Cnep1r1 (CTD nuclear envelope phosphatase 1 regulatory subunit 1) - Rat Genome Database

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Gene: Cnep1r1 (CTD nuclear envelope phosphatase 1 regulatory subunit 1) Rattus norvegicus
Analyze
Symbol: Cnep1r1
Name: CTD nuclear envelope phosphatase 1 regulatory subunit 1
RGD ID: 1308816
Description: Predicted to be involved in positive regulation of protein dephosphorylation; positive regulation of triglyceride biosynthetic process; and protein localization to nucleus. Predicted to be located in cytosol and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Predicted to be active in cytoplasm. Orthologous to human CNEP1R1 (CTD nuclear envelope phosphatase 1 regulatory subunit 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; fipronil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291914; nuclear envelope phosphatase-regulatory subunit 1; RGD1308816; similar to CG8009-PA; Tmem188; transmembrane protein 188
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81935,106,802 - 35,121,101 (-)NCBIGRCr8
mRatBN7.21918,932,631 - 18,947,667 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,932,682 - 18,947,667 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,612,912 - 20,627,209 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01925,807,543 - 25,821,844 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01928,765,619 - 28,779,906 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01919,899,306 - 19,913,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,899,306 - 19,913,605 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,924,101 - 30,938,400 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41920,245,264 - 20,259,563 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11920,190,231 - 20,264,375 (-)NCBI
Celera1918,818,035 - 18,832,334 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22134922  


Genomics

Comparative Map Data
Cnep1r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81935,106,802 - 35,121,101 (-)NCBIGRCr8
mRatBN7.21918,932,631 - 18,947,667 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,932,682 - 18,947,667 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,612,912 - 20,627,209 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01925,807,543 - 25,821,844 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01928,765,619 - 28,779,906 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01919,899,306 - 19,913,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,899,306 - 19,913,605 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,924,101 - 30,938,400 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41920,245,264 - 20,259,563 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11920,190,231 - 20,264,375 (-)NCBI
Celera1918,818,035 - 18,832,334 (-)NCBICelera
Cytogenetic Map19p11NCBI
CNEP1R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381650,025,225 - 50,037,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1650,024,410 - 50,037,088 (+)EnsemblGRCh38hg38GRCh38
GRCh371650,059,136 - 50,070,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361648,616,690 - 48,628,500 (+)NCBINCBI36Build 36hg18NCBI36
Celera1634,572,289 - 34,584,088 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
HuRef1635,946,539 - 35,958,328 (+)NCBIHuRef
CHM1_11651,466,454 - 51,478,264 (+)NCBICHM1_1
T2T-CHM13v2.01655,822,970 - 55,834,826 (+)NCBIT2T-CHM13v2.0
Cnep1r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39888,845,344 - 88,861,825 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl888,845,397 - 88,861,738 (+)EnsemblGRCm39 Ensembl
GRCm38888,118,716 - 88,135,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,118,769 - 88,135,110 (+)EnsemblGRCm38mm10GRCm38
MGSCv37890,642,658 - 90,659,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36891,008,905 - 91,024,585 (+)NCBIMGSCv36mm8
Celera892,390,385 - 92,406,789 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map843.06NCBI
Cnep1r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554338,161,994 - 8,176,258 (+)NCBIChiLan1.0ChiLan1.0
CNEP1R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21859,482,615 - 59,494,520 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11665,387,660 - 65,399,570 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01630,288,552 - 30,300,444 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11649,172,711 - 49,184,592 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,172,711 - 49,184,592 (+)Ensemblpanpan1.1panPan2
CNEP1R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1265,236,030 - 65,252,169 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl265,237,353 - 65,252,043 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,804,304 - 61,824,834 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,777,364 - 65,797,945 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,772,031 - 65,797,930 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1262,600,139 - 62,620,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0263,619,730 - 63,640,456 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0264,508,613 - 64,529,646 (-)NCBIUU_Cfam_GSD_1.0
Cnep1r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934956,412,860 - 56,425,812 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364753,162,995 - 3,176,669 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364753,163,275 - 3,176,210 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNEP1R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,775,446 - 34,788,252 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,775,444 - 34,788,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CNEP1R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1535,827,194 - 35,838,823 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl535,827,245 - 35,840,575 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604740,672,100 - 40,683,728 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnep1r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247576,599,592 - 6,615,699 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247576,601,395 - 6,615,307 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnep1r1
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:59
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000020816
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

