Lcat (lecithin cholesterol acyltransferase) - Rat Genome Database

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Gene: Lcat (lecithin cholesterol acyltransferase) Rattus norvegicus
Analyze
Symbol: Lcat
Name: lecithin cholesterol acyltransferase
RGD ID: 2993
Description: Enables phosphatidylcholine-sterol O-acyltransferase activity and phospholipase A2 activity. Involved in several processes, including aflatoxin metabolic process; cholesterol metabolic process; and response to copper ion. Predicted to be part of high-density lipoprotein particle. Predicted to be active in extracellular space. Used to study end stage renal disease; familial hyperlipidemia; and myocardial infarction. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase); PARTICIPATES IN reverse cholesterol transport pathway; glycerophospholipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-alkyl-2-acetylglycerophosphocholine esterase; Lecithin-cholesterol acyltransferase; MGC108718; PAF acetylhydrolase; phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase; platelet-activating factor acetylhydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Lcatm1Mcwi   Lcatm2Mcwi   Lcatm3Mcwi   Lcatm4Mcwi   Lcatm5Mcwi  
Genetic Models: SS-Lcatm4Mcwi SS-Lcatm5Mcwi FHH-Lcatm1Mcwi BN-Lcatm3Mcwi BN-Lcatm2Mcwi
Is Marker For: QTLs:   Insglur2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,834,748 - 33,838,214 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,834,403 - 33,838,231 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,650,291 - 40,653,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,303,606 - 41,307,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,602,142 - 43,605,607 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,913,333 - 37,916,799 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,913,336 - 37,916,813 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,780,364 - 48,783,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,781,507 - 35,784,966 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,786,383 - 35,789,855 (-)NCBI
Celera1933,262,304 - 33,265,763 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
26-hydroxycholesterol  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
alliin  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atorvastatin calcium  (EXP)
bafilomycin A1  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorogenic acid  (EXP)
cholesterol  (EXP,ISO)
cholic acid  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
dichlorine  (EXP,ISO)
dichlorvos  (ISO)
dioleoyl phosphatidylcholine  (ISO)
disodium selenite  (EXP)
doxorubicin  (ISO)
elemental selenium  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenitrothion  (ISO)
flavonoids  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
hexadecanoic acid  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
magnesium atom  (EXP)
manganese(II) chloride  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
myricetin  (EXP)
N-nitrosodiethylamine  (EXP)
naringin  (EXP)
nevirapine  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
obeticholic acid  (ISO)
omeprazole  (EXP)
orlistat  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phenytoin  (ISO)
piperine  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (EXP)
quercetin  (EXP,ISO)
resveratrol  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP)
sodium chloride  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
tetrahydrocurcumin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Reversible inhibition of LCAT by penicillins. Kinetic and mechanistic investigations. Bojesen E Scand J Clin Lab Invest Suppl. 1978;150:26-31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Compromised LCAT function is associated with increased atherosclerosis. Hovingh GK, etal., Circulation. 2005 Aug 9;112(6):879-84. Epub 2005 Aug 1.
5. Opposite regulation of hepatic lipase and lecithin: cholesterol acyltransferase by glucocorticoids in rats. Jansen H, etal., Biochim Biophys Acta. 1992 Oct 30;1128(2-3):181-5.
6. Plasma lecithin: cholesterol acyltransferase in copper-deficient rats. Lau BW and Klevay LM, J Nutr. 1981 Oct;111(10):1698-703.
7. Nucleotide sequence of the cDNA for lecithin-cholesterol acyl transferase (LCAT) from the rat. Meroni G, etal., Nucleic Acids Res 1990 Sep 11;18(17):5308.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat. Morgado N, etal., Ann Nutr Metab. 2005 Nov-Dec;49(6):397-406. Epub 2005 Oct 14.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Isolation and specificity of rat lecithin: cholesterol acyltransferase: comparison with the human enzyme using reassembled high-density lipoproteins containing ether analogs of phosphatidylcholine. Pownall HJ, etal., Biochim Biophys Acta. 1985 Mar 6;833(3):456-62.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Acute aflatoxin B1 - Induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein metabolism in rats. Rotimi OA, etal., Toxicol Rep. 2017 Jul 24;4:408-414. doi: 10.1016/j.toxrep.2017.07.006. eCollection 2017.
19. Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury. Sangeetha T and Darlin Quine S, J Pharm Pharmacol. 2006 May;58(5):617-23.
20. Endotoxin-lipoprotein complex formation as a factor in atherogenesis: associations with hyperlipidemia and with lecithin:cholesterol acyltransferase activity. Schwartz YSh and Dushkin MI, Biochemistry (Mosc). 2002 Jul;67(7):747-52.
21. ACAT inhibition reverses LCAT deficiency and improves plasma HDL in chronic renal failure. Vaziri ND and Liang K, Am J Physiol Renal Physiol. 2004 Nov;287(5):F1038-43. Epub 2004 Jul 27.
22. Cloning and in vitro expression of rat lecithin:cholesterol acyltransferase. Wang J, etal., Biochim Biophys Acta 1997 Jun 23;1346(3):207-11.
23. Poloxamer 407-mediated alterations in the activities of enzymes regulating lipid metabolism in rats. Wasan KM, etal., J Pharm Pharm Sci. 2003 May-Aug;6(2):189-97.
24. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics Zhang K, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Apr;20(2):135-7.
25. Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains. Zhao Y, etal., Biochemistry. 2003 Dec 2;42(47):13941-9.
Additional References at PubMed
PMID:1587806   PMID:3104518   PMID:3458198   PMID:4335615   PMID:8016111   PMID:9300780   PMID:10549415   PMID:10559507   PMID:10722751   PMID:11966470   PMID:12167653   PMID:12354767  
PMID:12477932   PMID:15210842   PMID:15654758   PMID:16245952   PMID:19065001   PMID:23376485   PMID:23533145   PMID:24620755   PMID:26195816  


Genomics

Comparative Map Data
Lcat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,834,748 - 33,838,214 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,834,403 - 33,838,231 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,650,291 - 40,653,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,303,606 - 41,307,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,602,142 - 43,605,607 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,913,333 - 37,916,799 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,913,336 - 37,916,813 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,780,364 - 48,783,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,781,507 - 35,784,966 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,786,383 - 35,789,855 (-)NCBI
Celera1933,262,304 - 33,265,763 (-)NCBICelera
Cytogenetic Map19q12NCBI
LCAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,939,750 - 67,944,120 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,939,750 - 67,944,131 (-)EnsemblGRCh38hg38GRCh38
GRCh371667,973,653 - 67,978,023 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,531,288 - 66,535,516 (-)NCBINCBI36Build 36hg18NCBI36
Build 341666,531,287 - 66,535,516NCBI
Celera1652,482,244 - 52,486,472 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,847,357 - 53,851,585 (-)NCBIHuRef
CHM1_11669,381,858 - 69,386,086 (-)NCBICHM1_1
T2T-CHM13v2.01673,735,523 - 73,739,893 (-)NCBIT2T-CHM13v2.0
Lcat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,666,183 - 106,670,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,666,183 - 106,670,014 (-)EnsemblGRCm39 Ensembl
GRCm388105,939,551 - 105,943,402 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,939,551 - 105,943,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv378108,463,451 - 108,467,302 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,828,681 - 108,832,511 (-)NCBIMGSCv36mm8
Celera8110,167,599 - 110,171,451 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.06NCBI
Lcat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,772,692 - 8,776,122 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,772,692 - 8,776,122 (+)NCBIChiLan1.0ChiLan1.0
LCAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11683,374,671 - 83,381,831 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,278,137 - 48,285,305 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,668,646 - 67,673,127 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,668,646 - 67,673,127 (-)Ensemblpanpan1.1panPan2
LCAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,556,047 - 81,559,313 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,545,969 - 81,549,297 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0581,991,308 - 81,994,637 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,968,753 - 81,994,636 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,817,519 - 81,820,847 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,499,651 - 81,502,979 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,141,864 - 82,145,195 (+)NCBIUU_Cfam_GSD_1.0
