenamidone | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | fenamidone results in increased expression of SLC12A4 mRNA | CTD | PMID:27029645 | folic acid | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | genistein | decreases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Genistein results in decreased expression of SLC12A4 mRNA | CTD | PMID:16705744 | genistein | decreases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Genistein results in decreased expression of SLC12A4 mRNA | CTD | PMID:21048042 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SLC12A4 mRNA | CTD | PMID:33387578 | L-methionine | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC12A4 gene | CTD | PMID:20938992 | lead(0) | affects expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Lead affects the expression of SLC12A4 mRNA | CTD | PMID:28903495 | leflunomide | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | leflunomide results in increased expression of SLC12A4 mRNA | CTD | PMID:28988120 | magnesium atom | affects expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Magnesium affects the expression of SLC12A4 mRNA | CTD | PMID:11703599 | magnesium atom | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | Magnesium affects the reaction [SLC12A4 protein results in increased transport of Potassium] | CTD | PMID:11703599 | methotrexate | affects expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Methotrexate affects the expression of SLC12A4 mRNA | CTD | PMID:18502557 | N-methyl-4-phenylpyridinium | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of SLC12A4 mRNA | CTD | PMID:22776087 | N-methyl-4-phenylpyridinium | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of SLC12A4 mRNA | CTD | PMID:24810058 | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of SLC12A4 mRNA | CTD | PMID:22546817 | orphenadrine | affects expression | EXP | | 6480464 | Orphenadrine affects the expression of SLC12A4 mRNA | CTD | PMID:23665939 | ozone | multiple interactions | ISO | SLC12A4 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of SLC12A4 mRNA | CTD | PMID:35430440 | paracetamol | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Acetaminophen results in increased expression of SLC12A4 mRNA | CTD | PMID:17585979 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SLC12A4 mRNA | CTD | PMID:33387578 | paracetamol | affects expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SLC12A4 mRNA | CTD | PMID:17562736 | potassium atom | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | Amiloride inhibits the reaction [SLC12A4 protein results in increased transport of Potassium] more ... | CTD | PMID:11703599 | potassium atom | increases transport | ISO | Slc12a4 (Mus musculus) | 6480464 | SLC12A4 protein results in increased transport of Potassium | CTD | PMID:11703599 | quercetin | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Quercetin results in increased expression of SLC12A4 mRNA | CTD | PMID:21632981 | quercetin | increases phosphorylation | ISO | SLC12A4 (Homo sapiens) | 6480464 | Quercetin results in increased phosphorylation of SLC12A4 protein | CTD | PMID:35688186 | resveratrol | multiple interactions | ISO | SLC12A4 (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of SLC12A4 mRNA | CTD | PMID:19167446 | resveratrol | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | resveratrol results in increased expression of SLC12A4 mRNA | CTD | PMID:25436977 | rotenone | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Rotenone results in increased expression of SLC12A4 mRNA | CTD | PMID:29955902 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SLC12A4 mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of SLC12A4 mRNA | CTD | PMID:31919559 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SLC12A4 mRNA | CTD | PMID:31150632 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SLC12A4 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Slc12a4 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of SLC12A4 mRNA | CTD | PMID:27760801 | titanium dioxide | multiple interactions | ISO | Slc12a4 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SLC12A4 mRNA | CTD | PMID:29950665 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SLC12A4 mRNA | CTD | PMID:33387578 | valproic acid | increases methylation | ISO | SLC12A4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SLC12A4 gene | CTD | PMID:29154799 | zidovudine | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Zidovudine results in increased expression of SLC12A4 mRNA | CTD | PMID:24292225 | zinc atom | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of SLC12A4 mRNA | CTD | PMID:18356318 | zinc(0) | increases expression | ISO | SLC12A4 (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of SLC12A4 mRNA | CTD | PMID:18356318 | |