EP300 (E1A binding protein p300) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: EP300 (E1A binding protein p300) Homo sapiens
Symbol: EP300
Name: E1A binding protein p300
RGD ID: 1348463
Description: Enables several functions, including N-acyltransferase activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and beta-catenin binding activity. Involved in several processes, including protein acylation; regulation of nucleobase-containing compound metabolic process; and regulation of signal transduction. Located in cytosol and nucleoplasm. Implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Biomarker of several diseases, including Alzheimer's disease; breast carcinoma; cardiac arrest; clear cell renal cell carcinoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E1A-associated protein p300; E1A-binding protein, 300kD; histone acetyltransferase p300; histone butyryltransferase p300; histone crotonyltransferase p300; KAT3B; MKHK2; p300; p300 HAT; RSTS2
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2241,092,592 - 41,180,077 (+)EnsemblGRCh38hg38GRCh38
GRCh382241,092,592 - 41,180,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372241,488,596 - 41,576,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,818,553 - 39,906,024 (+)NCBINCBI36hg18NCBI36
Build 342239,813,106 - 39,900,578NCBI
Celera2225,294,977 - 25,382,428 (+)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2224,453,007 - 24,540,433 (+)NCBIHuRef
CHM1_12241,448,337 - 41,535,740 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
adenoid cystic carcinoma  (EXP)
Agenesis of Corpus Callosum  (IAGP)
Alzheimer's disease  (IEP)
Brain Hypoxia  (ISO)
breast carcinoma  (IEP)
Breast Neoplasms  (EXP)
cardiac arrest  (IEP)
Cardiomegaly  (ISO)
cardiomyopathy  (IEP)
CHARGE syndrome  (IAGP)
clear cell renal cell carcinoma  (IEP)
colon carcinoma  (IAGP)
colorectal cancer  (IAGP)
Colorectal Neoplasms  (EXP)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (IMP)
Craniofacial Abnormalities  (EXP)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Dwarfism  (IAGP)
Endometrial Neoplasms  (EXP)
Endotoxemia  (ISO)
esophageal carcinoma  (IAGP)
esophagus squamous cell carcinoma  (EXP)
Experimental Diabetes Mellitus  (ISO)
genetic disease  (IAGP)
glomerulonephritis  (IEP)
head and neck squamous cell carcinoma  (IAGP)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (IAGP)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
intellectual disability  (IAGP)
Kidney Reperfusion Injury  (ISO)
Lead Poisoning, Nervous System  (ISO)
lung adenocarcinoma  (EXP)
lung small cell carcinoma  (EXP)
lung squamous cell carcinoma  (IAGP)
medulloblastoma  (IAGP)
melanoma  (EXP)
membranoproliferative glomerulonephritis  (ISO)
Menke-Hennekam Syndrome 2  (IAGP)
microcephaly  (IAGP)
Multicystic Dysplastic Kidney  (IAGP)
Multiple Abnormalities  (IAGP)
nephronophthisis-like nephropathy 1  (IAGP)
Neurodevelopmental Disorders  (IAGP)
obesity  (EXP)
Optic Nerve Injuries  (IMP,ISO)
Painful Neuropathy  (ISO)
prostate cancer  (IEP)
Reperfusion Injury  (ISO)
Rubinstein-Taybi syndrome  (IAGP)
Sepsis  (ISO)
squamous cell carcinoma  (EXP)
Stevens-Johnson syndrome  (EXP)
systemic lupus erythematosus  (ISS)
T-Cell Lymphoma  (EXP)
Thumb Deformity  (IAGP)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (EXP,IAGP)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (EXP)
Uterine Cervical Neoplasms  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
11-deoxycorticosterone  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3-aminobenzamide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
8-Br-cAMP  (EXP)
aconitine  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinyl palmitate  (ISO)
allethrin  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphotericin B  (EXP)
antimycin A  (EXP)
apigenin  (EXP)
apocynin  (EXP)
arsenous acid  (EXP)
azoxystrobin  (EXP)
berberine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (EXP)
butyric acid  (EXP)
cadmium atom  (ISO)
calcitriol  (ISO)
camptothecin  (EXP)
carbon nanotube  (ISO)
casticin  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
cyproterone acetate  (EXP)
D-glucose  (EXP)
deguelin  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (EXP)
dicrotophos  (EXP)
diethylstilbestrol  (EXP,ISO)
dinophysistoxin 1  (EXP)
dioxygen  (EXP)
disodium selenite  (EXP)
doxorubicin  (EXP,ISO)
ellagic acid  (EXP)
entinostat  (EXP)
enzalutamide  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (EXP)
fenpyroximate  (EXP)
fenvalerate  (ISO)
fisetin  (EXP)
flavone  (EXP)
folic acid  (ISO)
furan  (ISO)
galangin  (EXP)
gallic acid  (EXP)
