Ucp1 (uncoupling protein 1) - Rat Genome Database

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Gene: Ucp1 (uncoupling protein 1) Rattus norvegicus
Symbol: Ucp1
Name: uncoupling protein 1
RGD ID: 3931
Description: Enables GDP binding activity; GTP binding activity; and oxidative phosphorylation uncoupler activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to lipid; and proton transmembrane transport. Located in mitochondrion. Biomarker of prediabetes syndrome. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; Huntington's disease pathway; INTERACTS WITH (+)-taxifolin; (R)-noradrenaline; (S)-naringenin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100909612; MGC108736; mitochondrial brown fat uncoupling protein 1; mitochondrial brown fat uncoupling protein 1-like; solute carrier family 25 member 7; thermogenin; Ucp; UCP 1; Ucpa; Uncoupling protein; uncoupling protein 1 (mitochondrial, proton carrier); uncoupling protein 1 mitochondrial; uncoupling protein 1, mitochondrial; Uncp
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21924,808,782 - 24,816,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,808,783 - 24,816,852 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1931,627,843 - 31,635,958 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01932,282,249 - 32,290,366 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,500,303 - 34,508,418 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,456,976 - 24,464,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,456,976 - 24,464,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01935,434,980 - 35,442,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41926,527,548 - 26,535,621 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11926,532,373 - 26,540,447 (-)NCBI
Celera1924,348,444 - 24,356,517 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(R)-noradrenaline  (EXP,ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,4-dinitrophenol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
9-cis-retinoic acid  (EXP,ISO)
abacavir  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
Amibegron  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (EXP)
Butylbenzyl phthalate  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
clenbuterol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
cortisol  (ISO)
curcumin  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (ISO)
D-glucose  (EXP,ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
enniatin  (ISO)
ethylparaben  (ISO)
flavonoids  (EXP)
fonofos  (ISO)
fructose  (EXP)
Ganoderic acid A  (ISO)
Geniposide  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
harmine  (ISO)
hexadecanoic acid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (ISO)
indometacin  (ISO)
Iopanoic acid  (EXP)
isoprenaline  (EXP)
kaempferol  (EXP)
Licarin A  (ISO)
Liensinine  (ISO)
LY294002  (EXP)
mangiferin  (ISO)
mercury dichloride  (EXP)
methimazole  (EXP)
methoprene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
nevirapine  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
ochratoxin A  (ISO)
olanzapine  (EXP)
orlistat  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
parathion  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
Prenalterol  (ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
ruxolitinib  (ISO)
selumetinib  (ISO)
sodium arsenite  (ISO)
stavudine  (ISO)
superoxide  (EXP)
T-2 toxin  (EXP)
telmisartan  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. The gene for rat uncoupling protein: complete sequence, structure of primary transcript and evolutionary relationship between exons. Bouillaud F, etal., Biochem Biophys Res Commun 1988 Dec 15;157(2):783-92.
2. Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein. Bouillaud F, etal., J Biol Chem 1986 Feb 5;261(4):1487-90.
3. Central stimulatory effect of leptin on T3 production is mediated by brown adipose tissue type II deiodinase. Cettour-Rose P, etal., Am J Physiol Endocrinol Metab 2002 Nov;283(5):E980-7.
4. Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity. Clement K, etal., Int J Obes Relat Metab Disord. 1996 Dec;20(12):1062-6.
5. Cellular stress response, sirtuins and UCP proteins in Alzheimer disease: role of vitagenes. Cornelius C, etal., Immun Ageing. 2013 Oct 17;10(1):41. doi: 10.1186/1742-4933-10-41.
6. High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content. Couplan E, etal., J Biol Chem 2002 Nov 8;277(45):43079-88.
7. Fatty acids change the conformation of uncoupling protein 1 (UCP1). Divakaruni AS, etal., J Biol Chem. 2012 Oct 26;287(44):36845-53. doi: 10.1074/jbc.M112.381780. Epub 2012 Sep 5.
