Smpd3 (sphingomyelin phosphodiesterase 3) - Rat Genome Database

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Gene: Smpd3 (sphingomyelin phosphodiesterase 3) Rattus norvegicus
Symbol: Smpd3
Name: sphingomyelin phosphodiesterase 3
RGD ID: 619754
Description: Predicted to enable identical protein binding activity; neutral sphingomyelin phosphodiesterase activity; and phospholipid binding activity. Involved in several processes, including positive regulation of cellular biosynthetic process; positive regulation of exosomal secretion; and positive regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in Golgi cis cisterna and plasma membrane. Predicted to be active in cytoplasm. Used to study pulmonary hypertension and transient cerebral ischemia. Biomarker of chronic obstructive pulmonary disease. Orthologous to human SMPD3 (sphingomyelin phosphodiesterase 3); PARTICIPATES IN ceramide signaling pathway; sphingolipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cca1; confluent 3Y1 cell-associated 1; confluent 3Y1 cell-associated protein 1; neutral sphingomyelin phosphodiesterase 3; neutral sphingomyelinase 2; neutral sphingomyelinase II; nSMase-2; nSMase2; sphingomyelin phosphodiesterase 3, neutral; sphingomyelin phosphodiesterase 3, neutral membrane
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21934,162,337 - 34,245,786 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,162,341 - 34,245,749 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,977,903 - 41,061,312 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,631,214 - 41,714,614 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,930,363 - 44,013,762 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,237,963 - 38,321,572 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,237,965 - 38,321,528 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,107,658 - 49,191,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,112,166 - 36,195,564 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11936,117,046 - 36,200,445 (-)NCBI
Celera1933,589,416 - 33,672,639 (-)NCBICelera
RH 3.4 Map19304.3RGD
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
caffeine  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
cholesterol  (ISO)
choline  (ISO)
chrysene  (ISO)
clothianidin  (ISO)
copper(II) sulfate  (ISO)
cyproconazole  (ISO)
daunorubicin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
diuron  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
magnesium dichloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (EXP)
nicotine  (ISO)
O-methyleugenol  (ISO)
Octicizer  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
triadimefon  (ISO)
tributyl phosphate  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
artery smooth muscle contraction  (IMP)
BMP signaling pathway  (IEA,ISO)
bone development  (ISO)
bone growth  (IEA,ISO)
bone mineralization  (IEA,ISO)
cartilage development  (ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to interleukin-1  (IEP)
cellular response to magnesium ion  (IEA,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
cellular response to peptide  (IEA,ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to redox state  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
ceramide metabolic process  (IEA,ISO)
chondrocyte development  (ISO)
chondrocyte development involved in endochondral bone morphogenesis  (IEA,ISO)
collagen metabolic process  (IEA,ISO)
dentinogenesis  (IEA,ISO)
DNA biosynthetic process  (IEA,ISO)
dopamine uptake  (IMP)
endochondral ossification  (IEA,ISO)
extracellular matrix assembly  (IEA,ISO)
G1 to G0 transition  (IEA,ISO)
hematopoietic progenitor cell differentiation  (IEA,ISO)
lung alveolus development  (IEA,ISO)
lung development  (ISO)
mitotic nuclear division  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of cytosolic calcium ion concentration  (IMP)
negative regulation of hyaluronan biosynthetic process  (IEA,ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
ossification  (ISO)
peptide hormone secretion  (IEA,ISO)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
polysaccharide transport  (IEA,ISO)
positive regulation of ceramide biosynthetic process  (IMP)
positive regulation of exosomal secretion  (IMP)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of non-canonical NF-kappaB signal transduction  (IMP)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
regulation of cartilage development  (IEA,ISO)
regulation of hyaluronan biosynthetic process  (ISO)
regulation of leukocyte migration  (IEA,ISO)
regulation of protein phosphorylation  (IEA,ISO)
respiratory system development  (ISO)
signal transduction  (ISO)
skeletal system development  (ISO)
sphingolipid mediated signaling pathway  (IEA,ISO)
sphingolipid metabolic process  (ISO)
sphingomyelin catabolic process  (IEA,ISO)
sphingomyelin metabolic process  (IBA,IEA,ISO,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. Bang C, etal., J Clin Invest. 2014 May;124(5):2136-46. doi: 10.1172/JCI70577. Epub 2014 Apr 17.
2. Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction. Cogolludo A, etal., Cardiovasc Res. 2009 May 1;82(2):296-302. doi: 10.1093/cvr/cvn349. Epub 2008 Dec 16.
3. Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: implication for sensitivity to stress and inflammation. Crivello NA, etal., Neurochem Int. 2005 Dec;47(8):573-9. Epub 2005 Sep 2.
4. Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury. Filosto S, etal., Am J Respir Cell Mol Biol. 2011 Mar;44(3):350-60. doi: 10.1165/rcmb.2009-0422OC. Epub 2010 May 6.
5. Complementary nucleotide sequence for monitor peptide, a novel cholecystokinin-releasing peptide in the rat. Fukuoka SI and Scheele G, Nucleic Acids Res 1989 Dec 11;17(23):10111.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi. Gu L, etal., J Neuroinflammation. 2013 Sep 3;10:109. doi: 10.1186/1742-2094-10-109.
9. cca1 is required for formation of growth-arrested confluent monolayer of rat 3Y1 cells. Hayashi Y, etal., J Biol Chem 1997 Jul 18;272(29):18082-6.
10. Neutral sphingomyelinase 2 induces dopamine uptake through regulation of intracellular calcium. Kim SK, etal., Cell Signal. 2010 May;22(5):865-70. doi: 10.1016/j.cellsig.2010.01.012. Epub 2010 Jan 21.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation. Rutkute K, etal., J Lipid Res. 2007 Nov;48(11):2443-52. Epub 2007 Aug 10.
20. The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase. Won JS, etal., J Neurochem. 2004 Feb;88(3):583-93.
Additional References at PubMed
PMID:10823942   PMID:15059969   PMID:15764706   PMID:16025116   PMID:17561096   PMID:17591962   PMID:17626887   PMID:19476542   PMID:20352118   PMID:21708940   PMID:21788370   PMID:22383528  
PMID:22871113   PMID:22910579   PMID:22945695   PMID:23046545   PMID:23651497   PMID:23973266   PMID:24029230   PMID:24505141   PMID:24585429   PMID:25287744   PMID:27325675   PMID:28377412  
PMID:29043558   PMID:29867196   PMID:34089907  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21934,162,337 - 34,245,786 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,162,341 - 34,245,749 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,977,903 - 41,061,312 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,631,214 - 41,714,614 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,930,363 - 44,013,762 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,237,963 - 38,321,572 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,237,965 - 38,321,528 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,107,658 - 49,191,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,112,166 - 36,195,564 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11936,117,046 - 36,200,445 (-)NCBI
Celera1933,589,416 - 33,672,639 (-)NCBICelera
RH 3.4 Map19304.3RGD
Cytogenetic Map19q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381668,358,327 - 68,448,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1668,358,327 - 68,448,508 (-)EnsemblGRCh38hg38GRCh38
GRCh371668,392,230 - 68,482,411 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,949,731 - 67,039,905 (-)NCBINCBI36Build 36hg18NCBI36
Build 341666,949,732 - 67,039,905NCBI
Celera1652,900,779 - 52,990,952 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1654,265,453 - 54,355,875 (-)NCBIHuRef
CHM1_11669,800,294 - 69,890,458 (-)NCBICHM1_1
T2T-CHM13v2.01674,154,167 - 74,244,330 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm398106,979,180 - 107,064,597 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,979,180 - 107,064,620 (-)EnsemblGRCm39 Ensembl
GRCm388106,252,548 - 106,337,965 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,252,548 - 106,337,988 (-)EnsemblGRCm38mm10GRCm38
MGSCv378108,776,448 - 108,861,888 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368109,141,677 - 109,227,117 (-)NCBIMGSCv36mm8
