Agrp (agouti related neuropeptide) - Rat Genome Database

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Gene: Agrp (agouti related neuropeptide) Rattus norvegicus
Analyze
Symbol: Agrp
Name: agouti related neuropeptide
RGD ID: 2068
Description: Predicted to have neuropeptide hormone activity and type 1 melanocortin receptor binding activity. Involved in several processes, including adult feeding behavior; neuropeptide signaling pathway; and positive regulation of feeding behavior. Localizes to extracellular space and neuronal cell body. Biomarker of obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human AGRP (agouti related neuropeptide); PARTICIPATES IN altered melanocortin system pathway; melanocortin system pathway; obesity pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; AM-251.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Agouti (mouse) related protein; agouti related protein; agouti related protein homolog (mouse); Agouti-related protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,447,992 - 33,523,068 (-)NCBI
Rnor_6.0 Ensembl1937,526,419 - 37,528,011 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01937,525,941 - 37,584,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01948,391,845 - 48,406,659 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,386,682 - 35,388,274 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,391,672 - 35,392,244 (-)NCBI
Celera1932,876,306 - 32,877,927 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Hyperphagia  (IEP)
obesity  (IEP,ISO)
Thinness  (ISO)
type 2 diabetes mellitus  (IEP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,ISO,TAS)
Golgi lumen  (ISO)
neuronal cell body  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Argyropoulos G, etal., J Clin Endocrinol Metab. 2002 Sep;87(9):4198-202.
2. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Collden G, etal., Neuroscience. 2010 Nov 24;171(1):62-78. Epub 2010 Aug 22.
4. Creemers JW, etal., Endocrinology. 2006 Apr;147(4):1621-31. Epub 2005 Dec 29.
5. Dhillo WS, etal., Biochem Biophys Res Commun 2003 Jan 31;301(1):102-7.
6. Fraley GS and Ritter S, Endocrinology 2003 Jan;144(1):75-83.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Ghanbari-Niaki A, etal., Metabolism. 2009 Dec;58(12):1747-52. Epub 2009 Jul 25.
9. GOA data from the GO Consortium
10. Gyte A, etal., J Neuroendocrinol. 2007 Dec;19(12):941-51.
11. Katsuki A, etal., J Clin Endocrinol Metab 2001 May;86(5):1921-4.
12. Kitamura T, etal., Nat Med. 2006 May;12(5):534-40. Epub 2006 Apr 9.
13. Korner J, etal., Endocrinology 2000 Jul;141(7):2465-71.
14. Leibowitz SF, etal., Brain Res. 2005 Mar 2;1036(1-2):180-91.
15. Mayfield DK, etal., Biochem Biophys Res Commun. 2001 Sep 21;287(2):568-73.
16. MGD data from the GO Consortium
17. Mul JD, etal., Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28.
18. NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline
20. Orozco-Solis R, etal., Int J Obes (Lond). 2011 Jul;35(7):990-1000. doi: 10.1038/ijo.2010.223. Epub 2010 Nov 9.
21. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Qu SY, etal., Regul Pept. 2001 Apr 2;98(1-2):69-75.
23. RGD automated data pipeline
24. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. RGD automated import pipeline for gene-chemical interactions
26. Ross AW, etal., J Neuroendocrinol. 2009 Jul;21(7):610-9. Epub 2009 Apr 13.
27. Seeley RJ, etal., Annu Rev Nutr 2004;24:133-49.
28. Toshinai K, etal., Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E394-401. Epub 2010 Jun 15.
29. Trujillo ML, etal., Endocrinology. 2011 Apr;152(4):1355-65. Epub 2011 Feb 8.
30. Uchoa ET, etal., Neuropeptides. 2012 Mar 15.
Additional References at PubMed
PMID:9311920   PMID:12126733   PMID:12213628   PMID:12832105   PMID:12851299   PMID:14636173   PMID:15582725   PMID:15589525   PMID:15616803   PMID:15890775   PMID:15927146   PMID:16046456  
PMID:16087729   PMID:16226323   PMID:16484442   PMID:17289093   PMID:17374702   PMID:17873059   PMID:18384674   PMID:18467436   PMID:18535107   PMID:18583425   PMID:18955035   PMID:19017729  
PMID:19151514   PMID:19255506   PMID:19403567   PMID:19817504   PMID:20335227   PMID:21334429   PMID:21589937   PMID:22450045   PMID:22715380   PMID:23376485   PMID:25509169   PMID:26907996  


