Acd (ACD, shelterin complex subunit and telomerase recruitment factor) - Rat Genome Database

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Gene: Acd (ACD, shelterin complex subunit and telomerase recruitment factor) Rattus norvegicus
Analyze
Symbol: Acd
Name: ACD, shelterin complex subunit and telomerase recruitment factor
RGD ID: 1565053
Description: Predicted to enable DNA polymerase binding activity and telomeric DNA binding activity. Predicted to be involved in several processes, including establishment of protein localization; regulation of DNA biosynthetic process; and telomere organization. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; telomere maintenance; and urogenital system development. Predicted to be located in chromosome, telomeric region and nuclear body. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in autosomal dominant dyskeratosis congenita 6. Orthologous to human ACD (ACD shelterin complex subunit and telomerase recruitment factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adrenocortical dysplasia; adrenocortical dysplasia homolog; adrenocortical dysplasia homolog (mouse); adrenocortical dysplasia protein homolog; LOC307798; MGC116400; similar to 24432 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,586,739 - 33,589,481 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,586,745 - 33,589,461 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,402,316 - 40,405,008 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01941,055,648 - 41,058,340 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01943,353,421 - 43,356,113 (-)NCBIRnor_WKY
Rnor_6.01937,665,289 - 37,668,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,665,296 - 37,667,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,531,999 - 48,534,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,530,557 - 35,533,249 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1933,014,692 - 33,017,384 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15181449   PMID:15380063   PMID:15383534   PMID:15489334   PMID:15537664   PMID:16880378   PMID:17237767   PMID:17237768   PMID:17632522   PMID:18185984   PMID:19135898   PMID:21852327  
PMID:23685356   PMID:24270157   PMID:25172512   PMID:25589350   PMID:35805162  


Genomics

Comparative Map Data
Acd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,586,739 - 33,589,481 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,586,745 - 33,589,461 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,402,316 - 40,405,008 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01941,055,648 - 41,058,340 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01943,353,421 - 43,356,113 (-)NCBIRnor_WKY
Rnor_6.01937,665,289 - 37,668,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,665,296 - 37,667,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,531,999 - 48,534,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,530,557 - 35,533,249 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1933,014,692 - 33,017,384 (-)NCBICelera
Cytogenetic Map19q12NCBI
ACD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,657,512 - 67,660,260 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1667,657,512 - 67,660,810 (-)EnsemblGRCh38hg38GRCh38
GRCh371667,691,415 - 67,694,163 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,248,916 - 66,252,219 (-)NCBINCBI36Build 36hg18NCBI36
Build 341666,248,933 - 66,252,214NCBI
Celera1652,199,905 - 52,203,208 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,564,327 - 53,567,630 (-)NCBIHuRef
CHM1_11669,099,128 - 69,102,431 (-)NCBICHM1_1
T2T-CHM13v2.01673,452,280 - 73,455,028 (-)NCBIT2T-CHM13v2.0
Acd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,424,787 - 106,427,860 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,422,492 - 106,427,734 (-)EnsemblGRCm39 Ensembl
GRCm388105,698,155 - 105,701,228 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,695,860 - 105,701,102 (-)EnsemblGRCm38mm10GRCm38
MGSCv378108,222,059 - 108,224,995 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,587,288 - 108,590,224 (-)NCBIMGSCv36mm8
Celera8109,923,077 - 109,926,013 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Acd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,022,520 - 9,025,446 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554849,022,520 - 9,025,446 (+)NCBIChiLan1.0ChiLan1.0
ACD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11667,390,703 - 67,393,685 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,390,703 - 67,393,685 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01648,001,408 - 48,004,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,789,915 - 81,792,725 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,789,997 - 81,792,639 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,779,673 - 81,782,484 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,225,079 - 82,227,897 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,225,104 - 82,286,231 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,051,408 - 82,054,221 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,732,943 - 81,735,752 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,375,492 - 82,378,294 (+)NCBIUU_Cfam_GSD_1.0
Acd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,536,955 - 41,539,974 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,045,662 - 18,052,172 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647518,049,134 - 18,052,123 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,277,614 - 28,280,405 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,277,649 - 28,280,409 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ACD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,783,842 - 59,787,117 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,784,178 - 59,787,032 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,537,668 - 22,540,863 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,689,364 - 18,695,944 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474618,688,898 - 18,692,216 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acd
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:86
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000059577
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat

Markers in Region
RH128404  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,586,774 - 33,587,057 (+)MAPPERmRatBN7.2
Rnor_6.01937,665,325 - 37,665,607NCBIRnor6.0
Rnor_5.01948,532,029 - 48,532,311UniSTSRnor5.0
RGSC_v3.41935,530,587 - 35,530,869UniSTSRGSC3.4
Celera1933,014,722 - 33,015,004UniSTS
RH 3.4 Map19359.92UniSTS
Cytogenetic Map19q12UniSTS
RH132532  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,586,484 - 33,586,757 (+)MAPPERmRatBN7.2
Rnor_6.01937,665,035 - 37,665,307NCBIRnor6.0
Rnor_5.01948,531,739 - 48,532,011UniSTSRnor5.0
RGSC_v3.41935,530,297 - 35,530,569UniSTSRGSC3.4
Celera1933,014,432 - 33,014,704UniSTS
RH 3.4 Map19358.3UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium 32 30 30 30 63 24 30
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000059577   ⟹   ENSRNOP00000056334
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,586,745 - 33,589,461 (-)Ensembl
Rnor_6.0 Ensembl1937,665,296 - 37,667,987 (-)Ensembl
RefSeq Acc Id: NM_001037193   ⟹   NP_001032270
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,586,745 - 33,589,437 (-)NCBI
Rnor_6.01937,665,295 - 37,667,987 (-)NCBI
Rnor_5.01948,531,999 - 48,534,691 (-)NCBI
RGSC_v3.41935,530,557 - 35,533,249 (-)RGD
Celera1933,014,692 - 33,017,384 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772496   ⟹   XP_008770718
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,586,739 - 33,589,481 (-)NCBI
Rnor_6.01937,665,289 - 37,668,043 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097730   ⟹   XP_038953658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,586,739 - 33,589,225 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001032270   ⟸   NM_001037193
- UniProtKB: Q4FZR5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770718   ⟸   XM_008772496
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QTF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056334   ⟸   ENSRNOT00000059577
RefSeq Acc Id: XP_038953658   ⟸   XM_039097730
- Peptide Label: isoform X2
Protein Domains
TPP1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZR5-F1-model_v2 AlphaFold Q4FZR5 1-417 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701083
Promoter ID:EPDNEW_R11607
Type:multiple initiation site
Name:Acd_1
Description:ACD, shelterin complex subunit and telomerase recruitment factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01937,668,018 - 37,668,078EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565053 AgrOrtholog
BioCyc Gene G2FUF-5818 BioCyc
Ensembl Genes ENSRNOG00000038973 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000056334 ENTREZGENE
  ENSRNOP00000056334.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059577 ENTREZGENE
  ENSRNOT00000059577.3 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7388035 IMAGE-MGC_LOAD
InterPro ACD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP1/Est3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:307798 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116400 IMAGE-MGC_LOAD
NCBI Gene 307798 ENTREZGENE
PANTHER PTHR14487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TPP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acd PhenoGen
UniProt A0A8L2QTF0 ENTREZGENE, UniProtKB/TrEMBL
  ACD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-09 Acd  ACD, shelterin complex subunit and telomerase recruitment factor  Acd  adrenocortical dysplasia homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-05 Acd  adrenocortical dysplasia homolog  Acd  adrenocortical dysplasia homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Acd  adrenocortical dysplasia homolog (mouse)  Acd  adrenocortical dysplasia  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Acd  adrenocortical dysplasia  LOC307798  similar to 24432 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC307798  similar to 24432 protein      Symbol and Name status set to provisional 70820 PROVISIONAL