Garcinol  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glucose  (EXP)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
hyaluronic acid  (EXP)
irinotecan  (EXP)
ivermectin  (EXP)
kaempferol  (EXP)
kojic acid  (EXP)
KT 5720  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
LY294002  (ISO)
menadione  (EXP)
miconazole  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
myricetin  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
niclosamide  (EXP)
nitrofen  (ISO)
ochratoxin A  (EXP)
okadaic acid  (EXP)
omeprazole  (EXP)
oxaliplatin  (ISO)
p-menthan-3-ol  (EXP)
phenylephrine  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
picoxystrobin  (EXP)
pirinixic acid  (EXP,ISO)
prochloraz  (ISO)
prostaglandin E2  (EXP)
prostaglandin J2  (EXP)
pyrazinecarboxamide  (ISO)
quercetin  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 203580  (ISO)
scutellarin  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
silicon dioxide  (EXP)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
superoxide  (EXP)
tamoxifen  (EXP)
tetrathiomolybdate(2-)  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (EXP,ISO)
tungsten  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IEA,ISO)
apoptotic process  (IMP)
B cell differentiation  (IEA,ISO)
behavioral defense response  (IEA)
cellular response to antibiotic  (ISO)
cellular response to cAMP  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to mineralocorticoid stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to trichostatin A  (ISO)
cellular response to UV  (IDA)
cellular response to xenobiotic stimulus  (ISO)
chromatin organization  (IEA)
circadian rhythm  (ISS)
digestive tract development  (ISO)
epigenetic maintenance of chromatin in transcription-competent conformation  (IDA)
face morphogenesis  (IEA)
fat cell differentiation  (ISS)
heart development  (IEA,ISO)
histone acetylation  (IBA,IDA,IEA,ISO)
histone H2B acetylation  (IDA)
histone H3 acetylation  (ISO)
histone H3-K56 acetylation  (IEA,ISO)
histone H4 acetylation  (IMP)
internal peptidyl-lysine acetylation  (IDA,ISO)
internal protein amino acid acetylation  (IDA)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IDA)
learning or memory  (IEA)
lung development  (IEA,ISO)
macrophage derived foam cell differentiation  (IDA)
megakaryocyte development  (IEA,ISO)
memory  (ISO)
multicellular organism growth  (IEA)
N-terminal peptidyl-lysine acetylation  (IDA)
negative regulation of cell death  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of gluconeogenesis  (IDA)
negative regulation of miRNA metabolic process  (ISO)
negative regulation of protein-containing complex assembly  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA)
nervous system development  (TAS)
peptidyl-lysine acetylation  (IDA,ISO)
peptidyl-lysine butyrylation  (IDA)
peptidyl-lysine crotonylation  (IDA)
peptidyl-lysine propionylation  (IDA)
platelet formation  (IEA,ISO)
positive regulation by host of viral transcription  (IDA)
positive regulation of axon extension  (ISO)
positive regulation of cell death  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell size  (ISO)
positive regulation of cellular response to hypoxia  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (IDA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of histone acetylation  (ISO)
positive regulation of muscle atrophy  (ISO)
positive regulation of neuron projection development  (IDA)
positive regulation of NF-kappaB transcription factor activity  (IDA)
positive regulation of NIK/NF-kappaB signaling  (IDA)
positive regulation of protein acetylation  (ISO)
positive regulation of protein binding  (IEA,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IDA)
positive regulation of sarcomere organization  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,IMP,ISO)
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  (ISS)
positive regulation of transcription, DNA-templated  (IDA,ISO,TAS)
positive regulation of transforming growth factor beta receptor signaling pathway  (IMP)
positive regulation of translation  (ISO)
protein acetylation  (IDA,TAS)
protein destabilization  (IMP)
protein kinase B signaling  (ISO)
protein stabilization  (ISS)
protein-DNA complex assembly  (ISO)
regulation of androgen receptor signaling pathway  (IDA)
regulation of angiotensin metabolic process  (ISO)
regulation of autophagy  (TAS)
regulation of cellular response to heat  (TAS)
regulation of glycolytic process  (IDA)
regulation of mitochondrion organization  (ISS)
regulation of signal transduction by p53 class mediator  (TAS)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (IEA)
regulation of tubulin deacetylation  (IDA)
