Agrp (agouti related neuropeptide) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Agrp (agouti related neuropeptide) Rattus norvegicus
Symbol: Agrp
Name: agouti related neuropeptide
RGD ID: 2068
Description: Predicted to enable neuropeptide hormone activity and type 1 melanocortin receptor binding activity. Involved in several processes, including adult feeding behavior; neuropeptide signaling pathway; and positive regulation of feeding behavior. Located in extracellular space and neuronal cell body. Biomarker of obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human AGRP (agouti related neuropeptide); PARTICIPATES IN altered melanocortin system pathway; melanocortin system pathway; obesity pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; AM-251.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Agouti (mouse) related protein; agouti related protein; agouti related protein homolog (mouse); Agouti-related protein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bw130
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21933,447,992 - 33,523,068 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,447,992 - 33,449,584 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,263,577 - 40,265,169 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01940,916,914 - 40,918,506 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01943,214,688 - 43,216,280 (-)NCBIRnor_WKY
Rnor_6.01937,525,941 - 37,584,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,526,419 - 37,528,011 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,391,845 - 48,406,659 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,386,682 - 35,388,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,391,672 - 35,392,244 (-)NCBI
Celera1932,876,306 - 32,877,927 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,ISO,TAS)
Golgi lumen  (ISO)
neuronal cell body  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. A polymorphism in the human agouti-related protein is associated with late-onset obesity. Argyropoulos G, etal., J Clin Endocrinol Metab. 2002 Sep;87(9):4198-202.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. P2X2 purinoreceptor protein in hypothalamic neurons associated with the regulation of food intake. Collden G, etal., Neuroscience. 2010 Nov 24;171(1):62-78. Epub 2010 Aug 22.
4. Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3. Creemers JW, etal., Endocrinology. 2006 Apr;147(4):1621-31. Epub 2005 Dec 29.
5. Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland. Dhillo WS, etal., Biochem Biophys Res Commun 2003 Jan 31;301(1):102-7.
6. Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Fraley GS and Ritter S, Endocrinology 2003 Jan;144(1):75-83.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Treadmill training enhances rat agouti-related protein in plasma and reduces ghrelin levels in plasma and soleus muscle. Ghanbari-Niaki A, etal., Metabolism. 2009 Dec;58(12):1747-52. Epub 2009 Jul 25.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats. Gyte A, etal., J Neuroendocrinol. 2007 Dec;19(12):941-51.
11. Plasma levels of agouti-related protein are increased in obese men. Katsuki A, etal., J Clin Endocrinol Metab 2001 May;86(5):1921-4.
12. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Kitamura T, etal., Nat Med. 2006 May;12(5):534-40. Epub 2006 Apr 9.
13. Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats. Korner J, etal., Endocrinology 2000 Jul;141(7):2465-71.
14. Function of neuropeptide Y and agouti-related protein at weaning: relation to corticosterone, dietary carbohydrate and body weight. Leibowitz SF, etal., Brain Res. 2005 Mar 2;1036(1-2):180-91.
15. A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes. Mayfield DK, etal., Biochem Biophys Res Commun. 2001 Sep 21;287(2):568-73.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Mul JD, etal., Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism. Orozco-Solis R, etal., Int J Obes (Lond). 2011 Jul;35(7):990-1000. doi: 10.1038/ijo.2010.223. Epub 2010 Nov 9.
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Agouti-related protein is a mediator of diabetic hyperphagia. Qu SY, etal., Regul Pept. 2001 Apr 2;98(1-2):69-75.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Divergent regulation of hypothalamic neuropeptide Y and agouti-related protein by photoperiod in F344 rats with differential food intake and growth. Ross AW, etal., J Neuroendocrinol. 2009 Jul;21(7):610-9. Epub 2009 Apr 13.
27. The critical role of the melanocortin system in the control of energy balance. Seeley RJ, etal., Annu Rev Nutr 2004;24:133-49.
28. Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus. Toshinai K, etal., Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E394-401. Epub 2010 Jun 15.
29. Hyperphagia and central mechanisms for leptin resistance during pregnancy. Trujillo ML, etal., Endocrinology. 2011 Apr;152(4):1355-65. Epub 2011 Feb 8.
30. Glucocorticoids are required for meal-induced changes in the expression of hypothalamic neuropeptides. Uchoa ET, etal., Neuropeptides. 2012 Mar 15.