Celera8110,480,448 - 110,565,952 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.12NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554848,272,572 - 8,298,144 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,207,686 - 8,298,164 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11683,816,346 - 83,906,775 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,734,664 - 48,825,241 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11668,129,034 - 68,219,625 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1668,131,905 - 68,142,871 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1581,089,657 - 81,172,173 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,142,888 - 81,172,189 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,080,156 - 81,162,625 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0581,524,565 - 81,607,194 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,553,588 - 81,606,670 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,351,425 - 81,433,990 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,034,510 - 81,116,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,675,446 - 81,757,898 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934940,833,996 - 40,920,586 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,671,428 - 18,755,208 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,667,563 - 18,755,132 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl628,938,290 - 29,025,357 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,938,287 - 29,025,397 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,117,915 - 26,204,889 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1558,965,965 - 59,057,823 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,029,093 - 59,059,577 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604721,702,920 - 21,795,181 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474617,920,835 - 17,948,468 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474617,857,779 - 17,948,469 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Smpd3
170 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1298
Count of miRNA genes:288
Interacting mature miRNAs:348
Transcripts:ENSRNOT00000000274, ENSRNOT00000031977
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,205,359 - 34,205,608 (+)MAPPERmRatBN7.2
Rnor_6.01938,280,979 - 38,281,227NCBIRnor6.0
Rnor_5.01949,150,672 - 49,150,920UniSTSRnor5.0
RGSC_v3.41936,155,176 - 36,155,425RGDRGSC3.4
RGSC_v3.41936,155,177 - 36,155,425UniSTSRGSC3.4
RGSC_v3.11936,160,058 - 36,160,306RGD
Celera1933,632,282 - 33,632,530UniSTS
RH 3.4 Map19322.2UniSTS
RH 3.4 Map19322.2RGD
RH 2.0 Map19433.5RGD
Cytogenetic Map19q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,205,436 - 34,205,661 (+)MAPPERmRatBN7.2
Rnor_6.01938,281,056 - 38,281,280NCBIRnor6.0
Rnor_5.01949,150,749 - 49,150,973UniSTSRnor5.0
RGSC_v3.41936,155,253 - 36,155,478RGDRGSC3.4
RGSC_v3.41936,155,254 - 36,155,478UniSTSRGSC3.4
RGSC_v3.11936,160,135 - 36,160,359RGD
Celera1933,632,359 - 33,632,583UniSTS
RH 3.4 Map19316.9UniSTS
RH 3.4 Map19316.9RGD
RH 2.0 Map19438.3RGD
Cytogenetic Map19q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,162,184 - 34,162,381 (+)MAPPERmRatBN7.2
Rnor_6.01938,237,809 - 38,238,005NCBIRnor6.0
Rnor_5.01949,107,502 - 49,107,698UniSTSRnor5.0
RGSC_v3.41936,112,010 - 36,112,206UniSTSRGSC3.4
Celera1933,589,260 - 33,589,456UniSTS
RH 3.4 Map19304.6UniSTS
Cytogenetic Map19q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,165,117 - 34,165,442 (+)MAPPERmRatBN7.2
Rnor_6.01938,240,742 - 38,241,066NCBIRnor6.0
Rnor_5.01949,110,435 - 49,110,759UniSTSRnor5.0
RGSC_v3.41936,114,943 - 36,115,267UniSTSRGSC3.4
Celera1933,592,193 - 33,592,517UniSTS
RH 3.4 Map19304.3UniSTS
Cytogenetic Map19q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,164,511 - 34,165,050 (+)MAPPERmRatBN7.2
Rnor_6.01938,240,136 - 38,240,674NCBIRnor6.0
Rnor_5.01949,109,829 - 49,110,367UniSTSRnor5.0
RGSC_v3.41936,114,337 - 36,114,875UniSTSRGSC3.4
Celera1933,591,587 - 33,592,125UniSTS
Cytogenetic Map19q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map19304.3UniSTS
