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Gene: Lcat (lecithin cholesterol acyltransferase) Rattus norvegicus
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Symbol: Lcat
Name: lecithin cholesterol acyltransferase
Description: Exhibits phosphatidylcholine-sterol O-acyltransferase activity and phospholipase A2 activity. Involved in several processes, including cholesterol metabolic process; response to copper ion; and response to glucocorticoid. Predicted to localize to the high-density lipoprotein particle. Used to study end stage renal failure; familial hyperlipidemia; and myocardial infarction. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase); PARTICIPATES IN reverse cholesterol transport pathway; glycerophospholipid metabolic pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-schisandrin B; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Lecithin-cholesterol acyltransferase; MGC108718; phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase
Orthologs:
Homo sapiens (human) : LCAT (lecithin-cholesterol acyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Lcat (lecithin cholesterol acyltransferase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lcat (lecithin-cholesterol acyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : LCAT (lecithin-cholesterol acyltransferase)
Canis lupus familiaris (dog) : LCAT (lecithin-cholesterol acyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lcat (lecithin-cholesterol acyltransferase)
Sus scrofa (pig) : LCAT (lecithin-cholesterol acyltransferase)
more info ...
Allele / Splice: Lcatm1Mcwi   Lcatm2Mcwi   Lcatm3Mcwi   Lcatm4Mcwi   Lcatm5Mcwi  
Genetic Models: FHH-Lcatm1Mcwi BN-Lcatm2Mcwi SS-Lcatm4Mcwi SS-Lcatm5Mcwi BN-Lcatm3Mcwi
Is Marker For: QTLs:   Insglur2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01937,913,333 - 37,916,799 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,913,336 - 37,916,813 (-)Ensembl
Rnor_5.01948,780,364 - 48,783,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,781,507 - 35,784,966 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,786,383 - 35,789,855 (-)NCBI
Celera1933,262,304 - 33,265,763 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lcat
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2993
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.