response to calcium ion  (ISO)
response to cobalt ion  (ISO)
response to dexamethasone  (ISO)
response to estrogen  (IDA,ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucose  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (IDA,ISO)
response to organic cyclic compound  (ISO)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic process  (IEA)
skeletal muscle tissue development  (IEA,ISO)
somitogenesis  (IEA,ISO)
stimulatory C-type lectin receptor signaling pathway  (TAS)
swimming  (IEA)
thigmotaxis  (IEA)

Cellular Component

Molecular Function
acetyltransferase activity  (EXP,IDA,IMP)
acyltransferase activity  (IDA)
androgen receptor binding  (IPI)
antigen binding  (ISO)
beta-catenin binding  (IPI)
bHLH transcription factor binding  (ISO)
chromatin binding  (IDA,IMP,ISO)
chromatin DNA binding  (IBA,ISO)
cis-regulatory region sequence-specific DNA binding  (ISO)
damaged DNA binding  (IDA)
DNA binding  (IDA)
DNA-binding transcription factor binding  (IEA,IPI,ISO)
glucocorticoid receptor binding  (ISO)
H3 histone acetyltransferase activity  (IDA)
H4 histone acetyltransferase activity  (IDA)
histone acetyltransferase activity  (IBA,IDA,IEA,ISO,TAS)
histone butyryltransferase activity  (IEA)
histone crotonyltransferase activity  (IDA)
histone lactyltransferase activity  (IDA)
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  (IDA)
mitogen-activated protein kinase binding  (ISO)
NF-kappaB binding  (IPI,ISO)
nuclear receptor binding  (IPI)
p53 binding  (IEA,ISO)
peptide 2-hydroxyisobutyryltransferase activity  (IEA)
peptide butyryltransferase activity  (IDA)
peptide N-acetyltransferase activity  (TAS)
peptide-lysine-N-acetyltransferase activity  (TAS)
peroxisome proliferator activated receptor binding  (ISO)
pre-mRNA intronic binding  (IEA)
promoter-specific chromatin binding  (ISO)
protein antigen binding  (ISO)
protein binding  (IPI,ISO)
protein C-terminus binding  (IDA)
protein kinase binding  (ISO)
protein propionyltransferase activity  (IDA)
protein-containing complex binding  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (IPI)
SMAD binding  (ISO)
STAT family protein binding  (IPI)
tau protein binding  (NAS)
transcription coactivator activity  (IBA,IDA,IEA,IMP,IPI,TAS)
transcription coactivator binding  (IPI)
transcription coregulator activity  (IEA)
transcription coregulator binding  (IPI,ISO)
transcription factor binding  (ISO)
zinc ion binding  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal cornea morphology  (IAGP)
Abnormal corpus callosum morphology  (IAGP)
Abnormal facial shape  (IAGP)
Abnormal lateral ventricle morphology  (IAGP)
Abnormal number of teeth  (IAGP)
Abnormal posterior cranial fossa morphology  (IAGP)
Abnormal proximal phalanx morphology of the hand  (IAGP)
Abnormal subclavian artery morphology  (IAGP)
Abnormal thumb morphology  (IAGP)
Abnormality of refraction  (IAGP)
Abnormality of the cervical spine  (IAGP)
Abnormality of the curvature of the vertebral column  (IAGP)
Abnormality of the kidney  (IAGP)
Abnormality of the pinna  (IAGP)
Absent earlobe  (IAGP)
Absent speech  (IAGP)
Adducted thumb  (IAGP)
Aganglionic megacolon  (IAGP)
Agenesis of corpus callosum  (IAGP)
Agenesis of permanent teeth  (IAGP)
Aggressive behavior  (IAGP)
Agoraphobia  (IAGP)
Aortic valve stenosis  (IAGP)
Arnold-Chiari type I malformation  (IAGP)
Arrhythmia  (IAGP)
Aspiration  (IAGP)
Asthma  (IAGP)
Atrial septal defect  (IAGP)
Autism  (IAGP)
Autistic behavior  (IAGP)
Autosomal dominant inheritance  (IAGP)
Avascular necrosis of the capital femoral epiphysis  (IAGP)
Bicuspid aortic valve  (IAGP)
Bifid uterus  (IAGP)
Bimanual synkinesia  (IAGP)
Blepharophimosis  (IAGP)
Brain imaging abnormality  (IAGP)
Broad distal phalanx of finger  (IAGP)
Broad hallux  (IAGP)
Broad thumb  (IAGP)
Cafe-au-lait spot  (IAGP)
Capillary hemangioma  (IAGP)
Cardiac conduction abnormality  (IAGP)
Carious teeth  (IAGP)
Cataract  (IAGP)
Cellular immunodeficiency  (IAGP)
Cervical cord compression  (IAGP)
Chorioretinal dystrophy  (IAGP)
Chronic constipation  (IAGP)
Clinodactyly of the 5th finger  (IAGP)
Coarctation of aorta  (IAGP)
Coloboma  (IAGP)
Colon cancer  (IAGP)
Conductive hearing impairment  (IAGP)
Congenital onset  (IAGP)
Constipation  (IAGP)
Convex nasal ridge  (IAGP)
Corneal scarring  (IAGP)
Cryptorchidism  (IAGP)
Cutaneous syndactyly of toes  (IAGP)
Deep philtrum  (IAGP)
Deeply set eye  (IAGP)
Delayed ability to walk  (IAGP)
Delayed cranial suture closure  (IAGP)
Delayed gross motor development  (IAGP)
Delayed myelination  (IAGP)
Delayed skeletal maturation  (IAGP)
Delayed speech and language development  (IAGP)
Dental crowding  (IAGP)
Dental malocclusion  (IAGP)
