Gpt2 (glutamic--pyruvic transaminase 2) - Rat Genome Database

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Gene: Gpt2 (glutamic--pyruvic transaminase 2) Rattus norvegicus
Analyze
Symbol: Gpt2
Name: glutamic--pyruvic transaminase 2
RGD ID: 1305462
Description: Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity. Involved in several processes, including cellular response to insulin stimulus; positive regulation of gluconeogenesis; and response to testosterone. Located in extracellular space and mitochondrion. Biomarker of type 2 diabetes mellitus. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alanine aminotransferase 2; ALT2; Cc2-5; glutamic pyruvate transaminase (alanine aminotransferase) 2; glutamic pyruvate transaminase 2; glutamic-pyruvate transaminase 2; LOC307759
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21921,526,800 - 21,561,314 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1921,517,621 - 21,560,610 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1923,215,489 - 23,248,192 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01928,410,012 - 28,442,715 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01931,372,800 - 31,405,503 (-)NCBIRnor_WKY
Rnor_6.01922,599,003 - 22,633,529 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1922,590,881 - 22,632,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01933,605,445 - 33,644,015 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41922,884,586 - 22,915,553 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11922,889,411 - 22,920,379 (-)NCBI
Celera1921,389,431 - 21,420,291 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminobutyric acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
neomycin  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxycodone  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
prothioconazole  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Alanine aminotransferase regulation by androgens in non-hepatic tissues. Coss CC, etal., Pharm Res. 2012 Apr;29(4):1046-56. doi: 10.1007/s11095-011-0649-5. Epub 2011 Dec 14.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver. Jadhao SB, etal., Hepatology. 2004 May;39(5):1297-302. doi: 10.1002/hep.20182.
4. Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis. Liu R, etal., Liver Int. 2009 Mar;29(3):337-43. doi: 10.1111/j.1478-3231.2008.01862.x. Epub 2008 Aug 14.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level. Qian K, etal., Diabetes Metab Res Rev. 2015 Sep;31(6):562-71. doi: 10.1002/dmrr.2655. Epub 2015 Jun 17.
7. Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans. Rafter I, etal., Int J Mol Med. 2012 Nov;30(5):1241-9. doi: 10.3892/ijmm.2012.1106. Epub 2012 Aug 23.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. Yang RZ, etal., Hepatology. 2009 Feb;49(2):598-607. doi: 10.1002/hep.22657.
Additional References at PubMed
PMID:11863375   PMID:18614015  


