Prkaca (protein kinase cAMP-activated catalytic subunit alpha) - Rat Genome Database

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Gene: Prkaca (protein kinase cAMP-activated catalytic subunit alpha) Rattus norvegicus
Symbol: Prkaca
Name: protein kinase cAMP-activated catalytic subunit alpha
RGD ID: 3389
Description: Enables cAMP-dependent protein kinase activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including peptidyl-serine phosphorylation; regulation of glutamatergic synaptic transmission; and spontaneous exocytosis of neurotransmitter. Located in perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Is active in neuromuscular junction; postsynapse; and presynapse. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
Previously known as: cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit C alpha; Cs-PKA; PKA C-alpha; PKCA1; protein kinase A; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21924,155,081 - 24,178,430 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,155,090 - 24,178,430 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,976,206 - 30,999,561 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01931,630,613 - 31,653,968 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01933,853,335 - 33,876,684 (-)NCBIRnor_WKY
Rnor_6.01925,095,089 - 25,118,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,095,089 - 25,118,860 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,073,104 - 36,096,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,840,795 - 25,864,786 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,845,620 - 25,861,927 (-)NCBI
Celera1923,703,180 - 23,726,723 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-aminopyridine  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bucladesine  (EXP)
buprenorphine  (EXP)
buspirone  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
captopril  (EXP)
CGP 52608  (ISO)
chaetocin  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clenbuterol  (EXP)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dobutamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
glycitein  (ISO)
glycitin  (ISO)
glyphosate  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroxysafflor yellow A  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
KT 5720  (EXP)
Lappaconitine  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
Licarin A  (ISO)
maneb  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
methidathion  (ISO)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (ISO)
oxidopamine  (EXP)
oxycodone  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregabalin  (EXP)
prostaglandin E2  (ISO)
Pyridostigmine bromide  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP)
reserpine  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulindac  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
taurine  (EXP)
taurolithocholic acid  (EXP)
tebufenpyrad  (ISO)
telmisartan  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triclosan  (EXP)
Triptolide  (EXP)
Tylophorine  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vismodegib  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
cellular response to cold  (ISO)
cellular response to glucagon stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to heat  (ISO,ISS)
cellular response to parathyroid hormone stimulus  (ISO)
mesoderm formation  (ISO)
modulation of chemical synaptic transmission  (ISO)
mRNA processing  (ISO)
negative regulation of glycolytic process through fructose-6-phosphate  (ISO)
negative regulation of meiotic cell cycle  (IDA)
negative regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  (ISO)
neural tube closure  (ISO)
peptidyl-serine phosphorylation  (IBA,IDA,IMP,ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of gluconeogenesis  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of protein export from nucleus  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
protein autophosphorylation  (ISO)
protein export from nucleus  (ISO)
protein kinase A signaling  (IBA)
protein localization to lipid droplet  (ISO)
protein phosphorylation  (IDA,IEA,ISO)
regulation of bicellular tight junction assembly  (ISO)
regulation of cell cycle  (ISO)
regulation of cellular respiration  (IDA)
regulation of osteoblast differentiation  (ISO)
regulation of proteasomal protein catabolic process  (ISO)
regulation of protein processing  (ISO)
regulation of synaptic transmission, glutamatergic  (IDA)
sperm capacitation  (ISO)
spontaneous exocytosis of neurotransmitter  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
apoptotic cell death pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
carvedilol pharmacodynamics pathway  (ISO)
chemokine mediated signaling pathway  (IEA)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
dopamine signaling pathway  (ISO)
eicosanoid signaling pathway  (ISO)
Entamoebiasis pathway  (IEA)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
Hedgehog signaling pathway  (IEA,ISO)
ibutilide pharmacodynamics pathway  (ISO)
insulin signaling pathway  (IEA)
interleukin-3 signaling pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term potentiation  (IEA)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prion disease pathway  (IEA)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
protein kinase A (PKA) signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
syndecan signaling pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)
vasopressin signaling pathway via receptor type 2  (IEA)
verapamil pharmacodynamics pathway  (ISO)
Wnt signaling pathway  (IEA)


References - curated
# Reference Title Reference Citation
1. Cyclic AMP signaling and gene regulation. Daniel PB, etal., Annu Rev Nutr 1998;18:353-83.
2. Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep. Datta S and Desarnaud F, J Neurosci. 2010 Sep 15;30(37):12263-73. doi: 10.1523/JNEUROSCI.1563-10.2010.
3. SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation. Ding X, etal., J Exp Clin Cancer Res. 2019 Sep 13;38(1):404. doi: 10.1186/s13046-019-1411-9.
4. Differential effects of haloperidol and clozapine on cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. Dwivedi Y, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):197-209.
5. CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma. Engelholm LH, etal., Gastroenterology. 2017 Dec;153(6):1662-1673.e10. doi: 10.1053/j.gastro.2017.09.008. Epub 2017 Sep 18.
6. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Fang X, etal., Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11960-5.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Regulation of cyclin D2 expression and degradation by follicle-stimulating hormone during rat granulosa cell proliferation in vitro. Han Y, etal., Biol Reprod. 2013 Mar 7;88(3):57. doi: 10.1095/biolreprod.112.105106. Print 2013 Mar.
10. A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1. Jeske NA, etal., Pain. 2008 Sep 15;138(3):604-16. Epub 2008 Apr 1.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Regulation of mRNA expression involved in Ras and PKA signal pathways during rat hypoglossal nerve regeneration. Kiryu S, etal., Brain Res Mol Brain Res. 1995 Mar;29(1):147-56.
13. An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes. Kovo M, etal., Reproduction. 2006 Jul;132(1):33-43.
14. Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells. Manni S, etal., J Biol Chem. 2008 Aug 29;283(35):24145-54. Epub 2008 Jun 12.
15. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Marx SO, etal., Cell. 2000 May 12;101(4):365-76.
16. Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. Maximov A, etal., J Cell Biol. 2007 Jan 1;176(1):113-24. Epub 2006 Dec 26.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Impairment of cerebral cAMP-mediated signal transduction system and of spatial memory function after microsphere embolism in rats. Nagakura A, etal., Neuroscience. 2002;113(3):519-28.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells. Obara Y, etal., J Cell Sci. 2004 Dec 1;117(Pt 25):6085-94. Epub 2004 Nov 16.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. PKA, PKC, and AKAP localization in and around the neuromuscular junction. Perkins GA, etal., BMC Neurosci. 2001;2:17. Epub 2001 Oct 23.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma. Riggle KM, etal., Pediatr Res. 2016 Jul;80(1):110-8. doi: 10.1038/pr.2016.36. Epub 2016 Mar 8.
30. Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome. Sato Y, etal., Science. 2014 May 23;344(6186):917-20. doi: 10.1126/science.1252328.
31. Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C. Schmidtmann A, etal., FEBS J. 2005 Dec;272(23):6087-97.
32. Modulation of AMPA receptors by cAMP-dependent protein kinase in preBotzinger complex inspiratory neurons regulates respiratory rhythm in the rat. Shao XM, etal., J Physiol. 2003 Mar 1;547(Pt 2):543-53. Epub 2003 Jan 24.
33. RAB13 regulates Sertoli cell permeability barrier dynamics through protein kinase A. Su W and Liu X, J Mol Endocrinol. 2013 Apr 12;50(3):305-18. doi: 10.1530/JME-13-0011. Print 2013 Jun.
34. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
35. Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells. Widen C, etal., Biochem J. 2003 Jul 1;373(Pt 1):211-20.
36. Rat C alpha catalytic subunit of the cAMP-dependent protein kinase: cDNA sequence and evidence that it is the only isoform expressed in myoblasts. Wiemann S, etal., Biochim Biophys Acta 1991 Jun 13;1089(2):254-6.
37. betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Yao L, etal., Cell. 2002 Jun 14;109(6):733-43.
38. Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-beta gamma dimers. Yao L, etal., Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14379-84. Epub 2003 Nov 6.
39. A developmental switch in the signaling cascades for LTP induction. Yasuda H, etal., Nat Neurosci. 2003 Jan;6(1):15-6.
40. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:1862342   PMID:6281762   PMID:7864897   PMID:7905001   PMID:8200992   PMID:8598227   PMID:8647104   PMID:8794865   PMID:9218452   PMID:9413984   PMID:9521123   PMID:9688563  
PMID:10805756   PMID:10906071   PMID:10970852   PMID:11029056   PMID:11590243   PMID:11739747   PMID:11799117   PMID:12004056   PMID:12167631   PMID:12200423   PMID:12475942   PMID:12477932  
PMID:12628924   PMID:12931191   PMID:14514679   PMID:15375008   PMID:15465019   PMID:15499025   PMID:15533936   PMID:15539636   PMID:15557275   PMID:15569306   PMID:15574738   PMID:15590926  
PMID:15634677   PMID:15692043   PMID:15760935   PMID:15905176   PMID:16004991   PMID:16088955   PMID:16123333   PMID:16129693   PMID:16481613   PMID:16519540   PMID:16531999   PMID:16538385  
PMID:16554304   PMID:16782699   PMID:16793902   PMID:16901946   PMID:16916513   PMID:17001449   PMID:17043310   PMID:17120015   PMID:17166179   PMID:17296605   PMID:17373911   PMID:17392500  
PMID:17565987   PMID:17594903   PMID:17693412   PMID:17855365   PMID:17895835   PMID:17901878   PMID:17911601   PMID:17938178   PMID:17942071   PMID:17960568   PMID:17964599   PMID:17978575  
PMID:18191828   PMID:18202122   PMID:18239846   PMID:18385332   PMID:18430554   PMID:18450967   PMID:18467524   PMID:18551621   PMID:18631385   PMID:19056373   PMID:19104749   PMID:19197368  
PMID:19223768   PMID:19233842   PMID:19377265   PMID:19387418   PMID:19418263   PMID:19447092   PMID:19501060   PMID:19560455   PMID:19601643   PMID:19723499   PMID:19842549   PMID:19949837  
PMID:20007468   PMID:20026202   PMID:20107112   PMID:20147366   PMID:20457802   PMID:20554643   PMID:20610540   PMID:20640531   PMID:20838877   PMID:21085490   PMID:21357689   PMID:21399614  
PMID:21423175   PMID:21438013   PMID:21438014   PMID:21526220   PMID:21572420   PMID:21613513   PMID:21630459   PMID:21718540   PMID:21723926   PMID:21807900   PMID:21808064   PMID:21812984  
PMID:21957496   PMID:22007132   PMID:22076955   PMID:22354948   PMID:22357862   PMID:22389500   PMID:22402347   PMID:22527640   PMID:22674394   PMID:22797923   PMID:22871113   PMID:23193054  
PMID:23376485   PMID:23533145   PMID:23933165   PMID:24006303   PMID:24125809   PMID:24277933   PMID:24349260   PMID:24431445   PMID:24469067   PMID:24585759   PMID:24733293   PMID:24859650  
PMID:24904057   PMID:24912137   PMID:25073061   PMID:25793374   PMID:25802336   PMID:25932647   PMID:26225746   PMID:26258546   PMID:26403276   PMID:26462734   PMID:26475678   PMID:26537248  
PMID:26767953   PMID:27097102   PMID:27105888   PMID:27206677   PMID:27245613   PMID:28077322   PMID:28222740   PMID:28337441   PMID:28463107   PMID:28656205   PMID:28717010   PMID:29473541  
PMID:29476059   PMID:30026308   PMID:30053369   PMID:34817332  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21924,155,081 - 24,178,430 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,155,090 - 24,178,430 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,976,206 - 30,999,561 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01931,630,613 - 31,653,968 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01933,853,335 - 33,876,684 (-)NCBIRnor_WKY
Rnor_6.01925,095,089 - 25,118,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,095,089 - 25,118,860 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,073,104 - 36,096,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,840,795 - 25,864,786 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,845,620 - 25,861,927 (-)NCBI
Celera1923,703,180 - 23,726,723 (-)NCBICelera
Cytogenetic Map19q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381914,091,688 - 14,117,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1914,091,688 - 14,118,084 (-)EnsemblGRCh38hg38GRCh38
GRCh371914,202,500 - 14,228,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,063,500 - 14,089,559 (-)NCBINCBI36Build 36hg18NCBI36
Build 341914,063,508 - 14,085,992NCBI
Celera1914,096,777 - 14,122,833 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,774,379 - 13,800,126 (-)NCBIHuRef
CHM1_11914,202,926 - 14,228,985 (-)NCBICHM1_1
T2T-CHM13v2.01914,218,299 - 14,244,374 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39884,699,607 - 84,723,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,699,622 - 84,723,072 (+)EnsemblGRCm39 Ensembl
GRCm38883,972,978 - 83,996,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,972,993 - 83,996,443 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,496,877 - 86,520,344 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36886,863,093 - 86,886,544 (+)NCBIMGSCv36mm8
Celera888,266,474 - 88,289,645 (+)NCBICelera
Cytogenetic Map8C2NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541532,793,718 - 32,812,930 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,794,172 - 32,807,944 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11918,025,838 - 18,051,913 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01913,657,344 - 13,683,864 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,385,183 - 14,406,205 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,385,191 - 14,406,205 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12048,416,730 - 48,425,237 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,409,045 - 48,426,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,283,546 - 48,299,768 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02048,926,811 - 48,944,065 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,926,580 - 48,944,481 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,138,017 - 48,154,228 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,564,570 - 48,580,793 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,807,387 - 48,823,603 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118207,588,938 - 207,605,559 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,750,537 - 2,765,753 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366592,750,015 - 2,765,914 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl265,074,870 - 65,095,551 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,074,876 - 65,095,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,350,544 - 65,371,236 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1612,743,752 - 12,759,155 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660746,888,080 - 6,914,845 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046249011,319,062 - 1,336,744 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249011,319,426 - 1,336,848 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Prkaca