Depressed nasal bridge  (IAGP)
Deviated nasal septum  (IAGP)
Deviation of the hallux  (IAGP)
Dislocated radial head  (IAGP)
Downslanted palpebral fissures  (IAGP)
Duane anomaly  (IAGP)
Duodenal ulcer  (IAGP)
Duplication of phalanx of hallux  (IAGP)
EEG abnormality  (IAGP)
Emotional lability  (IAGP)
Enamel hypoplasia  (IAGP)
Epicanthus  (IAGP)
Esophageal carcinoma  (IAGP)
Facial grimacing  (IAGP)
Failure to thrive  (IAGP)
Feeding difficulties  (IAGP)
Feeding difficulties in infancy  (IAGP)
Flared iliac wing  (IAGP)
Flat face  (IAGP)
Flexion contracture  (IAGP)
Frontal bossing  (IAGP)
Frontal upsweep of hair  (IAGP)
Full cheeks  (IAGP)
Gastroesophageal reflux  (IAGP)
Generalized hypotonia  (IAGP)
Glaucoma  (IAGP)
Global developmental delay  (IAGP)
Hearing impairment  (IAGP)
Hereditary nonpolyposis colorectal carcinoma  (IAGP)
Heterogeneous  (IAGP)
High axial triradius  (IAGP)
High palate  (IAGP)
Highly arched eyebrow  (IAGP)
Hip dysplasia  (IAGP)
Hirsutism  (IAGP)
Humoral immunodeficiency  (IAGP)
Hydrocele testis  (IAGP)
Hydronephrosis  (IAGP)
Hyperactivity  (IAGP)
Hypermetropia  (IAGP)
Hyperreflexia  (IAGP)
Hypertelorism  (IAGP)
Hypodontia  (IAGP)
Hypoplasia of the maxilla  (IAGP)
Hypoplastic iliac wing  (IAGP)
Hypospadias  (IAGP)
Hypotonia  (IAGP)
Impaired social interactions  (IAGP)
Impulsivity  (IAGP)
Increased overbite  (IAGP)
Intellectual disability  (IAGP)
Intellectual disability, mild  (IAGP)
Intellectual disability, moderate  (IAGP)
Intestinal malrotation  (IAGP)
Intrauterine growth retardation  (IAGP)
Joint hypermobility  (IAGP)
Joint laxity  (IAGP)
Keloids  (IAGP)
Large foramen magnum  (IAGP)
Laryngeal cartilage malformation  (IAGP)
Laryngomalacia  (IAGP)
Leukemia  (IAGP)
Long eyelashes  (IAGP)
Low anterior hairline  (IAGP)
Low hanging columella  (IAGP)
Low posterior hairline  (IAGP)
Low-set ears  (IAGP)
Medulloblastoma  (IAGP)
Meningioma  (IAGP)
Microcephaly  (IAGP)
Micrognathia  (IAGP)
Multicystic kidney dysplasia  (IAGP)
Myopia  (IAGP)
Narrow mouth  (IAGP)
Narrow nasal bridge  (IAGP)
Narrow palate  (IAGP)
Nasogastric tube feeding in infancy  (IAGP)
Nasolacrimal duct obstruction  (IAGP)
Natal tooth  (IAGP)
Neoplasm of the stomach  (IAGP)
Nephrolithiasis  (IAGP)
Nystagmus  (IAGP)
Obesity  (IAGP)
Obsessive-compulsive behavior  (IAGP)
Obstructive sleep apnea  (IAGP)
Otitis media  (IAGP)
Overlapping toe  (IAGP)
Panic attack  (IAGP)
Papillary cystadenoma of the epididymis  (IAGP)
Parietal foramina  (IAGP)
Patellar dislocation  (IAGP)
Patent ductus arteriosus  (IAGP)
Patent foramen ovale  (IAGP)
Pectus excavatum  (IAGP)
Pes planus  (IAGP)
Phonophobia  (IAGP)
Pilomatrixoma  (IAGP)
Plantar crease between first and second toes  (IAGP)
Pneumonia  (IAGP)
Polydactyly  (IAGP)
Polyhydramnios  (IAGP)
Poor coordination  (IAGP)
Posterior helix pit  (IAGP)
Postnatal growth retardation  (IAGP)
Preeclampsia  (IAGP)
Premature thelarche  (IAGP)
Primary microcephaly  (IAGP)
Prominent fingertip pads  (IAGP)
Prominent forehead  (IAGP)
Prominent nasal septum  (IAGP)
Prominent nose  (IAGP)
Proptosis  (IAGP)
Ptosis  (IAGP)
Pulmonic stenosis  (IAGP)
Radial deviation of thumb terminal phalanx  (IAGP)
Recurrent respiratory infections  (IAGP)
Recurrent upper respiratory tract infections  (IAGP)
Recurrent urinary tract infections  (IAGP)
Renal cell carcinoma  (IAGP)
Respiratory distress  (IAGP)
Retrognathia  (IAGP)
Sandal gap  (IAGP)
Scoliosis  (IAGP)
Secondary microcephaly  (IAGP)
Seizure  (IAGP)
Self-injurious behavior  (IAGP)
Self-mutilation  (IAGP)
Sensorineural hearing impairment  (IAGP)
Shawl scrotum  (IAGP)
Short attention span  (IAGP)
Short palpebral fissure  (IAGP)
Short stature  (IAGP)
Short thumb  (IAGP)
Single transverse palmar crease  (IAGP)
Social and occupational deterioration  (IAGP)
Somatic mutation  (IAGP)
Spina bifida occulta  (IAGP)
Sporadic  (IAGP)
Squamous cell lung carcinoma  (IAGP)
Square face  (IAGP)
Stereotypy  (IAGP)
Strabismus  (IAGP)
Supernumerary tooth  (IAGP)
Syndactyly  (IAGP)
Synophrys  (IAGP)
Syringomyelia  (IAGP)
Talon cusp  (IAGP)
Tethered cord  (IAGP)
Thick eyebrow  (IAGP)
Thin upper lip vermilion  (IAGP)
Transitional cell carcinoma of the bladder  (IAGP)
Trichiasis  (IAGP)
Truncal obesity  (IAGP)
Unsteady gait  (IAGP)
Upslanted palpebral fissure  (IAGP)
Uterine leiomyosarcoma  (IAGP)
Variable expressivity  (IAGP)
Vascular ring  (IAGP)
Ventricular septal defect  (IAGP)
Vesicoureteral reflux  (IAGP)
Wide anterior fontanel  (IAGP)
Wide nasal bridge  (IAGP)
Widened distal phalanges  (IAGP)

References - curated
1. Alamdari N, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R509-20. doi: 10.1152/ajpregu.00858.2009. Epub 2010 Jun 10.
