Nr3c2 (nuclear receptor subfamily 3, group C, member 2) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Nr3c2 (nuclear receptor subfamily 3, group C, member 2) Rattus norvegicus
Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
RGD ID: 3094
Description: Enables several functions, including DNA binding activity; histone acetyltransferase binding activity; and transcription coactivator binding activity. Involved in cellular response to aldosterone; positive regulation of transcription by RNA polymerase II; and regulation of cell population proliferation. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynaptic active zone cytoplasmic component. Used to study alcohol use disorder; morphine dependence; and polycystic ovary syndrome. Biomarker of alcohol dependence; fetal alcohol spectrum disorder; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2); PARTICIPATES IN aldosterone signaling pathway; amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MCR; mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); Mlr; MR; nuclear receptor subfamily 3 group C member 2
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Salc2   Gmadr1   Bw28  
Candidate Gene For: Salc2 Gmadr1 Bw28 Bw130
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81947,619,853 - 47,964,089 (-)NCBIGRCr8
mRatBN7.21930,715,634 - 31,059,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,715,648 - 31,059,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1937,554,315 - 37,898,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01938,208,168 - 38,552,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01940,460,411 - 40,809,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01934,408,275 - 34,761,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1934,448,289 - 34,752,695 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01945,287,442 - 45,639,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,527,752 - 32,875,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11932,532,632 - 32,880,250 (-)NCBI
Celera1930,192,512 - 30,534,995 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
11-deoxycorticosterone  (EXP)
11-deoxycortisol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acephate  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alachlor  (ISO)
aldosterone  (EXP,ISO)
allethrin  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
beclomethasone  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (EXP,ISO)
betamethasone  (ISO)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bleomycin A2  (EXP)
budesonide  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
caffeine  (EXP)
candesartan  (EXP)
canrenoic acid  (EXP)
carbamazepine  (ISO)
chlormequat chloride  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
corticosterone  (ISO)
cortisol  (ISO)
cortisone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
dimethoate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drospirenone  (EXP)
EC (peptidyl-dipeptidase A) inhibitor  (EXP)
enalapril  (EXP)
enzacamene  (EXP)
eplerenone  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP,ISO)
fipronil  (ISO)
flavonoids  (EXP)
fludrocortisone  (ISO)
flumethasone  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
gypenoside LXXV  (ISO)
hydrochlorothiazide  (EXP)
irinotecan  (EXP)
L-methionine  (ISO)
lycopene  (ISO)
medroxyprogesterone acetate  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
mometasone furoate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
permethrin  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
prednylidene  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
pyrethrins  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
spironolactone  (EXP,ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
terbutylazine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
torasemide  (EXP)
torcetrapib  (ISO)
trametinib  (ISO)
triamcinolone  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP,ISO)
zineb  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. Spironolactone reversed hepato-ovarian triglyceride accumulation caused by letrozole-induced polycystic ovarian syndrome: tissue uric acid-a familiar foe. Adeyanju OA, etal., Naunyn Schmiedebergs Arch Pharmacol. 2020 Jun;393(6):1055-1066. doi: 10.1007/s00210-020-01809-1. Epub 2020 Jan 10.
2. A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans. Aoun EG, etal., Mol Psychiatry. 2018 Jun;23(6):1466-1473. doi: 10.1038/mp.2017.97. Epub 2017 May 2.
3. Blocking the Mineralocorticoid Receptor Improves Cognitive Impairment after Anesthesia/Splenectomy in Rats. Feng X, etal., Int J Med Sci. 2021 Jan 1;18(2):387-397. doi: 10.7150/ijms.48767. eCollection 2021.
4. Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats. Francis J, etal., Am J Physiol Regul Integr Comp Physiol 2003 Feb;284(2):R328-35.
5. Characterization of transactivational property and coactivator mediation of rat mineralocorticoid receptor activation function-1 (AF-1). Fuse H, etal., Mol Endocrinol. 2000 Jun;14(6):889-99. doi: 10.1210/mend.14.6.0467.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated. Ge RS, etal., Mol Cell Endocrinol. 2005 Nov 24;243(1-2):35-42. Epub 2005 Sep 26.
8. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Geller DS, etal., Nat Genet. 1998 Jul;19(3):279-81.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation. Ishizawa K, etal., Hypertension. 2005 Oct;46(4):1046-52. doi: 10.1161/01.HYP.0000172622.51973.f5. Epub 2005 Aug 8.
11. Rapid corticosteroid-dependent regulation of mineralocorticoid receptor protein expression in rat brain. Kalman BA and Spencer RL, Endocrinology 2002 Nov;143(11):4184-95.
12. Marinobufagenin in Urine: A Potential Marker of Predisposition to Ethanol and a Target for Spironolactone. Kashkin VA, etal., Curr Hypertens Rev. 2018;14(1):35-38. doi: 10.2174/1573402114666180212115518.
13. Chronic intermittent stress does not differentially alter brain corticosteroid receptor densities in rats prenatally exposed to ethanol. Kim CK, etal., Psychoneuroendocrinology. 1999 Aug;24(6):585-611. doi: 10.1016/s0306-4530(99)00015-3.
14. Ligand-selective potentiation of rat mineralocorticoid receptor activation function 1 by a CBP-containing histone acetyltransferase complex. Kitagawa H, etal., Mol Cell Biol 2002 Jun;22(11):3698-706.
15. Interactive effects of prenatal alcohol exposure and chronic stress in adulthood on anxiety-like behavior and central stress-related receptor mRNA expression: Sex- and time-dependent effects. Lam VYY, etal., Psychoneuroendocrinology. 2018 Nov;97:8-19. doi: 10.1016/j.psyneuen.2018.06.018. Epub 2018 Jun 23.
16. Prenatal alcohol exposure and prenatal stress differentially alter glucocorticoid signaling in the placenta and fetal brain. Lan N, etal., Neuroscience. 2017 Feb 7;342:167-179. doi: 10.1016/j.neuroscience.2015.08.058. Epub 2015 Sep 2.
17. Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action. Li G, etal., J Biol Chem. 2003 Oct 24;278(43):41779-88. Epub 2003 Aug 5.
18. Steroid receptor heterodimerization demonstrated in vitro and in vivo. Liu W, etal., Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12480-4.
19. Central amygdala mineralocorticoid receptors modulate alcohol self-administration. Makhijani VH, etal., Neuropharmacology. 2020 Dec 15;181:108337. doi: 10.1016/j.neuropharm.2020.108337. Epub 2020 Sep 29.
20. The mineralocorticoid receptor antagonist spironolactone reduces alcohol self-administration in female and male rats. Makhijani VH, etal., Pharmacol Biochem Behav. 2018 Dec;175:10-18. doi: 10.1016/j.pbb.2018.07.011. Epub 2018 Aug 29.
21. Gain of function mutation in the mineralocorticoid receptor of the Brown Norway rat. Marissal-Arvy N, etal., J Biol Chem 2004 Sep 17;279(38):39232-9. Epub 2004 Jul 12.
22. Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats. Mesripour A, etal., Basic Clin Pharmacol Toxicol. 2012 Aug;111(2):75-80. doi: 10.1111/j.1742-7843.2012.00860.x. Epub 2012 Feb 28.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. Nakamura M, etal., J Toxicol Sci. 2018;43(10):611-621. doi: 10.2131/jts.43.611.
25. Spironolactone decreases the somatic signs of opiate withdrawal by blocking the mineralocorticoid receptors (MR). Navarro-Zaragoza J, etal., Toxicology. 2014 Dec 4;326:36-43. doi: 10.1016/j.tox.2014.10.002. Epub 2014 Oct 11.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain. Ngai YF, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R613-22. doi: 10.1152/ajpregu.00075.2015. Epub 2015 Jul 15.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Molecular cloning of a mineralocorticoid (type I) receptor complementary DNA from rat hippocampus. Patel PD, etal., Mol Endocrinol 1989 Nov;3(11):1877-85.
