Gene: Nr3c2 (nuclear receptor subfamily 3, group C, member 2) Rattus norvegicus
Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Description: ENCODES a protein that exhibits DNA binding transcription factor activity; double-stranded DNA binding; hormone binding; INVOLVED IN mineralocorticoid receptor signaling pathway; regulation of cell proliferation; cellular sodium ion homeostasis (ortholog); PARTICIPATES IN aldosterone signaling pathway; amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; ASSOCIATED WITH autosomal dominant pseudohypoaldosteronism type 1 (ortholog); dilated cardiomyopathy (ortholog); Endometriosis (ortholog); FOUND IN cytoplasm; nucleus; nucleoplasm (ortholog); INTERACTS WITH (S)-nicotine; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
Also known as: MCR; mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); Mlr; MR; nuclear receptor subfamily 3 group C member 2
Homo sapiens (human) : NR3C2 (nuclear receptor subfamily 3 group C member 2)  HGNC  Alliance
Mus musculus (house mouse) : Nr3c2 (nuclear receptor subfamily 3, group C, member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr3c2 (nuclear receptor subfamily 3 group C member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NR3C2 (nuclear receptor subfamily 3 group C member 2)
Canis lupus familiaris (dog) : NR3C2 (nuclear receptor subfamily 3 group C member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr3c2 (nuclear receptor subfamily 3 group C member 2)
more info ...
Is Marker For: QTLs:   Salc2   Gmadr1   Bw28  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01934,408,275 - 34,761,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01945,287,442 - 45,639,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,527,752 - 32,875,369 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11932,532,632 - 32,880,250 (-)NCBI
Celera1930,192,512 - 30,534,995 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nr3c2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3094
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-04-10
Status: ACTIVE