Additional References at PubMed
PMID:9311920   PMID:12126733   PMID:12213628   PMID:12832105   PMID:12851299   PMID:14636173   PMID:15582725   PMID:15589525   PMID:15616803   PMID:15890775   PMID:15927146   PMID:16046456  
PMID:16087729   PMID:16226323   PMID:16484442   PMID:17289093   PMID:17374702   PMID:17873059   PMID:18384674   PMID:18467436   PMID:18535107   PMID:18583425   PMID:18955035   PMID:19017729  
PMID:19151514   PMID:19255506   PMID:19403567   PMID:19817504   PMID:20335227   PMID:21334429   PMID:21589937   PMID:22450045   PMID:22715380   PMID:23376485   PMID:25509169   PMID:26907996  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21933,447,992 - 33,523,068 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,447,992 - 33,449,584 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,263,577 - 40,265,169 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01940,916,914 - 40,918,506 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01943,214,688 - 43,216,280 (-)NCBIRnor_WKY
Rnor_6.01937,525,941 - 37,584,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,526,419 - 37,528,011 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,391,845 - 48,406,659 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,386,682 - 35,388,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,391,672 - 35,392,244 (-)NCBI
Celera1932,876,306 - 32,877,927 (-)NCBICelera
Cytogenetic Map19q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381667,482,571 - 67,483,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1667,482,571 - 67,483,547 (-)EnsemblGRCh38hg38GRCh38
GRCh371667,516,474 - 67,517,450 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,073,975 - 66,075,217 (-)NCBINCBI36Build 36hg18NCBI36
Build 341666,073,974 - 66,074,805NCBI
Celera1652,024,676 - 52,025,918 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,389,602 - 53,390,844 (-)NCBIHuRef
CHM1_11668,923,856 - 68,925,098 (-)NCBICHM1_1
T2T-CHM13v2.01673,277,343 - 73,278,319 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm398106,293,327 - 106,306,477 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,293,330 - 106,364,025 (-)EnsemblGRCm39 Ensembl
GRCm388105,566,695 - 105,579,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,566,698 - 105,637,393 (-)EnsemblGRCm38mm10GRCm38
MGSCv378108,090,598 - 108,092,198 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,455,827 - 108,457,427 (-)NCBIMGSCv36mm8
Celera8109,789,930 - 109,791,530 (-)NCBICelera
Cytogenetic Map8D3NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554849,165,120 - 9,166,789 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554849,165,120 - 9,166,789 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11667,216,008 - 67,217,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,216,008 - 67,217,258 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01647,827,532 - 47,872,727 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1581,924,249 - 81,926,510 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,925,055 - 81,925,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,914,032 - 81,915,572 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,359,662 - 82,361,202 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,360,349 - 82,361,139 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,185,812 - 82,187,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,866,912 - 81,868,452 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,510,362 - 82,511,902 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934941,652,027 - 41,660,973 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,927,985 - 17,937,147 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647517,927,991 - 17,929,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl628,132,615 - 28,134,900 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,132,614 - 28,135,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,399,704 - 25,401,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1559,972,728 - 59,974,728 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,973,922 - 59,974,660 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,722,627 - 22,723,740 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474618,826,545 - 18,827,299 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474618,826,206 - 18,827,453 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Agrp
155 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:61
Interacting mature miRNAs:62
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,448,678 - 33,448,781 (+)MAPPERmRatBN7.2
Rnor_6.01937,527,106 - 37,527,208NCBIRnor6.0
Rnor_5.01948,393,005 - 48,393,107UniSTSRnor5.0
RGSC_v3.41935,387,369 - 35,387,471UniSTSRGSC3.4
Celera1932,877,022 - 32,877,124UniSTS
Cytogenetic Map19q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 2 20 36 25 19 25 74 30 37 7
Below cutoff 1 21 12 7 7 5 8 5 4 4 5


Reference Sequences
RefSeq Acc Id: ENSRNOT00000059628   ⟹   ENSRNOP00000056384
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,447,992 - 33,449,584 (-)Ensembl
Rnor_6.0 Ensembl1937,526,419 - 37,528,011 (-)Ensembl
RefSeq Acc Id: NM_033650   ⟹   NP_387499
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,447,992 - 33,449,584 (-)NCBI
Rnor_6.01937,526,419 - 37,528,011 (-)NCBI
Rnor_5.01948,391,845 - 48,406,659 (-)NCBI
RGSC_v3.41935,386,682 - 35,388,274 (-)RGD
Celera1932,876,306 - 32,877,927 (-)RGD
RefSeq Acc Id: XM_039097498   ⟹   XP_038953426
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,447,992 - 33,481,602 (-)NCBI
RefSeq Acc Id: XM_039097499   ⟹   XP_038953427
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,448,897 - 33,523,068 (-)NCBI
RefSeq Acc Id: XM_039097500   ⟹   XP_038953428
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,447,992 - 33,523,068 (-)NCBI
RefSeq Acc Id: XR_005496618
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,507,454 - 33,523,068 (-)NCBI
Protein Sequences
Protein RefSeqs NP_387499 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953426 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953427 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953428 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF20203 (Get FASTA)   NCBI Sequence Viewer  
  EDL92383 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_387499   ⟸   NM_033650
- Peptide Label: precursor
- UniProtKB: F1MAG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056384   ⟸   ENSRNOT00000059628
RefSeq Acc Id: XP_038953428   ⟸   XM_039097500
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953426   ⟸   XM_039097498
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953427   ⟸   XM_039097499
- Peptide Label: isoform X2
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAG1-F1-model_v2 AlphaFold F1MAG1 1-129 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2068 AgrOrtholog
BioCyc Gene G2FUF-5824 BioCyc
Ensembl Genes ENSRNOG00000039001 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000056384 ENTREZGENE
  ENSRNOP00000056384.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059628 ENTREZGENE
  ENSRNOT00000059628.4 UniProtKB/TrEMBL
Gene3D-CATH 4.10.760.10 UniProtKB/TrEMBL
InterPro Agouti UniProtKB/TrEMBL
  Agouti_dom UniProtKB/TrEMBL
  Agouti_dom_sf UniProtKB/TrEMBL
KEGG Report rno:25582 UniProtKB/TrEMBL
Pfam Agouti UniProtKB/TrEMBL
PhenoGen Agrp PhenoGen
Superfamily-SCOP Agouti UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-23 Agrp  agouti related neuropeptide  Agrp  agouti related protein homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Agrp  agouti related protein homolog (mouse)  Agrp  agouti related protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Agrp  agouti related protein  Agrp  agouti related protein homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Agrp  agouti related protein homolog (mouse)  Agrp  Agouti (mouse) related protein  Name updated 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression detected in hypothalamus 632165
gene_function may interact with melanocortin receptors 632165
gene_process may play a role in appetite stimulation 632165
gene_regulation expression may be inhibited by leptin 632165
gene_regulation expression increases in response to food deprivation 632165