Ndufb7 (NADH:ubiquinone oxidoreductase subunit B7) - Rat Genome Database

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Gene: Ndufb7 (NADH:ubiquinone oxidoreductase subunit B7) Rattus norvegicus
Analyze
Symbol: Ndufb7
Name: NADH:ubiquinone oxidoreductase subunit B7
RGD ID: 1308550
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of mitochondrial respiratory chain complex I. Biomarker of mental depression. Orthologous to human NDUFB7 (NADH:ubiquinone oxidoreductase subunit B7); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361385; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21924,568,241 - 24,572,579 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,568,241 - 24,572,579 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1931,389,561 - 31,393,899 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01932,043,973 - 32,048,311 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01934,266,607 - 34,270,946 (-)NCBIRnor_WKY
Rnor_6.01924,701,067 - 24,705,405 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,701,049 - 24,705,405 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01935,680,097 - 35,684,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41926,259,362 - 26,263,700 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11926,264,245 - 26,268,461 (-)NCBI
Celera1924,108,863 - 24,113,201 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression. Henningsen K, etal., Mol Cell Proteomics. 2012 Jul;11(7):M111.016428. doi: 10.1074/mcp.M111.016428. Epub 2012 Feb 6.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12611891   PMID:12865426   PMID:14651853   PMID:18614015   PMID:20833797   PMID:21310150   PMID:21700703   PMID:27626371  


Genomics

Comparative Map Data
Ndufb7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21924,568,241 - 24,572,579 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,568,241 - 24,572,579 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1931,389,561 - 31,393,899 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01932,043,973 - 32,048,311 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01934,266,607 - 34,270,946 (-)NCBIRnor_WKY
Rnor_6.01924,701,067 - 24,705,405 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,701,049 - 24,705,405 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01935,680,097 - 35,684,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41926,259,362 - 26,263,700 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11926,264,245 - 26,268,461 (-)NCBI
Celera1924,108,863 - 24,113,201 (-)NCBICelera
Cytogenetic Map19q11NCBI
NDUFB7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,566,078 - 14,572,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1914,566,078 - 14,572,066 (-)EnsemblGRCh38hg38GRCh38
GRCh371914,676,890 - 14,682,878 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,537,890 - 14,543,886 (-)NCBINCBI36Build 36hg18NCBI36
Build 341914,537,890 - 14,543,886NCBI
Celera1914,568,834 - 14,574,833 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,246,376 - 14,252,432 (-)NCBIHuRef
CHM1_11914,677,719 - 14,683,723 (-)NCBICHM1_1
T2T-CHM13v2.01914,692,819 - 14,698,809 (-)NCBIT2T-CHM13v2.0
Ndufb7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,293,387 - 84,298,252 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,293,300 - 84,298,255 (+)EnsemblGRCm39 Ensembl
GRCm38883,566,758 - 83,571,623 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,566,671 - 83,571,626 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,090,657 - 86,095,522 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36886,456,863 - 86,461,728 (+)NCBIMGSCv36mm8
Celera887,856,763 - 87,857,558 (+)NCBICelera
Cytogenetic Map8C2NCBI
Ndufb7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541533,134,474 - 33,143,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541533,138,888 - 33,142,663 (-)NCBIChiLan1.0ChiLan1.0
NDUFB7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11914,972,882 - 14,978,730 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,972,882 - 14,978,730 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01914,129,123 - 14,135,129 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NDUFB7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,090,740 - 48,094,823 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,090,775 - 48,094,819 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2047,967,433 - 47,971,515 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02048,607,911 - 48,611,993 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,607,946 - 48,611,985 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12047,821,904 - 47,825,981 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,248,138 - 48,252,205 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,491,112 - 48,495,189 (+)NCBIUU_Cfam_GSD_1.0
Ndufb7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,269,964 - 207,273,697 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366593,079,365 - 3,084,788 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366593,081,009 - 3,084,737 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFB7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl264,718,906 - 64,723,627 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1264,718,892 - 64,723,631 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,191,266 - 65,191,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFB7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,225,005 - 13,230,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,225,006 - 13,230,630 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660746,424,439 - 6,430,083 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufb7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249011,668,618 - 1,672,296 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249011,668,619 - 1,672,275 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ndufb7
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:71
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000035890
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000035890   ⟹   ENSRNOP00000034511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,568,241 - 24,572,579 (-)Ensembl
Rnor_6.0 Ensembl1924,701,049 - 24,705,405 (+)Ensembl
RefSeq Acc Id: NM_001108442   ⟹   NP_001101912
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,568,241 - 24,572,579 (-)NCBI
Rnor_6.01924,701,067 - 24,705,405 (+)NCBI
Rnor_5.01935,680,097 - 35,684,435 (+)NCBI
RGSC_v3.41926,259,362 - 26,263,700 (-)RGD
Celera1924,108,863 - 24,113,201 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101912 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92270 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101912   ⟸   NM_001108442
- UniProtKB: D3ZLT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034511   ⟸   ENSRNOT00000035890

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLT1-F1-model_v2 AlphaFold D3ZLT1 1-137 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701000
Promoter ID:EPDNEW_R11523
Type:initiation region
Name:Ndufb7_1
Description:NADH:ubiquinone oxidoreductase subunit B7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01924,701,071 - 24,701,131EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308550 AgrOrtholog
BioCyc Gene G2FUF-6014 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
Ensembl Genes ENSRNOG00000028717 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034511 ENTREZGENE
  ENSRNOP00000034511.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035890 ENTREZGENE
  ENSRNOT00000035890.6 UniProtKB/TrEMBL
InterPro NADH_UbQ_OxRdtase_B18_su UniProtKB/TrEMBL
KEGG Report rno:361385 UniProtKB/TrEMBL
NCBI Gene 361385 ENTREZGENE
PANTHER NDUFB7 UniProtKB/TrEMBL
Pfam NDUF_B7 UniProtKB/TrEMBL
PhenoGen Ndufb7 PhenoGen
UniProt D3ZLT1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Ndufb7  NADH:ubiquinone oxidoreductase subunit B7  Ndufb7  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ndufb7  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7   Ndufb7_predicted  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ndufb7_predicted  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED