Nr3c2 (nuclear receptor subfamily 3, group C, member 2) - Rat Genome Database

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Gene: Nr3c2 (nuclear receptor subfamily 3, group C, member 2) Rattus norvegicus
Analyze
Symbol: Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
RGD ID: 3094
Description: Exhibits several functions, including DNA binding activity; identical protein binding activity; and steroid hormone receptor activity. Involved in regulation of cell population proliferation. Localizes to several cellular components, including glutamatergic synapse; postsynaptic density, intracellular component; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2); PARTICIPATES IN aldosterone signaling pathway; amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MCR; mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); Mlr; MR; nuclear receptor subfamily 3 group C member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Salc2   Gmadr1   Bw28  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21930,715,648 - 31,059,885 (-)NCBI
Rnor_6.0 Ensembl1934,448,289 - 34,752,695 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01934,408,275 - 34,761,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01945,287,442 - 45,639,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,527,752 - 32,875,369 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11932,532,632 - 32,880,250 (-)NCBI
Celera1930,192,512 - 30,534,995 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
11-deoxycorticosterone  (EXP)
11-deoxycortisol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acephate  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alachlor  (ISO)
aldosterone  (EXP,ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (EXP,ISO)
betamethasone  (ISO)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bleomycin A2  (EXP)
budesonide  (ISO)
Butylparaben  (EXP)
caffeine  (EXP)
candesartan  (EXP)
canrenoic acid  (EXP)
carbamazepine  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
corticosterone  (ISO)
cortisol  (ISO)
cortisone  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dichlorine  (EXP)
dimethoate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drospirenone  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
enalapril  (EXP)
enzacamene  (EXP)
eplerenone  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (ISO)
fipronil  (ISO)
flavonoids  (EXP)
fludrocortisone  (ISO)
flumethasone  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
hydrochlorothiazide  (EXP)
irinotecan  (EXP)
L-methionine  (ISO)
medroxyprogesterone acetate  (ISO)
methoxychlor  (ISO)
mometasone furoate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
permethrin  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
prednylidene  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
spironolactone  (EXP,ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
terbutylazine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
torasemide  (EXP)
torcetrapib  (ISO)
triamcinolone  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP,ISO)
zineb  (ISO)

References

References - curated
1. Francis J, etal., Am J Physiol Regul Integr Comp Physiol 2003 Feb;284(2):R328-35.
2. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Ge RS, etal., Mol Cell Endocrinol. 2005 Nov 24;243(1-2):35-42. Epub 2005 Sep 26.
4. Geller DS, etal., Nat Genet. 1998 Jul;19(3):279-81.
5. GOA data from the GO Consortium
6. Kalman BA and Spencer RL, Endocrinology 2002 Nov;143(11):4184-95.
7. Kitagawa H, etal., Mol Cell Biol 2002 Jun;22(11):3698-706.
8. Li G, etal., J Biol Chem. 2003 Oct 24;278(43):41779-88. Epub 2003 Aug 5.
9. Liu W, etal., Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12480-4.
10. Marissal-Arvy N, etal., J Biol Chem 2004 Sep 17;279(38):39232-9. Epub 2004 Jul 12.
11. MGD data from the GO Consortium
12. NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline
14. Patel PD, etal., Mol Endocrinol 1989 Nov;3(11):1877-85.
15. Pilipuk GP, etal., Biochemistry. 2007 Feb 6;46(5):1389-97.
16. Pipeline to import KEGG annotations from KEGG into RGD
17. Pipeline to import SMPDB annotations from SMPDB into RGD
18. Prager EM, etal., PLoS One. 2010 Dec 15;5(12):e14344.
19. Pujo L, etal., Hum Mutat. 2007 Jan;28(1):33-40.
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Schulman G, etal., J Clin Invest. 1996 Jul 1;98(1):157-66.
23. Wong EY and Herbert J, Eur J Neurosci. 2005 Aug;22(4):785-92.
24. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:7495694   PMID:7982810   PMID:8401570   PMID:9111344   PMID:9677313   PMID:9689096   PMID:10687858   PMID:11809749   PMID:12810555   PMID:12943733   PMID:14960289   PMID:15100355  
PMID:15280098   PMID:15289366   PMID:15699469   PMID:15940303   PMID:15975997   PMID:16580234   PMID:16627578   PMID:17244200   PMID:17347454   PMID:17546625   PMID:17670862   PMID:17715265  
PMID:18337591   PMID:18434352   PMID:18547242   PMID:19007760   PMID:19038868   PMID:19261739   PMID:19433261   PMID:19541744   PMID:19638349   PMID:19819939   PMID:19875699   PMID:19966502  
PMID:20196138   PMID:20421514   PMID:20466668   PMID:20861076   PMID:21135038   PMID:21248754   PMID:22205374   PMID:22371232   PMID:22564091   PMID:22579827   PMID:22871113   PMID:22911865  
PMID:23096235   PMID:23152847   PMID:23290935   PMID:23382219   PMID:23470864   PMID:24040049   PMID:24913911   PMID:25109280   PMID:25555524   PMID:26073023   PMID:26305887   PMID:26336165  
PMID:26403275   PMID:26598419   PMID:27215035   PMID:28324065   PMID:28472300   PMID:28523794   PMID:30769772   PMID:32305433  


Genomics

Candidate Gene Status
Nr3c2 is a candidate Gene for QTL Salc2
Nr3c2 is a candidate Gene for QTL Gmadr1
Nr3c2 is a candidate Gene for QTL Bw28
Nr3c2 is a candidate Gene for QTL Bw130
Comparative Map Data
Nr3c2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21930,715,648 - 31,059,885 (-)NCBI
Rnor_6.0 Ensembl1934,448,289 - 34,752,695 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01934,408,275 - 34,761,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01945,287,442 - 45,639,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,527,752 - 32,875,369 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11932,532,632 - 32,880,250 (-)NCBI
Celera1930,192,512 - 30,534,995 (-)NCBICelera
Cytogenetic Map19q11NCBI
NR3C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4148,078,762 - 148,444,698 (-)EnsemblGRCh38hg38GRCh38
GRCh384148,078,764 - 148,444,698 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374148,999,915 - 149,365,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364149,219,370 - 149,582,973 (-)NCBINCBI36hg18NCBI36
Build 344149,357,524 - 149,721,128NCBI
Celera4146,321,236 - 146,684,999 (-)NCBI
Cytogenetic Map4q31.23NCBI
HuRef4144,727,062 - 145,090,717 (-)NCBIHuRef
CHM1_14148,978,561 - 149,342,342 (-)NCBICHM1_1
Nr3c2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39877,624,711 - 77,971,641 (+)NCBIGRCm39mm39
GRCm39 Ensembl877,626,070 - 77,971,641 (+)Ensembl
GRCm38876,898,083 - 77,245,012 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl876,899,442 - 77,245,012 (+)EnsemblGRCm38mm10GRCm38
MGSCv37879,426,407 - 79,767,538 (+)NCBIGRCm37mm9NCBIm37
MGSCv36879,765,155 - 80,141,081 (+)NCBImm8
Celera881,194,433 - 81,532,459 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.34NCBI
Nr3c2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554713,061,735 - 3,395,520 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554713,059,210 - 3,397,894 (-)NCBIChiLan1.0ChiLan1.0
NR3C2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14152,072,962 - 152,435,965 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4152,108,508 - 152,430,298 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04140,418,624 - 140,785,180 (-)NCBIMhudiblu_PPA_v0panPan3
NR3C2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11546,390,030 - 46,718,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1546,390,023 - 46,710,131 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1546,783,147 - 47,111,076 (-)NCBI
ROS_Cfam_1.01547,065,842 - 47,394,398 (-)NCBI
UMICH_Zoey_3.11546,332,314 - 46,660,048 (-)NCBI
UNSW_CanFamBas_1.01546,430,796 - 46,758,507 (-)NCBI
UU_Cfam_GSD_1.01546,738,917 - 47,073,793 (-)NCBI
Nr3c2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530143,702,929 - 44,030,134 (+)NCBI
SpeTri2.0NW_0049365351,139,687 - 1,467,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR3C2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl880,290,715 - 80,669,404 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1880,303,172 - 80,669,050 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2885,308,914 - 85,644,752 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR3C2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1794,574,010 - 94,935,348 (-)NCBI

Position Markers
PMC124545P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01934,751,833 - 34,752,152NCBIRnor6.0
Rnor_5.01945,630,664 - 45,630,983UniSTSRnor5.0
RGSC_v3.41932,866,199 - 32,866,518UniSTSRGSC3.4
Celera1930,525,825 - 30,526,144UniSTS
Cytogenetic Map19q11UniSTS
NR3C2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01934,751,526 - 34,751,773NCBIRnor6.0
Rnor_5.01945,630,357 - 45,630,604UniSTSRnor5.0
RGSC_v3.41932,865,892 - 32,866,139UniSTSRGSC3.4
Celera1930,525,518 - 30,525,765UniSTS
Cytogenetic Map19q11UniSTS
RH130444  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01934,408,442 - 34,408,638NCBIRnor6.0
Rnor_5.01945,287,609 - 45,287,805UniSTSRnor5.0
RGSC_v3.41932,527,919 - 32,528,115UniSTSRGSC3.4
Celera1930,192,679 - 30,192,875UniSTS
Cytogenetic Map19q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19138221845Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19138221845Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19138221845Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19138221845Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19104464846044648Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19195770746957707Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19243296347217667Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19243296362275575Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)19370183548701835Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)19370183548701835Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19500757143907843Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19650676160220581Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19807254547318201Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191130392747879277Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191593952838798459Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191702800352538299Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191899398262275575Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191917749562275575Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)192140778762275575Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192445572643907843Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192445762737140233Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192481825762275575Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)193119430141686140Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)193119430141686140Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)193119430141686140Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)193299439262275575Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:77
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000052018
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 7 8 1 6 1 4 4 23 22 2 9 4
Low 1 30 47 38 13 38 4 7 41 13 34 2 4
Below cutoff 6 2 2 2 10 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000052018   ⟹   ENSRNOP00000045942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1934,448,289 - 34,752,695 (-)Ensembl
RefSeq Acc Id: NM_013131   ⟹   NP_037263
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21930,715,648 - 31,059,885 (-)NCBI
Rnor_6.01934,408,275 - 34,761,003 (-)NCBI
Rnor_5.01945,287,442 - 45,639,834 (-)NCBI
RGSC_v3.41932,527,752 - 32,875,369 (-)RGD
Celera1930,192,512 - 30,534,995 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097523   ⟹   XP_038953451
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21930,718,100 - 31,057,367 (-)NCBI
RefSeq Acc Id: XM_039097524   ⟹   XP_038953452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21930,718,100 - 31,058,171 (-)NCBI
RefSeq Acc Id: XM_039097525   ⟹   XP_038953453
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21930,718,100 - 31,059,537 (-)NCBI
RefSeq Acc Id: XM_039097526   ⟹   XP_038953454
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21930,718,100 - 31,057,365 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037263   ⟸   NM_013131
- UniProtKB: P22199 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000045942   ⟸   ENSRNOT00000052018
RefSeq Acc Id: XP_038953453   ⟸   XM_039097525
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953452   ⟸   XM_039097524
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953451   ⟸   XM_039097523
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953454   ⟸   XM_039097526
- Peptide Label: isoform X2
Protein Domains
NR LBD   Nuclear receptor

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3094 AgrOrtholog
Ensembl Genes ENSRNOG00000034007 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000045942 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000052018 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25672 UniProtKB/Swiss-Prot
NCBI Gene 25672 ENTREZGENE
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NR3C2 RGD
PhenoGen Nr3c2 PhenoGen
PRINTS STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1M6V2_RAT UniProtKB/TrEMBL
  MCR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q63763 UniProtKB/Swiss-Prot
  Q64174 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Nr3c2  nuclear receptor subfamily 3, group C, member 2  Mlr  Mineralocorticoid receptor (aldosterone receptor)  Symbol and Name updated 625702 APPROVED
2002-06-10 Mlr  Mineralocorticoid receptor (aldosterone receptor)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression Y73C substitution in the BN/OrlIco strain is associated with increased receptor transactivation by aldosterone and also by progesterone 1302889
gene_process activation in the central nervous system plays a critical role in regulating TNF-alpha release in heart failure 729123