30. Evidence for NL1-independent nuclear translocation of the mineralocorticoid receptor. Pilipuk GP, etal., Biochemistry. 2007 Feb 6;46(5):1389-97.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
33. Localization of mineralocorticoid receptors at mammalian synapses. Prager EM, etal., PLoS One. 2010 Dec 15;5(12):e14344.
34. Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism. Pujo L, etal., Hum Mutat. 2007 Jan;28(1):33-40.
35. Impact of adolescent stress on the expression of stress-related receptors in the hippocampus of animals exposed to alcohol prenatally. Raineki C, etal., Hippocampus. 2018 Mar;28(3):201-216. doi: 10.1002/hipo.22823. Epub 2018 Jan 8.
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Atrial natriuretic peptide inhibits mineralocorticoid receptor function in rat colonic surface cells. Schulman G, etal., J Clin Invest. 1996 Jul 1;98(1):157-66.
39. Basal regulation of HPA and dopamine systems is altered differentially in males and females by prenatal alcohol exposure and chronic variable stress. Uban KA, etal., Psychoneuroendocrinology. 2013 Oct;38(10):1953-66. doi: 10.1016/j.psyneuen.2013.02.017. Epub 2013 Apr 8.
40. Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats. Van Waes V, etal., Eur J Neurosci. 2006 Aug;24(4):1193-200. doi: 10.1111/j.1460-9568.2006.04973.x. Epub 2006 Aug 21.
41. Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus. Wong EY and Herbert J, Eur J Neurosci. 2005 Aug;22(4):785-92.
42. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:7495694   PMID:7982810   PMID:8401570   PMID:9111344   PMID:9677313   PMID:9689096   PMID:10687858   PMID:11809749   PMID:12810555   PMID:12943733   PMID:14960289   PMID:15100355  
PMID:15280098   PMID:15289366   PMID:15699469   PMID:15940303   PMID:15975997   PMID:16580234   PMID:16627578   PMID:17244200   PMID:17347454   PMID:17546625   PMID:17670862   PMID:17715265  
PMID:18337591   PMID:18434352   PMID:18547242   PMID:19007760   PMID:19038868   PMID:19261739   PMID:19433261   PMID:19541744   PMID:19638349   PMID:19819939   PMID:19875699   PMID:19966502  
PMID:20196138   PMID:20421514   PMID:20466668   PMID:20861076   PMID:21135038   PMID:21248754   PMID:22205374   PMID:22371232   PMID:22564091   PMID:22579827   PMID:22871113   PMID:22911865  
PMID:23096235   PMID:23152847   PMID:23290935   PMID:23382219   PMID:23470864   PMID:24040049   PMID:24913911   PMID:25109280   PMID:25555524   PMID:26073023   PMID:26305887   PMID:26336165  
PMID:26403275   PMID:26598419   PMID:27215035   PMID:28324065   PMID:28472300   PMID:28523794   PMID:30769772   PMID:32305433   PMID:32582979   PMID:38255827  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81947,619,853 - 47,964,089 (-)NCBIGRCr8
mRatBN7.21930,715,634 - 31,059,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,715,648 - 31,059,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1937,554,315 - 37,898,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01938,208,168 - 38,552,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01940,460,411 - 40,809,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01934,408,275 - 34,761,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1934,448,289 - 34,752,695 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01945,287,442 - 45,639,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,527,752 - 32,875,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11932,532,632 - 32,880,250 (-)NCBI
Celera1930,192,512 - 30,534,995 (-)NCBICelera
Cytogenetic Map19q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384148,078,764 - 148,445,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4148,078,762 - 148,444,698 (-)EnsemblGRCh38hg38GRCh38
GRCh374148,999,915 - 149,365,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364149,219,370 - 149,582,973 (-)NCBINCBI36Build 36hg18NCBI36
Build 344149,357,524 - 149,721,128NCBI
Celera4146,321,236 - 146,684,999 (-)NCBICelera
Cytogenetic Map4q31.23NCBI
HuRef4144,727,062 - 145,090,717 (-)NCBIHuRef
CHM1_14148,978,561 - 149,342,342 (-)NCBICHM1_1
T2T-CHM13v2.04151,402,689 - 151,769,605 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39877,626,422 - 77,971,641 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl877,626,070 - 77,971,641 (+)EnsemblGRCm39 Ensembl
GRCm38876,898,083 - 77,245,012 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl876,899,442 - 77,245,012 (+)EnsemblGRCm38mm10GRCm38
MGSCv37879,426,407 - 79,767,538 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36879,765,155 - 80,141,081 (+)NCBIMGSCv36mm8
Celera881,194,433 - 81,532,459 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.34NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554713,061,735 - 3,395,520 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554713,059,210 - 3,397,894 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v23145,955,891 - 146,322,035 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14146,318,234 - 146,684,514 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04140,418,624 - 140,785,180 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14152,072,962 - 152,435,965 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4152,108,508 - 152,430,298 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11546,390,030 - 46,718,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1546,390,023 - 46,710,131 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1546,783,147 - 47,111,076 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01547,065,842 - 47,394,398 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1547,065,445 - 47,392,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11546,332,314 - 46,660,048 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01546,430,796 - 46,758,507 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01546,738,917 - 47,073,793 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530143,702,929 - 44,030,134 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365351,140,178 - 1,467,471 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365351,139,687 - 1,467,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl880,312,234 - 80,668,412 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1880,303,172 - 80,669,050 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2885,308,914 - 85,644,752 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1794,574,010 - 94,935,348 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603774,281,853 - 74,644,245 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Nr3c2
1900 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:77
Interacting mature miRNAs:78
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21931,050,713 - 31,051,033 (+)MAPPERmRatBN7.2
Rnor_6.01934,751,833 - 34,752,152NCBIRnor6.0
Rnor_5.01945,630,664 - 45,630,983UniSTSRnor5.0
RGSC_v3.41932,866,199 - 32,866,518UniSTSRGSC3.4
Celera1930,525,825 - 30,526,144UniSTS
Cytogenetic Map19q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21931,050,406 - 31,050,654 (+)MAPPERmRatBN7.2
Rnor_6.01934,751,526 - 34,751,773NCBIRnor6.0
Rnor_5.01945,630,357 - 45,630,604UniSTSRnor5.0
RGSC_v3.41932,865,892 - 32,866,139UniSTSRGSC3.4
Celera1930,525,518 - 30,525,765UniSTS
Cytogenetic Map19q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21930,715,814 - 30,716,011 (+)MAPPERmRatBN7.2
Rnor_6.01934,408,442 - 34,408,638NCBIRnor6.0
Rnor_5.01945,287,609 - 45,287,805UniSTSRnor5.0
RGSC_v3.41932,527,919 - 32,528,115UniSTSRGSC3.4
Celera1930,192,679 - 30,192,875UniSTS
Cytogenetic Map19q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 7 8 1 6 1 4 4 23 22 2 9 4
Low 1 30 47 38 13 38 4 7 41 13 34 2 4
Below cutoff 6 2 2 2 10 5


RefSeq Acc Id: ENSRNOT00000052018   ⟹   ENSRNOP00000045942
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,715,648 - 31,059,885 (-)Ensembl
Rnor_6.0 Ensembl1934,448,289 - 34,752,695 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096148   ⟹   ENSRNOP00000081905
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,715,648 - 31,059,885 (-)Ensembl
RefSeq Acc Id: NM_001395077   ⟹   NP_001382006
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,853 - 47,962,284 (-)NCBI
mRatBN7.21930,715,634 - 31,058,091 (-)NCBI
RefSeq Acc Id: NM_013131   ⟹   NP_037263
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,853 - 47,964,078 (-)NCBI
mRatBN7.21930,715,634 - 31,059,885 (-)NCBI
Rnor_6.01934,408,275 - 34,761,003 (-)NCBI
Rnor_5.01945,287,442 - 45,639,834 (-)NCBI
RGSC_v3.41932,527,752 - 32,875,369 (-)RGD
Celera1930,192,512 - 30,534,995 (-)RGD
RefSeq Acc Id: XM_039097523   ⟹   XP_038953451
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,856 - 47,962,073 (-)NCBI
mRatBN7.21930,718,100 - 31,057,367 (-)NCBI
RefSeq Acc Id: XM_039097524   ⟹   XP_038953452
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,856 - 47,963,488 (-)NCBI
mRatBN7.21930,718,100 - 31,058,171 (-)NCBI
RefSeq Acc Id: XM_039097525   ⟹   XP_038953453
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,856 - 47,964,089 (-)NCBI
mRatBN7.21930,718,100 - 31,059,537 (-)NCBI
RefSeq Acc Id: XM_039097526   ⟹   XP_038953454
Rat AssemblyChrPosition (strand)Source
GRCr81947,619,856 - 47,962,072 (-)NCBI
mRatBN7.21930,718,100 - 31,057,365 (-)NCBI
RefSeq Acc Id: NP_037263   ⟸   NM_013131
- UniProtKB: Q64174 (UniProtKB/Swiss-Prot),   Q63763 (UniProtKB/Swiss-Prot),   P22199 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000045942   ⟸   ENSRNOT00000052018
RefSeq Acc Id: XP_038953453   ⟸   XM_039097525
- Peptide Label: isoform X1
- UniProtKB: Q64174 (UniProtKB/Swiss-Prot),   Q63763 (UniProtKB/Swiss-Prot),   P22199 (UniProtKB/Swiss-Prot),   F1M6V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953452   ⟸   XM_039097524
- Peptide Label: isoform X1
- UniProtKB: Q64174 (UniProtKB/Swiss-Prot),   Q63763 (UniProtKB/Swiss-Prot),   P22199 (UniProtKB/Swiss-Prot),   F1M6V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953451   ⟸   XM_039097523
- Peptide Label: isoform X1
- UniProtKB: Q64174 (UniProtKB/Swiss-Prot),   Q63763 (UniProtKB/Swiss-Prot),   P22199 (UniProtKB/Swiss-Prot),   F1M6V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953454   ⟸   XM_039097526
- Peptide Label: isoform X2
- UniProtKB: Q64174 (UniProtKB/Swiss-Prot),   Q63763 (UniProtKB/Swiss-Prot),   P22199 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000081905   ⟸   ENSRNOT00000096148
RefSeq Acc Id: NP_001382006   ⟸   NM_001395077
- UniProtKB: Q64174 (UniProtKB/Swiss-Prot),   Q63763 (UniProtKB/Swiss-Prot),   P22199 (UniProtKB/Swiss-Prot)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22199-F1-model_v2 AlphaFold P22199 1-981 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3094 AgrOrtholog
BioCyc Gene G2FUF-5900 BioCyc
Ensembl Genes ENSRNOG00000034007 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000052018.5 UniProtKB/TrEMBL
  ENSRNOT00000096148.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25672 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nr3c2 PhenoGen
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000034007 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6G6P1_RAT UniProtKB/TrEMBL
UniProt Secondary Q63763 UniProtKB/Swiss-Prot
  Q64174 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Nr3c2  nuclear receptor subfamily 3, group C, member 2  Mlr  Mineralocorticoid receptor (aldosterone receptor)  Symbol and Name updated 625702 APPROVED
2002-06-10 Mlr  Mineralocorticoid receptor (aldosterone receptor)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression Y73C substitution in the BN/OrlIco strain is associated with increased receptor transactivation by aldosterone and also by progesterone 1302889
gene_process activation in the central nervous system plays a critical role in regulating TNF-alpha release in heart failure 729123