Genomics

Comparative Map Data
Gpt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21921,526,800 - 21,561,314 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1921,517,621 - 21,560,610 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1923,215,489 - 23,248,192 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01928,410,012 - 28,442,715 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01931,372,800 - 31,405,503 (-)NCBIRnor_WKY
Rnor_6.01922,599,003 - 22,633,529 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1922,590,881 - 22,632,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01933,605,445 - 33,644,015 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41922,884,586 - 22,915,553 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11922,889,411 - 22,920,379 (-)NCBI
Celera1921,389,431 - 21,420,291 (-)NCBICelera
Cytogenetic Map19p11NCBI
GPT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381646,884,362 - 46,931,289 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1646,884,362 - 46,931,289 (+)EnsemblGRCh38hg38GRCh38
GRCh371646,918,274 - 46,965,201 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361645,475,809 - 45,522,699 (+)NCBINCBI36Build 36hg18NCBI36
Build 341645,475,808 - 45,522,699NCBI
Celera1631,426,465 - 31,473,333 (+)NCBICelera
Cytogenetic Map16q11.2NCBI
HuRef1632,808,713 - 32,855,581 (+)NCBIHuRef
CHM1_11648,325,402 - 48,372,269 (+)NCBICHM1_1
T2T-CHM13v2.01652,681,247 - 52,728,152 (+)NCBIT2T-CHM13v2.0
Gpt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39886,219,090 - 86,255,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl886,219,205 - 86,254,189 (+)EnsemblGRCm39 Ensembl
GRCm38885,492,576 - 85,528,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,492,576 - 85,527,560 (+)EnsemblGRCm38mm10GRCm38
MGSCv37888,016,516 - 88,051,457 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36888,382,722 - 88,417,663 (+)NCBIMGSCv36mm8
Celera889,788,449 - 89,823,364 (+)NCBICelera
Cytogenetic Map8C3NCBI
Gpt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554748,250,759 - 8,285,227 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554748,248,622 - 8,285,449 (-)NCBIChiLan1.0ChiLan1.0
GPT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11646,040,439 - 46,086,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1646,040,439 - 46,086,840 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01627,150,159 - 27,197,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GPT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,238,295 - 8,250,789 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha158,390,680 - 8,414,551 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,352,399 - 8,376,276 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1158,180,716 - 8,204,556 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,261,783 - 8,285,636 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0158,277,131 - 8,301,012 (-)NCBIUU_Cfam_GSD_1.0
Gpt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934959,289,309 - 59,326,531 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936475262,920 - 297,459 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936475262,558 - 299,766 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl637,625,436 - 37,669,663 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1637,625,428 - 37,669,695 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2632,865,392 - 32,909,952 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1532,743,850 - 32,791,299 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl532,744,065 - 32,791,479 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604743,782,468 - 43,830,157 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624914459,701 - 501,765 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624914460,240 - 501,087 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpt2
68 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:458
Count of miRNA genes:242
Interacting mature miRNAs:274
Transcripts:ENSRNOT00000022851, ENSRNOT00000071992
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 49 41 41 8 11 72 12 41 8
Low 3 43 8 19 2 23 11
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000077275   ⟹   ENSRNOP00000069387
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1921,526,800 - 21,559,733 (-)Ensembl
Rnor_6.0 Ensembl1922,600,868 - 22,632,071 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078348   ⟹   ENSRNOP00000071498
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1921,517,621 - 21,554,447 (-)Ensembl
Rnor_6.0 Ensembl1922,590,881 - 22,626,653 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099582   ⟹   ENSRNOP00000090767
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1921,526,800 - 21,560,610 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111228   ⟹   ENSRNOP00000091514
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1921,517,621 - 21,549,661 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115000   ⟹   ENSRNOP00000095516
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1921,526,963 - 21,559,863 (-)Ensembl
RefSeq Acc Id: NM_001012057   ⟹   NP_001012057
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21921,526,800 - 21,559,533 (-)NCBI
Rnor_6.01922,600,883 - 22,631,743 (-)NCBI
Rnor_5.01933,605,445 - 33,644,015 (-)NCBI
RGSC_v3.41922,884,586 - 22,915,553 (-)RGD
Celera1921,389,431 - 21,420,291 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772405   ⟹   XP_008770627
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21921,526,800 - 21,559,877 (-)NCBI
Rnor_6.01922,599,003 - 22,632,080 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772406   ⟹   XP_008770628
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21921,526,800 - 21,561,314 (-)NCBI
Rnor_6.01922,599,003 - 22,633,529 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012057 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770627 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770628 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP92646 (Get FASTA)   NCBI Sequence Viewer  
  EDL87488 (Get FASTA)   NCBI Sequence Viewer  
  EDL87489 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001012057   ⟸   NM_001012057
- UniProtKB: A0A8I6ARL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770628   ⟸   XM_008772406
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770627   ⟸   XM_008772405
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069387   ⟸   ENSRNOT00000077275
RefSeq Acc Id: ENSRNOP00000071498   ⟸   ENSRNOT00000078348
RefSeq Acc Id: ENSRNOP00000095516   ⟸   ENSRNOT00000115000
RefSeq Acc Id: ENSRNOP00000091514   ⟸   ENSRNOT00000111228
RefSeq Acc Id: ENSRNOP00000090767   ⟸   ENSRNOT00000099582
Protein Domains
Aminotran_1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TP13-F1-model_v2 AlphaFold Q7TP13 1-789 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700991
Promoter ID:EPDNEW_R11514
Type:initiation region
Name:Gpt2_1
Description:glutamic--pyruvic transaminase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01922,632,046 - 22,632,106EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305462 AgrOrtholog
BioCyc Gene G2FUF-6211 BioCyc
BioCyc Pathway ALANINE-DEG3-PWY [L-alanine degradation III] BioCyc
  ALANINE-SYN2-PWY [L-alanine biosynthesis II] BioCyc
Ensembl Genes ENSRNOG00000059579 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069387 ENTREZGENE
  ENSRNOP00000069387.1 UniProtKB/TrEMBL
  ENSRNOP00000071498.1 UniProtKB/TrEMBL
  ENSRNOP00000090767.1 UniProtKB/TrEMBL
  ENSRNOP00000091514.1 UniProtKB/TrEMBL
  ENSRNOP00000095516 ENTREZGENE
  ENSRNOP00000095516.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077275 ENTREZGENE
  ENSRNOT00000077275.2 UniProtKB/TrEMBL
  ENSRNOT00000078348.2 UniProtKB/TrEMBL
  ENSRNOT00000099582.1 UniProtKB/TrEMBL
  ENSRNOT00000111228.1 UniProtKB/TrEMBL
  ENSRNOT00000115000 ENTREZGENE
  ENSRNOT00000115000.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro ALAT1/2-like UniProtKB/TrEMBL
  Aminotransferase_I/II UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_dom UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_sub1 UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_sub2 UniProtKB/TrEMBL
NCBI Gene 307759 ENTREZGENE
PANTHER PTHR11751 UniProtKB/TrEMBL
Pfam Aminotran_1_2 UniProtKB/TrEMBL
PhenoGen Gpt2 PhenoGen
Superfamily-SCOP PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
UniProt A0A0G2JV84_RAT UniProtKB/TrEMBL
  A0A8I6ACI1_RAT UniProtKB/TrEMBL
  A0A8I6ARL0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJ17_RAT UniProtKB/TrEMBL
  Q7TP13_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Gpt2  glutamic--pyruvic transaminase 2  Gpt2  glutamic pyruvate transaminase (alanine aminotransferase) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gpt2  glutamic pyruvate transaminase (alanine aminotransferase) 2   Gpt2_predicted  glutamic pyruvate transaminase (alanine aminotransferase) 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gpt2_predicted  glutamic pyruvate transaminase (alanine aminotransferase) 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED