Mir181d (microRNA 181d) - Rat Genome Database

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Gene: Mir181d (microRNA 181d) Rattus norvegicus
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Symbol: Mir181d
Name: microRNA 181d
RGD ID: 2325361
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in negative regulation of gene expression; positive regulation of cell migration; and positive regulation of p38MAPK cascade. Predicted to act upstream of or within several processes, including SMAD protein signal transduction; long-term synaptic potentiation; and sensory perception of sound. Predicted to be located in cytoplasm. Orthologous to human MIR181D (microRNA 181d); INTERACTS WITH bleomycin A2; endosulfan; mechlorethamine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-181d; rno-mir-181d
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,983,706 - 23,983,788 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,983,706 - 23,983,788 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,804,537 - 30,804,619 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01931,458,951 - 31,459,033 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01933,681,704 - 33,681,786 (+)NCBIRnor_WKY
Rnor_6.01925,290,051 - 25,290,133 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,290,051 - 25,290,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,267,151 - 36,267,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1923,532,249 - 23,532,331 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:20223197   PMID:20403161   PMID:23390484   PMID:23646144   PMID:25858512   PMID:28961370   PMID:35672285  


Genomics

Comparative Map Data
Mir181d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,983,706 - 23,983,788 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,983,706 - 23,983,788 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,804,537 - 30,804,619 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01931,458,951 - 31,459,033 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01933,681,704 - 33,681,786 (+)NCBIRnor_WKY
Rnor_6.01925,290,051 - 25,290,133 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,290,051 - 25,290,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,267,151 - 36,267,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1923,532,249 - 23,532,331 (+)NCBICelera
Cytogenetic Map19q11NCBI
MIR181D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381913,874,875 - 13,875,011 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1913,874,875 - 13,875,011 (+)EnsemblGRCh38hg38GRCh38
GRCh371913,985,689 - 13,985,825 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,846,688 - 13,846,824 (+)NCBINCBI36Build 36hg18NCBI36
Celera1913,879,434 - 13,879,570 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,557,000 - 13,557,136 (+)NCBIHuRef
CHM1_11913,986,385 - 13,986,521 (+)NCBICHM1_1
T2T-CHM13v2.01914,001,031 - 14,001,167 (+)NCBIT2T-CHM13v2.0
Mir181d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,905,345 - 84,905,416 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,905,345 - 84,905,416 (-)EnsemblGRCm39 Ensembl
GRCm38884,178,716 - 84,178,787 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,178,716 - 84,178,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,702,615 - 86,702,686 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera888,479,159 - 88,479,230 (-)NCBICelera
Cytogenetic Map8C2NCBI

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:7230
Count of gene targets:5119
Count of transcripts:5527
Interacting mature miRNAs:rno-miR-181d-3p, rno-miR-181d-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 6 4 4 56 8 23 2
Below cutoff 1 9 1 1 4 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_032266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000054529
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,983,706 - 23,983,788 (+)Ensembl
Rnor_6.0 Ensembl1925,290,051 - 25,290,133 (-)Ensembl
RefSeq Acc Id: NR_032266
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21923,983,706 - 23,983,788 (+)NCBI
Rnor_6.01925,290,051 - 25,290,133 (-)NCBI
Rnor_5.01936,267,151 - 36,267,233 (-)NCBI
Celera1923,532,249 - 23,532,331 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325361 AgrOrtholog
BioCyc Gene G2FUF-6067 BioCyc
Ensembl Genes ENSRNOG00000036417 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000054529 ENTREZGENE
miRBase MI0006132 ENTREZGENE
NCBI Gene 100314262 ENTREZGENE
PhenoGen Mir181d PhenoGen
RNAcentral URS0000236310 RNACentral
  URS000075BC1D RNACentral
  URS000075C395 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir181d  microRNA 181d  Mir181d  microRNA mir-181d  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir181d  microRNA mir-181d      Symbol and Name status set to provisional 70820 PROVISIONAL