Fhod1 (formin homology 2 domain containing 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Fhod1 (formin homology 2 domain containing 1) Rattus norvegicus
Analyze
Symbol: Fhod1
Name: formin homology 2 domain containing 1
RGD ID: 1589776
Description: Predicted to enable identical protein binding activity; protein domain specific binding activity; and protein self-association. Predicted to be involved in positive regulation of stress fiber assembly and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within establishment of centrosome localization and nuclear migration. Predicted to be located in cytosol; intercalated disc; and nucleoplasm. Predicted to colocalize with stress fiber. Orthologous to human FHOD1 (formin homology 2 domain containing 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FH1/FH2 domain-containing protein 1; LOC291964; similar to FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,206,492 - 33,225,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,206,492 - 33,225,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,022,100 - 40,041,009 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,675,425 - 40,694,335 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01942,964,310 - 42,983,325 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,284,923 - 37,303,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,284,923 - 37,303,788 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,150,419 - 48,169,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,144,278 - 35,163,130 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1932,635,094 - 32,653,786 (-)NCBICelera
Cytogenetic Map19q11-q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytoskeleton  (IBA)
cytosol  (IEA,ISO)
intercalated disc  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)
stress fiber  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7988697   PMID:15095401   PMID:15642356   PMID:16361249   PMID:18239683   PMID:18786395   PMID:19946888   PMID:24880667   PMID:25125170   PMID:25555464   PMID:37482037  


Genomics

Comparative Map Data
Fhod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,206,492 - 33,225,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,206,492 - 33,225,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,022,100 - 40,041,009 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,675,425 - 40,694,335 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01942,964,310 - 42,983,325 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,284,923 - 37,303,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,284,923 - 37,303,788 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,150,419 - 48,169,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,144,278 - 35,163,130 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1932,635,094 - 32,653,786 (-)NCBICelera
Cytogenetic Map19q11-q12NCBI
FHOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,229,389 - 67,247,481 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,229,387 - 67,247,481 (-)EnsemblGRCh38hg38GRCh38
GRCh371667,263,292 - 67,281,384 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,820,793 - 65,838,926 (-)NCBINCBI36Build 36hg18NCBI36
Build 341665,820,794 - 65,838,832NCBI
Celera1651,771,526 - 51,789,659 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,136,470 - 53,154,499 (-)NCBIHuRef
CHM1_11668,670,620 - 68,688,753 (-)NCBICHM1_1
T2T-CHM13v2.01673,023,673 - 73,041,798 (-)NCBIT2T-CHM13v2.0
Fhod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,055,792 - 106,074,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,055,795 - 106,074,585 (-)EnsemblGRCm39 Ensembl
GRCm388105,329,160 - 105,348,062 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,329,163 - 105,347,953 (-)EnsemblGRCm38mm10GRCm38
MGSCv378107,853,060 - 107,871,870 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,218,294 - 108,237,060 (-)NCBIMGSCv36mm8
Celera8109,552,309 - 109,571,118 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Fhod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,380,216 - 9,396,202 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554849,380,202 - 9,396,400 (+)NCBIChiLan1.0ChiLan1.0
FHOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11682,671,593 - 82,689,704 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01647,574,949 - 47,593,022 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11666,963,790 - 66,981,890 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1666,963,790 - 66,981,896 (-)Ensemblpanpan1.1panPan2
FHOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1582,129,846 - 82,145,605 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl582,129,965 - 82,145,604 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha582,119,368 - 82,135,124 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,565,040 - 82,580,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,565,051 - 82,580,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,391,138 - 82,406,892 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0582,076,692 - 82,092,442 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,715,958 - 82,731,714 (+)NCBIUU_Cfam_GSD_1.0
Fhod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,879,091 - 41,894,849 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,694,240 - 17,709,985 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647517,694,265 - 17,709,984 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl627,867,502 - 27,883,079 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1627,867,499 - 27,883,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,107,426 - 25,111,432 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FHOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,207,972 - 60,227,032 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl560,208,109 - 60,229,272 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,960,229 - 22,979,001 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fhod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474619,074,290 - 19,090,337 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474619,072,775 - 19,090,561 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fhod1
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:44
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000021935
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 21 21 6 19 6 4 7 14 30 33 11 4
Low 22 36 35 35 4 4 60 5 8 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000084734   ⟹   ENSRNOP00000070898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,206,492 - 33,225,356 (-)Ensembl
Rnor_6.0 Ensembl1937,284,923 - 37,303,788 (-)Ensembl
RefSeq Acc Id: NM_001395129   ⟹   NP_001382058
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,206,492 - 33,225,406 (-)NCBI
RefSeq Acc Id: XM_008772483   ⟹   XP_008770705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,206,492 - 33,225,445 (-)NCBI
Rnor_6.01937,284,923 - 37,303,855 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097608   ⟹   XP_038953536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,206,492 - 33,224,948 (-)NCBI
RefSeq Acc Id: XM_039097609   ⟹   XP_038953537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,208,651 - 33,225,448 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001382058 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770705 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953536 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953537 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92372 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070898
  ENSRNOP00000070898.2
RefSeq Acc Id: XP_008770705   ⟸   XM_008772483
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000070898   ⟸   ENSRNOT00000084734
RefSeq Acc Id: XP_038953536   ⟸   XM_039097608
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953537   ⟸   XM_039097609
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001382058   ⟸   NM_001395129
- UniProtKB: A0A0G2JZ38 (UniProtKB/TrEMBL)
Protein Domains
FH2   GBD/FH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZ38-F1-model_v2 AlphaFold A0A0G2JZ38 1-1158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701074
Promoter ID:EPDNEW_R11597
Type:multiple initiation site
Name:Fhod1_1
Description:formin homology 2 domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01937,303,838 - 37,303,898EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589776 AgrOrtholog
BioCyc Gene G2FUF-5835 BioCyc
Ensembl Genes ENSRNOG00000054625 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084734 ENTREZGENE
  ENSRNOT00000084734.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.2220 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  FH2_actin-bd UniProtKB/TrEMBL
  FH2_Formin_sf UniProtKB/TrEMBL
  FHOD1_GBD_N UniProtKB/TrEMBL
  GTPase-bd/formin_homology_3 UniProtKB/TrEMBL
NCBI Gene 291964 ENTREZGENE
PANTHER FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I UniProtKB/TrEMBL
  PTHR45920:SF2 UniProtKB/TrEMBL
Pfam FH2 UniProtKB/TrEMBL
  Formin_GBD_N UniProtKB/TrEMBL
PhenoGen Fhod1 PhenoGen
PROSITE FH2 UniProtKB/TrEMBL
  GBD_FH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054625 RatGTEx
SMART FH2 UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Formin homology 2 domain (FH2 domain) UniProtKB/TrEMBL
UniProt A0A0G2JZ38 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Fhod1  formin homology 2 domain containing 1  LOC291964  similar to FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC291964  similar to FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1)      Symbol and Name status set to provisional 70820 PROVISIONAL