Cytogenetic Map19q12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 68 2
Low 21 37 21 19 21 8 11 6 17 35 11 8
Below cutoff 12 20 20 20 18 4


RefSeq Acc Id: ENSRNOT00000031977   ⟹   ENSRNOP00000030458
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,162,341 - 34,245,749 (-)Ensembl
Rnor_6.0 Ensembl1938,237,965 - 38,321,528 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097806   ⟹   ENSRNOP00000096473
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,162,341 - 34,175,864 (-)Ensembl
RefSeq Acc Id: NM_053605   ⟹   NP_446057
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21934,162,339 - 34,245,749 (-)NCBI
Rnor_6.01938,237,965 - 38,321,528 (-)NCBI
Rnor_5.01949,107,658 - 49,191,221 (-)NCBI
RGSC_v3.41936,112,166 - 36,195,564 (-)RGD
Celera1933,589,416 - 33,672,639 (-)RGD
RefSeq Acc Id: XM_006255543   ⟹   XP_006255605
Rat AssemblyChrPosition (strand)Source
mRatBN7.21934,162,337 - 34,245,786 (-)NCBI
Rnor_6.01938,237,963 - 38,321,572 (-)NCBI
Rnor_5.01949,107,658 - 49,191,221 (-)NCBI
RefSeq Acc Id: XM_017601396   ⟹   XP_017456885
Rat AssemblyChrPosition (strand)Source
mRatBN7.21934,162,337 - 34,188,352 (-)NCBI
Rnor_6.01938,237,963 - 38,265,752 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446057 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255605 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456885 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA22932 (Get FASTA)   NCBI Sequence Viewer  
  EDL92444 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030458
GenBank Protein O35049 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446057   ⟸   NM_053605
- UniProtKB: O35049 (UniProtKB/Swiss-Prot),   D4A8L3 (UniProtKB/TrEMBL),   A6IYW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255605   ⟸   XM_006255543
- Peptide Label: isoform X1
- UniProtKB: O35049 (UniProtKB/Swiss-Prot),   D4A8L3 (UniProtKB/TrEMBL),   A6IYW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456885   ⟸   XM_017601396
- Peptide Label: isoform X1
- UniProtKB: O35049 (UniProtKB/Swiss-Prot),   D4A8L3 (UniProtKB/TrEMBL),   A6IYW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030458   ⟸   ENSRNOT00000031977
RefSeq Acc Id: ENSRNOP00000096473   ⟸   ENSRNOT00000097806
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35049-F1-model_v2 AlphaFold O35049 1-655 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701108
Promoter ID:EPDNEW_R11631
Type:multiple initiation site
Description:sphingomyelin phosphodiesterase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01938,321,524 - 38,321,584EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619754 AgrOrtholog
BioCyc Gene G2FUF-5782 BioCyc
BioCyc Pathway PWY3DJ-11281 [sphingomyelin metabolism] BioCyc
BioCyc Pathway Image PWY3DJ-11281 BioCyc
Ensembl Genes ENSRNOG00000000257 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031977 ENTREZGENE
  ENSRNOT00000031977.5 UniProtKB/TrEMBL
  ENSRNOT00000097806.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sph/SMPD2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sphingomyelinase/PLipase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:94338 UniProtKB/Swiss-Prot
Pfam Exo_endo_phos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smpd3 PhenoGen
RatGTEx ENSRNOG00000000257 RatGTEx
Superfamily-SCOP SSF56219 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Smpd3  sphingomyelin phosphodiesterase 3  Smpd3  sphingomyelin phosphodiesterase 3, neutral membrane  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-01-19 Smpd3  sphingomyelin phosphodiesterase 3, neutral membrane  Smpd3  sphingomyelin phosphodiesterase 3, neutral  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Smpd3  sphingomyelin phosphodiesterase 3, neutral      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Smpd3  sphingomyelin phosphodiesterase 3, neutral      Symbol and Name status set to provisional 70820 PROVISIONAL