Genomics

Candidate Gene Status
Agrp is a candidate Gene for QTL Bw130
Comparative Map Data
Agrp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,447,992 - 33,523,068 (-)NCBI
Rnor_6.0 Ensembl1937,526,419 - 37,528,011 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01937,525,941 - 37,584,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01948,391,845 - 48,406,659 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,386,682 - 35,388,274 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,391,672 - 35,392,244 (-)NCBI
Celera1932,876,306 - 32,877,927 (-)NCBICelera
Cytogenetic Map19q12NCBI
AGRP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1667,482,571 - 67,483,547 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1667,482,571 - 67,483,813 (-)EnsemblGRCh38hg38GRCh38
GRCh381667,482,571 - 67,483,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371667,516,474 - 67,517,450 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,073,975 - 66,075,217 (-)NCBINCBI36hg18NCBI36
Build 341666,073,974 - 66,074,805NCBI
Celera1652,024,676 - 52,025,918 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,389,602 - 53,390,844 (-)NCBIHuRef
CHM1_11668,923,856 - 68,925,098 (-)NCBICHM1_1
Agrp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,293,327 - 106,306,477 (-)NCBIGRCm39mm39
GRCm39 Ensembl8106,293,330 - 106,364,025 (-)Ensembl
GRCm388105,566,695 - 105,579,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,566,698 - 105,637,393 (-)EnsemblGRCm38mm10GRCm38
MGSCv378108,090,598 - 108,092,198 (-)NCBIGRCm37mm9NCBIm37
MGSCv368108,455,827 - 108,457,427 (-)NCBImm8
Celera8109,789,930 - 109,791,530 (-)NCBICelera
Cytogenetic Map8D3NCBI
Agrp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,165,120 - 9,166,789 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554849,165,120 - 9,166,789 (+)NCBIChiLan1.0ChiLan1.0
AGRP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11667,216,008 - 67,217,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,216,008 - 67,217,258 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01647,827,532 - 47,872,727 (-)NCBIMhudiblu_PPA_v0panPan3
AGRP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,924,249 - 81,926,510 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,925,055 - 81,925,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,914,032 - 81,915,572 (+)NCBI
ROS_Cfam_1.0582,359,662 - 82,361,202 (+)NCBI
UMICH_Zoey_3.1582,185,812 - 82,187,352 (+)NCBI
UNSW_CanFamBas_1.0581,866,912 - 81,868,452 (+)NCBI
UU_Cfam_GSD_1.0582,510,362 - 82,511,902 (+)NCBI
LOC101958244
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,652,027 - 41,660,973 (+)NCBI
SpeTri2.0NW_00493647517,927,991 - 17,929,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGRP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,132,615 - 28,133,743 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,132,614 - 28,135,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,399,704 - 25,401,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233275
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,972,728 - 59,974,728 (+)NCBI
ChlSab1.1 Ensembl559,973,922 - 59,974,660 (+)Ensembl
Vero_WHO_p1.0NW_02366604722,722,627 - 22,723,740 (+)NCBI
Agrp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474618,826,206 - 18,827,453 (+)NCBI