2. Andreassen OA, etal., Neurobiol Dis. 2002 Dec;11(3):410-24.
3. Bartholdi D, etal., J Med Genet. 2007 May;44(5):327-33. Epub 2007 Jan 12.
4. Bomsztyk K, etal., PLoS One. 2013 Jul 30;8(7):e70322. doi: 10.1371/journal.pone.0070322. Print 2013.
5. Chamberlain W, etal., Biochem Cell Biol. 2012 Apr;90(2):200-8. doi: 10.1139/o11-082. Epub 2012 Jan 31.
6. Chiu J, etal., J Mol Cell Cardiol. 2008 Sep;45(3):385-93. Epub 2008 Jul 8.
7. Chiu J, etal., Nutrition. 2009 Mar 4.
8. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
9. Debes JD, etal., Cancer Res. 2003 Nov 15;63(22):7638-40.
10. Duan Y, etal., Exp Cell Res. 2013 Feb 1;319(3):173-84. doi: 10.1016/j.yexcr.2012.11.015. Epub 2012 Dec 2.
11. Emani S, etal., J Thorac Cardiovasc Surg. 2009 Jul;138(1):185-91. Epub 2009 Mar 13.
12. Feng B, etal., Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1119-26. Epub 2008 Apr 15.
13. Feng B, etal., Diabetes. 2011 Nov;60(11):2975-84. doi: 10.2337/db11-0478. Epub 2011 Sep 1.
14. Gaub P, etal., Brain. 2011 Jul;134(Pt 7):2134-48. doi: 10.1093/brain/awr142.
15. GOA_HUMAN data from the GO Consortium
16. Godlewski J, etal., Anticancer Res. 2017 Jun;37(6):2927-2937. doi: 10.21873/anticanres.11646.
17. Haldar SM, etal., Sci Transl Med. 2010 Apr 7;2(26):26ra26. doi: 10.1126/scitranslmed.3000502.
18. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
19. Hansson ML, etal., PLoS One. 2012;7(9):e46001. doi: 10.1371/journal.pone.0046001. Epub 2012 Sep 27.
20. Hong S, etal., Gastroenterology. 2014 Sep 25. pii: S0016-5085(14)01186-X. doi: 10.1053/j.gastro.2014.09.032.
21. Hudelist G, etal., Breast Cancer Res Treat. 2003 Mar;78(2):193-204.
22. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
23. Kassimatis TI, etal., J Cell Mol Med. 2006 Oct-Dec;10(4):908-21.
24. Kato M, etal., Sci Signal. 2013 Jun 4;6(278):ra43. doi: 10.1126/scisignal.2003389.
25. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
26. Luo M, etal., Toxicol Lett. 2014 Feb 10;225(1):78-85. doi: 10.1016/j.toxlet.2013.11.025. Epub 2013 Dec 1.
27. Morimoto T, etal., J Clin Invest. 2008 Mar;118(3):868-78.
28. Ohta K, etal., Biochem J. 2007 Mar 15;402(3):559-66.
29. OMIM Disease Annotation Pipeline
30. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
31. Pipeline to import KEGG annotations from KEGG into RGD
32. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
33. Prajapati KD, etal., Neurol Res. 2012 Jan;34(1):25-31. doi: 10.1179/1743132811Y.0000000052.
34. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. RGD automated import pipeline for gene-chemical interactions
36. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
37. Roelfsema JH, etal., Am J Hum Genet. 2005 Apr;76(4):572-80. Epub 2005 Feb 10.
38. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
39. Takahashi H, etal., Pediatr Surg Int. 2014 Apr;30(4):431-5. doi: 10.1007/s00383-014-3466-1.
40. Tan XL, etal., Brain Res. 2009 Feb 13;1254:1-9. Epub 2008 Dec 10.
41. Wang C, etal., Diabetes Metab Res Rev. 2012 May;28(4):329-37. doi: 10.1002/dmrr.2279.
42. Wei JQ, etal., Circulation. 2008 Aug 26;118(9):934-46. Epub 2008 Aug 12.
43. Wong HK, etal., Hum Mol Genet. 2013 Aug 1;22(15):3077-92. doi: 10.1093/hmg/ddt164. Epub 2013 Apr 11.
44. Xu B, etal., Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):404-12.
45. Yanazume T, etal., Mol Cell Biol. 2003 May;23(10):3593-606.
46. Zhang J, etal., FASEB J. 2014 Mar;28(3):1511-25. doi: 10.1096/fj.13-242693. Epub 2013 Dec 16.
47. Zhang Z, etal., Exp Eye Res. 2012 Jan;94(1):98-108. Epub 2011 Nov 28.
48. Zhu XY, etal., Mol Pain. 2012 Nov 23;8:84. doi: 10.1186/1744-8069-8-84.
Additional References at PubMed
PMID:1331501   PMID:7523245   PMID:7566098   PMID:7758944   PMID:7760804   PMID:7870179   PMID:8621548   PMID:8684459   PMID:8824223   PMID:8889548   PMID:8889549   PMID:8917528  
PMID:8918891   PMID:8945521   PMID:8986769   PMID:8995708   PMID:9001254   PMID:9018065   PMID:9096323   PMID:9194564   PMID:9194565   PMID:9199306   PMID:9267036   PMID:9288740  
PMID:9343424   PMID:9383702   PMID:9407140   PMID:9488451   PMID:9528808   PMID:9560267   PMID:9590696   PMID:9625762   PMID:9652736   PMID:9659901   PMID:9660747   PMID:9660935  
PMID:9679056   PMID:9710619   PMID:9733796   PMID:9733868   PMID:9742083   PMID:9744860   PMID:9773981   PMID:9799238   PMID:9806899   PMID:9809062   PMID:9811832   PMID:9812974  
PMID:9826778   PMID:9843502   PMID:9843571   PMID:9858599   PMID:9859997   PMID:9862959   PMID:9881977   PMID:9887100   PMID:9891054   PMID:9920895   PMID:9989503   PMID:9990060  
PMID:10025406   PMID:10049825   PMID:10075648   PMID:10075656   PMID:10199400   PMID:10205054   PMID:10207070   PMID:10235267   PMID:10327051   PMID:10330164   PMID:10336495   PMID:10347196  
