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Gene: Smpd3 (sphingomyelin phosphodiesterase 3) Rattus norvegicus
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Symbol: Smpd3
Name: sphingomyelin phosphodiesterase 3
Description: Predicted to have neutral sphingomyelin phosphodiesterase activity. Involved in several processes, including aging; positive regulation of cellular biosynthetic process; and positive regulation of exosomal secretion. Localizes to the cytoplasm and membrane. Used to study pulmonary hypertension and transient cerebral ischemia. Biomarker of chronic obstructive pulmonary disease. Orthologous to human SMPD3 (sphingomyelin phosphodiesterase 3); PARTICIPATES IN ceramide signaling pathway; sphingolipid metabolic pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cca1; confluent 3Y1 cell-associated 1; confluent 3Y1 cell-associated protein 1; neutral sphingomyelin phosphodiesterase 3; neutral sphingomyelinase 2; neutral sphingomyelinase II; nSMase-2; nSMase2; sphingomyelin phosphodiesterase 3, neutral; sphingomyelin phosphodiesterase 3, neutral membrane
Orthologs:
Homo sapiens (human) : SMPD3 (sphingomyelin phosphodiesterase 3)  HGNC  Alliance
Mus musculus (house mouse) : Smpd3 (sphingomyelin phosphodiesterase 3, neutral)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smpd3 (sphingomyelin phosphodiesterase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SMPD3 (sphingomyelin phosphodiesterase 3)
Canis lupus familiaris (dog) : SMPD3 (sphingomyelin phosphodiesterase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smpd3 (sphingomyelin phosphodiesterase 3)
Sus scrofa (pig) : SMPD3 (sphingomyelin phosphodiesterase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01938,237,963 - 38,321,572 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01949,107,658 - 49,191,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,112,166 - 36,195,564 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11936,117,046 - 36,200,445 (-)NCBI
Celera1933,589,416 - 33,672,639 (-)NCBICelera
Cytogenetic Map19q12NCBI
RH 3.4 Map19304.3RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Smpd3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619754
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.