8. The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue. Dlaskova A, etal., Biochim Biophys Acta. 2010 Aug;1797(8):1470-6. doi: 10.1016/j.bbabio.2010.04.008. Epub 2010 Apr 21.
9. Superoxide activates mitochondrial uncoupling proteins. Echtay KS, etal., Nature 2002 Jan 3;415(6867):96-9.
10. Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria. Esteves TC, etal., Biochem J. 2006 May 1;395(3):619-28.
11. Nutritional and hormonal regulation of uncoupling protein gene expression in rat adipocytes. Fukuda H, etal., J Nutr Sci Vitaminol (Tokyo). 2007 Oct;53(5):426-31.
12. Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes. Fukuyama K, etal., Biochem Biophys Res Commun. 2006 Jan 27;339(4):1212-6. Epub 2005 Dec 5.
13. Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes. Garcia B and Obregon MJ, Am J Physiol Cell Physiol 2002 Jan;282(1):C105-12.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Energy metabolism and expression of uncoupling proteins 1, 2, and 3 after 21 days of recovery from intracerebroventricular mouse leptin in rats. Gullicksen PS, etal., Physiol Behav 2002 Apr 1;75(4):473-82.
17. Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. Ho DJ, etal., Exp Neurol. 2010 Sep;225(1):74-84. doi: 10.1016/j.expneurol.2010.05.006. Epub 2010 Jun 1.
18. Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1. Jimenez-Jimenez J, etal., Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1292-6. Epub 2006 May 24.
19. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Kazak L, etal., Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7981-7986. doi: 10.1073/pnas.1705406114. Epub 2017 Jun 19.
20. The uncoupling protein-1 gene -3826A/G polymorphism and hypertension in Japanese subjects. Kotani K, etal., Clin Chem Lab Med. 2007;45(9):1186-9.
21. Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy. Lindholm E, etal., J Diabetes Complications. 2004 Mar-Apr;18(2):103-7.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus. Mori H, etal., Diabetologia. 2001 Mar;44(3):373-6.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. GOA pipeline RGD automated data pipeline
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Complete nucleotide and derived amino acid sequence of cDNA encoding the mitochondrial uncoupling protein of rat brown adipose tissue: lack of a mitochondrial targeting presequence. Ridley RG, etal., Nucleic Acids Res 1986 May 27;14(10):4025-35.
30. DHEA administration increases brown fat uncoupling protein 1 levels in obese OLETF rats. Ryu JW, etal., Biochem Biophys Res Commun. 2003 Apr 4;303(2):726-31.
31. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
32. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
33. Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes. Teruel T, etal., J Biol Chem 2003 Jan 3;278(1):263-9.
34. Substitutional mutations in the uncoupling protein-specific sequences of mitochondrial uncoupling protein UCP1 lead to the reduction of fatty acid-induced H+ uniport. Urbankova E, etal., Int J Biochem Cell Biol. 2003 Feb;35(2):212-20.
35. Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Weydt P, etal., Cell Metab. 2006 Nov;4(5):349-62. Epub 2006 Oct 19.
