Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ednra (endothelin receptor type A) Rattus norvegicus
Symbol: Ednra
Name: endothelin receptor type A
Description: Exhibits endothelin receptor activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of cytosolic calcium ion concentration; and positive regulation of response to external stimulus. Localizes to T-tubule and nuclear membrane. Colocalizes with membrane raft. Used to study hypertension; myocardial infarction; portal hypertension; pulmonary emphysema; and pulmonary hypertension. Biomarker of several diseases, including hyperhomocysteinemia; impotence; obstructive sleep apnea; renal fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A); PARTICIPATES IN endothelin signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; 11-deoxycorticosterone; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ENDOR; endothelin A receptor; endothelin-1 receptor; endothelin-1 receptor-like; ET-A; ET-AR; Eta; LOC100366209; RATENDOR; RGD1559432
Homo sapiens (human) : EDNRA (endothelin receptor type A)  HGNC  Alliance
Mus musculus (house mouse) : Ednra (endothelin receptor type A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ednra (endothelin receptor type A)
Pan paniscus (bonobo/pygmy chimpanzee) : EDNRA (endothelin receptor type A)
Canis lupus familiaris (dog) : EDNRA (endothelin receptor type A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ednra (endothelin receptor type A)
Sus scrofa (pig) : EDNRA (endothelin receptor type A)
Chlorocebus sabaeus (African green monkey) : EDNRA (endothelin receptor type A)
Heterocephalus glaber (naked mole-rat) : Ednra (endothelin receptor type A)
more info ...
Is Marker For: QTLs:   Scl12  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11932,051,058 - 32,110,066 (+)NCBI
Celera1929,719,589 - 29,778,843 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ednra
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2535
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.