Lcat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,291,681 - 41,295,101 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,293,716 - 18,298,248 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647518,294,013 - 18,297,433 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LCAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,550,358 - 28,553,566 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,550,356 - 28,553,561 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LCAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,495,936 - 59,500,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,497,115 - 59,500,448 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,222,310 - 22,225,874 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lcat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,437,429 - 18,441,806 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474618,438,308 - 18,441,650 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lcat
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:55
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000026585
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
RH129859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,834,761 - 33,834,928 (+)MAPPERmRatBN7.2
Rnor_6.01937,913,347 - 37,913,513NCBIRnor6.0
Rnor_5.01948,780,378 - 48,780,544UniSTSRnor5.0
RGSC_v3.41935,781,514 - 35,781,680UniSTSRGSC3.4
Celera1933,262,311 - 33,262,477UniSTS
RH 3.4 Map19317.7UniSTS
Cytogenetic Map19q12UniSTS
RH134132  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,838,472 - 33,838,676 (+)MAPPERmRatBN7.2
Rnor_6.01937,917,058 - 37,917,261NCBIRnor6.0
Rnor_5.01948,784,089 - 48,784,292UniSTSRnor5.0
RGSC_v3.41935,785,225 - 35,785,428UniSTSRGSC3.4
Celera1933,266,022 - 33,266,225UniSTS
RH 3.4 Map19317.4UniSTS
Cytogenetic Map19q12UniSTS


Genetic Models
This gene Lcat is modified in the following models/strains:
SS-Lcatm4Mcwi     SS-Lcatm5Mcwi     FHH-Lcatm1Mcwi     BN-Lcatm3Mcwi     BN-Lcatm2Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 41 41 41 31 18 31 6
Low 3 35 16 19 8 11 43 17 10 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026585   ⟹   ENSRNOP00000026583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,834,403 - 33,838,231 (-)Ensembl
Rnor_6.0 Ensembl1937,913,336 - 37,916,813 (-)Ensembl
RefSeq Acc Id: NM_017024   ⟹   NP_058720
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,834,755 - 33,838,214 (-)NCBI
Rnor_6.01937,913,340 - 37,916,799 (-)NCBI
Rnor_5.01948,780,364 - 48,783,830 (-)NCBI
RGSC_v3.41935,781,507 - 35,784,966 (-)RGD
Celera1933,262,304 - 33,265,763 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255441   ⟹   XP_006255503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,834,748 - 33,838,046 (-)NCBI
Rnor_6.01937,913,333 - 37,916,632 (-)NCBI
Rnor_5.01948,780,364 - 48,783,830 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097472   ⟹   XP_038953400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,834,748 - 33,838,171 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_058720   ⟸   NM_017024
- Peptide Label: precursor
- UniProtKB: P18424 (UniProtKB/Swiss-Prot),   O35849 (UniProtKB/TrEMBL),   A0A8L2QED8 (UniProtKB/TrEMBL),   A6IYU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255503   ⟸   XM_006255441
- Peptide Label: isoform X2
- UniProtKB: A6IYU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026583   ⟸   ENSRNOT00000026585
RefSeq Acc Id: XP_038953400   ⟸   XM_039097472
- Peptide Label: isoform X1
- UniProtKB: A6IYU9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18424-F1-model_v2 AlphaFold P18424 1-440 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701095
Promoter ID:EPDNEW_R11619
Type:multiple initiation site
Name:Lcat_1
Description:lecithin cholesterol acyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01937,916,813 - 37,916,873EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2993 AgrOrtholog
BioCyc Gene G2FUF-5799 BioCyc
Ensembl Genes ENSRNOG00000019573 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026585 ENTREZGENE
  ENSRNOT00000026585.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7370790 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LACT/PDAT_acylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24530 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108718 IMAGE-MGC_LOAD
NCBI Gene 24530 ENTREZGENE
PANTHER LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHATIDYLCHOLINE-STEROL ACYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LCAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lcat PhenoGen
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019573 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QED8 ENTREZGENE, UniProtKB/TrEMBL
  A6IYU5_RAT UniProtKB/TrEMBL
  A6IYU6 ENTREZGENE, UniProtKB/TrEMBL
  A6IYU8_RAT UniProtKB/TrEMBL
  A6IYU9 ENTREZGENE, UniProtKB/TrEMBL
  LCAT_RAT UniProtKB/Swiss-Prot
  O35849 ENTREZGENE
  P18424 ENTREZGENE
  Q9R1M1_RAT UniProtKB/TrEMBL
UniProt Secondary O35849 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lcat  Lecithin-cholesterol acyltransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization enzyme is secreted from the cell 729077