Prdx2 (peroxiredoxin 2) - Rat Genome Database

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Gene: Prdx2 (peroxiredoxin 2) Rattus norvegicus
Analyze
Symbol: Prdx2
Name: peroxiredoxin 2
RGD ID: 3838
Description: Predicted to enable thioredoxin peroxidase activity. Involved in negative regulation of neuron apoptotic process and response to oxidative stress. Predicted to be active in cytosol. Orthologous to human PRDX2 (peroxiredoxin 2); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: peroxiredoxin-2; Tdpx1; thiol-specific antioxidant protein; thioredoxin peroxidase 1; thioredoxin-dependent peroxide reductase 1; thioredoxin-dependent peroxiredoxin 2; TSA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,180,927 - 23,186,217 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,180,930 - 23,186,194 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,003,892 - 30,009,102 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,658,254 - 30,663,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01932,880,931 - 32,886,142 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01926,084,816 - 26,090,095 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,084,903 - 26,090,094 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,060,439 - 37,065,718 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,836,199 - 24,841,390 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,841,024 - 24,846,203 (-)NCBI
Celera1922,738,487 - 22,743,678 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
ATP  (EXP)
atrazine  (ISO)
azoxystrobin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calycosin  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
ceruletide  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clotrimazole  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cypermethrin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
diethyldithiocarbamic acid  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
genistein  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
graphite  (ISO)
herbicide  (ISO)
hexachlorobenzene  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
indometacin  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kojic acid  (EXP)
L-ethionine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lycopene  (ISO)
mancozeb  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
microcystin-LR  (EXP)
minocycline  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP,ISO)
omeprazole  (EXP)
ozone  (EXP)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picloram  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
Propiverine  (EXP)
Pyridostigmine bromide  (EXP)
quartz  (ISO)
quercetin  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (ISO)
SB 203580  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP,ISO)
Tributyltin oxide  (EXP)
trichlopyr  (ISO)
trichloroethene  (EXP)
troglitazone  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
withaferin A  (ISO)
zinc atom  (EXP)
zinc protoporphyrin  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury. Boulos S, etal., J Neurosci Res. 2007 Nov 1;85(14):3089-97.
2. Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Chae HZ, etal., Proc Natl Acad Sci U S A 1994 Jul 19;91(15):7017-21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Peroxiredoxin-2 and zinc-alpha-2-glycoprotein as potentially combined novel salivary biomarkers for early detection of oral squamous cell carcinoma using proteomic approaches. Heawchaiyaphum C, etal., J Proteomics. 2018 Feb 20;173:52-61. doi: 10.1016/j.jprot.2017.11.022. Epub 2017 Dec 1.
6. Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients. Ji D, etal., Carcinogenesis. 2013 Jun;34(6):1265-72. doi: 10.1093/carcin/bgt056. Epub 2013 Feb 7.
7. Rat lung peroxiredoxins I and II are differentially regulated during development and by hyperoxia. Kim HS, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1212-7.
8. cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles. Koike E, etal., Toxicol Sci 2002 Jun;67(2):241-6.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8144038   PMID:9115640   PMID:10514471   PMID:10751410   PMID:12688630   PMID:12943237   PMID:15259009   PMID:15489334   PMID:15902258   PMID:16178011   PMID:16290204   PMID:17325201  
PMID:17519234   PMID:17634366   PMID:18491044   PMID:18614015   PMID:19030911   PMID:19182904   PMID:19199708   PMID:20458337   PMID:20568815   PMID:20978343   PMID:21814176   PMID:22166015  
PMID:23106098   PMID:23533145   PMID:24625528   PMID:25002582   PMID:26316108   PMID:26945066   PMID:27082744   PMID:29036266   PMID:29339092   PMID:29476059   PMID:29867124   PMID:30315937  
PMID:30655626   PMID:31273681   PMID:31904090   PMID:32279622   PMID:33268762  


Genomics

Comparative Map Data
Prdx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,180,927 - 23,186,217 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,180,930 - 23,186,194 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,003,892 - 30,009,102 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,658,254 - 30,663,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01932,880,931 - 32,886,142 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01926,084,816 - 26,090,095 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,084,903 - 26,090,094 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,060,439 - 37,065,718 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,836,199 - 24,841,390 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,841,024 - 24,846,203 (-)NCBI
Celera1922,738,487 - 22,743,678 (-)NCBICelera
Cytogenetic Map19q11NCBI
PRDX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,796,823 - 12,801,800 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,796,820 - 12,801,800 (-)EnsemblGRCh38hg38GRCh38
GRCh371912,907,637 - 12,912,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,768,634 - 12,773,694 (-)NCBINCBI36Build 36hg18NCBI36
Build 341912,772,426 - 12,773,694NCBI
Celera1912,797,342 - 12,802,402 (-)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,479,370 - 12,484,460 (-)NCBIHuRef
CHM1_11912,908,110 - 12,913,203 (-)NCBICHM1_1
T2T-CHM13v2.01912,921,315 - 12,926,305 (-)NCBIT2T-CHM13v2.0
Prdx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,696,251 - 85,701,440 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,696,216 - 85,701,463 (+)EnsemblGRCm39 Ensembl
GRCm38884,969,622 - 84,974,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,969,587 - 84,974,834 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,493,547 - 87,498,212 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,859,727 - 87,864,913 (+)NCBIMGSCv36mm8
Celera889,264,392 - 89,268,992 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.4NCBI
Prdx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,880,588 - 31,884,778 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,880,801 - 31,884,453 (-)NCBIChiLan1.0ChiLan1.0
PRDX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11916,726,747 - 16,731,211 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,359,084 - 12,363,552 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,103,422 - 13,107,369 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,103,422 - 13,107,369 (-)Ensemblpanpan1.1panPan2
PRDX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,352,271 - 49,356,755 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,352,266 - 49,356,682 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,226,357 - 49,230,400 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,871,142 - 49,875,184 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,871,137 - 49,875,176 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,082,268 - 49,086,289 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,508,565 - 49,512,576 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,751,214 - 49,755,260 (+)NCBIUU_Cfam_GSD_1.0
Prdx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,456,986 - 208,460,283 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366591,894,423 - 1,897,690 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRDX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,207,828 - 66,212,009 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,207,829 - 66,211,474 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,509,636 - 66,513,280 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRDX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,484,452 - 11,489,067 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,481,784 - 11,489,051 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,306,513 - 8,311,508 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prdx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901406,257 - 410,866 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901407,240 - 410,902 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prdx2
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:47
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000004799
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat

Markers in Region
UniSTS:234183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21151,736,394 - 151,736,491 (+)MAPPERmRatBN7.2
Rnor_6.01162,394,027 - 162,394,123NCBIRnor6.0
Rnor_5.01168,601,156 - 168,601,252UniSTSRnor5.0
RGSC_v3.41154,660,832 - 154,660,928UniSTSRGSC3.4
Celera1149,835,862 - 149,835,958UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map19q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 10 12 12 3 12 39 8 10
Medium 3 33 45 29 16 29 8 11 35 27 31 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004799   ⟹   ENSRNOP00000004799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,180,930 - 23,186,194 (-)Ensembl
Rnor_6.0 Ensembl1926,084,903 - 26,090,094 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101130   ⟹   ENSRNOP00000078297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,182,375 - 23,186,145 (-)Ensembl
RefSeq Acc Id: NM_017169   ⟹   NP_058865
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21923,180,928 - 23,186,122 (-)NCBI
Rnor_6.01926,084,903 - 26,090,094 (+)NCBI
Rnor_5.01937,060,439 - 37,065,718 (+)NCBI
RGSC_v3.41924,836,199 - 24,841,390 (-)RGD
Celera1922,738,487 - 22,743,678 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255244   ⟹   XP_006255306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21923,180,927 - 23,186,217 (-)NCBI
Rnor_6.01926,084,816 - 26,090,095 (+)NCBI
Rnor_5.01937,060,439 - 37,065,718 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058865 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255306 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19959 (Get FASTA)   NCBI Sequence Viewer  
  AAH58481 (Get FASTA)   NCBI Sequence Viewer  
  EDL92175 (Get FASTA)   NCBI Sequence Viewer  
  P35704 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_058865   ⟸   NM_017169
- UniProtKB: Q6PDV3 (UniProtKB/Swiss-Prot),   P35704 (UniProtKB/Swiss-Prot),   A0A0G2JSH9 (UniProtKB/TrEMBL),   A6IY46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255306   ⟸   XM_006255244
- Peptide Label: isoform X1
- UniProtKB: Q6PDV3 (UniProtKB/Swiss-Prot),   P35704 (UniProtKB/Swiss-Prot),   A0A0G2JSH9 (UniProtKB/TrEMBL),   A6IY46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004799   ⟸   ENSRNOT00000004799
RefSeq Acc Id: ENSRNOP00000078297   ⟸   ENSRNOT00000101130
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35704-F1-model_v2 AlphaFold P35704 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3838 AgrOrtholog
BioCyc Gene G2FUF-6135 BioCyc
Ensembl Genes ENSRNOG00000003520 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004799 ENTREZGENE
  ENSRNOP00000004799.2 UniProtKB/TrEMBL
  ENSRNOP00000078297 ENTREZGENE
  ENSRNOP00000078297.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004799 ENTREZGENE
  ENSRNOT00000004799.6 UniProtKB/TrEMBL
  ENSRNOT00000101130 ENTREZGENE
  ENSRNOT00000101130.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6921522 IMAGE-MGC_LOAD
InterPro AhpC/TSA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peroxiredoxin_AhpC-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peroxiredoxin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29338 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72863 IMAGE-MGC_LOAD
NCBI Gene 29338 ENTREZGENE
PANTHER PEROXIREDOXIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN PEROXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 1-cysPrx_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AhpC-TSA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prdx2 PhenoGen
PIRSF AHPC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228632
UniProt A0A0G2JSH9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G2K0_RAT UniProtKB/TrEMBL
  A6IY46 ENTREZGENE, UniProtKB/TrEMBL
  P35704 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6PDV3 ENTREZGENE
UniProt Secondary Q6PDV3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prdx2  peroxiredoxin 2    peroxiredoxin 2   Name updated 1299863 APPROVED
2002-06-10 Prdx2  peroxiredoxin 2       Name updated 70584 APPROVED
2001-12-10 Prdx2  peroxiredoxin 2      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of AhpC/TSA family 70035