Gene: Lcat (lecithin cholesterol acyltransferase) Rattus norvegicus
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Symbol: Lcat
Name: lecithin cholesterol acyltransferase
Description: ENCODES a protein that exhibits phosphatidylcholine-sterol O-acyltransferase activity; phospholipase A2 activity; apolipoprotein A-I binding (ortholog); INVOLVED IN cholesterol metabolic process; lipoprotein metabolic process; response to copper ion; PARTICIPATES IN reverse cholesterol transport pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH end stage renal failure; familial hyperlipidemia; myocardial infarction; FOUND IN extracellular space (ortholog); high-density lipoprotein particle (ortholog); INTERACTS WITH (+)-alpha-tocopherol; (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine
AGR Description: Exhibits phosphatidylcholine-sterol O-acyltransferase activity and phospholipase A2 activity; involved in several processes, including cholesterol metabolic process, lipoprotein metabolic process, and response to copper ion; predicted to localize to the high-density lipoprotein particle; used to study end stage renal failure, familial hyperlipidemia, and myocardial infarction; orthologous to human LCAT (lecithin-cholesterol acyltransferase).
Merged Description: Exhibits phosphatidylcholine-sterol O-acyltransferase activity and phospholipase A2 activity; involved in several processes, including cholesterol metabolic process, lipoprotein metabolic process, and response to copper ion; predicted to localize to the high-density lipoprotein particle; used to study end stage renal failure, familial hyperlipidemia, and myocardial infarction; orthologous to human LCAT (lecithin-cholesterol acyltransferase); PARTICIPATES IN reverse cholesterol transport pathway; glycerophospholipid metabolic pathway; INTERACTS WITH (+)-alpha-tocopherol; (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Lecithin-cholesterol acyltransferase; MGC108718; phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase
Orthologs:
Homo sapiens (human) : LCAT (lecithin-cholesterol acyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Lcat (lecithin cholesterol acyltransferase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lcat (lecithin-cholesterol acyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : LCAT (lecithin-cholesterol acyltransferase)
Canis lupus familiaris (dog) : LCAT (lecithin-cholesterol acyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lcat (lecithin-cholesterol acyltransferase)
Sus scrofa (pig) : LCAT (lecithin-cholesterol acyltransferase)
more info ...
Allele / Splice: Lcatm1Mcwi   Lcatm2Mcwi   Lcatm3Mcwi   Lcatm4Mcwi   Lcatm5Mcwi  
Genetic Models: FHH-Lcatm1Mcwi BN-Lcatm2Mcwi SS-Lcatm4Mcwi SS-Lcatm5Mcwi BN-Lcatm3Mcwi
Is Marker For: QTLs:   Insglur2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01937,913,333 - 37,916,799 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01948,780,364 - 48,783,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,781,507 - 35,784,966 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,786,383 - 35,789,855 (-)NCBI
Celera1933,262,304 - 33,265,763 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
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Sequence

Nucleotide Sequences
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Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
RGD Curation Notes
  
More on Lcat
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2993
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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