PMID:10350644   PMID:10358095   PMID:10362258   PMID:10364202   PMID:10434034   PMID:10438822   PMID:10440698   PMID:10454341   PMID:10454579   PMID:10464260   PMID:10487758   PMID:10490106  
PMID:10490830   PMID:10497212   PMID:10497242   PMID:10506141   PMID:10518217   PMID:10545121   PMID:10545951   PMID:10567378   PMID:10567390   PMID:10567538   PMID:10575014   PMID:10593900  
PMID:10601022   PMID:10607594   PMID:10648616   PMID:10651903   PMID:10655477   PMID:10656693   PMID:10673036   PMID:10700188   PMID:10702269   PMID:10708567   PMID:10722728   PMID:10733570  
PMID:10753971   PMID:10779504   PMID:10783242   PMID:10801418   PMID:10823961   PMID:10824998   PMID:10825153   PMID:10846067   PMID:10851229   PMID:10866661   PMID:10887155   PMID:10891508  
PMID:10893273   PMID:10899165   PMID:10918613   PMID:10924503   PMID:10933397   PMID:10942770   PMID:10944526   PMID:10973497   PMID:10999956   PMID:11020388   PMID:11029584   PMID:11030335  
PMID:11030627   PMID:11050151   PMID:11058129   PMID:11063749   PMID:11070080   PMID:11073989   PMID:11073990   PMID:11073993   PMID:11080476   PMID:11096067   PMID:11113179   PMID:11116148  
PMID:11118214   PMID:11134049   PMID:11163245   PMID:11196199   PMID:11239394   PMID:11252719   PMID:11264182   PMID:11268218   PMID:11278389   PMID:11278891   PMID:11279157   PMID:11283613  
PMID:11287611   PMID:11296295   PMID:11304541   PMID:11313407   PMID:11314014   PMID:11340085   PMID:11349124   PMID:11359905   PMID:11371641   PMID:11425514   PMID:11430825   PMID:11433299  
PMID:11438528   PMID:11443112   PMID:11448987   PMID:11463815   PMID:11463834   PMID:11481322   PMID:11481323   PMID:11486036   PMID:11500849   PMID:11511361   PMID:11517158   PMID:11533489  
PMID:11547919   PMID:11559821   PMID:11564735   PMID:11564893   PMID:11567019   PMID:11581164   PMID:11581372   PMID:11585920   PMID:11585930   PMID:11604511   PMID:11689053   PMID:11689448  
PMID:11689449   PMID:11691934   PMID:11701890   PMID:11707411   PMID:11726517   PMID:11733503   PMID:11739381   PMID:11744733   PMID:11755530   PMID:11756538   PMID:11773079   PMID:11782371  
PMID:11782467   PMID:11788592   PMID:11804596   PMID:11823643   PMID:11823864   PMID:11830591   PMID:11864601   PMID:11864910   PMID:11867769   PMID:11877444   PMID:11884585   PMID:11896584  
PMID:11907332   PMID:11909954   PMID:11912212   PMID:11923478   PMID:11931765   PMID:11931769   PMID:11940575   PMID:11940591   PMID:11940655   PMID:11940656   PMID:11943779   PMID:11956210  
PMID:11959990   PMID:11964378   PMID:11967287   PMID:11973335   PMID:11978637   PMID:11980644   PMID:11983172   PMID:11994297   PMID:11997499   PMID:12015309   PMID:12034848   PMID:12040021  
PMID:12042299   PMID:12050117   PMID:12071960   PMID:12080085   PMID:12082103   PMID:12101186   PMID:12101239   PMID:12107188   PMID:12107410   PMID:12136661   PMID:12162806   PMID:12189208  
PMID:12200149   PMID:12208951   PMID:12237408   PMID:12242694   PMID:12244100   PMID:12297501   PMID:12368347   PMID:12371907   PMID:12379213   PMID:12379484   PMID:12384515   PMID:12391150  
PMID:12402037   PMID:12403783   PMID:12408818   PMID:12408825   PMID:12419806   PMID:12435739   PMID:12437352   PMID:12446687   PMID:12453427   PMID:12456660   PMID:12471036   PMID:12473110  
PMID:12477932   PMID:12479814   PMID:12482752   PMID:12482985   PMID:12483531   PMID:12498683   PMID:12499368   PMID:12501250   PMID:12514134   PMID:12527917   PMID:12569362   PMID:12569367  
PMID:12574227   PMID:12586840   PMID:12588875   PMID:12604599   PMID:12609999   PMID:12640139   PMID:12646247   PMID:12649209   PMID:12651889   PMID:12665587   PMID:12690203   PMID:12696060  
PMID:12697832   PMID:12714702   PMID:12718889   PMID:12724314   PMID:12730195   PMID:12732631   PMID:12738788   PMID:12743039   PMID:12743606   PMID:12748286   PMID:12750254   PMID:12754253  
PMID:12758070   PMID:12776737   PMID:12778114   PMID:12788643   PMID:12789259   PMID:12840021   PMID:12861022   PMID:12887902   PMID:12888487   PMID:12904943   PMID:12914934   PMID:12917345  
PMID:12929931   PMID:12937166   PMID:12941701   PMID:12960163   PMID:12970734   PMID:12972427   PMID:14550555   PMID:14576772   PMID:14585496   PMID:14605447   PMID:14612398   PMID:14612417  
PMID:14612423   PMID:14615581   PMID:14630807   PMID:14633989   PMID:14645221   PMID:14662860   PMID:14668346   PMID:14691252   PMID:14691445   PMID:14701856   PMID:14716005   PMID:14722092  
PMID:14726487   PMID:14747462   PMID:14752053   PMID:14752096   PMID:14755691   PMID:14759370   PMID:14761960   PMID:14767476   PMID:14966293   PMID:14968110   PMID:14976201   PMID:14985122  
PMID:14988403   PMID:15001660   PMID:15004546   PMID:15013777   PMID:15023334   PMID:15024082   PMID:15060161   PMID:15066326   PMID:15075319   PMID:15102857   PMID:15117818   PMID:15123636  
PMID:15123817   PMID:15133024   PMID:15136563   PMID:15136591   PMID:15138260   PMID:15142377   PMID:15145939   PMID:15146197   PMID:15154850   PMID:15155277   PMID:15171254   PMID:15171256  
PMID:15175157   PMID:15175427   PMID:15186775   PMID:15189737   PMID:15192014   PMID:15220332   PMID:15224190   PMID:15225550   PMID:15261140   PMID:15280364   PMID:15282304   PMID:15295102  
PMID:15297880   PMID:15308641   PMID:15308690   PMID:15315758   PMID:15333839   PMID:15337767   PMID:15342390   PMID:15345715   PMID:15350211   PMID:15380363   PMID:15454570   PMID:15494311  
PMID:15509808   PMID:15542844   PMID:15546612   PMID:15558054   PMID:15572674   PMID:15572696   PMID:15588252   PMID:15598887   PMID:15611041   PMID:15615775   PMID:15616592   PMID:15623506  
PMID:15632055   PMID:15632193   PMID:15641773   PMID:15647825   PMID:15649887   PMID:15653507   PMID:15664194   PMID:15668237   PMID:15674325   PMID:15688032   PMID:15691758   PMID:15701643  
PMID:15705864   PMID:15718293   PMID:15725353   PMID:15731352   PMID:15735682   PMID:15782138   PMID:15806138   PMID:15824515   PMID:15834423   PMID:15843474   PMID:15890677   PMID:15893728  
PMID:15917652   PMID:15932940   PMID:15933712   PMID:15943569   PMID:15951563   PMID:15961999   PMID:15964811   PMID:15965232   PMID:15987677   PMID:16001085   PMID:16024799   PMID:16051665  
PMID:16081065   PMID:16096645   PMID:16102021   PMID:16107701   PMID:16109717   PMID:16122695   PMID:16126174   PMID:16135789   PMID:16135803   PMID:16150697   PMID:16169070   PMID:16170350  
PMID:16179804   PMID:16189267   PMID:16204234   PMID:16219772   PMID:16227615   PMID:16264271   PMID:16287840   PMID:16291753   PMID:16319895   PMID:16325578   PMID:16326861   PMID:16332960  
PMID:16337145   PMID:16344560   PMID:16356938   PMID:16397300   PMID:16415179   PMID:16438982   PMID:16461764   PMID:16478997   PMID:16516194   PMID:16537907   PMID:16537920   PMID:16543236  
PMID:16581781   PMID:16582966   PMID:16601680   PMID:16611888   PMID:16613856   PMID:16617102   PMID:16622451   PMID:16630816   PMID:16636310   PMID:16645043   PMID:16648821   PMID:16652169  
PMID:16672693   PMID:16678111   PMID:16687403   PMID:16696975   PMID:16704985   PMID:16708385   PMID:16712791   PMID:16717280   PMID:16728531   PMID:16734381   PMID:16760386   PMID:16782091  
PMID:16787918   PMID:16804902   PMID:16809786   PMID:16847340   PMID:16864582   PMID:16876108   PMID:16878158   PMID:16916636   PMID:16916647   PMID:16917507   PMID:16922677   PMID:16923966  
PMID:16928824   PMID:16930961   PMID:16931570   PMID:16959611   PMID:16990252   PMID:17050667   PMID:17050673   PMID:17065153   PMID:17065349   PMID:17073437   PMID:17075044   PMID:17126870  
PMID:17150957   PMID:17157259   PMID:17158926   PMID:17182677   PMID:17189186   PMID:17217336   PMID:17226766   PMID:17237818   PMID:17250547   PMID:17267393   PMID:17272271   PMID:17289570  
PMID:17299436   PMID:17304221   PMID:17382325   PMID:17392787   PMID:17403783   PMID:17410209   PMID:17438265   PMID:17452980   PMID:17468099   PMID:17469184   PMID:17475621   PMID:17476304  
PMID:17502379   PMID:17510411   PMID:17525731   PMID:17623675   PMID:17641689   PMID:17661632   PMID:17692505   PMID:17707401   PMID:17761950   PMID:17872950   PMID:17882273   PMID:17884810  
PMID:17906639   PMID:17906695   PMID:17906698   PMID:17908689   PMID:17923090   PMID:17964260   PMID:17970752   PMID:17975022   PMID:17977830   PMID:17982102   PMID:18029348   PMID:18047470  
PMID:18055455   PMID:18070920   PMID:18089809   PMID:18160048   PMID:18182168   PMID:18215124   PMID:18226242   PMID:18243116   PMID:18252717   PMID:18263614   PMID:18268343   PMID:18280497  
PMID:18391200   PMID:18397880   PMID:18408753   PMID:18418072   PMID:18451878   PMID:18458062   PMID:18485870   PMID:18487222   PMID:18495195   PMID:18509338   PMID:18542060   PMID:18552833  
PMID:18559531   PMID:18566411   PMID:18583929   PMID:18612383   PMID:18644873   PMID:18660489   PMID:18663001   PMID:18678383   PMID:18690848   PMID:18722353   PMID:18760861   PMID:18765668  
PMID:18782771   PMID:18786403   PMID:18797151   PMID:18809579   PMID:18838386   PMID:18850005   PMID:18854154   PMID:18950845   PMID:18995842   PMID:19001415   PMID:19041714   PMID:19047049  
PMID:19062177   PMID:19064572   PMID:19064921   PMID:19071119   PMID:19074848   PMID:19124466   PMID:19124506   PMID:19132086   PMID:19146826   PMID:19166313   PMID:19183483   PMID:19188451  
PMID:19200568   PMID:19203349   PMID:19217391   PMID:19218448   PMID:19234109   PMID:19270680   PMID:19273602   PMID:19275580   PMID:19275588   PMID:19275888   PMID:19276081   PMID:19279113  
