Thsd8 (thrombospondin type 1 domain containing 8) - Rat Genome Database

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Gene: Thsd8 (thrombospondin type 1 domain containing 8) Rattus norvegicus
Analyze
Symbol: Thsd8 (Ensembl: Rnaseh2a)
Name: thrombospondin type 1 domain containing 8 (Ensembl:ribonuclease H2, subunit A)
RGD ID: 41288257
Description: Predicted to be located in external side of plasma membrane and sperm head plasma membrane; INTERACTS WITH bisphenol A; C60 fullerene; thioacetamide.
Type: protein-coding
Previously known as: thrombospondin type-1 domain-containing protein 8
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,186,394 - 23,188,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,186,364 - 23,196,042 (+)EnsemblmRatBN7.2 Ensembl
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
Thsd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,186,394 - 23,188,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,186,364 - 23,196,042 (+)EnsemblmRatBN7.2 Ensembl
Cytogenetic Map19q11NCBI
THSD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,802,069 - 12,804,389 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,802,031 - 12,813,581 (+)EnsemblGRCh38hg38GRCh38
GRCh371912,912,883 - 12,915,203 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map19p13.13NCBI
T2T-CHM13v2.01912,926,574 - 12,928,889 (+)NCBIT2T-CHM13v2.0
Adam26a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39844,021,310 - 44,029,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl844,021,315 - 44,029,744 (-)EnsemblGRCm39 Ensembl
GRCm38843,568,273 - 43,576,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl843,568,278 - 43,576,707 (-)EnsemblGRCm38mm10GRCm38
MGSCv37844,653,627 - 44,662,061 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36845,067,090 - 45,075,483 (-)NCBIMGSCv36mm8
Celera846,254,925 - 46,263,359 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map824.02NCBI
THSD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,730,785 - 17,735,994 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,731,366 - 16,736,584 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1913,107,406 - 13,109,635 (+)Ensemblpanpan1.1panPan2
THSD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2049,224,524 - 49,227,082 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,869,308 - 49,871,867 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12049,080,437 - 49,082,993 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,506,730 - 49,509,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,749,381 - 49,751,939 (-)NCBIUU_Cfam_GSD_1.0
Thsd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,453,734 - 208,456,935 (-)NCBIHiC_Itri_2
THSD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660748,302,316 - 8,306,383 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Thsd8
3 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_039098331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000083159   ⟹   ENSRNOP00000070694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,186,364 - 23,196,042 (+)Ensembl
RefSeq Acc Id: XM_039098331   ⟹   XP_038954259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21923,186,394 - 23,188,323 (+)NCBI
Protein Sequences
Ensembl Protein ENSRNOP00000070694.2
RefSeq Acc Id: XP_038954259   ⟸   XM_039098331
Ensembl Acc Id: ENSRNOP00000070694   ⟸   ENSRNOT00000083159

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-6133 BioCyc
Ensembl Genes ENSRNOG00000003504 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083159.2 UniProtKB/TrEMBL
InterPro TSP1_rpt UniProtKB/TrEMBL
NCBI Gene Thsd8 ENTREZGENE
PhenoGen Thsd8 PhenoGen
PROSITE TSP1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003504 RatGTEx
UniProt A0A8L2R2S7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-27 Thsd8  thrombospondin type 1 domain containing 8      Symbol and Name status set to provisional 70820 PROVISIONAL