Slc12a4 (solute carrier family 12 member 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Slc12a4 (solute carrier family 12 member 4) Rattus norvegicus
Analyze
Symbol: Slc12a4
Name: solute carrier family 12 member 4
RGD ID: 3687
Description: Predicted to enable ATP binding activity; potassium:chloride symporter activity; and protein kinase binding activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human SLC12A4 (solute carrier family 12 member 4); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: electroneutral potassium-chloride cotransporter 1; erythroid K-Cl cotransporter 1; furosemide-sensitive K-Cl cotransporter; Kcc1; rKCC1; solute carrier family 12 (potassium/chloride transporter), member 4; solute carrier family 12 (potassium/chloride transporters), member 4; solute carrier family 12, member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,748,268 - 50,770,217 (-)NCBIGRCr8
mRatBN7.21933,838,418 - 33,860,369 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,838,419 - 33,860,331 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,653,965 - 40,675,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,307,280 - 41,329,122 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,605,822 - 43,627,712 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,917,003 - 37,938,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,917,014 - 37,938,857 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,784,035 - 48,805,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,785,181 - 35,807,024 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,790,067 - 35,811,905 (-)NCBI
Celera1933,265,978 - 33,287,821 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
caffeine  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dieldrin  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
magnesium atom  (ISO)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
potassium atom  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (ISS)
plasma membrane  (IBA,IEA,ISS)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression of K+-Cl- cotransporters in the alpha-cells of rat endocrine pancreas. Davies SL, etal., Biochim Biophys Acta 2004 Nov 17;1667(1):7-14.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. Gillen CM, etal., J Biol Chem 1996 Jul 5;271(27):16237-44.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. Payne JA, etal., J Biol Chem 1996 Jul 5;271(27):16245-52.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10564083   PMID:15094054   PMID:15356206   PMID:17897319   PMID:21112289   PMID:24393035  


Genomics

Comparative Map Data
Slc12a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,748,268 - 50,770,217 (-)NCBIGRCr8
mRatBN7.21933,838,418 - 33,860,369 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,838,419 - 33,860,331 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,653,965 - 40,675,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,307,280 - 41,329,122 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,605,822 - 43,627,712 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,917,003 - 37,938,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,917,014 - 37,938,857 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,784,035 - 48,805,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,785,181 - 35,807,024 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,790,067 - 35,811,905 (-)NCBI
Celera1933,265,978 - 33,287,821 (-)NCBICelera
Cytogenetic Map19q12NCBI
SLC12A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,943,474 - 67,968,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,943,474 - 67,969,601 (-)EnsemblGRCh38hg38GRCh38
GRCh371667,977,377 - 68,002,597 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,535,731 - 66,560,026 (-)NCBINCBI36Build 36hg18NCBI36
Build 341666,535,730 - 66,560,026NCBI
Celera1652,485,834 - 52,511,054 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,850,947 - 53,876,165 (-)NCBIHuRef
CHM1_11669,385,448 - 69,410,667 (-)NCBICHM1_1
T2T-CHM13v2.01673,739,247 - 73,764,467 (-)NCBIT2T-CHM13v2.0
Slc12a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,670,222 - 106,692,781 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,670,222 - 106,692,729 (-)EnsemblGRCm39 Ensembl
GRCm388105,943,590 - 105,966,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,943,590 - 105,966,097 (-)EnsemblGRCm38mm10GRCm38
MGSCv378108,467,493 - 108,489,939 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,832,722 - 108,855,168 (-)NCBIMGSCv36mm8
Celera8110,171,642 - 110,194,085 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.06NCBI
Slc12a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,749,194 - 8,772,599 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,749,194 - 8,772,599 (+)NCBIChiLan1.0ChiLan1.0
SLC12A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,470,550 - 77,494,899 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,381,969 - 83,406,307 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,285,265 - 48,309,614 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,673,087 - 67,698,223 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,673,087 - 67,697,280 (-)Ensemblpanpan1.1panPan2
SLC12A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,533,491 - 81,555,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,533,470 - 81,559,313 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,523,512 - 81,545,458 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0581,968,814 - 81,991,227 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,968,753 - 81,994,636 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,795,063 - 81,817,008 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,477,196 - 81,499,140 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,119,391 - 82,141,353 (+)NCBIUU_Cfam_GSD_1.0
Slc12a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,269,207 - 41,291,720 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,297,394 - 18,321,892 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,297,394 - 18,319,191 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,553,616 - 28,576,504 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,554,162 - 28,576,458 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,043,412 - 26,056,523 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC12A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,472,831 - 59,495,690 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,472,874 - 59,495,669 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,198,442 - 22,221,522 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,414,520 - 18,441,806 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474618,414,589 - 18,438,278 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc12a4
120 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:70
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000026730
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat

Markers in Region
RH134132  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,838,472 - 33,838,676 (+)MAPPERmRatBN7.2
Rnor_6.01937,917,058 - 37,917,261NCBIRnor6.0
Rnor_5.01948,784,089 - 48,784,292UniSTSRnor5.0
RGSC_v3.41935,785,225 - 35,785,428UniSTSRGSC3.4
Celera1933,266,022 - 33,266,225UniSTS
RH 3.4 Map19317.4UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026730   ⟹   ENSRNOP00000026730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,838,419 - 33,860,331 (-)Ensembl
Rnor_6.0 Ensembl1937,917,014 - 37,938,857 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095105   ⟹   ENSRNOP00000078286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,838,419 - 33,858,763 (-)Ensembl
RefSeq Acc Id: NM_019229   ⟹   NP_062102
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,748,279 - 50,770,122 (-)NCBI
mRatBN7.21933,838,429 - 33,860,273 (-)NCBI
Rnor_6.01937,917,014 - 37,938,857 (-)NCBI
Rnor_5.01948,784,035 - 48,805,888 (-)NCBI
RGSC_v3.41935,785,181 - 35,807,024 (-)RGD
Celera1933,265,978 - 33,287,821 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255482   ⟹   XP_006255544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,748,268 - 50,768,510 (-)NCBI
mRatBN7.21933,838,418 - 33,860,123 (-)NCBI
Rnor_6.01937,917,003 - 37,938,725 (-)NCBI
Rnor_5.01948,784,035 - 48,805,888 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772492   ⟹   XP_008770714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,748,268 - 50,770,217 (-)NCBI
mRatBN7.21933,838,419 - 33,860,368 (-)NCBI
Rnor_6.01937,917,003 - 37,938,952 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097677   ⟹   XP_038953605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,754,070 - 50,770,216 (-)NCBI
mRatBN7.21933,844,221 - 33,860,369 (-)NCBI
RefSeq Acc Id: NP_062102   ⟸   NM_019229
- UniProtKB: Q63632 (UniProtKB/Swiss-Prot),   P70632 (UniProtKB/Swiss-Prot),   A6IYV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255544   ⟸   XM_006255482
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZKL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770714   ⟸   XM_008772492
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000026730   ⟸   ENSRNOT00000026730
RefSeq Acc Id: XP_038953605   ⟸   XM_039097677
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000078286   ⟸   ENSRNOT00000095105
Protein Domains
Amino acid permease/ SLC12A   SLC12A transporter C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63632-F1-model_v2 AlphaFold Q63632 1-1085 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701096
Promoter ID:EPDNEW_R11620
Type:initiation region
Name:Slc12a4_1
Description:solute carrier family 12 member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01937,938,915 - 37,938,975EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3687 AgrOrtholog
BioCyc Gene G2FUF-5798 BioCyc
Ensembl Genes ENSRNOG00000019651 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026730.5 UniProtKB/Swiss-Prot
  ENSRNOT00000095105.1 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA-permease/SLC12A_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCL_cotranspt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12A_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29501 ENTREZGENE
PANTHER PTHR11827 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11827:SF46 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc12a4 PhenoGen
PRINTS KCLTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCLTRNSPORT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019651 RatGTEx
  ENSRNOG00055018092 RatGTEx
  ENSRNOG00060012273 RatGTEx
  ENSRNOG00065012060 RatGTEx
UniProt A0A8I5ZKL7 ENTREZGENE, UniProtKB/TrEMBL
  A6IYV0 ENTREZGENE, UniProtKB/TrEMBL
  P70632 ENTREZGENE
  Q63632 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P70632 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc12a4  solute carrier family 12 member 4  Slc12a4  solute carrier family 12 (potassium/chloride transporter), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc12a4  solute carrier family 12 (potassium/chloride transporter), member 4  Slc12a4  solute carrier family 12 (potassium/chloride transporters), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc12a4  solute carrier family 12 (potassium/chloride transporters), member 4  Slc12a4  solute carrier family 12, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Slc12a4  solute carrier family 12, member 4      Name updated 70584 APPROVED