PMID:19281832   PMID:19297328   PMID:19299466   PMID:19332536   PMID:19336370   PMID:19339993   PMID:19344692   PMID:19353645   PMID:19395477   PMID:19419955   PMID:19456861   PMID:19489936  
PMID:19526283   PMID:19539243   PMID:19569050   PMID:19570987   PMID:19589782   PMID:19592618   PMID:19596656   PMID:19622798   PMID:19666581   PMID:19680224   PMID:19696166   PMID:19710011  
PMID:19716452   PMID:19730683   PMID:19732026   PMID:19754958   PMID:19801601   PMID:19805293   PMID:19812265   PMID:19828133   PMID:19838210   PMID:19880525   PMID:19880750   PMID:19883617  
PMID:19887647   PMID:19913121   PMID:19915063   PMID:19934257   PMID:19940151   PMID:19948376   PMID:19961954   PMID:19966416   PMID:19995069   PMID:19996091   PMID:20000859   PMID:20012529  
PMID:20014264   PMID:20018936   PMID:20019387   PMID:20065107   PMID:20069553   PMID:20081228   PMID:20089040   PMID:20101207   PMID:20107328   PMID:20154269   PMID:20226045   PMID:20227660  
PMID:20228809   PMID:20234175   PMID:20301390   PMID:20301699   PMID:20333651   PMID:20347598   PMID:20348541   PMID:20364308   PMID:20368990   PMID:20388208   PMID:20418869   PMID:20438716  
PMID:20448036   PMID:20452968   PMID:20471956   PMID:20505343   PMID:20534441   PMID:20564330   PMID:20578042   PMID:20587414   PMID:20590529   PMID:20603618   PMID:20604809   PMID:20609350  
PMID:20620956   PMID:20628086   PMID:20660480   PMID:20663877   PMID:20676058   PMID:20711222   PMID:20716062   PMID:20717166   PMID:20720004   PMID:20808282   PMID:20810990   PMID:20817729  
PMID:20829524   PMID:20851880   PMID:20856196   PMID:20859991   PMID:20869593   PMID:20870727   PMID:20932315   PMID:20935208   PMID:20936779   PMID:21030595   PMID:21041953   PMID:21057544  
PMID:21079652   PMID:21102443   PMID:21108945   PMID:21131905   PMID:21148070   PMID:21179216   PMID:21187066   PMID:21187340   PMID:21204735   PMID:21205329   PMID:21212407   PMID:21232847  
PMID:21245169   PMID:21252119   PMID:21268077   PMID:21268080   PMID:21282530   PMID:21304179   PMID:21357426   PMID:21390126   PMID:21413932   PMID:21444723   PMID:21471221   PMID:21482710  
PMID:21483817   PMID:21489275   PMID:21493871   PMID:21513714   PMID:21524463   PMID:21525722   PMID:21565167   PMID:21567395   PMID:21620138   PMID:21629263   PMID:21669392   PMID:21669397  
PMID:21670263   PMID:21697490   PMID:21701559   PMID:21726808   PMID:21764211   PMID:21764752   PMID:21775285   PMID:21789216   PMID:21791614   PMID:21812888   PMID:21828133   PMID:21857970  
PMID:21873635   PMID:21875947   PMID:21901101   PMID:21903422   PMID:21937452   PMID:21951552   PMID:21967847   PMID:21988832   PMID:22013068   PMID:22013210   PMID:22033265   PMID:22071692  
PMID:22074660   PMID:22075993   PMID:22100137   PMID:22100894   PMID:22116549   PMID:22132193   PMID:22177454   PMID:22179676   PMID:22203677   PMID:22207202   PMID:22219185   PMID:22227192  
PMID:22227247   PMID:22231458   PMID:22266186   PMID:22303793   PMID:22318730   PMID:22365546   PMID:22384255   PMID:22387215   PMID:22415975   PMID:22440742   PMID:22474372   PMID:22544934  
PMID:22578841   PMID:22672907   PMID:22684029   PMID:22709982   PMID:22731250   PMID:22735262   PMID:22770219   PMID:22778253   PMID:22787115   PMID:22789427   PMID:22807441   PMID:22810585  
PMID:22810586   PMID:22908229   PMID:22936669   PMID:23001041   PMID:23010591   PMID:23065768   PMID:23121466   PMID:23125313   PMID:23133622   PMID:23145062   PMID:23172223   PMID:23184057  
PMID:23269275   PMID:23275444   PMID:23285190   PMID:23307557   PMID:23329847   PMID:23384777   PMID:23402884   PMID:23403292   PMID:23407894   PMID:23415232   PMID:23419874   PMID:23437037  
PMID:23441852   PMID:23443559   PMID:23448368   PMID:23455922   PMID:23461825   PMID:23523631   PMID:23559008   PMID:23587423   PMID:23589370   PMID:23602568   PMID:23602572   PMID:23618863  
PMID:23640055   PMID:23643164   PMID:23670564   PMID:23708658   PMID:23714681   PMID:23728348   PMID:23746844   PMID:23759652   PMID:23762317   PMID:23770402   PMID:23792675   PMID:23796514  
PMID:23811396   PMID:23863879   PMID:23870121   PMID:23880157   PMID:23880760   PMID:23934153   PMID:23962722   PMID:23966271   PMID:23986795   PMID:23999430   PMID:24001231   PMID:24042437  
PMID:24058639   PMID:24096006   PMID:24101509   PMID:24112038   PMID:24142575   PMID:24157709   PMID:24158816   PMID:24167073   PMID:24229708   PMID:24236097   PMID:24255919   PMID:24270407  
PMID:24270410   PMID:24278015   PMID:24338025   PMID:24382891   PMID:24413532   PMID:24419059   PMID:24421387   PMID:24457600   PMID:24468085   PMID:24469461   PMID:24476420   PMID:24480624  
PMID:24529102   PMID:24530506   PMID:24551300   PMID:24581496   PMID:24636898   PMID:24722339