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:590
Count of miRNA genes:230
Interacting mature miRNAs:278
Transcripts:ENSRNOT00000007281, ENSRNOT00000041717
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,155,247 - 24,155,471 (-)MAPPERmRatBN7.2
Rnor_6.01925,118,479 - 25,118,702NCBIRnor6.0
Rnor_5.01936,096,494 - 36,096,717UniSTSRnor5.0
RGSC_v3.41925,840,962 - 25,841,185UniSTSRGSC3.4
Celera1923,703,347 - 23,703,570UniSTS
Cytogenetic Map19q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,155,451 - 24,155,566 (-)MAPPERmRatBN7.2
Rnor_6.01925,118,384 - 25,118,498NCBIRnor6.0
Rnor_5.01936,096,399 - 36,096,513UniSTSRnor5.0
RGSC_v3.41925,841,166 - 25,841,280UniSTSRGSC3.4
Celera1923,703,551 - 23,703,665UniSTS
Cytogenetic Map19q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,174,399 - 24,174,661 (-)MAPPERmRatBN7.2
Rnor_6.01925,098,864 - 25,099,125NCBIRnor6.0
Rnor_5.01936,076,879 - 36,077,140UniSTSRnor5.0
RGSC_v3.41925,860,749 - 25,861,010UniSTSRGSC3.4
Celera1923,722,943 - 23,723,204UniSTS
Cytogenetic Map19q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000041717   ⟹   ENSRNOP00000044732
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,155,090 - 24,178,430 (-)Ensembl
Rnor_6.0 Ensembl1925,095,089 - 25,118,860 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095425   ⟹   ENSRNOP00000082120
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,155,090 - 24,173,242 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103388   ⟹   ENSRNOP00000076567
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,155,090 - 24,171,305 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107553   ⟹   ENSRNOP00000079272
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,155,090 - 24,172,860 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109274   ⟹   ENSRNOP00000086764
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,155,090 - 24,174,427 (-)Ensembl
RefSeq Acc Id: NM_001100922   ⟹   NP_001094392
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,155,081 - 24,178,430 (-)NCBI
Rnor_6.01925,095,089 - 25,118,869 (+)NCBI
Rnor_5.01936,073,104 - 36,096,884 (+)NCBI
RGSC_v3.41925,840,795 - 25,864,786 (-)RGD
Celera1923,703,180 - 23,726,723 (-)RGD
RefSeq Acc Id: XM_006255219   ⟹   XP_006255281
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,155,081 - 24,174,663 (-)NCBI
Rnor_6.01925,099,001 - 25,117,832 (+)NCBI
Rnor_5.01936,073,104 - 36,096,884 (+)NCBI
RefSeq Acc Id: XM_017601184   ⟹   XP_017456673
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,155,081 - 24,175,513 (-)NCBI
Rnor_6.01925,097,867 - 25,117,832 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001094392   ⟸   NM_001100922
- UniProtKB: A1L1M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255281   ⟸   XM_006255219
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AD31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456673   ⟸   XM_017601184
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000044732   ⟸   ENSRNOT00000041717
RefSeq Acc Id: ENSRNOP00000082120   ⟸   ENSRNOT00000095425
RefSeq Acc Id: ENSRNOP00000086764   ⟸   ENSRNOT00000109274
RefSeq Acc Id: ENSRNOP00000076567   ⟸   ENSRNOT00000103388
RefSeq Acc Id: ENSRNOP00000079272   ⟸   ENSRNOT00000107553
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27791-F1-model_v2 AlphaFold P27791 1-351 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701007
Promoter ID:EPDNEW_R11531
Type:initiation region
Description:protein kinase cAMP-activated catalytic subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01925,095,020 - 25,095,080EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3389 AgrOrtholog
BioCyc Gene G2FUF-6039 BioCyc
Ensembl Genes ENSRNOG00000005257 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000044732 ENTREZGENE
  ENSRNOP00000044732.3 UniProtKB/TrEMBL
  ENSRNOP00000076567.1 UniProtKB/TrEMBL
  ENSRNOP00000079272.1 UniProtKB/TrEMBL
  ENSRNOP00000082120.1 UniProtKB/TrEMBL
  ENSRNOP00000086764.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041717 ENTREZGENE
  ENSRNOT00000041717.5 UniProtKB/TrEMBL
  ENSRNOT00000095425.1 UniProtKB/TrEMBL
  ENSRNOT00000103388.1 UniProtKB/TrEMBL
  ENSRNOT00000107553.1 UniProtKB/TrEMBL
  ENSRNOT00000109274.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STKc_PKA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25636 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkaca PhenoGen
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q6UA68 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Prkaca  protein kinase cAMP-activated catalytic subunit alpha  Prkaca  protein kinase, cAMP-dependent, alpha catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Prkaca  protein kinase, cAMP-dependent, alpha catalytic subunit  Prkaca  protein kinase, cAMP-dependent, catalytic, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Prkaca  protein kinase, cAMP-dependent, catalytic, alpha       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function phosphorylates serine and threonine contained within the motif RRX 724621