Additional References at PubMed
PMID:2421800   PMID:7691596   PMID:9054939   PMID:9139827   PMID:11748291   PMID:11940593   PMID:12127082   PMID:12477932   PMID:12603007   PMID:12678439   PMID:12706490   PMID:12734183  
PMID:12910269   PMID:12912909   PMID:12960080   PMID:14529581   PMID:14605003   PMID:14651853   PMID:14766012   PMID:15099666   PMID:15262832   PMID:15489334   PMID:15567149   PMID:15695816  
PMID:15720470   PMID:15727948   PMID:15887043   PMID:15891081   PMID:15896707   PMID:16291746   PMID:17592729   PMID:17670746   PMID:17686539   PMID:17878603   PMID:17923681   PMID:18239634  
PMID:18471433   PMID:18479902   PMID:18614015   PMID:18626658   PMID:19187776   PMID:19227473   PMID:19747168   PMID:20719854   PMID:20948513   PMID:22226924   PMID:22531154   PMID:23063128  
PMID:23084644   PMID:23169784   PMID:23404793   PMID:24196960   PMID:25132457   PMID:25858881   PMID:26129910   PMID:26767982   PMID:27027295   PMID:27438137   PMID:27560796   PMID:27686967  
PMID:27750036   PMID:27916641   PMID:28763438   PMID:30624981   PMID:33202085   PMID:33441773   PMID:33815288   PMID:36650072  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21924,808,782 - 24,816,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,808,783 - 24,816,852 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1931,627,843 - 31,635,958 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01932,282,249 - 32,290,366 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,500,303 - 34,508,418 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,456,976 - 24,464,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,456,976 - 24,464,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01935,434,980 - 35,442,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41926,527,548 - 26,535,621 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11926,532,373 - 26,540,447 (-)NCBI
Celera1924,348,444 - 24,356,517 (-)NCBICelera
Cytogenetic Map19q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384140,559,431 - 140,568,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4140,559,431 - 140,568,961 (-)EnsemblGRCh38hg38GRCh38
GRCh374141,480,585 - 141,490,115 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364141,700,500 - 141,709,457 (-)NCBINCBI36Build 36hg18NCBI36
Build 344141,838,654 - 141,847,612NCBI
Celera4138,811,044 - 138,819,947 (-)NCBICelera
Cytogenetic Map4q31.1NCBI
HuRef4137,211,503 - 137,220,406 (-)NCBIHuRef
CHM1_14141,458,398 - 141,467,306 (-)NCBICHM1_1
T2T-CHM13v2.04143,879,138 - 143,888,662 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39884,016,977 - 84,025,085 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,016,981 - 84,025,081 (+)EnsemblGRCm39 Ensembl
GRCm38883,290,348 - 83,298,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,290,352 - 83,298,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv37885,814,247 - 85,822,355 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36886,180,467 - 86,188,157 (+)NCBIMGSCv36mm8
Celera887,564,747 - 87,572,801 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map839.65NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554283,274,810 - 3,283,237 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,253,363 - 3,282,518 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan14138,823,275 - 138,832,954 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04132,921,033 - 132,930,714 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14144,230,858 - 144,239,803 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4144,230,858 - 144,240,178 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1192,254,881 - 2,289,902 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha192,528,227 - 2,536,537 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0192,346,071 - 2,354,913 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl192,344,973 - 2,354,916 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1192,283,269 - 2,291,546 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0192,644,470 - 2,652,732 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,000,436 - 3,008,747 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530149,820,808 - 49,828,140 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365357,258,343 - 7,265,398 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365357,258,146 - 7,265,475 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1886,522,028 - 86,526,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2891,981,524 - 91,985,738 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1787,492,444 - 87,502,894 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl787,492,195 - 87,502,665 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603767,019,274 - 67,029,935 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004625006155,100 - 162,551 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004625006155,179 - 162,544 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ucp1
37 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:51
Interacting mature miRNAs:53
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,816,041 - 24,816,202 (-)MAPPERmRatBN7.2
Rnor_6.01924,457,627 - 24,457,787NCBIRnor6.0
Rnor_5.01935,435,631 - 35,435,791UniSTSRnor5.0
RGSC_v3.41926,534,810 - 26,534,971RGDRGSC3.4
RGSC_v3.41926,534,809 - 26,534,971UniSTSRGSC3.4
RGSC_v3.11926,539,634 - 26,539,797RGD
Celera1924,355,706 - 24,355,866UniSTS
Cytogenetic Map19p11-q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,817,978 - 24,818,103 (-)MAPPERmRatBN7.2
Rnor_6.01924,455,726 - 24,455,850NCBIRnor6.0
Rnor_5.01935,433,730 - 35,433,854UniSTSRnor5.0
RGSC_v3.41926,536,747 - 26,536,872RGDRGSC3.4
RGSC_v3.41926,536,748 - 26,536,872UniSTSRGSC3.4
RGSC_v3.11926,541,573 - 26,541,698RGD
Celera1924,357,643 - 24,357,761UniSTS
Cytogenetic Map19p11-q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,813,116 - 24,813,393 (-)MAPPERmRatBN7.2
mRatBN7.21924,813,116 - 24,813,393 (+)MAPPERmRatBN7.2
Rnor_6.01929,400,398 - 29,400,674NCBIRnor6.0
Rnor_6.01924,460,436 - 24,460,712NCBIRnor6.0
Rnor_5.01935,438,440 - 35,438,716UniSTSRnor5.0
Rnor_5.01940,308,557 - 40,308,833UniSTSRnor5.0
RGSC_v3.41926,531,884 - 26,532,160UniSTSRGSC3.4
RGSC_v3.41926,531,883 - 26,532,160RGDRGSC3.4
RGSC_v3.11926,536,709 - 26,536,986RGD
Celera1924,352,781 - 24,353,057UniSTS
SHRSP x BN Map1918.5999RGD
SHRSP x BN Map1918.5999UniSTS
FHH x ACI Map1921.16RGD
Cytogenetic Map19p11-q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,816,612 - 24,816,715 (-)MAPPERmRatBN7.2
Rnor_6.01924,457,114 - 24,457,216NCBIRnor6.0
Rnor_5.01935,435,118 - 35,435,220UniSTSRnor5.0
RGSC_v3.41926,535,382 - 26,535,484UniSTSRGSC3.4
Celera1924,356,277 - 24,356,379UniSTS
Cytogenetic Map19p11-q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,815,082 - 24,815,182 (-)MAPPERmRatBN7.2
Rnor_6.01924,458,647 - 24,458,746NCBIRnor6.0
Rnor_5.01935,436,651 - 35,436,750UniSTSRnor5.0
RGSC_v3.41926,533,850 - 26,533,949UniSTSRGSC3.4
Celera1924,354,747 - 24,354,846UniSTS
Cytogenetic Map19p11-q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,815,524 - 24,815,690 (-)MAPPERmRatBN7.2
Rnor_6.01924,458,139 - 24,458,304NCBIRnor6.0
Rnor_5.01935,436,143 - 35,436,308UniSTSRnor5.0
RGSC_v3.41926,534,292 - 26,534,457UniSTSRGSC3.4
Celera1924,355,189 - 24,355,354UniSTS
Cytogenetic Map19p11-q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,808,802 - 24,808,876 (-)MAPPERmRatBN7.2
mRatBN7.21924,808,802 - 24,808,876 (+)MAPPERmRatBN7.2
Rnor_6.01924,464,714 - 24,464,787NCBIRnor6.0
Rnor_6.01929,396,084 - 29,396,157NCBIRnor6.0
Rnor_5.01940,304,243 - 40,304,316UniSTSRnor5.0
Rnor_5.01935,442,718 - 35,442,791UniSTSRnor5.0
RGSC_v3.41926,527,568 - 26,527,641UniSTSRGSC3.4
Celera1924,348,465 - 24,348,538UniSTS
Cytogenetic Map19p11-q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,815,774 - 24,816,631 (-)MAPPERmRatBN7.2
Rnor_6.01924,457,198 - 24,458,054NCBIRnor6.0
Rnor_5.01935,435,202 - 35,436,058UniSTSRnor5.0
RGSC_v3.41926,534,542 - 26,535,400UniSTSRGSC3.4
Celera1924,355,439 - 24,356,295UniSTS
Cytogenetic Map19p11-q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,816,042 - 24,816,202 (-)MAPPERmRatBN7.2
Rnor_6.01924,457,627 - 24,457,786NCBIRnor6.0
Rnor_5.01935,435,631 - 35,435,790UniSTSRnor5.0
RGSC_v3.41926,534,810 - 26,534,971UniSTSRGSC3.4
Celera1924,355,707 - 24,355,866UniSTS
Cytogenetic Map15p11UniSTS
Cytogenetic Map19p11-q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 8 15 8 12 7
Low 8 5 4 1 4 5 5 5 5 2 5
Below cutoff 2 1 4 4 8 4 3 3 9 3 17 2 3


RefSeq Acc Id: ENSRNOT00000004900   ⟹   ENSRNOP00000004900
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,808,783 - 24,816,852 (-)Ensembl
Rnor_6.0 Ensembl1924,456,976 - 24,464,807 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000072100   ⟹   ENSRNOP00000065918
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1929,396,157 - 29,400,355 (-)Ensembl
RefSeq Acc Id: NM_012682   ⟹   NP_036814
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,808,782 - 24,816,853 (-)NCBI
Rnor_6.01924,456,976 - 24,464,808 (+)NCBI
Rnor_5.01935,434,980 - 35,442,812 (+)NCBI
RGSC_v3.41926,527,548 - 26,535,621 (-)RGD
Celera1924,348,444 - 24,356,517 (-)NCBI
RefSeq Acc Id: NP_036814   ⟸   NM_012682
- UniProtKB: P04633 (UniProtKB/Swiss-Prot),   A6IYF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004900   ⟸   ENSRNOT00000004900
RefSeq Acc Id: ENSRNOP00000065918   ⟸   ENSRNOT00000072100

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8W3-F1-model_v2 AlphaFold M0R8W3 1-196 view protein structure
AF-P04633-F1-model_v2 AlphaFold P04633 1-307 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700995
Promoter ID:EPDNEW_R11518
Type:single initiation site
Description:uncoupling protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01924,456,978 - 24,457,038EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3931 AgrOrtholog
BioCyc Gene G2FUF-6005 BioCyc
Ensembl Genes ENSRNOG00000003580 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000046239 Ensembl
  ENSRNOG00055007544 UniProtKB/Swiss-Prot
  ENSRNOG00060013476 UniProtKB/Swiss-Prot
  ENSRNOG00065010414 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004900 ENTREZGENE
  ENSRNOT00000004900.5 UniProtKB/Swiss-Prot
  ENSRNOT00055012593 UniProtKB/Swiss-Prot
  ENSRNOT00060022981 UniProtKB/Swiss-Prot
  ENSRNOT00065016851 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Mit_uncoupling_UCP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24860 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45618:SF19 UniProtKB/Swiss-Prot
Pfam Mito_carr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ucp1 PhenoGen
RatGTEx ENSRNOG00000003580 RatGTEx
  ENSRNOG00000046239 RatGTEx
  ENSRNOG00055007544 RatGTEx
  ENSRNOG00060013476 RatGTEx
  ENSRNOG00065010414 RatGTEx
Superfamily-SCOP Mitochondrial carrier UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC218948
  P04633 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ucp1  uncoupling protein 1  LOC100909612  mitochondrial brown fat uncoupling protein 1-like  Data merged from RGD:6502621 737654 PROVISIONAL
2016-05-05 Ucp1  uncoupling protein 1  Ucp1  uncoupling protein 1 (mitochondrial, proton carrier)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909612  mitochondrial brown fat uncoupling protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Ucp1  uncoupling protein 1 (mitochondrial, proton carrier)    uncoupling protein 1  Name updated 1299863 APPROVED
2004-12-14 Ucp1  uncoupling protein 1      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Ucp1  uncoupling protein 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in the inner mitochondrial membrane of brown adipocytes 70670
gene_function inner mitochondrial membrane transporter 70670
gene_pathway increased mRNA expression is induced by activation of the retinoic acid and retinoid X receptors and occurs via activation of a MAP kinase signaling pathway 730207
gene_process T3 by itself induces the transcription of Ucp1 70670
gene_process uncouples electron transport from oxidative phosphorylation 70670
gene_regulation aFGF and bFGF increase the expression, EGF and vasopressin decrease the expression 70670
gene_regulation triiodothyronine (T3) inhibits the mitogenic activity of aFGF and bFGF 70670
gene_regulation mRNA expression is upregulated by leptin 631305