Markers in Region
RH143240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21918,942,530 - 18,942,655 (+)MAPPERmRatBN7.2
Rnor_6.01919,908,469 - 19,908,593NCBIRnor6.0
Rnor_5.01930,933,264 - 30,933,388UniSTSRnor5.0
RGSC_v3.41920,254,427 - 20,254,551UniSTSRGSC3.4
Celera1918,827,198 - 18,827,322UniSTS
Cytogenetic Map19p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 41 11 8
Low 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000020816   ⟹   ENSRNOP00000020816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1918,937,161 - 18,947,667 (-)Ensembl
Rnor_6.0 Ensembl1919,899,306 - 19,913,605 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099062   ⟹   ENSRNOP00000097009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1918,938,098 - 18,947,667 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102991   ⟹   ENSRNOP00000097689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1918,932,682 - 18,947,627 (-)Ensembl
RefSeq Acc Id: NM_001106173   ⟹   NP_001099643
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81935,106,802 - 35,121,101 (-)NCBI
mRatBN7.21918,933,368 - 18,947,667 (-)NCBI
Rnor_6.01919,899,306 - 19,913,605 (-)NCBI
Rnor_5.01930,924,101 - 30,938,400 (-)NCBI
RGSC_v3.41920,245,264 - 20,259,563 (-)RGD
Celera1918,818,035 - 18,832,334 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099643 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87520 (Get FASTA)   NCBI Sequence Viewer  
  EDL87521 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020816
  ENSRNOP00000020816.5
  ENSRNOP00000097009.1
  ENSRNOP00000097689.1
RefSeq Acc Id: NP_001099643   ⟸   NM_001106173
- UniProtKB: D3ZJA8 (UniProtKB/TrEMBL),   A6KDA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020816   ⟸   ENSRNOT00000020816
RefSeq Acc Id: ENSRNOP00000097689   ⟸   ENSRNOT00000102991
RefSeq Acc Id: ENSRNOP00000097009   ⟸   ENSRNOT00000099062

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJA8-F1-model_v2 AlphaFold D3ZJA8 1-125 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700981
Promoter ID:EPDNEW_R11505
Type:initiation region
Name:Cnep1r1_1
Description:CTD nuclear envelope phosphatase 1 regulatory subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01919,913,583 - 19,913,643EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308816 AgrOrtholog
BioCyc Gene G2FUF-6271 BioCyc
Ensembl Genes ENSRNOG00000015534 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020816 ENTREZGENE
  ENSRNOT00000020816.5 UniProtKB/TrEMBL
  ENSRNOT00000099062.1 UniProtKB/TrEMBL
  ENSRNOT00000102991.1 UniProtKB/TrEMBL
InterPro Transmembrane_protein_188 UniProtKB/TrEMBL
KEGG Report rno:291914 UniProtKB/TrEMBL
NCBI Gene 291914 ENTREZGENE
PANTHER NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1 UniProtKB/TrEMBL
  PTHR20996 UniProtKB/TrEMBL
Pfam Tmemb_18A UniProtKB/TrEMBL
PhenoGen Cnep1r1 PhenoGen
RatGTEx ENSRNOG00000015534 RatGTEx
UniProt A0A8I6AR79_RAT UniProtKB/TrEMBL
  A0A8I6GM63_RAT UniProtKB/TrEMBL
  A6KDA5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJA8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-16 Cnep1r1  CTD nuclear envelope phosphatase 1 regulatory subunit 1  Tmem188  transmembrane protein 188  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Tmem188  transmembrane protein 188  RGD1308816_predicted  similar to CG8009-PA (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308816_predicted  similar to CG8009-PA (predicted)  LOC291914_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291914_predicted  similar to CG8009-PA (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL