Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | affects expression | ISO | Lonp2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of LONP2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of LONP2 mRNA | CTD | PMID:17108234 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31826744 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Lonp2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of LONP2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LONP2 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Lonp2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of LONP2 mRNA | CTD | PMID:16214954 | 4,4'-sulfonyldiphenol | increases methylation | ISO | LONP2 (Homo sapiens) | 6480464 | bisphenol S results in increased methylation of LONP2 gene | CTD | PMID:31601247 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of LONP2 mRNA | CTD | PMID:31881176 | acrylamide | decreases expression | ISO | LONP2 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of LONP2 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | LONP2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of LONP2 gene | CTD | PMID:27153756 | aldrin | increases expression | ISO | Lonp2 (Mus musculus) | 6480464 | Aldrin results in increased expression of LONP2 mRNA | CTD | PMID:18579281 | aristolochic acid A | decreases expression | ISO | LONP2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of LONP2 mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | LONP2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of LONP2 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | LONP2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of LONP2 gene | CTD | PMID:25304211 | benzo[a]pyrene | multiple interactions | ISO | Lonp2 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of LONP2 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | LONP2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of LONP2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Lonp2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of LONP2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | Lonp2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of LONP2 mRNA | CTD | PMID:20127859 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | LONP2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:20018196 | benzo[e]pyrene | increases methylation | ISO | LONP2 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of LONP2 polyA tail | CTD | PMID:30157460 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LONP2 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | LONP2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of LONP2 gene | CTD | PMID:31601247 | bisphenol A | affects methylation | ISO | LONP2 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of LONP2 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of LONP2 mRNA | CTD | PMID:30816183 more ... | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of LONP2 gene | CTD | PMID:28505145 | caffeine | decreases phosphorylation | ISO | LONP2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of LONP2 protein | CTD | PMID:35688186 | carbamazepine | affects expression | ISO | LONP2 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of LONP2 mRNA | CTD | PMID:25979313 | cisplatin | increases expression | ISO | LONP2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of LONP2 mRNA | CTD | PMID:27392435 | clofibrate | multiple interactions | ISO | Lonp2 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of LONP2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LONP2 mRNA] | CTD | PMID:17585979 | clofibrate | increases expression | ISO | Lonp2 (Mus musculus) | 6480464 | Clofibrate results in increased expression of LONP2 mRNA | CTD | PMID:17585979 and PMID:23811191 | cyclosporin A | decreases expression | ISO | LONP2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of LONP2 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | Lonp2 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of LONP2 mRNA | CTD | PMID:19770486 | dorsomorphin | multiple interactions | ISO | LONP2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LONP2 mRNA | CTD | PMID:27188386 | fenthion | decreases expression | ISO | Lonp2 (Mus musculus) | 6480464 | Fenthion results in decreased expression of LONP2 mRNA | CTD | PMID:34813904 | fulvestrant | multiple interactions | ISO | LONP2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of LONP2 gene | CTD | PMID:31601247 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of LONP2 mRNA | CTD | PMID:24136188 | ivermectin | decreases expression | ISO | LONP2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of LONP2 protein | CTD | PMID:32959892 | lead(0) | affects methylation | ISO | LONP2 (Homo sapiens) | 6480464 | Lead affects the methylation of LONP2 gene | CTD | PMID:31636367 | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of LONP2 mRNA | CTD | PMID:30467583 | methapyrilene | increases methylation | ISO | LONP2 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of LONP2 polyA tail | CTD | PMID:30157460 | methidathion | affects expression | ISO | Lonp2 (Mus musculus) | 6480464 | methidathion affects the expression of LONP2 mRNA | CTD | PMID:34813904 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of LONP2 gene | CTD | PMID:35440735 | methyl methanesulfonate | increases expression | ISO | LONP2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of LONP2 mRNA | CTD | PMID:23649840 | Muraglitazar | increases expression | EXP | | 6480464 | muraglitazar results in increased expression of LONP2 mRNA | CTD | PMID:21515302 | paracetamol | affects expression | ISO | Lonp2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of LONP2 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | LONP2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of LONP2 mRNA | CTD | PMID:21420995 and PMID:29067470 | paracetamol | multiple interactions | ISO | Lonp2 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of LONP2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LONP2 mRNA] | CTD | PMID:17585979 | phenobarbital | affects expression | ISO | Lonp2 (Mus musculus) | 6480464 | Phenobarbital affects the expression of LONP2 mRNA | CTD | PMID:23091169 | phenylmercury acetate | multiple interactions | ISO | LONP2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LONP2 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | Lonp2 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LONP2 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | Lonp2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of LONP2 mRNA | CTD | PMID:17426115 more ... | propiconazole | decreases expression | ISO | Lonp2 (Mus musculus) | 6480464 | propiconazole results in decreased expression of LONP2 mRNA | CTD | PMID:21278054 | resveratrol | multiple interactions | ISO | LONP2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of LONP2 mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | LONP2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LONP2 mRNA | CTD | PMID:27188386 | sodium arsenate | increases expression | ISO | Lonp2 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of LONP2 mRNA | CTD | PMID:21795629 | sodium fluoride | decreases expression | ISO | Lonp2 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of LONP2 protein | CTD | PMID:28918527 | temozolomide | decreases expression | ISO | LONP2 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of LONP2 mRNA | CTD | PMID:31758290 | Tesaglitazar | increases expression | EXP | | 6480464 | tesaglitazar results in increased expression of LONP2 mRNA | CTD | PMID:21515302 | tetrachloromethane | decreases expression | ISO | Lonp2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of LONP2 mRNA | CTD | PMID:31919559 | thapsigargin | increases expression | EXP | | 6480464 | Thapsigargin results in increased expression of LONP2 protein | CTD | PMID:35544339 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of LONP2 mRNA | CTD | PMID:34492290 | trichostatin A | increases expression | ISO | LONP2 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of LONP2 mRNA | CTD | PMID:24935251 | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of LONP2 mRNA | CTD | PMID:21515302 | uranium atom | increases expression | ISO | LONP2 (Homo sapiens) | 6480464 | Uranium results in increased expression of LONP2 mRNA | CTD | PMID:15672453 | valproic acid | increases expression | ISO | LONP2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of LONP2 mRNA | CTD | PMID:23179753 and PMID:24935251 | valproic acid | affects expression | ISO | Lonp2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of LONP2 mRNA | CTD | PMID:17963808 | valproic acid | affects expression | ISO | LONP2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of LONP2 mRNA | CTD | PMID:25979313 | |