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Gene: Siah1 (siah E3 ubiquitin protein ligase 1) Rattus norvegicus
Symbol: Siah1
Name: siah E3 ubiquitin protein ligase 1
Description: Exhibits protein C-terminus binding activity and ubiquitin-protein transferase activity. Involved in neuron apoptotic process; protein destabilization; and ubiquitin-dependent protein catabolic process. Localizes to several cellular components, including cytosol; early endosome; and nucleus. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1); PARTICIPATES IN p53 signaling pathway; ubiquitin/proteasome degradation pathway; Wnt signaling pathway; INTERACTS WITH (-)-selegiline; 2,4-dinitrotoluene; 7-NITROINDAZOLE.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase SIAH1; RING-type E3 ubiquitin transferase SIAH1; seven in absentia 1A; seven in absentia homolog 1; SIAH; siah-1; siah-1a; Siah1a
Homo sapiens (human) : SIAH1 (siah E3 ubiquitin protein ligase 1)  HGNC  Alliance
Mus musculus (house mouse) : Siah1a (siah E3 ubiquitin protein ligase 1A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Siah1 (siah E3 ubiquitin protein ligase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIAH1 (siah E3 ubiquitin protein ligase 1)
Canis lupus familiaris (dog) : SIAH1 (siah E3 ubiquitin protein ligase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Siah1 (siah E3 ubiquitin protein ligase 1)
Sus scrofa (pig) : SIAH1 (siah E3 ubiquitin protein ligase 1)
Chlorocebus sabaeus (African green monkey) : SIAH1 (siah E3 ubiquitin protein ligase 1)
Heterocephalus glaber (naked mole-rat) : Siah1 (siah E3 ubiquitin protein ligase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01921,372,163 - 21,395,773 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1921,372,163 - 21,395,767 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01932,381,464 - 32,405,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41921,717,141 - 21,740,751 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11921,723,004 - 21,745,060 (+)NCBI
Celera1920,251,923 - 20,275,533 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Siah1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620449
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.