Position Markers
RH94762  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,448,678 - 33,448,781 (+)MAPPER
Rnor_6.01937,527,106 - 37,527,208NCBIRnor6.0
Rnor_5.01948,393,005 - 48,393,107UniSTSRnor5.0
RGSC_v3.41935,387,369 - 35,387,471UniSTSRGSC3.4
Celera1932,877,022 - 32,877,124UniSTS
Cytogenetic Map19q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19138221845Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19138221845Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19138221845Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19138221845Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19104464846044648Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19195770746957707Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19243296347217667Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19243296362275575Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)19370183548701835Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)19370183548701835Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19500757143907843Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19650676160220581Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19807254547318201Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191130392747879277Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191593952838798459Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191702800352538299Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191899398262275575Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191917749562275575Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)192140778762275575Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192445572643907843Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192481825762275575Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)193119430141686140Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)193119430141686140Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)193119430141686140Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)193299439262275575Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:61
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000059628
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 20 36 25 19 25 74 30 37 7
Below cutoff 1 21 12 7 7 5 8 5 4 4 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000059628   ⟹   ENSRNOP00000056384
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1937,526,419 - 37,528,011 (-)Ensembl
RefSeq Acc Id: NM_033650   ⟹   NP_387499
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,447,992 - 33,449,584 (-)NCBI
Rnor_6.01937,526,419 - 37,528,011 (-)NCBI
Rnor_5.01948,391,845 - 48,406,659 (-)NCBI
RGSC_v3.41935,386,682 - 35,388,274 (-)RGD
Celera1932,876,306 - 32,877,927 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772474   ⟹   XP_008770696
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01937,525,941 - 37,584,875 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097498   ⟹   XP_038953426
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,447,992 - 33,481,602 (-)NCBI
RefSeq Acc Id: XM_039097499   ⟹   XP_038953427
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,448,897 - 33,523,068 (-)NCBI
RefSeq Acc Id: XM_039097500   ⟹   XP_038953428
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,447,992 - 33,523,068 (-)NCBI
RefSeq Acc Id: XR_005496618
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,507,454 - 33,523,068 (-)NCBI
Protein Sequences
Protein RefSeqs NP_387499 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953426 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953427 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953428 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF20203 (Get FASTA)   NCBI Sequence Viewer  
  EDL92383 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_387499   ⟸   NM_033650
- Peptide Label: precursor
- UniProtKB: F1MAG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770696   ⟸   XM_008772474
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000056384   ⟸   ENSRNOT00000059628
RefSeq Acc Id: XP_038953428   ⟸   XM_039097500
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953426   ⟸   XM_039097498
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953427   ⟸   XM_039097499
- Peptide Label: isoform X2
Protein Domains
Agouti

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2068 AgrOrtholog
Ensembl Genes ENSRNOG00000039001 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000056384 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059628 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 4.10.760.10 UniProtKB/TrEMBL
InterPro Agouti UniProtKB/TrEMBL
  Agouti_dom UniProtKB/TrEMBL
  Agouti_dom_sf UniProtKB/TrEMBL
KEGG Report rno:25582 UniProtKB/TrEMBL
NCBI Gene 25582 ENTREZGENE
PANTHER Agouti UniProtKB/TrEMBL
Pfam Agouti UniProtKB/TrEMBL
PhenoGen Agrp PhenoGen
PROSITE AGOUTI_2 UniProtKB/TrEMBL
SMART Agouti UniProtKB/TrEMBL
Superfamily-SCOP Agouti UniProtKB/TrEMBL
UniProt F1MAG1 ENTREZGENE, UniProtKB/TrEMBL
  Q9QXJ3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-23 Agrp  agouti related neuropeptide  Agrp  agouti related protein homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Agrp  agouti related protein homolog (mouse)  Agrp  agouti related protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Agrp  agouti related protein  Agrp  agouti related protein homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Agrp  agouti related protein homolog (mouse)  Agrp  Agouti (mouse) related protein  Name updated 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression detected in hypothalamus 632165
gene_function may interact with melanocortin receptors 632165
gene_process may play a role in appetite stimulation 632165
gene_regulation expression may be inhibited by leptin 632165
gene_regulation expression increases in response to food deprivation 632165