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Gene: EP300 (E1A binding protein p300) Homo sapiens
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Symbol: EP300
Name: E1A binding protein p300
Description: Exhibits several functions, including DNA binding activity; N-acyltransferase activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including protein acylation; regulation of nucleobase-containing compound metabolic process; and regulation of signal transduction. Localizes to cytosol and nucleoplasm. Implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Biomarker of several diseases, including Alzheimer's disease; breast carcinoma; cardiac arrest; clear cell renal cell carcinoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E1A-associated protein p300; E1A-binding protein, 300kD; histone acetyltransferase p300; histone butyryltransferase p300; histone crotonyltransferase p300; KAT3B; MKHK2; p300; p300 HAT; RSTS2
Orthologs:
Mus musculus (house mouse) : Ep300 (E1A binding protein p300)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ep300 (E1A binding protein p300)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ep300 (E1A binding protein p300)
Pan paniscus (bonobo/pygmy chimpanzee) : EP300 (E1A binding protein p300)
Canis lupus familiaris (dog) : EP300 (E1A binding protein p300)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ep300 (E1A binding protein p300)
Sus scrofa (pig) : EP300 (E1A binding protein p300)
Chlorocebus sabaeus (African green monkey) : EP300 (E1A binding protein p300)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2241,092,592 - 41,180,077 (+)EnsemblGRCh38hg38GRCh38
GRCh382241,092,592 - 41,180,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372241,488,614 - 41,576,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,818,553 - 39,906,024 (+)NCBINCBI36hg18NCBI36
Build 342239,813,106 - 39,900,578NCBI
Celera2225,294,977 - 25,382,428 (+)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2224,453,007 - 24,540,433 (+)NCBIHuRef
CHM1_12241,448,337 - 41,535,740 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants